Search Results - "COOPERSMITH, Craig M"

Redefining the gut as the motor of critical illness by Mittal, Rohit, Coopersmith, Craig M

“…Highlights • Critical illness alters apoptosis, permeability, proliferation, and mucus integrity. • Toxic gut-derived lymph induces distant organ damage. •…”
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The Gut as the Motor of Multiple Organ Dysfunction in Critical Illness by Klingensmith, Nathan J., MD, Coopersmith, Craig M., MD

“…All elements of the gut - the epithelium, the immune system, and the microbiome - are impacted by critical illness and can, in turn, propagate a pathologic…”
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Gut integrity in critical illness by Otani, Shunsuke, Coopersmith, Craig M

“…The gut is hypothesized to be the "motor" of critical illness. Under basal conditions, the gut plays a crucial role in the maintenance of health. However, in…”
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The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) by Singer, Mervyn, Deutschman, Clifford S, Seymour, Christopher Warren, Shankar-Hari, Manu, Annane, Djillali, Bauer, Michael, Bellomo, Rinaldo, Bernard, Gordon R, Chiche, Jean-Daniel, Coopersmith, Craig M, Hotchkiss, Richard S, Levy, Mitchell M, Marshall, John C, Martin, Greg S, Opal, Steven M, Rubenfeld, Gordon D, van der Poll, Tom, Vincent, Jean-Louis, Angus, Derek C

“…IMPORTANCE: Definitions of sepsis and septic shock were last revised in 2001. Considerable advances have since been made into the pathobiology (changes in…”
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Immune Checkpoint Inhibition in Sepsis: A Phase 1b Randomized, Placebo-Controlled, Single Ascending Dose Study of Antiprogrammed Cell Death-Ligand 1 Antibody (BMS-936559) by Hotchkiss, Richard S., Colston, Elizabeth, Yende, Sachin, Angus, Derek C., Moldawer, Lyle L., Crouser, Elliott D., Martin, Greg S., Coopersmith, Craig M., Brakenridge, Scott, Mayr, Florian B., Park, Pauline K., Ye, June, Catlett, Ian M., Girgis, Ihab G., Grasela, Dennis M.

“…OBJECTIVES:To assess for the first time the safety and pharmacokinetics of an antiprogrammed cell death-ligand 1 immune checkpoint inhibitor (BMS-936559;…”
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Surviving sepsis campaign: research priorities for sepsis and septic shock by Coopersmith, Craig M., De Backer, Daniel, Deutschman, Clifford S., Ferrer, Ricard, Lat, Ishaq, Machado, Flavia R., Martin, Greg S., Martin-Loeches, Ignacio, Nunnally, Mark E., Antonelli, Massimo, Evans, Laura E., Hellman, Judith, Jog, Sameer, Kesecioglu, Jozef, Levy, Mitchell M., Rhodes, Andrew

“…Objective To identify research priorities in the management, epidemiology, outcome and underlying causes of sepsis and septic shock. Design A consensus…”
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Targeting AMP-activated protein kinase in sepsis by Yumoto, Tetsuya, Coopersmith, Craig M

“…Sepsis is a global health challenge marked by limited clinical options and high mortality rates. AMP-activated protein kinase (AMPK) is a cellular energy…”
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Mechanisms of Intestinal Barrier Dysfunction in Sepsis by Yoseph, Benyam P, Klingensmith, Nathan J, Liang, Zhe, Breed, Elise R, Burd, Eileen M, Mittal, Rohit, Dominguez, Jessica A, Petrie, Benjamin, Ford, Mandy L, Coopersmith, Craig M

“…ABSTRACTIntestinal barrier dysfunction is thought to contribute to the development of multiple organ dysfunction syndrome in sepsis. Although there are…”
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Immune checkpoint inhibition in sepsis: a Phase 1b randomized study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of nivolumab by Hotchkiss, Richard S., Colston, Elizabeth, Yende, Sachin, Crouser, Elliott D., Martin, Greg S., Albertson, Timothy, Bartz, Raquel R., Brakenridge, Scott C., Delano, Matthew J., Park, Pauline K., Donnino, Michael W., Tidswell, Mark, Mayr, Florian B., Angus, Derek C., Coopersmith, Craig M., Moldawer, Lyle L., Catlett, Ian M., Girgis, Ihab G., Ye, June, Grasela, Dennis M.

“…Purpose Sepsis-associated immunosuppression increases hospital-acquired infection and viral reactivation risk. A key underlying mechanism is programmed cell…”
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OXIDATIVE study: A pilot prospective observational cohort study protocol examining the influence of peri-reperfusion hyperoxemia and immune dysregulation on early allograft dysfunction after orthotopic liver transplantation by Wilson, Elizabeth A, Woodbury, Anna, Williams, Kirsten M, Coopersmith, Craig M

“…Early allograft dysfunction (EAD) is a functional hepatic insufficiency within a week of orthotopic liver transplantation (OLT) and is associated with…”
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The Sequential Organ Failure Assessment (SOFA) Score: has the time come for an update? by Moreno, Rui, Rhodes, Andrew, Piquilloud, Lise, Hernandez, Glenn, Takala, Jukka, Gershengorn, Hayley B, Tavares, Miguel, Coopersmith, Craig M, Myatra, Sheila N, Singer, Mervyn, Rezende, Ederlon, Prescott, Hallie C, Soares, Márcio, Timsit, Jean-François, de Lange, Dylan W, Jung, Christian, De Waele, Jan J, Martin, Greg S, Summers, Charlotte, Azoulay, Elie, Fujii, Tomoko, McLean, Anthony S, Vincent, Jean-Louis

“…The Sequential Organ Failure Assessment (SOFA) score was developed more than 25 years ago to provide a simple method of assessing and monitoring organ…”
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The microbiome restrains melanoma bone growth by promoting intestinal NK and Th1 cell homing to bone by Pal, Subhashis, Perrien, Daniel S, Yumoto, Tetsuya, Faccio, Roberta, Stoica, Andreea, Adams, Jonathan, Coopersmith, Craig M, Jones, Rheinallt M, Weitzmann, M Neale, Pacifici, Roberto

“…Bone metastases are frequent complications of malignant melanoma leading to reduced quality of life and significant morbidity. Regulation of immune cells by…”
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IL-17, IL-27, and IL-33: A Novel Axis Linked to Immunological Dysfunction During Sepsis by Morrow, Kristen N, Coopersmith, Craig M, Ford, Mandy L

“…Sepsis is a major cause of morbidity and mortality worldwide despite numerous attempts to identify effective therapeutics. While some sepsis deaths are…”
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Cancer and sepsis by Williams, Jeroson C, Ford, Mandy L, Coopersmith, Craig M

“…Sepsis is one of the leading causes of death worldwide. While mortality is high regardless of inciting infection or comorbidities, mortality in patients with…”
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Cell death proteins in sepsis: key players and modern therapeutic approaches by Yang, Chloe S, Coopersmith, Craig M, Lyons, John D

“…Cell death proteins play a central role in host immune signaling during sepsis. These interconnected mechanisms trigger cell demise via apoptosis, necroptosis,…”
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Overexpression of BCL-2 in the Intestinal Epithelium Prevents Sepsis-Induced Gut Barrier Dysfunction via Altering Tight Junction Protein Expression by Otani, Shunsuke, Oami, Takehiko, Yoseph, Benyam P., Klingensmith, Nathan J., Chen, Ching-wen, Liang, Zhe, Coopersmith, Craig M.

“…ABSTRACTSepsis induces both intestinal hyperpermeability and epithelial apoptosis. While each has been implicated in mediating sepsis mortality, the…”
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Characterization and Modulation of the Immunosuppressive Phase of Sepsis by Muenzer, Jared T, Davis, Christopher G, Chang, Kathy, Schmidt, Robert E, Dunne, W. Michael, Coopersmith, Craig M, Hotchkiss, Richard S

“…Sepsis continues to cause significant morbidity and mortality in critically ill patients. Studies of patients and animal models have revealed that changes in…”
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Sepsis National Hospital Inpatient Quality Measure (SEP-1): Multistakeholder Work Group Recommendations for Appropriate Antibiotics for the Treatment of Sepsis by Septimus, Edward J., Coopersmith, Craig M., Whittle, Jessica, Hale, Caleb P., Fishman, Neil O., Kim, Thomas J.

“…The Center for Medicare and Medicaid Services adopted the Early Management Bundle, Severe Sepsis/Septic Shock (SEP-1) performance measure to the Hospital…”
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Metabolic support in the critically ill: a consensus of 19 by Wernerman, Jan, Christopher, Kenneth B, Annane, Djillali, Casaer, Michael P, Coopersmith, Craig M, Deane, Adam M, De Waele, Elisabeth, Elke, Gunnar, Ichai, Carole, Karvellas, Constantine J, McClave, Stephen A, Oudemans-van Straaten, Heleen M, Rooyackers, Olav, Stapleton, Renee D, Takala, Jukka, van Zanten, Arthur R H, Wischmeyer, Paul E, Preiser, Jean-Charles, Vincent, Jean-Louis

“…Metabolic alterations in the critically ill have been studied for more than a century, but the heterogeneity of the critically ill patient population, the…”
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Critical Care Organizations: Business of Critical Care and Value/Performance Building by Leung, Sharon, Gregg, Sara R., Coopersmith, Craig M., Layon, A. Joseph, Oropello, John, Brown, Daniel R., Pastores, Stephen M., Kvetan, Vladimir

“…OBJECTIVE:New, value-based regulations and reimbursement structures are creating historic care management challenges, thinning the margins and threatening the…”
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