Search Results - "COOPER, TYLER"

Wounding the stroma: Docetaxel’s role in dormant breast cancer escape by Cooper, Tyler T, Postovit, Lynne-Marie

“…The mechanistic underpinnings of breast cancer recurrence following periods of dormancy are largely undetermined. A new study in PLOS Biology reveals that…”
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Analytical Considerations in Nanoscale Flow Cytometry of Extracellular Vesicles to Achieve Data Linearity by Gomes, Janice, Lucien, Fabrice, Cooper, Tyler T, Kim, Yohan, Williams, Karla C, Liao, XinYang, Kaufman, Lauren, Lagugné-Labarthet, Francois, Kenyon, Oliver, Boysen, Justin, Kay, Neil E, McIntyre, Christopher W, Leong, Hon S

“…Platelet microparticles (PMPs) and their abundance in the blood are a prognostic biomarker in thrombotic disorders and cancer. Nanoscale flow cytometry (nFC)…”
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Lactate Enhances Mouse ES Cell Differentiation Toward XEN Cells In Vitro by Gatie, Mohamed I, Cooper, Tyler T, Khazaee, Reza, Lajoie, Gilles A, Kelly, Gregory M

“…Metabolism plays a crucial role for cell survival and function; however, recent evidence has implicated it in regulating embryonic development. In the embryo,…”
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Mechanically resilient injectable scaffolds for intramuscular stem cell delivery and cytokine release by Young, Stuart A., Sherman, Stephen E., Cooper, Tyler T., Brown, Cody, Anjum, Fraz, Hess, David A., Flynn, Lauren E., Amsden, Brian G.

“…A promising strategy for treating peripheral ischemia involves the delivery of stem cells to promote angiogenesis through paracrine signaling. Treatment…”
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Probing the effects of matrix‐derived microcarrier composition on human adipose‐derived stromal cells cultured dynamically within spinner flask bioreactors by Kornmuller, Anna, Cooper, Tyler T., Jani, Ammi, Lajoie, Gilles A., Flynn, Lauren E.

“…Recognizing the cell‐instructive capacity of the extracellular matrix (ECM), this study investigated the effects of expanding human adipose‐derived stromal…”
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Decellularized adipose tissue scaffolds guide hematopoietic differentiation and stimulate vascular regeneration in a hindlimb ischemia model by Leclerc, Christopher J., Cooper, Tyler T., Bell, Gillian I., Lajoie, Gilles A., Flynn, Lauren E., Hess, David A.

“…Cellular therapies to stimulate therapeutic angiogenesis in individuals with critical limb ischemia (CLI) remain under intense investigation. In this context,…”
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Characterization of extracellular vesicles derived from mesenchymal stromal cells by surface-enhanced Raman spectroscopy by Ćulum, Nina M., Cooper, Tyler T., Bell, Gillian I., Hess, David A., Lagugné-Labarthet, François

“…Extracellular vesicles (EVs) are secreted by all cells into bodily fluids and play an important role in intercellular communication through the transfer of…”
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Meaning in life, anxiety, depression, and general health among smoking cessation patients by Steger, Michael F, Mann, Joshua R, Michels, Phil, Cooper, Tyler C

“…Abstract Objective Psychosocial factors play a widely recognized role in health and health care utilization. The present study investigated relations among…”
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Never in Mitosis Kinase 2 regulation of metabolism is required for neural differentiation by Spice, Danielle M., Cooper, Tyler T., Lajoie, Gilles A., Kelly, Gregory M.

“…Wnt and Hh are known signalling pathways involved in neural differentiation and recent work has shown the cell cycle regulator, Never in Mitosis Kinase 2…”
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Vascular Organoids: Are We Entering a New Area of Cardiometabolic Research? by Cooper, Tyler T., Hess, David A., Verma, Subodh

“…Recently in Nature, Wimmer et al. (2019) reported on the development of a human organoid model of vascular development recapitulating vascular pathology during…”
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High Aldehyde Dehydrogenase Activity Identifies a Subset of Human Mesenchymal Stromal Cells with Vascular Regenerative Potential by Sherman, Stephen E., Kuljanin, Miljan, Cooper, Tyler T., Putman, David M., Lajoie, Gilles A., Hess, David A.

“…During culture expansion, multipotent mesenchymal stromal cells (MSCs) differentially express aldehyde dehydrogenase (ALDH), an intracellular detoxification…”
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Characterization of a Vimentinhigh/Nestinhigh proteome and tissue regenerative secretome generated by human pancreas‐derived mesenchymal stromal cells by Cooper, Tyler T., Sherman, Stephen E., Bell, Gillian I., Ma, Jun, Kuljanin, Miljan, Jose, Shauna E., Lajoie, Gilles A., Hess, David A.

“…Multipotent/mesenchymal stromal cells (MSCs) exist within a variety of postnatal tissues; however, global proteomic analyses comparing tissue‐specific MSC are…”
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Inhibition of Aldehyde Dehydrogenase‐Activity Expands Multipotent Myeloid Progenitor Cells with Vascular Regenerative Function by Cooper, Tyler T., Sherman, Stephen E., Kuljanin, Miljan, Bell, Gillian I., Lajoie, Gilles A., Hess, David A.

“…Blood‐derived progenitor cell transplantation holds potential for the treatment of severe vascular diseases. Human umbilical cord blood (UCB)‐derived…”
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Targeted proteomics of plasma extracellular vesicles uncovers MUC1 as combinatorial biomarker for the early detection of high-grade serous ovarian cancer by Cooper, Tyler T, Dieters-Castator, Dylan Z, Liu, Jiahui, Siegers, Gabrielle M, Pink, Desmond, Veliz, Lorena, Lewis, John D, Lagugné-Labarthet, François, Fu, Yangxin, Steed, Helen, Lajoie, Gilles A, Postovit, Lynne-Marie

“…The five-year prognosis for patients with late-stage high-grade serous carcinoma (HGSC) remains dismal, underscoring the critical need for identifying…”
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Ultrafiltration and Injection of Islet Regenerative Stimuli Secreted by Pancreatic Mesenchymal Stromal Cells by Cooper, Tyler T, Sherman, Stephen E, Bell, Gillian I, Dayarathna, Thamara, McRae, Danielle M, Ma, Jun, Lagugné-Labarthet, François, Pasternak, Stephen H, Lajoie, Gilles A, Hess, David A

“…The secretome of mesenchymal stromal cells (MSCs) is enriched for biotherapeutic effectors contained within and independent of extracellular vesicles (EVs)…”
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The IsletCore Program: Improving the Supply of Human Islets to Satisfy the Demand for Research See article in Endocrinology 2016;157:560–569 by Cooper, Tyler T, Hess, David A

“…The International Diabetes Federation estimates 415 million people have diabetes worldwide, and this number is expected to increase to 642 million by 2040 (1)…”
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Identifying clinical phenotypes of frontotemporal dementia in post-9/11 era veterans using natural language processing by Panahi, Samin, Mayo, Jamie, Kennedy, Eamonn, Christensen, Lee, Kamineni, Sreekanth, Sagiraju, Hari Krishna Raju, Cooper, Tyler, Tate, David F, Rupper, Randall, Pugh, Mary Jo

“…Frontotemporal dementia (FTD) encompasses a clinically and pathologically diverse group of neurodegenerative disorders, yet little work has quantified the…”
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Expanded Hematopoietic Progenitor Cells Reselected for High Aldehyde Dehydrogenase Activity Demonstrate Islet Regenerative Functions by Seneviratne, Ayesh K., Bell, Gillian I., Sherman, Stephen E., Cooper, Tyler T., Putman, David M., Hess, David A.

“…Human umbilical cord blood (UCB) hematopoietic progenitor cells (HPC) purified for high aldehyde dehydrogenase activity (ALDHhi) stimulate islet regeneration…”
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The association of cardiorespiratory fitness, body mass index, and age with testosterone levels at screening of healthy men undergoing preventive medical examinations: The Cooper Center Longitudinal Study by DeFina, Laura F., Radford, Nina B., Leonard, David, Wilson, Rick K., Cooper, Tyler C., Clark, S. Michael, Willis, Benjamin L., Vega, Gloria L., Barlow, Carolyn E., Farrell, Stephen W., Gibbons, Larry W., Yildiz, Bulent O., Gruntmanis, Ugis

“…•Testosterone levels did not decline with age up to 80 years.•Testosterone levels were inversely associated with body mass index.•Testosterone levels were…”
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Drosophila melanogaster as a function-based high-throughput screening model for antinephrolithiasis agents in kidney stone patients by Ali, Sohrab N, Dayarathna, Thamara K, Ali, Aymon N, Osumah, Tijani, Ahmed, Mohamed, Cooper, Tyler T, Power, Nicholas E, Zhang, Dongxing, Kim, Dajung, Kim, Rachel, St Amant, Andre, Hou, Jinqiang, Tailly, Thomas, Yang, Jun, Luyt, Len, Spagnuolo, Paul A, Burton, Jeremy P, Razvi, Hassan, Leong, Hon S

“…Kidney stone disease involves the aggregation of stone-forming salts consequent to solute supersaturation in urine. The development of novel therapeutic agents…”
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