Search Results - "COOPER, Arthur"

Thiosulfoxide (sulfane) sulfur: new chemistry and new regulatory roles in biology by Toohey, John I, Cooper, Arthur J L

“…The understanding of sulfur bonding is undergoing change. Old theories on hypervalency of sulfur and the nature of the chalcogen-chalcogen bond are now…”
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Central Role of Glutamate Metabolism in the Maintenance of Nitrogen Homeostasis in Normal and Hyperammonemic Brain by Cooper, Arthur J L, Jeitner, Thomas M

“…Glutamate is present in the brain at an average concentration-typically 10-12 mM-far in excess of those of other amino acids. In glutamate-containing vesicles…”
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The Role of Glutamine Synthetase and Glutamate Dehydrogenase in Cerebral Ammonia Homeostasis by Cooper, Arthur J. L.

“…In the brain, glutamine synthetase (GS), which is located predominantly in astrocytes, is largely responsible for the removal of both blood-derived and…”
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Editorial for the special issue on Brain Biochemistry in Liver Disease by Cudalbu, Cristina, Cooper, Arthur J.L.

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Lysine metabolism in mammalian brain: an update on the importance of recent discoveries by Hallen, André, Jamie, Joanne F, Cooper, Arthur J. L

“…The lysine catabolism pathway differs in adult mammalian brain from that in extracerebral tissues. The saccharopine pathway is the predominant lysine…”
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A tribute to William (Bill) B. Jakoby by Cooper, Arthur J.L., Hanover, John

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ω-Amidase and Its Substrate α-Ketoglutaramate (the α-Keto Acid Analogue of Glutamine) as Biomarkers in Health and Disease by Cooper, Arthur J. L., Denton, Travis T.

“…A large literature exists on the biochemistry, chemistry, metabolism, and clinical importance of the α-keto acid analogues of many amino acids. However,…”
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Astrocyte Glutamine Synthetase: Importance in Hyperammonemic Syndromes and Potential Target for Therapy by Brusilow, Saul W., Koehler, Raymond C., Traystman, Richard J., Cooper, Arthur J.L.

“…Many theories have been advanced to explain the encephalopathy associated with chronic liver disease and with the less common acute form. A major factor…”
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Chemistry, biochemistry and clinical relevance of the glutamine metabolite α-ketoglutaramate/2-hydroxy-5-oxoproline by Denton, Travis T, Cooper, Arthur J L

“…In the glutaminase II pathway (which we now refer to as the glutamine transaminase-ω-amidase (GTωA) pathway), l-glutamine is transaminated to α-ketoglutaramate…”
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α-Ketoglutaramate: an overlooked metabolite of glutamine and a biomarker for hepatic encephalopathy and inborn errors of the urea cycle by Cooper, Arthur J. L., Kuhara, Tomiko

“…Glutamine metabolism is generally regarded as proceeding via glutaminase-catalyzed hydrolysis to glutamate and ammonia, followed by conversion of glutamate to…”
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The metabolic importance of the glutaminase II pathway in normal and cancerous cells by Dorai, Thambi, Pinto, John T., Denton, Travis T., Krasnikov, Boris F., Cooper, Arthur J.L.

“…In rapidly dividing cells, including many cancer cells, l-glutamine is a major energy source. Utilization of glutamine is usually depicted as: l-glutamine →…”
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Reversible and irreversible protein glutathionylation: biological and clinical aspects by Cooper, Arthur Jl, Pinto, John T, Callery, Patrick S

“…Depending in part on the glutathione:glutathione disulfide ratio, reversible protein glutathionylation to a mixed disulfide may occur. Reversible…”
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Determination of Coenzyme A and Acetyl-Coenzyme A in Biological Samples Using HPLC with UV Detection by Shurubor, Yevgeniya I, D'Aurelio, Marilena, Clark-Matott, Joanne, Isakova, Elena P, Deryabina, Yulia I, Beal, M Flint, Cooper, Arthur J L, Krasnikov, Boris F

“…Coenzyme A (CoA) and acetyl-coenzyme A (acetyl-CoA) play essential roles in cell energy metabolism. Dysregulation of the biosynthesis and functioning of both…”
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'Nothing of chemistry disappears in biology': the Top 30 damage-prone endogenous metabolites by Lerma-Ortiz, Claudia, Jeffryes, James G, Cooper, Arthur J L, Niehaus, Thomas D, Thamm, Antje M K, Frelin, Océane, Aunins, Thomas, Fiehn, Oliver, de Crécy-Lagard, Valérie, Henry, Christopher S, Hanson, Andrew D

“…Many common metabolites are intrinsically unstable and reactive, and hence prone to chemical (i.e. non-enzymatic) damage in vivo Although this fact is widely…”
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Reciprocal Control of Thyroid Binding and the Pipecolate Pathway in the Brain by Hallen, André, Cooper, Arthur J. L.

“…Thyroid hormones have long been known to play an essential role in brain growth and development, with cytoplasmic thyroid hormone binding proteins (THBPs)…”
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Genomic and experimental evidence for multiple metabolic functions in the RidA/YjgF/YER057c/UK114 (Rid) protein family by Niehaus, Thomas D, Gerdes, Svetlana, Hodge-Hanson, Kelsey, Zhukov, Aleksey, Cooper, Arthur J L, ElBadawi-Sidhu, Mona, Fiehn, Oliver, Downs, Diana M, Hanson, Andrew D

“…It is now recognized that enzymatic or chemical side-reactions can convert normal metabolites to useless or toxic ones and that a suite of enzymes exists to…”
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ω-Amidase: an underappreciated, but important enzyme in L-glutamine and L-asparagine metabolism; relevance to sulfur and nitrogen metabolism, tumor biology and hyperammonemic diseases by Cooper, Arthur J. L, Shurubor, Yevgeniya I, Dorai, Thambi, Pinto, John T, Isakova, Elena P, Deryabina, Yulia I, Denton, Travis T, Krasnikov, Boris F

“…In mammals, two major routes exist for the metabolic conversion of L-glutamine to α-ketoglutarate. The most widely studied pathway involves the hydrolysis of…”
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Endostatin and transglutaminase 2 are involved in fibrosis of the aging kidney by Lin, Chi Hua Sarah, Chen, Jun, Zhang, Zhongtao, Johnson, Gail V W, Cooper, Arthur J L, Feola, Julianne, Bank, Alexander, Shein, Jonathan, Ruotsalainen, Heli J, Pihlajaniemi, Taina A, Goligorsky, Michael S

“…Endostatin (EST), an antiangiogenic factor, is enriched in aging kidneys. EST is also an interactive partner of transglutaminase 2 (TG2), an enzyme that…”
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Upregulation of the Glutaminase II Pathway Contributes to Glutamate Production upon Glutaminase 1 Inhibition in Pancreatic Cancer by Udupa, Sunag, Nguyen, Stephanie, Hoang, Giang, Nguyen, Tu, Quinones, Addison, Pham, Khoa, Asaka, Ryoichi, Nguyen, Kiet, Zhang, Cissy, Elgogary, Amira, Jung, Jin G., Xu, Qingguo, Fu, Jie, Thomas, Ajit G., Tsukamoto, Takashi, Hanes, Justin, Slusher, Barbara S., Cooper, Arthur J. L., Le, Anne

“…The targeting of glutamine metabolism specifically via pharmacological inhibition of glutaminase 1 (GLS1) has been translated into clinical trials as a novel…”
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Fragmentation and dewatering transform Great Plains stream fish communities by Perkin, Joshuah S., Gido, Keith B., Cooper, Arthur R., Turner, Thomas F., Osborne, Megan J., Johnson, Eric R., Mayes, Kevin B.

“…Biodiversity in stream networks is threatened globally by interactions between habitat fragmentation and altered hydrologic regimes. In the Great Plains of…”
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