Search Results - "COOMANS DE BRACHÈNE, ALEXANDRA"

IFN-α induces a preferential long-lasting expression of MHC class I in human pancreatic beta cells by Coomans de Brachène, Alexandra, Dos Santos, Reinaldo S., Marroqui, Laura, Colli, Maikel L., Marselli, Lorella, Mirmira, Raghavendra G., Marchetti, Piero, Eizirik, Decio L.

“…Aims/hypothesis IFN-α, a cytokine expressed in human islets from individuals affected by type 1 diabetes, plays a key role in the pathogenesis of diabetes by…”
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Preclinical evaluation of tyrosine kinase 2 inhibitors for human beta‐cell protection in type 1 diabetes by Coomans de Brachène, Alexandra, Castela, Angela, Op de Beeck, Anne, Mirmira, Raghavendra G., Marselli, Lorella, Marchetti, Piero, Masse, Craig, Miao, Wenyan, Leit, Silvana, Evans‐Molina, Carmella, Eizirik, Decio L.

“…Aim Type 1 diabetes (T1D) is a chronic autoimmune disease leading to progressive loss of pancreatic beta cells. Interferon (IFN)‐α plays a critical role in the…”
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FOXO transcription factors in cancer development and therapy by Coomans de Brachène, Alexandra, Demoulin, Jean-Baptiste

“…The forkhead box O (FOXO) transcription factors are considered as tumor suppressors that limit cell proliferation and induce apoptosis. FOXO gene alterations…”
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Interferon-α mediates human beta cell HLA class I overexpression, endoplasmic reticulum stress and apoptosis, three hallmarks of early human type 1 diabetes by Marroqui, Laura, Dos Santos, Reinaldo S., Op de beeck, Anne, Coomans de Brachène, Alexandra, Marselli, Lorella, Marchetti, Piero, Eizirik, Decio L.

“…Aims/hypothesis Three hallmarks of the pancreatic islets in early human type 1 diabetes are overexpression of HLA class I, endoplasmic reticulum (ER) stress…”
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PDGF-D expression is down-regulated by TGFβ in fibroblasts by Charni Chaabane, Saima, Coomans de Brachène, Alexandra, Essaghir, Ahmed, Velghe, Amélie, Lo Re, Sandra, Stockis, Julie, Lucas, Sophie, Khachigian, Levon M, Huaux, François, Demoulin, Jean-Baptiste

“…Transforming growth factor-β (TGFβ) is a key mediator of fibrogenesis. TGFβ is overexpressed and activated in fibrotic diseases, regulates fibroblast…”
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PDGF‐induced fibroblast growth requires monounsaturated fatty acid production by stearoyl‐CoA desaturase by Coomans de Brachène, Alexandra, Dif, Nicolas, Rocca Serra, Audrey, Bonnineau, Chloé, Velghe, Amélie I., Larondelle, Yvan, Tyteca, Donatienne, Demoulin, Jean‐Baptiste

“…Stearoyl‐coenzyme A desaturase (SCD) catalyzes the Δ9‐cis desaturation of saturated fatty acids (SFA) to generate monounsaturated fatty acids (MUFA). This…”
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Checks and Balances-The Limits of β-Cell Endurance to ER Stress by Eizirik, Decio L, Coomans de Brachène, Alexandra

“…To evaluate the limits of endurance of pancreatic β-cells when facing severe stress, Pappalardo et al made ingenious use of small interfering RNAs (siRNAs)…”
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ADAR1-dependent editing regulates human β cell transcriptome diversity during inflammation by Szymczak, Florian, Cohen-Fultheim, Roni, Thomaidou, Sofia, de Brachène, Alexandra Coomans, Castela, Angela, Colli, Maikel, Marchetti, Piero, Levanon, Erez, Eizirik, Decio, Zaldumbide, Arnaud

“…Enterovirus infection has long been suspected as a possible trigger for type 1 diabetes. Upon infection, viral double-stranded RNA (dsRNA) is recognized by…”
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Endogenous mitochondrial double-stranded RNA is not an activator of the type I interferon response in human pancreatic beta cells by Coomans de Brachène, Alexandra, Castela, Angela, Musuaya, Anyïshai E, Marselli, Lorella, Marchetti, Piero, Eizirik, Decio L

“…Type 1 diabetes (T1D) is an autoimmune disease characterized by the progressive destruction of pancreatic beta cells. Interferon-α (IFNα), an antiviral…”
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The expression of the tumour suppressor HBP1 is down-regulated by growth factors via the PI3K/PKB/FOXO pathway by Coomans de Brachène, Alexandra, Bollaert, Emeline, Eijkelenboom, Astrid, de Rocca Serra, Audrey, van der Vos, Kristan E, Burgering, Boudewijn M T, Coffer, Paul J, Essaghir, Ahmed, Demoulin, Jean-Baptiste

“…Growth factors inactivate the FOXO (forkhead box O) transcription factors through PI3K (phosphoinositide 3-kinase) and PKB (protein kinase B). By comparing…”
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Exercise as a non-pharmacological intervention to protect pancreatic beta cells in individuals with type 1 and type 2 diabetes by Coomans de Brachène, Alexandra, Scoubeau, Corentin, Musuaya, Anyïshai E., Costa-Junior, Jose Maria, Castela, Angela, Carpentier, Julie, Faoro, Vitalie, Klass, Malgorzata, Cnop, Miriam, Eizirik, Decio L.

“…Aims/hypothesis Diabetes is characterised by progressive loss of functional pancreatic beta cells. None of the therapeutic agents used to treat diabetes arrest…”
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An integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells by Colli, Maikel L., Ramos-Rodríguez, Mireia, Nakayasu, Ernesto S., Alvelos, Maria I., Lopes, Miguel, Hill, Jessica L. E., Turatsinze, Jean-Valery, Coomans de Brachène, Alexandra, Russell, Mark A., Raurell-Vila, Helena, Castela, Angela, Juan-Mateu, Jonàs, Webb-Robertson, Bobbie-Jo M., Krogvold, Lars, Dahl-Jorgensen, Knut, Marselli, Lorella, Marchetti, Piero, Richardson, Sarah J., Morgan, Noel G., Metz, Thomas O., Pasquali, Lorenzo, Eizirik, Décio L.

“…Interferon-α (IFNα), a type I interferon, is expressed in the islets of type 1 diabetic individuals, and its expression and signaling are regulated by T1D…”
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Interferons are key cytokines acting on pancreatic islets in type 1 diabetes by Coomans de Brachène, Alexandra, Alvelos, Maria Ines, Szymczak, Florian, Zimath, Priscila L., Castela, Angela, Marmontel de Souza, Bianca, Roca Rivada, Arturo, Marín-Cañas, Sandra, Yi, Xiaoyan, Op de Beeck, Anne, Morgan, Noel G., Sonntag, Sebastian, Jawurek, Sayro, Title, Alexandra C., Yesildag, Burcak, Pattou, François, Kerr-Conte, Julie, Montanya, Eduard, Nacher, Montserrat, Marselli, Lorella, Marchetti, Piero, Richardson, Sarah J., Eizirik, Decio L.

“…Aims/hypothesis The proinflammatory cytokines IFN-α, IFN-γ, IL-1β and TNF-α may contribute to innate and adaptive immune responses during insulitis in type 1…”
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PDL1 is expressed in the islets of people with type 1 diabetes and is up-regulated by interferons-α and-γ via IRF1 induction by Colli, Maikel L., Hill, Jessica L.E., Marroquí, Laura, Chaffey, Jessica, Dos Santos, Reinaldo S., Leete, Pia, Coomans de Brachène, Alexandra, Paula, Flavia M.M., Op de Beeck, Anne, Castela, Angela, Marselli, Lorella, Krogvold, Lars, Dahl-Jorgensen, Knut, Marchetti, Piero, Morgan, Noel G., Richardson, Sarah J., Eizirik, Décio L.

“…Antibodies targeting PD-1 and its ligand PDL1 are used in cancer immunotherapy but may lead to autoimmune diseases, including type 1 diabetes (T1D). It remains…”
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25-OR: ADA Presidents' Select Abstract: Preclinical Evaluation of TYK2 Inhibitors in Type 1 Diabetes by SYED, FAROOQ, BALLEW, OLIVIA, LEE, CHIH-CHUN, RANA, JYOTI, CASTELA, ANGELA, WEAVER, STACI A., THOMAIDOU, SOFIA, DEMINE, STÉPHANE, COOMANS DE BRACHÈNE, ALEXANDRA, ALVELOS, MARIA I., CHANG, GARRICK, ORR, KARA, YAMADA, KENTARO, LIU, JING, ZALDUMBIDE, ARNAUD, SCHEUNER, DONALYN, EIZIRIK, DECIO L., EVANS-MOLINA, CARMELLA

“…Interferon-α (IFNα) plays a prominent role in type 1 diabetes (T1D) pathogenesis and mediates its effects through the IFN receptor (IFNAR) and the protein…”
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Interferon-[alpha] mediates human beta cell HLA class I overexpression, endoplasmic reticulum stress and apoptosis, three hallmarks of early human type 1 diabetes by Marroqui, Laura, Dos Santos, Reinaldo S, Op De Beeck, Anne, Coomans De Brachène, Alexandra, Marselli, Lorella, Marchetti, Piero, Eizirik, Decio L

“…Aims/hypothesis Three hallmarks of the pancreatic islets in early human type 1 diabetes are overexpression of HLA class I, endoplasmic reticulum (ER) stress…”
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PDL1 is expressed in the islets of people with type 1 diabetes and is up-regulated by interferons-α and-γ via IRF1 inductionResearch in context by Maikel L. Colli, Jessica L.E. Hill, Laura Marroquí, Jessica Chaffey, Reinaldo S. Dos Santos, Pia Leete, Alexandra Coomans de Brachène, Flavia M.M. Paula, Anne Op de Beeck, Angela Castela, Lorella Marselli, Lars Krogvold, Knut Dahl-Jorgensen, Piero Marchetti, Noel G. Morgan, Sarah J. Richardson, Décio L. Eizirik

“…Background: Antibodies targeting PD-1 and its ligand PDL1 are used in cancer immunotherapy but may lead to autoimmune diseases, including type 1 diabetes…”
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