Search Results - "COOLS, Hans J"

Characterization of the sterol 14α-demethylases of Fusarium graminearum identifies a novel genus-specific CYP51 function by Fan, Jieru, Urban, Martin, Parker, Josie E., Brewer, Helen C., Kelly, Steven L., Hammond‐Kosack, Kim E., Fraaije, Bart A., Liu, Xili, Cools, Hans J.

“…CYP51 encodes the cytochrome P450 sterol 14α-demethylase, an enzyme essential for sterol biosynthesis and the target of azole fungicides. In Fusarium species,…”
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Are azole fungicides losing ground against Septoria wheat disease? Resistance mechanisms in Mycosphaerella graminicola by Cools, Hans J, Fraaije, Bart A

“…There has been a recent rapid decline in the efficacy of some, but not all, azole fungicides in controlling the Septoria leaf blotch pathogen of wheat,…”
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Impact of Recently Emerged Sterol 14α-Demethylase (CYP51) Variants of Mycosphaerella graminicola on Azole Fungicide Sensitivity by COOLS, Hans J, MULLINS, Jonathan G. L, FRAAIJE, Bart A, PARKER, Josie E, KELLY, Diane E, LUCAS, John A, KELLY, Steven L

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Prothioconazole and Prothioconazole-Desthio Activities against Candida albicans Sterol 14-α-Demethylase by PARKER, Josie E, WARRILOW, Andrew G. S, COOLS, Hans J, FRAAIJE, Bart A, LUCAS, John A, RIGDOVA, Katarina, GRIFFITHS, William J, KELLY, Diane E, KELLY, Steven L

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Molecular modelling of the emergence of azole resistance in Mycosphaerella graminicola by Mullins, Jonathan G L, Parker, Josie E, Cools, Hans J, Togawa, Roberto C, Lucas, John A, Fraaije, Bart A, Kelly, Diane E, Kelly, Steven L

“…A structural rationale for recent emergence of azole (imidazole and triazole) resistance associated with CYP51 mutations in the wheat pathogen Mycosphaerella…”
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Mechanism of Binding of Prothioconazole to Mycosphaerella graminicola CYP51 Differs from That of Other Azole Antifungals by Parker, Josie E, Warrilow, Andrew G.S, Cools, Hans J, Martel, Claire M, Nes, W. David, Fraaije, Bart A, Lucas, John A, Kelly, Diane E, Kelly, Steven L

“…Prothioconazole is one of the most important commercially available demethylase inhibitors (DMIs) used to treat Mycosphaerella graminicola infection of wheat,…”
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Update on mechanisms of azole resistance in Mycosphaerella graminicola and implications for future control by Cools, Hans J, Fraaije, Bart A

“…This review summarises recent investigations into the molecular mechanisms responsible for the decline in sensitivity to azole (imidazole and triazole)…”
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Risk assessment studies on succinate dehydrogenase inhibitors, the new weapons in the battle to control Septoria leaf blotch in wheat by FRAAIJE, BART A., BAYON, CARLOS, ATKINS, SARAH, COOLS, HANS J., LUCAS, JOHN A., FRAAIJE, MARCO W.

“…SUMMARY Chemical control of Septoria leaf blotch, caused by Mycosphaerella graminicola, is essential to ensure wheat yield and food security in most European…”
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Overexpression of the sterol 14α-demethylase gene (MgCYP51) in Mycosphaerella graminicola isolates confers a novel azole fungicide sensitivity phenotype by Cools, Hans J, Bayon, Carlos, Atkins, Sarah, Lucas, John A, Fraaije, Bart A

“…BACKGROUND: The recent evolution towards resistance to azole fungicides in European populations of the wheat pathogen Mycosphaerella graminicola has been…”
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Paralog re-emergence: a novel, historically contingent mechanism in the evolution of antimicrobial resistance by Hawkins, Nichola J, Cools, Hans J, Sierotzki, Helge, Shaw, Michael W, Knogge, Wolfgang, Kelly, Steven L, Kelly, Diane E, Fraaije, Bart A

“…Evolution of resistance to drugs and pesticides poses a serious threat to human health and agricultural production. CYP51 encodes the target site of azole…”
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Analysis of mutations in West Australian populations of Blumeria graminis f. sp. hordei CYP51 conferring resistance to DMI fungicides by Tucker, Madeline A, Lopez‐Ruiz, Francisco, Cools, Hans J, Mullins, Jonathon GL, Jayasena, Kithsiri, Oliver, Richard P

“…BACKGROUND Powdery mildew caused by Blumeria graminis f. sp. hordei (Bgh) is a constant threat to barley production but is generally well controlled through…”
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Exploitation of genomics in fungicide research: current status and future perspectives by Cools, Hans J., Hammond-Kosack, Kim E.

“…Summary Every year, fungicide use to control plant disease caused by pathogenic fungi increases. The global fungicide market is now worth more than £5.3…”
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Alterations in the predicted regulatory and coding regions of the sterol 14α‐demethylase gene (CYP51) confer decreased azole sensitivity in the oilseed rape pathogen Pyrenopeziza brassicae by Carter, Helen E, Fraaije, Bart A, West, Jonathan S, Kelly, Steven L, Mehl, Andreas, Shaw, Michael W, Cools, Hans J

“…The incidence and severity of light leaf spot epidemics caused by the ascomycete fungus Pyrenopeziza brassicae on UK oilseed rape crops are increasing. The…”
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Dose‐dependent selection drives lineage replacement during the experimental evolution of SDHI fungicide resistance in Zymoseptoria tritici by Gutiérrez‐Alonso, Omar, Hawkins, Nichola J., Cools, Hans J., Shaw, Michael W., Fraaije, Bart A.

“…Fungicide resistance is a constant threat to agricultural production worldwide. Molecular mechanisms of fungicide resistance have been studied extensively in…”
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Detection and molecular characterisation of Pyrenopeziza brassicae isolates resistant to methyl benzimidazole carbamates by Carter, Helen E, Cools, Hans J, West, Jonathan S, Shaw, Michael W, Fraaije, Bart A

“…BACKGROUND Methyl benzimidazole carbamate (MBC) fungicides are used to control the oilseed rape pathogen Pyrenopeziza brassicae. Resistance to MBCs has been…”
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Molecular screening for avirulence alleles AvrLm1 and AvrLm6 in airborne inoculum of Leptosphaeria maculans and winter oilseed rape (Brassica napus) plants from Poland and the UK by Kaczmarek, Joanna, Latunde-Dada, Akinwunmi O, Irzykowski, Witold, Cools, Hans J, Stonard, Jenna F, Brachaczek, Andrzej, Jedryczka, Malgorzata

“…A combination of staining, light microscopy and SYBR green- and dual-labelled fluorescent probe-based qPCR chemistries with species- and gene-specific primers…”
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Quantitative PCR analysis of abundance of airborne propagules of Leptosphaeria species in air samples from different regions of Poland by Kaczmarek, Joanna, Jedryczka, Malgorzata, Cools, Hans J, Fitt, Bruce D. L, Lucas, John A, Latunde-Dada, Akinwunmi O

“…When airborne propagules of Leptosphaeria maculans and L. biglobosa were collected in Poland at three ecologically different sites from 1 September to 30…”
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Sterol content analysis suggests altered eburicol 14α-demethylase (CYP51) activity in isolates of Mycosphaerella graminicola adapted to azole fungicides by Bean, Tim P, Cools, Hans J, Lucas, John A, Hawkins, Nathaniel D, Ward, Jane L, Shaw, Michael W, Fraaije, Bart A

“…The recent decline in the effectiveness of some azole fungicides in controlling the wheat pathogen Mycosphaerella graminicola has been associated with…”
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Detection and quantification of airborne inoculum of Pyrenopeziza brassicae in Polish and UK winter oilseed rape crops by real-time PCR assays by Karolewski, Zbigniew, Kaczmarek, Joanna, Jedryczka, Malgorzata, Cools, Hans J, Fraaije, Bart A, Lucas, John A, Latunde-dada, Akinwunmi O

“…Following a sudden outbreak of light leaf spot disease in Polish winter oilseed rape crops at the beginning of the last decade, volumetric spore traps…”
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Impact of proquinazid on appressorial development of the barley powdery mildew fungus Blumeria graminis f.sp hordei by Gilbert, Sally R., Cools, Hans J., Fraaije, Bart A., Bailey, Andy M., Lucas, John A.

“…The effect of a novel mildew-specific quinazolinone fungicide, proquinazid, on the barley powdery mildew fungus, Blumeria graminis f.sp. hordei, has been…”
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