Search Results - "COOLEY, B. C"

Human pancreatic tumors grown in mice release tissue factor‐positive microvesicles that increase venous clot size by Hisada, Y., Ay, C., Auriemma, A. C., Cooley, B. C., Mackman, N.

“…Essentials Tumor‐bearing mice have larger venous clots than controls. Human tissue factor is present in clots in tumor‐bearing mice. Inhibition of human tissue…”
Get full text

Factor XI‐deficient mice exhibit increased bleeding after injury to the saphenous vein by Ay, C., Hisada, Y., Cooley, B. C., Mackman, N.

“…Essentials Factor XI (FXI) deficient mice have normal hemostasis in a tail transection model. The hemostatic capacity of FXI−/− mice was assessed in three…”
Get full text

Tissue factor–positive tumor microvesicles activate platelets and enhance thrombosis in mice by Geddings, J. E., Hisada, Y., Boulaftali, Y., Getz, T. M., Whelihan, M., Fuentes, R., Dee, R., Cooley, B. C., Key, N. S., Wolberg, A. S., Bergmeier, W., Mackman, N.

“…Essentials Cancer patients have a high rate of venous thrombosis (VT) but the underlying mechanisms are unknown. Tumor‐derived, tissue factor‐positive…”
Get full text

Lentivirus‐mediated platelet gene therapy of murine hemophilia A with pre‐existing anti‐factor VIII immunity by KUETHER, E. L., SCHROEDER, J. A., FAHS, S. A., COOLEY, B. C., CHEN, Y., MONTGOMERY, R. R., WILCOX, D. A., SHI, Q.

“…Background:  The development of inhibitory antibodies, referred to as inhibitors, against exogenous factor VIII in a significant subset of patients with…”
Get full text

Multiple Combinations of Alternatively Spliced Exons in Rat Tropomyosin-α Gene mRNA: Evidence for 20 New Isoforms in Adult Tissues and Cultured Cells by Cooley, Brian C., Bergtrom, Gerald

“…Previous studies of the tropomyosin-α gene using Northern blot and ribonuclease protection assay methods identified the expression of nine isoforms generated…”
Get full text

A Phase II Trial of Intraluminal Irrigation with Recombinant Human Tissue Factor Pathway Inhibitor to Prevent Thrombosis in Free Flap Surgery by Khouri, Roger K, Sherman, Randolph, Buncke, Harry J, Feller, Axel-Mario, Hovius, Steven, Benes, Charles O, Ingram, Diana M, Natarajan, Nirmala N, Sherman, Jeffrey W, Yeramian, Patrick D, Cooley, Brian C

“…A multicenter, multinational, blinded, randomized, parallel-group, phase II study was conducted to investigate the use of recombinant human tissue factor…”
Get full text

A prospective study of Microvascular free-flap surgery and outcome by KHOURI, R. K, COOLEY, B. C, KUNSELMAN, A. R, LANDIS, J. R, YERAMIAN, P, INGRAM, D, NATARAJAN, N, BENES, C. O, WALLEMARK, C

“…Over a 6-month period, 23 members of the International Microvascular Research Group participated in a prospective survey of their microvascular free-flap…”
Get full text

Thrombosis risk modification in transgenic mice containing the human fibrinogen thrombin‐binding γ′ chain sequence by MOSESSON, M. W., COOLEY, B. C., HERNANDEZ, I., DIORIO, J. P., WEILER, H.

“…Background and objectives: Thrombin binding activity in murine fibrin (Antithrombin I) is restricted to its E domains inasmuch as murine γ′ chains (mu‐γ′) do…”
Get full text

Combined tissue factor pathway inhibitor and thrombomodulin deficiency produces an augmented hypercoagulable state with tissue‐specific fibrin deposition by MARONEY, S. A., COOLEY, B. C., SOOD, R., WEILER, H., MAST, A. E.

“…Background and Objective: Tissue factor pathway inhibitor (TFPI) and thrombomodulin (TM) are endothelial‐associated anticoagulant proteins thought to control…”
Get full text

Repair of Calvarial Defects with Flap Tissue: Role of Bone Morphogenetic Proteins and Competent Responding Tissues by Khouri, Roger K, Brown, David M, Koudsi, Basem, Deune, Gene E, Gilula, Louis A, Cooley, Brian C, Reddi, Hari A

“…Bone morphogenetic proteins 2 through 8 have the ability to induce the in vivo transformation of extraskeletal mesenchymal tissue into bone. The aims of this…”
Get full text

Influence of age on free flap tolerance to ischemia: an experimental study in rats by Cooley, B C, Gould, J S

“…Free tissue transfer and extremity replantation have been successfully performed in elderly patients. However, it is not known whether such procedures have an…”
Get more information

Effect of anticoagulation and inhibition of platelet aggregation on arterial versus venous microvascular thrombosis by Li, X, Cooley, B C

“…On the basis of clinical empirical observations and classic theory of platelet aggregation, microvascular surgeons have held that platelet aggregation is more…”
Get more information

Murine Microvascular Anastomosis Model of Thrombosis by Cooley, Brian C, Daley, Roger A

Get full text

Thrombosis of microvascular anastomoses in traumatized vessels: fibrin versus platelets by Khouri, R K, Cooley, B C, Kenna, D M, Edstrom, L E

“…Thrombosis is the end result of two closely interrelated processes: the coagulation cascade and the platelet aggregation process. To determine their relative…”
Get more information

The influence of diabetes on free flap transfer: I. Flap survival and microvascular healing by Cooley, B C, Hanel, D P, Anderson, R B, Foster, M D, Gould, J S

“…Although recent clinical case presentations suggest that diabetes does not predispose free tissue transfers to increased risk of failure, this remains an open…”
Get more information

Clinical outcome of digital replantation using the fibrin glue-assisted microvascular anastomosis technique by Isogai, N, Cooley, B G, Kamiishi, H

“…A series of 36 digital replants is reported in which microvascular anastomoses were each performed with four to six stitches and topically applied fibrin glue…”
Get more information

Characterization of a Mouse Model for Thrombomodulin Deficiency by Weiler, Hartmut, Lindner, Volkhard, Kerlin, Bryce, Isermann, Berend H, Hendrickson, Sara B, Cooley, Brian C, Meh, David A, Mosesson, Michael W, Shworak, Nicholas W, Post, Mark J, Conway, Edward M, Ulfman, Laurien H, von Andrian, Ulrich H, Weitz, Jeffrey I

“…Mutations in the gene encoding thrombomodulin (TM), a thrombin regulator, are suspected risk factors for venous and arterial thrombotic disease. We have…”
Get full text

Brief ex vivo perfusion with heparinized and/or citrated whole blood enhances tolerance of free muscle flaps to prolonged ischemia by Fowler, J. David, Li, Xiaolu, Cooley, Brian C.

“…This study investigated the use of heparinized and/or citrated whole blood as a perfusate for enhancing muscle tolerance to warm ischemia. Unilateral cutaneous…”
Get full text

Heat-induced tissue fusion for microvascular anastomosis by Cooley, Brian C.

“…Laser tissue welding was compared with a crude method of bipolar coagulator‐generated heat application for achieving the same heat‐induced welding effect in…”
Get full text

Comparison of arterial and venous patency in a rat model of subendothelium-stimulated thrombosis by Hupkens, Pieter, Cooley, Brian C.

“…The effectiveness of anticoagulants and platelet aggregation inhibitors was compared using comparable rat models of arterial and venous thrombosis. A…”
Get full text