Search Results - "CONTIN, Manuela"

A Rapid and Simple UHPLC-MS/MS Method for Quantification of Plasma Globotriaosylsphingosine (lyso-Gb3) by Perrone, Alessandro, Mohamed, Susan, Donadio, Vincenzo, Liguori, Rocco, Contin, Manuela

“…Fabry disease (FD) is a rare X-linked lysosomal storage disorder caused by α-galactosidase A gene (GLA) mutations, resulting in loss of activity of the…”
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Mathematical modeling and parameter estimation of levodopa motor response in patients with parkinson disease by Ursino, Mauro, Magosso, Elisa, Lopane, Giovanna, Calandra-Buonaura, Giovanna, Cortelli, Pietro, Contin, Manuela

“…Parkinson disease (PD) is characterized by a clear beneficial motor response to levodopa (LD) treatment. However, with disease progression and longer LD…”
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Simple and rapid validated HPLC-fluorescence determination of perampanel in the plasma of patients with epilepsy by Mohamed, Susan, Candela, Carmina, Riva, Roberto, Contin, Manuela

“…We present a simple and fast high-performance liquid chromatography method with fluorescence detection for the determination of the antiepileptic drug…”
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Relationship between plasma concentrations and clinical effects of perampanel: A prospective observational study by Contin, Manuela, Pondrelli, Federica, Muccioli, Lorenzo, Mohamed, Susan, Santucci, Margherita, Ferri, Lorenzo, Licchetta, Laura, Tinuper, Paolo, Bisulli, Francesca, Ambrosetti, Irene, Boni, Antonella, Messana, Tullio, Michelucci, Roberto, Mostacci, Barbara, Parmeggiani, Antonia, Passarelli, Daniela, Rizzi, Romana, Russo, Angelo, Volpi, Lilia

“…The purpose of the study was to investigate the potential correlation between plasma concentration of the newer antiseizure medication (ASM) perampanel (PMP)…”
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Cannabidiol in Pharmacoresistant Epilepsy: Clinical Pharmacokinetic Data From an Expanded Access Program by Contin, Manuela, Mohamed, Susan, Santucci, Margherita, Lodi, Monica Anna Maria, Russo, Emilio, Mecarelli, Oriano, Cbd Lice Italy Study Group

“…Data on the clinical pharmacokinetics of cannabidiol (CBD) are scanty. We explored the effect of demographic and clinical variables on plasma concentrations of…”
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Cannabis-Based Products in a Neurological Setting: A Clinical and Pharmacokinetic Survey by Mohamed, Susan, Lopane, Giovanna, Sabattini, Loredana, Scandellari, Cinzia, Zardi, Diletta, Donadio, Vincenzo, Rizzo, Giovanni, Perrone, Alessandro, Lugaresi, Alessandra, Contin, Manuela

“…Limited data are available in clinical settings on the pharmacokinetics of delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). We investigated the use of…”
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TELEmedicine for EPIlepsy Care (TELE-EPIC): protocol of a randomised, open controlled non-inferiority clinical trial by Licchetta, Laura, Trivisano, Marina, Baldin, Elisa, Mohamed, Susan, Raschi, Emanuel, Mostacci, Barbara, Zenesini, Corrado, Contin, Manuela, Vigevano, Federico, Bisulli, Francesca, Tinuper, Paolo, Vignatelli, Luca

“…IntroductionEpilepsy is a chronic condition requiring consistent follow-up aimed at seizure control, and monitoring of anti-seizure medication (ASM) levels and…”
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Results From an Italian Expanded Access Program on Cannabidiol Treatment in Highly Refractory Dravet Syndrome and Lennox–Gastaut Syndrome by Iannone, Luigi Francesco, Arena, Gabriele, Battaglia, Domenica, Bisulli, Francesca, Bonanni, Paolo, Boni, Antonella, Canevini, Maria Paola, Cantalupo, Gaetano, Cesaroni, Elisabetta, Contin, Manuela, Coppola, Antonietta, Cordelli, Duccio Maria, Cricchiuti, Giovanni, De Giorgis, Valentina, De Leva, Maria Fulvia, De Rinaldis, Marta, d'Orsi, Giuseppe, Elia, Maurizio, Galimberti, Carlo Andrea, Morano, Alessandra, Granata, Tiziana, Guerrini, Renzo, Lodi, Monica A. M., La Neve, Angela, Marchese, Francesca, Masnada, Silvia, Michelucci, Roberto, Nosadini, Margherita, Pilolli, Nicola, Pruna, Dario, Ragona, Francesca, Rosati, Anna, Santucci, Margherita, Spalice, Alberto, Pietrafusa, Nicola, Striano, Pasquale, Tartara, Elena, Tassi, Laura, Papa, Amanda, Zucca, Claudio, Russo, Emilio, Mecarelli, Oriano

“…Background: Purified cannabidiol (CBD) was administered to highly refractory patients with Dravet (DS) or Lennox–Gastaut (LGS) syndromes in an ongoing expanded…”
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Simultaneous HPLC–UV analysis of rufinamide, zonisamide, lamotrigine, oxcarbazepine monohydroxy derivative and felbamate in deproteinized plasma of patients with epilepsy by Contin, Manuela, Mohamed, Susan, Candela, Carmina, Albani, Fiorenzo, Riva, Roberto, Baruzzi, Agostino

“…We present an implementation of a method we previously reported allowing the newer antiepileptic drugs (AEDs) rufinamide (RFN) and zonisamide (ZNS) to be…”
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TYMP Variants Result in Late-Onset Mitochondrial Myopathy With Altered Muscle Mitochondrial DNA Homeostasis by Ronchi, Dario, Caporali, Leonardo, Manenti, Giulia Francesca, Meneri, Megi, Mohamed, Susan, Bordoni, Andreina, Tagliavini, Francesca, Contin, Manuela, Piga, Daniela, Sciacco, Monica, Saetti, Cristina, Carelli, Valerio, Comi, Giacomo Pietro

“…Biallelic TYMP variants result in the mitochondrial neurogastrointestinal encephalomyopathy (MNGIE), a juvenile-onset disorder with progressive course and…”
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Simple and validated HPLC–UV analysis of levetiracetam in deproteinized plasma of patients with epilepsy by Contin, Manuela, Mohamed, Susan, Albani, Fiorenzo, Riva, Roberto, Baruzzi, Agostino

“…We present a simple, fast and validated method for the determination of the new generation antiepileptic drug (AED) levetiracetam (LEV) in plasma of patients…”
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The Bologna motor and non-motor prospective study on parkinsonism at onset (BoProPark): study design and population by Calandra-Buonaura, Giovanna, Sambati, Luisa, Baschieri, Francesca, Vitiello, Maria, Contin, Manuela, Tonon, Caterina, Capellari, Sabina, Provini, Federica, Cortelli, Pietro

“…Objective The Bologna motor and non-motor prospective study on parkinsonism at onset (BoProPark) was designed to prospectively characterize motor and non-motor…”
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Iodine-123-meta-iodobenzylguanidine Myocardial Scintigraphy in Isolated Autonomic Failure: Potential Red Flag for Future Multiple System Atrophy by Baschieri, Francesca, Calandra-Buonaura, Giovanna, Cecere, Annagrazia, Barletta, Giorgio, Contin, Manuela, Parchi, Piero, Cortelli, Pietro

“…Pure autonomic failure is challenging as it can be the presenting feature of a central nervous system syncleinopathy such as Parkinson's disease (PD) or…”
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Simultaneous liquid chromatographic determination of lamotrigine, oxcarbazepine monohydroxy derivative and felbamate in plasma of patients with epilepsy by Contin, Manuela, Balboni, Monica, Callegati, Erica, Candela, Carmina, Albani, Fiorenzo, Riva, Roberto, Baruzzi, Agostino

“…A very simple and fast method has been developed and validated for simultaneous determination of the new generation antiepileptic drugs (AEDs) lamotrigine…”
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Pharmacokinetics of levodopa by Contin, Manuela, Martinelli, Paolo

“…This paper reviews the clinically relevant determinants of levodopa peripheral pharmacokinetics and main observed changes in the levodopa concentration–effect…”
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Polysomnographic and pharmacokinetic findings in levodopa-induced augmentation of restless legs syndrome by Vetrugno, Roberto, Contin, Manuela, Baruzzi, Agostino, Provini, Federica, Plazzi, Giuseppe, Montagna, Pasquale

“…Augmentation, defined as a loss of circadian recurrence with progressively earlier daily onset and increase in the duration, intensity, and anatomy of…”
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Evidence of polymorphic CYP2C19 involvement in the human metabolism of N-desmethylclobazam by CONTIN, Manuela, SANGIORGI, Simonetta, RIVA, Roberto, PARMEGGIANI, Antonia, ALBANI, Fiorenzo, BARUZZI, Agostino

“…The authors report preliminary findings on the potential contribution of CYP2C19 isoenzyme to the human metabolism of N-desmethylclobazam (N-CLB), the main…”
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Development and Validation of an UHPLC-MS/MS Assay for the Therapeutic Monitoring of Brivaracetam Plasma Concentrations in Patients with Epilepsy by Mohamed, Susan, Riva, Roberto, Contin, Manuela

“…Brivaracetam is an antiepileptic drug used as an add-on therapy for partial-onset seizures in subjects aged 4 years and older. Owing to potential drug…”
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Simple and validated UHPLC–MS/MS analysis of nimodipine in plasma and cerebrospinal fluid of patients with subarachnoid haemorrhage by Mohamed, Susan, Riva, Roberto, Contin, Manuela

“…•Plasma and CSF analysis of nimodipine is proposed in a single validated assay.•The analysis is based on UHPLC–MS/MS with acetonitrile pretreatment on 250μL…”
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Mucuna pruriens in Parkinson disease: A double-blind, randomized, controlled, crossover study by Cilia, Roberto, Laguna, Janeth, Cassani, Erica, Cereda, Emanuele, Pozzi, Nicolò G, Isaias, Ioannis U, Contin, Manuela, Barichella, Michela, Pezzoli, Gianni

“…OBJECTIVE:To investigate whether Mucuna pruriens (MP), a levodopa-containing leguminous plant growing in all tropical areas worldwide, may be used as…”
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