Search Results - "CONTI, C. J"

Transgenic expression of E2F3a causes DNA damage leading to ATM-dependent apoptosis by Paulson, Q X, Pusapati, R V, Hong, S, Weaks, R L, Conti, C J, Johnson, D G

“…Many early stage human tumors display markers of a DNA-damage response (DDR), including ataxia telangiectasia mutated (ATM) kinase activation. This suggests…”
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Expression of a dominant negative mutant of epidermal growth factor receptor in the epidermis of transgenic mice elicits striking alterations in hair follicle development and skin structure by Murillas, R., Larcher, F., Conti, C. J., Santos, M., Ullrich, A., Jorcano, J. L.

“…Epidermal growth factor receptor (EGFR) is a key regulator of keratinocyte biology. However, the physiological role of EGFR in vivo has not been well…”
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A recurrent nonsense mutation occurring as a de novo event in a patient with recessive dystrophic epidermolysis bullosa by Cuadrado-Corrales, N, Sánchez-Jimeno, C, García, M, Ayuso, C, De Lucas, R, Vicario, J L, Conti, C J, Zambruno, G, Escamez, M J, Del Rio, M

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Cyclin D2 and cyclin D3 play opposite roles in mouse skin carcinogenesis by ROJAS, P, CADENAS, M. B, LIN, P.-C, BENAVIDES, F, CONTI, C. J, RODRIGUEZ-PUEBLA, M. L

“…D-type cyclins are components of the cell-cycle engine that link cell signaling pathways and passage throughout G1 phase. We previously described the effects…”
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VEGF/VPF overexpression in skin of transgenic mice induces angiogenesis, vascular hyperpermeability and accelerated tumor development by LARCHER, F, MURILLAS, R, BOLONTRADE, M, CONTI, C. J, JORCANO, J. L

“…Upregulation of keratinocyte-derived VEGF-A expression has recently been established in non-neoplastic processes of skin such as wound healing, blistering…”
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Fibroblast activation and abnormal extracellular matrix remodelling as common hallmarks in three cancer‐prone genodermatoses by Chacón‐Solano, E., León, C., Díaz, F., García‐García, F., García, M., Escámez, M.J., Guerrero‐Aspizua, S., Conti, C.J., Mencía, Á., Martínez‐Santamaría, L., Llames, S., Pévida, M., Carbonell‐Caballero, J., Puig‐Butillé, J.A., Maseda, R., Puig, S., de Lucas, R., Baselga, E., Larcher, F., Dopazo, J., Río, M.

“…Summary Background Recessive dystrophic epidermolysis bullosa (RDEB), Kindler syndrome (KS) and xeroderma pigmentosum complementation group C (XPC) are three…”
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Autophagy mediates HIF2α degradation and suppresses renal tumorigenesis by Liu, X-D, Yao, J, Tripathi, D N, Ding, Z, Xu, Y, Sun, M, Zhang, J, Bai, S, German, P, Hoang, A, Zhou, L, Jonasch, D, Zhang, X, Conti, C J, Efstathiou, E, Tannir, N M, Eissa, N T, Mills, G B, Walker, C L, Jonasch, E

“…Autophagy is a conserved process involved in lysosomal degradation of protein aggregates and damaged organelles. The role of autophagy in cancer is a topic of…”
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High susceptibility to ultraviolet-induced carcinogenesis in mice lacking XPC by Sands, Arthur T, Abuin, Alejandro, Sanchez, Ana, Conti, Claudio J, Bradley, Allan

“…Compromise of genetic information by mutation may result in the dysregulation of cellular growth control and subsequent tumour formation. Xeroderma pigmentosum…”
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Deregulated expression of E2F1 induces hyperplasia and cooperates with ras in skin tumor development by PIERCE, A. M, FISHER, S. M, CONTI, C. J, JOHNSON, D. G

“…In cell culture studies, overexpression of the E2F1 transcription factor has been shown to stimulate proliferation, induce apoptosis, and cooperate with an…”
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p53 protein accumulation and gene mutation in the progression of human prostate carcinoma by Navone, N M, Troncoso, P, Pisters, L L, Goodrow, T L, Palmer, J L, Nichols, W W, von Eschenbach, A C, Conti, C J

“…Nuclear accumulation of p53 protein has been shown to be strongly associated with missense p53 mutations. Studies of nuclear accumulation of p53 protein in…”
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Alterations of the p53 tumor suppressor gene during mouse skin tumor progression by RUGGERI, B, CAAMANO, J, GOODROW, T, DIRADO, M, BIANCHI, A, TRONO, D, CONTI, C. J, KLEIN-SZANTO, A. J. P

“…The two-stage murine skin tumorigenesis model is widely used to study the development of squamous cell neoplasias. We have investigated expression of the p53…”
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Expression of Cyclin D1 in Epithelial Tissues of Transgenic Mice Results in Epidermal Hyperproliferation and Severe Thymic Hyperplasia by Robles, Ana I., Larcher, Fernando, Whalin, Robert B., Murillas, Rodolfo, Richie, Ellen, Gimenez-Conti, Irma B., Jorcano, Jose L., Conti, Claudio J.

“…To study the involvement of cyclin D1 in epithelial growth and differentiation and its putative role as an oncogene in skin, transgenic mice were developed…”
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Loss of heterozygosity in human primary prostate carcinomas: a possible tumor suppressor gene at 7q31.1 by ZENKLUSEN, J. C, THOMPSON, J. C, TRONCOSO, P, KAGAN, J, CONTI, C. J

“…We studied loss of heterozygosity (LOH) on human chromosome 7q to determine the location of a putative tumor suppressor gene (TSG) in human primary prostate…”
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Alterations of p53, cyclin D1, rb, and H‐ras in human oral carcinomas related to tobacco use by Xu, Jie, Gimenez‐Conti, Irma B., Cunningham, Joan E., Collet, Ana M., Luna, Mario A., Lanfranchi, Hector E., Spitz, Margaret R., Conti, Claudio J.

“…BACKGROUND Epidemiologic studies have indicated that environmental and personal habits, particularly tobacco use and alcohol abuse, are major etiologic factors…”
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Up-regulation of Vascular endothelial growth factor/vascular permeability factor in mouse skin carcinogenesis correlates with malignant progression state and activated H-ras expression levels by LARCHER, F, ROBLES, A. I, DURAN, H, MURILLAS, R, QUINTANILLA, M, CANO, A, CONTI, C. J, JORCANO, J. L

“…Angiogenesis is a crucial process for tumor growth and metastasis regulated by the balance of positive and negative factors. Vascular endothelial growth factor…”
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Increased cell growth and tumorigenicity in human prostate LNCaP cells by overexpression to cyclin D1 by YIAN CHEN, MARTINEZ, L. A, LACAVA, M, COGHLAN, L, CONTI, C. J

“…Deregulated expression of cyclin D1 has been found in several types of human tumors. In order to investigate factors involved in human prostate cancer…”
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A Variant of Pulmonary Alveolar Microlithiasis in nackt Mice by Starost, M. F., Benavides, F., Conti, C. J.

“…Four adult mutant nackt mice, which demonstrate alopecia and CD4+ T-cell deficiency, and two outbred SENCAR mice (sentinels) were presented for routine health…”
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Coordinated changes in cell cycle machinery occur during keratinocyte terminal differentiation by MARTINEZ, L. A, CHEN, Y, FISCHER, S. M, CONTI, C. J

“…Differentiation of cells is typically marked by a cessation of proliferation with a concurrent entrance into a distinct metabolic state marked by tissue…”
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Myc lacks E2F1's ability to suppress skin carcinogenesis by ROUNBEHLER, Robert J, SCHNEIDER-BROUSSARD, Robin, CONTI, Claudio J, JOHNSON, David G

“…Myc and E2F1 can each stimulate proliferation, induce apoptosis, and contribute to oncogenic transformation. However, only E2F1 has been shown to have a tumor…”
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Angiogenesis is an early event in the development of chemically induced skin tumors by BOLONTRADE, M. F, STERN, M. C, BINDER, R. L, ZENKLUSEN, J. C, GIMENEZ-CONTI, I. B, CONTI, C. J

“…In this study we have analyzed the vascular response induced in the two-stage carcinogenesis model in SENCAR mice. The role of angiogenesis has not been…”
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