Search Results - "CONSEIL, Gwenaëlle"

Structure-guided probing of the leukotriene C 4 binding site in human multidrug resistance protein 1 (MRP1; ABCC1) by Conseil, Gwenaëlle, Arama-Chayoth, May, Tsfadia, Yossi, Cole, Susan P C

“…The human multidrug resistance protein 1 (hMRP1) transporter is implicated in cancer multidrug resistance as well as immune responses involving its physiologic…”
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The First Cytoplasmic Loop in the Core Structure of the ABCC1 (Multidrug Resistance Protein 1; MRP1) Transporter Contains Multiple Amino Acids Essential for Its Expression by Conseil, Gwenaëlle, Cole, Susan P. C.

“…ABCC1 (human multidrug resistance protein 1 (hMRP1)) is an ATP-binding cassette transporter which effluxes xeno- and endobiotic organic anions and confers…”
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Conserved amino acids in the region connecting membrane spanning domain 1 to nucleotide binding domain 1 are essential for expression of the MRP1 (ABCC1) transporter by Smith, Emma E, Conseil, Gwenaëlle, Cole, Susan P C

“…Multidrug resistance protein 1 (MRP1) (gene symbol ABCC1) is an ATP-binding cassette (ABC) transporter which effluxes xeno- and endobiotic organic anions…”
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Polymorphic variants of MRP4/ABCC4 differentially modulate the transport of methylated arsenic metabolites and physiological organic anions by Banerjee, Mayukh, Marensi, Vanessa, Conseil, Gwenaëlle, Le, X. Chris, Cole, Susan P.C., Leslie, Elaine M.

“…[Display omitted] Broad inter-individual variation exists in susceptibility to arsenic-induced tumours, likely involving differences in the ability of…”
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Mutagenic Analysis of the Putative ABCC6 Substrate-Binding Cavity Using a New Homology Model by Szeri, Flora, Corradi, Valentina, Niaziorimi, Fatemeh, Donnelly, Sylvia, Conseil, Gwenaëlle, Cole, Susan P C, Tieleman, D Peter, van de Wetering, Koen

“…Inactivating mutations in ABCC6 underlie the rare hereditary mineralization disorder pseudoxanthoma elasticum. ABCC6 is an ATP-binding cassette (ABC) integral…”
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Differential Selectivity of Human and Mouse ABCC4/Abcc4 for Arsenic Metabolites by Whitlock, Brayden D, Ma, Yingze, Conseil, Gwenaelle, O'Brien, Alicia R, Banerjee, Mayukh, Swanlund, Diane P, Lin, Z Ping, Wang, Yao, Le, X Chris, Schuetz, John D, Cole, Susan P C, Leslie, Elaine M

“…Millions of people globally are exposed to the proven human carcinogen arsenic at unacceptable levels in drinking water. In contrast, arsenic is a poor rodent…”
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MRP1 modulators synergize with buthionine sulfoximine to exploit collateral sensitivity and selectively kill MRP1-expressing cancer cells by Gana, Christine C., Hanssen, Kimberley M., Yu, Denise M.T., Flemming, Claudia L., Wheatley, Madeleine S., Conseil, Gwenaëlle, Cole, Susan P.C., Norris, Murray D., Haber, Michelle, Fletcher, Jamie I.

“…[Display omitted] Members of the ABC transporter family, particularly P-glycoprotein (P-gp, ABCB1), breast cancer resistance protein (BCRP, ABCG2) and…”
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GSH facilitates the binding and inhibitory activity of novel multidrug resistance protein 1 (MRP1) modulators by Hanssen, Kimberley M., Wheatley, Madeleine S., Yu, Denise M. T., Conseil, Gwenaëlle, Norris, Murray D., Haber, Michelle, Cole, Susan P. C., Fletcher, Jamie I.

“…MRP1 (ABCC1) is a membrane transporter that confers multidrug resistance in cancer cells by exporting chemotherapeutic agents, often in a reduced glutathione…”
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Cysteinyl Leukotriene Receptor 1/2 Antagonists Nonselectively Modulate Organic Anion Transport by Multidrug Resistance Proteins (MRP1-4) by Csandl, Mark A, Conseil, Gwenaëlle, Cole, Susan P C

“…Active efflux of both drugs and organic anion metabolites is mediated by the multidrug resistance proteins (MRPs). MRP1 (ABCC1), MRP2 (ABCC2), MRP3 (ABCC3),…”
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Prostaglandin signalling regulates ciliogenesis by modulating intraflagellar transport by Jin, Daqing, Ni, Terri T., Sun, Jianjian, Wan, Haiyan, Amack, Jeffrey D., Yu, Guangju, Fleming, Jonathan, Chiang, Chin, Li, Wenyan, Papierniak, Anna, Cheepala, Satish, Conseil, Gwenaëlle, Cole, Susan P. C., Zhou, Bin, Drummond, Iain A., Schuetz, John D., Malicki, Jarema, Zhong, Tao P.

“…Cilia are microtubule-based organelles that mediate signal transduction in a variety of tissues. Despite their importance, the signalling cascades that…”
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An Outward-Facing Aromatic Amino Acid Is Crucial for Signaling between the Membrane-Spanning and Nucleotide-Binding Domains of Multidrug Resistance Protein 1 (MRP1; ABCC1) by Weigl, Kevin E, Conseil, Gwenaëlle, Rothnie, Alice J, Arama, May, Tsfadia, Yossi, Cole, Susan P C

“…The 190-kDa human MRP1 is an ATP-binding cassette multidrug and multiorganic anion efflux transporter. The 17 transmembrane helices of its three…”
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Chalcogenopyrylium Compounds as Modulators of the ATP-Binding Cassette Transporters P-Glycoprotein (P-gp/ABCB1) and Multidrug Resistance Protein 1 (MRP1/ABCC1) by Ebert, Sean P, Wetzel, Bryan, Myette, Robert L, Conseil, Gwenaëlle, Cole, Susan P. C, Sawada, Geri A, Loo, Tip W, Bartlett, M. Claire, Clarke, David M, Detty, Michael R

“…Twenty-seven chalcogenopyrylium derivatives varying in the heteroatom of the pyrylium core and substituents at the 2-, 4-, and 6-positions were examined for…”
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Atypical B Cells Promote Cancer Progression and Poor Response to Bacillus Calmette-Guérin in Non-Muscle Invasive Bladder Cancer by Yolmo, Priyanka, Rahimi, Sadaf, Chenard, Stephen, Conseil, Gwenaëlle, Jenkins, Danielle, Sachdeva, Kartik, Emon, Isaac, Hamilton, Jake, Xu, Minqi, Rangachari, Manu, Michaud, Eva, Mansure, Jose J, Kassouf, Wassim, Berman, David M, Siemens, David R, Koti, Madhuri

“…Poor response to Bacillus Calmette-Guérin (BCG) immunotherapy remains a major barrier in the management of patients with non-muscle invasive bladder cancer…”
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Two polymorphic variants of ABCC1 selectively alter drug resistance and inhibitor sensitivity of the multidrug and organic anion transporter multidrug resistance protein 1 by Conseil, Gwenaëlle, Cole, Susan P C

“…In this study we compared the in silico predictions of the effect of ABCC1 nonsynonymous single nucleotide polymorphisms (nsSNPs) with experimental data on…”
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High-throughput screening identifies Ceefourin 1 and Ceefourin 2 as highly selective inhibitors of multidrug resistance protein 4 (MRP4) by Cheung, Leanna, Flemming, Claudia L., Watt, Fujiko, Masada, Nanako, Yu, Denise M.T., Huynh, Tony, Conseil, Gwenaëlle, Tivnan, Amanda, Polinsky, Alexander, Gudkov, Andrei V., Munoz, Marcia A., Vishvanath, Anasuya, Cooper, Dermot M.F., Henderson, Michelle J., Cole, Susan P.C., Fletcher, Jamie I., Haber, Michelle, Norris, Murray D.

“…Multidrug resistance protein 4 (MRP4/ABCC4), a member of the ATP-binding cassette (ABC) transporter superfamily, is an organic anion transporter capable of…”
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Molecular modeling of the human multidrug resistance protein 1 (MRP1/ABCC1) by DeGorter, Marianne K., Conseil, Gwenaëlle, Deeley, Roger G., Campbell, Robert L., Cole, Susan P.C.

“…Multidrug resistance protein 1 (MRP1/ABCC1) is a 190 kDa member of the ATP-binding cassette (ABC) superfamily of transmembrane transporters that is clinically…”
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Chalcogenopyrylium dyes as differential modulators of organic anion transport by multidrug resistance protein 1 (MRP1), MRP2, and MRP4 by Myette, Robert L, Conseil, Gwenaëlle, Ebert, Sean P, Wetzel, Bryan, Detty, Michael R, Cole, Susan P C

“…Multidrug resistance proteins (MRPs) mediate the ATP-dependent efflux of structurally diverse compounds, including anticancer drugs and physiologic organic…”
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Involvement of NHERF1 in apical membrane localization of MRP4 in polarized kidney cells by Hoque, Md. Tozammel, Conseil, Gwenaëlle, Cole, Susan P.C.

“…Multidrug resistance protein 4 (MRP4/ABCC4), a member of the ATP-binding cassette protein superfamily, confers resistance to nucleoside and nucleotide analogs…”
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Mechanistic differences between GSH transport by multidrug resistance protein 1 (MRP1/ABCC1) and GSH modulation of MRP1-mediated transport by Rothnie, Alice, Conseil, Gwenaëlle, Lau, Andrea Y T, Deeley, Roger G, Cole, Susan P C

“…Multidrug resistance protein 1 (MRP1/ABCC1) is an ATP-dependent polytopic membrane protein that transports many anticancer drugs and organic anions. Its…”
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Molecular Basis for Reduced Estrone Sulfate Transport and Altered Modulator Sensitivity of Transmembrane Helix (TM) 6 and TM17 Mutants of Multidrug Resistance Protein 1 (ABCC1) by MAENO, Kazuma, NAKAJIMA, Akio, CONSEIL, Gwenaëlle, ROTHNIE, Alice, DEELEY, Roger G, COLE, Susan P. C

“…Multidrug resistance protein 1 (MRP1) confers drug resistance and also mediates cellular efflux of many organic anions. MRP1 also transports glutathione (GSH);…”
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