Search Results - "CONROY, Jeffrey"

Indoleamine 2,3-dioxygenase (IDO) inhibitors and cancer immunotherapy by Fujiwara, Yu, Kato, Shumei, Nesline, Mary K, Conroy, Jeffrey M, DePietro, Paul, Pabla, Sarabjot, Kurzrock, Razelle

“…•Indoleamine 2,3-dioxygenase (IDO) 1 degrades tryptophan, causing immunosuppression.•IDO1 inhibitors attenuate tryptophan depletion and immunosuppression.•IDO…”
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A scalable high-throughput targeted next-generation sequencing assay for comprehensive genomic profiling of solid tumors by Conroy, Jeffrey M, Pabla, Sarabjot, Glenn, Sean T, Seager, R J, Van Roey, Erik, Gao, Shuang, Burgher, Blake, Andreas, Jonathan, Giamo, Vincent, Mallon, Melissa, Lee, Yong Hee, DePietro, Paul, Nesline, Mary, Wang, Yirong, Lenzo, Felicia L, Klein, Roger, Zhang, Shengle

“…Timely and accurate identification of molecular alterations in solid tumors is essential for proper management of patients with advanced cancers. This has…”
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Intratumoral and Intertumoral Genomic Heterogeneity of Multifocal Localized Prostate Cancer Impacts Molecular Classifications and Genomic Prognosticators by Wei, Lei, Wang, Jianmin, Lampert, Erika, Schlanger, Simon, DePriest, Adam D, Hu, Qiang, Gomez, Eduardo Cortes, Murakam, Mitsuko, Glenn, Sean T, Conroy, Jeffrey, Morrison, Carl, Azabdaftari, Gissou, Mohler, James L, Liu, Song, Heemers, Hannelore V

“…Abstract Background Next-generation sequencing is revealing genomic heterogeneity in localized prostate cancer (CaP). Incomplete sampling of CaP multiclonality…”
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Clinical and Biologic Correlates of ADORA2A Transcriptomic Expression in Cancer by Shreenivas, Aditya, Nishizaki, Daisuke, Lee, Suzanna, Pabla, Sarabjot, Nesline, Mary, Conroy, Jeffrey M, DePietro, Paul, Kato, Shumei, Kurzrock, Razelle

“…ADORA2A (adenosine A2a receptor) and ADORA2B propagate immunoregulatory signals, including restricting both innate and adaptive immunity, though recent data…”
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Information and Ethnic Politics in Africa by Conroy-Krutz, Jeffrey

“…Political scientists’ explanations for ethnic voting differ. Some have argued that the utility of ethnicity lies partly in the information that demographic…”
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Cancer-Immunity Marker RNA Expression Levels across Gynecologic Cancers: Implications for Immunotherapy by Jou, Jessica, Kato, Shumei, Miyashita, Hirotaka, Thangathurai, Kartheeswaran, Pabla, Sarabjot, DePietro, Paul, Nesline, Mary K, Conroy, Jeffrey M, Rubin, Eitan, Eskander, Ramez N, Kurzrock, Razelle

“…Our objective was to characterize cancer-immunity marker expression in gynecologic cancers and compare immune landscapes between gynecologic tumor subtypes and…”
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Analytical Validation of a Next-Generation Sequencing Assay to Monitor Immune Responses in Solid Tumors by Conroy, Jeffrey M., Pabla, Sarabjot, Glenn, Sean T., Burgher, Blake, Nesline, Mary, Papanicolau-Sengos, Antonios, Andreas, Jonathan, Giamo, Vincent, Lenzo, Felicia L., Hyland, Fiona C.L., Omilian, Angela, Bshara, Wiam, Qin, Moachun, He, Ji, Puzanov, Igor, Ernstoff, Marc S., Gardner, Mark, Galluzzi, Lorenzo, Morrison, Carl

“…We have developed a next-generation sequencing assay to quantify biomarkers of the host immune response in formalin-fixed, paraffin-embedded (FFPE) tumor…”
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TCR Convergence in Individuals Treated With Immune Checkpoint Inhibition for Cancer by Looney, Timothy John, Topacio-Hall, Denise, Lowman, Geoffrey, Conroy, Jeffrey, Morrison, Carl, Oh, David, Fong, Lawrence, Zhang, Li

“…Tumor antigen-driven selection may expand T cells having T cell receptors (TCRs) of shared antigen specificity but different amino acid or nucleotide sequence…”
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Dissection of a Down syndrome-associated trisomy to separate the gene dosage-dependent and -independent effects of an extra chromosome by Xing, Zhuo, Li, Yichen, Cortes-Gomez, Eduardo, Jiang, Xiaoling, Gao, Shuang, Pao, Annie, Shan, Jidong, Song, Yinghui, Perez, Amanda, Yu, Tao, Highsmith, Max R, Boadu, Frimpong, Conroy, Jeffrey M, Singh, Prashant K, Bakin, Andrei V, Cheng, Jianlin, Duan, Zhijun, Wang, Jianmin, Liu, Song, Tycko, Benjamin, Yu, Y Eugene

“…Abstract As an aneuploidy, trisomy is associated with mammalian embryonic and postnatal abnormalities. Understanding the underlying mechanisms involved in…”
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Association of Antifolate Response Signature Status and Clinical Activity of Pemetrexed-Platinum Chemotherapy in Non-Small Cell Lung Cancer: The Piedmont Study by Eisner, Joel R, Mayhew, Gregory M, Davison, James M, Beebe, Kirk D, Shibata, Yoichiro, Guo, Yuelong, Farhangfar, Carol, Farhangfar, Farhang, Uronis, Joshua M, Conroy, Jeffrey M, Milburn, Michael V, Hayes, David Neil, Mileham, Kathryn F

“…The Piedmont study is a prospectively designed retrospective evaluation of a new 48-gene antifolate response signature (AF-PRS) in patients with locally…”
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LAG‐3 transcriptomic expression patterns across malignancies: Implications for precision immunotherapeutics by Adashek, Jacob J., Kato, Shumei, Nishizaki, Daisuke, Miyashita, Hirotaka, De, Pradip, Lee, Suzanna, Pabla, Sarabjot, Nesline, Mary, Conroy, Jeffrey M., DePietro, Paul, Lippman, Scott, Kurzrock, Razelle

“…Background Lymphocyte activation gene 3 (LAG‐3) or CD223 is a transmembrane protein that serves as an immune checkpoint which attenuates T‐cell activation…”
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OSAT: a tool for sample-to-batch allocations in genomics experiments by Yan, Li, Ma, Changxing, Wang, Dan, Hu, Qiang, Qin, Maochun, Conroy, Jeffrey M, Sucheston, Lara E, Ambrosone, Christine B, Johnson, Candace S, Wang, Jianmin, Liu, Song

“…Batch effect is one type of variability that is not of primary interest but ubiquitous in sizable genomic experiments. To minimize the impact of batch effects,…”
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OncoKids: A Comprehensive Next-Generation Sequencing Panel for Pediatric Malignancies by Hiemenz, Matthew C, Ostrow, Dejerianne G, Busse, Tracy M, Buckley, Jonathan, Maglinte, Dennis T, Bootwalla, Moiz, Done, James, Ji, Jianling, Raca, Gordana, Ryutov, Alex, Xu, Xinjie, Zhen, Chao Jie, Conroy, Jeffrey M, Hazard, Florette K, Deignan, Joshua L, Rogers, Beverly B, Treece, Amanda L, Parham, David M, Gai, Xiaowu, Judkins, Alexander R, Triche, Timothy J, Biegel, Jaclyn A

“…The OncoKids panel is an amplification-based next-generation sequencing assay designed to detect diagnostic, prognostic, and therapeutic markers across the…”
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Whole-genome sequencing identifies genomic heterogeneity at a nucleotide and chromosomal level in bladder cancer by Morrison, Carl D, Liu, Pengyuan, Woloszynska-Read, Anna, Zhang, Jianmin, Luo, Wei, Qin, Maochun, Bshara, Wiam, Conroy, Jeffrey M, Sabatini, Linda, Vedell, Peter, Xiong, Donghai, Liu, Song, Wang, Jianmin, Shen, He, Li, Yinwei, Omilian, Angela R, Hill, Annette, Head, Karen, Guru, Khurshid, Kunnev, Dimiter, Leach, Robert, Eng, Kevin H, Darlak, Christopher, Hoeflich, Christopher, Veeranki, Srividya, Glenn, Sean, You, Ming, Pruitt, Steven C, Johnson, Candace S, Trump, Donald L

“…Using complete genome analysis, we sequenced five bladder tumors accrued from patients with muscle-invasive transitional cell carcinoma of the urinary bladder…”
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Cancer testis antigen burden (CTAB): a novel biomarker of tumor-associated antigens in lung cancer by Seager, R J, Senosain, Maria-Fernanda, Van Roey, Erik, Gao, Shuang, DePietro, Paul, Nesline, Mary K, Dash, Durga Prasad, Zhang, Shengle, Ko, Heidi, Hastings, Stephanie B, Strickland, Kyle C, Previs, Rebecca A, Jensen, Taylor J, Eisenberg, Marcia, Caveney, Brian J, Severson, Eric A, Ramkissoon, Shakti, Conroy, Jeffrey M, Pabla, Sarabjot

“…Cancer-testis antigens (CTAs) are tumor antigens that are normally expressed in the testes but are aberrantly expressed in several cancers. CTA overexpression…”
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Case report: Single gene testing and comprehensive genomic profiling in non-small cell lung cancer—a case series of divergent results from a large reference laboratory by Strickland, Kyle C., Nesline, Mary K., Previs, Rebecca A., Ko, Heidi, Cooper, Maureen, Rushton, Jennifer R., Wallen, Zachary D., Pabla, Sarabjot, Conroy, Jeffrey M., Sausen, Mark, Saini, Kamal S., Cantini, Luca, Jensen, Taylor J., Caveney, Brian J., Eisenberg, Marcia, Severson, Eric A., Ramkissoon, Shakti

“…Clinical management of non-small cell lung cancer (NSCLC) requires accurate identification of tumor-specific genetic alterations to inform treatment options…”
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High CTLA-4 transcriptomic expression correlates with high expression of other checkpoints and with immunotherapy outcome by Krishnamurthy, Nithya, Nishizaki, Daisuke, Lippman, Scott M, Miyashita, Hirotaka, Nesline, Mary K, Pabla, Sarabjot, Conroy, Jeffrey M, DePietro, Paul, Kato, Shumei, Kurzrock, Razelle

“…CTLA-4 impedes the immune system's antitumor response. There are two Food and Drug Administration-approved anti-CTLA-4 agents - ipilimumab and tremelimumab -…”
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A consensus-based classification workflow to determine genetically inferred ancestry from comprehensive genomic profiling of patients with solid tumors by Wallen, Zachary D, Nesline, Mary K, Pabla, Sarabjot, Gao, Shuang, Vanroey, Erik, Hastings, Stephanie B, Ko, Heidi, Strickland, Kyle C, Previs, Rebecca A, Zhang, Shengle, Conroy, Jeffrey M, Jensen, Taylor J, George, Elizabeth, Eisenberg, Marcia, Caveney, Brian, Sathyan, Pratheesh, Ramkissoon, Shakti, Severson, Eric A

“…Abstract Disparities in cancer diagnosis, treatment, and outcomes based on self-identified race and ethnicity (SIRE) are well documented, yet these variables…”
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Computational methods for detecting copy number variations in cancer genome using next generation sequencing: principles and challenges by Liu, Biao, Morrison, Carl D, Johnson, Candace S, Trump, Donald L, Qin, Maochun, Conroy, Jeffrey C, Wang, Jianmin, Liu, Song

“…Accurate detection of somatic copy number variations (CNVs) is an essential part of cancer genome analysis, and plays an important role in oncotarget…”
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PD-L1 Expression by RNA-Sequencing in Non-Small Cell Lung Cancer: Concordance with Immunohistochemistry and Associations with Pembrolizumab Treatment Outcomes by Nesline, Mary K, Previs, Rebecca A, Dy, Grace K, Deng, Lei, Lee, Yong Hee, DePietro, Paul, Zhang, Shengle, Meyers, Nathan, Severson, Eric, Ramkissoon, Shakti, Pabla, Sarabjot, Conroy, Jeffrey M

“…Programmed cell death ligand (PD-L1) expression by immunohistochemistry (IHC) lacks sensitivity for pembrolizumab immunotherapy selection in non-small cell…”
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