Search Results - "CONOLLY, B"

Development of a Novel AOP for Cyp2F2-Mediated Lung Cancer in Mice by Hill, Thomas, Conolly, Rory B

“…Traditional methods for carcinogenicity testing rely heavily on the rodent bioassay as the standard for identification of tumorigenic risk. As such,…”
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Bridging the Data Gap From in vitro Toxicity Testing to Chemical Safety Assessment Through Computational Modeling by Zhang, Qiang, Li, Jin, Middleton, Alistair, Bhattacharya, Sudin, Conolly, Rory B

“…Chemical toxicity testing is moving steadily toward a human cell and organoid-based approach for reasons including scientific relevancy, efficiency, cost, and…”
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Nonmonotonic Dose-Response Relationships: Mechanistic Basis, Kinetic Modeling, and Implications for Risk Assessment by Conolly, Rory B., Lutz, Werner K.

“…Dose-response curves for the first interaction of a chemical with a biochemical target molecule are usually monotonic; i.e., they increase or decrease over the…”
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Endocrine disrupting chemicals in fish: Developing exposure indicators and predictive models of effects based on mechanism of action by Ankley, Gerald T., Bencic, David C., Breen, Michael S., Collette, Timothy W., Conolly, Rory B., Denslow, Nancy D., Edwards, Stephen W., Ekman, Drew R., Garcia-Reyero, Natalia, Jensen, Kathleen M., Lazorchak, James M., Martinović, Dalma, Miller, David H., Perkins, Edward J., Orlando, Edward F., Villeneuve, Daniel L., Wang, Rong-Lin, Watanabe, Karen H.

“…Knowledge of possible toxic mechanisms (or modes) of action (MOA) of chemicals can provide valuable insights as to appropriate methods for assessing exposure…”
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A Physiologically Based Pharmacokinetic (PBPK) Modeling Framework for Mixtures of Dioxin-like Compounds by Liu, Rongrui, Zacharewski, Tim R, Conolly, Rory B, Zhang, Qiang

“…Humans are exposed to persistent organic pollutants, such as dioxin-like compounds (DLCs), as mixtures. Understanding and predicting the toxicokinetics and…”
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Case Study in 21st‐Century Ecotoxicology: Using In Vitro Aromatase Inhibition Data to Predict Reproductive Outcomes in Fish In Vivo by Villeneuve, Daniel L., Blackwell, Brett R., Blanksma, Chad A., Cavallin, Jenna E., Cheng, Wan‐Yun, Conolly, Rory B., Conrow, Kendra, Feifarek, David J., Heinis, Larry J., Jensen, Kathleen M., Kahl, Michael D., Milsk, Rebecca Y., Poole, Shane T., Randolph, Eric C., Saari, Travis W., Watanabe, Karen H., Ankley, Gerald T.

“…To reduce the use of intact animals for chemical safety testing, while ensuring protection of ecosystems and human health, there is a demand for new approach…”
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Human Respiratory Tract Cancer Risks of Inhaled Formaldehyde: Dose-Response Predictions Derived From Biologically-Motivated Computational Modeling of a Combined Rodent and Human Dataset by Conolly, Rory B., Kimbell, Julia S., Janszen, Derek, Schlosser, Paul M., Kalisak, Darin, Preston, Julian, Miller, Frederick J.

“…Formaldehyde inhalation at 6 ppm and above causes nasal squamous cell carcinoma (SCC) in F344 rats. The quantitative implications of the rat tumors for human…”
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Biologically Motivated Computational Modeling of Formaldehyde Carcinogenicity in the F344 Rat by Conolly, Rory B., Kimbell, Julia S., Janszen, Derek, Schlosser, Paul M., Kalisak, Darin, Preston, Julian, Miller, Frederick J.

“…Formaldehyde inhalation at 6 ppm and above causes nasal squamous cell carcinoma (SCC) in F344 rats. The human health implications of this effect are of…”
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Dose-dependent transitions in mechanisms of toxicity: case studies by Slikker, William, Andersen, Melvin E., Bogdanffy, Matthew S., Bus, James S., Cohen, Steven D., Conolly, Rory B., David, Raymond M., Doerrer, Nancy G., Dorman, David C., Gaylor, David W., Hattis, Dale, Rogers, John M., Setzer, R. Woodrow, Swenberg, James A., Wallace, Kendall

“…Experience with dose response and mechanisms of toxicity has shown that multiple mechanisms may exist for a single agent along the continuum of the full…”
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Dose-dependent transitions in mechanisms of toxicity by Slikker, William, Andersen, Melvin E., Bogdanffy, Matthew S., Bus, James S., Cohen, Steven D., Conolly, Rory B., David, Raymond M., Doerrer, Nancy G., Dorman, David C., Gaylor, David W., Hattis, Dale, Rogers, John M., Woodrow Setzer, R., Swenberg, James A., Wallace, Kendall

“…Scientists and decision makers from all sectors agree that risk assessments should be based on the best available science. Several years ago, the Health and…”
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Use of a Physiologically Based Pharmacokinetic Model to Identify Exposures Consistent With Human Biomonitoring Data for Chloroform by Tan, Yu-Mei, Liao, Kai H., Conolly, Rory B., Blount, Benjamin C., Mason, Ann M., Clewell, Harvey J.

“…Biomonitoring data provide evidence of human exposure to environmental chemicals by quantifying the chemical or its metabolite in a biological matrix. To…”
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Modeling Interindividual Variation in Physiological Factors Used in PBPK Models of Humans by Price, Paul S., Conolly, Rory B., Chaisson, Christine F., Gross, Elizabeth A., Young, John S., Mathis, Eric T., Tedder, Douglas R.

“…Modeling interindividual variation in internal doses in humans using PBPK models requires data on the variation in physiological parameters across the…”
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Assessing The Health Effects and Risks Associated with Children's Inhalation Exposures-Asthma and Allergy by Selgrade, MaryJane K., Plopper, Charles G., Gilmour, M. Ian, Conolly, Rory B., Foos, Brenda S. P.

“…Adults and children may have different reactions to inhalation exposures due to differences in target tissue doses following similar exposures, and/or…”
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Computational Modeling of Signaling Pathways Mediating Cell Cycle Checkpoint Control and Apoptotic Responses to Ionizing Radiation-Induced DNA Damage by Zhao, Yuchao, Lou, In Chio, Conolly, Rory B.

“…The shape of dose response of ionizing radiation (IR) induced cancer at low dose region, either linear non-threshold or J-shaped, has been a debate for a long…”
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Quantitative Adverse Outcome Pathways and Their Application to Predictive Toxicology by Conolly, Rory B, Ankley, Gerald T, Cheng, WanYun, Mayo, Michael L, Miller, David H, Perkins, Edward J, Villeneuve, Daniel L, Watanabe, Karen H

“…A quantitative adverse outcome pathway (qAOP) consists of one or more biologically based, computational models describing key event relationships linking a…”
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Mechanistic computational model of ovarian steroidogenesis to predict biochemical responses to endocrine active compounds by Breen, Michael S, Villeneuve, Daniel L, Breen, Miyuki, Ankley, Gerald T, Conolly, Rory B

“…Sex steroids, which have an important role in a wide range of physiological and pathological processes, are synthesized primarily in the gonads and adrenal…”
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Updating the biologically based dose-response model for the nasal carcinogenicity of inhaled formaldehyde in the F344 rat by Conolly, Rory B, Schroeter, Jeffry, Kimbell, Julia S, Clewell, Harvey, Andersen, Melvin E, Gentry, P Robinan

“…Abstract Chronic inhalation of formaldehyde by F344 rats causes nasal squamous cell carcinoma (SCC). This outcome is well-characterized: including…”
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A Quantitative Source-to-Outcome Case Study To Demonstrate the Integration of Human Health and Ecological End Points Using the Aggregate Exposure Pathway and Adverse Outcome Pathway Frameworks by Hines, David E, Conolly, Rory B, Jarabek, Annie M

“…Exposure to environmental contaminants can lead to adverse outcomes in both human and nonhuman receptors. The Aggregate Exposure Pathway (AEP) and Adverse…”
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New directions in incidence-dose modeling by ANDERSEN, Melvin E, DENNISON, James E, THOMAS, Russell S, CONOLLY, Rory B

“…Many cellular responses are quantal; that is, they either take place or they do not. Examples of "either-or" responses include cell replication,…”
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Relative contributions of endogenous and exogenous formaldehyde to formation of deoxyguanosine monoadducts and DNA-protein crosslink adducts of DNA in rat nasal mucosa by Conolly, Rory B, Campbell, Jerry L, Clewell, Harvey J, Schroeter, Jeffry, Kimbell, Julia S, Gentry, P Robinan

“…Abstract Understanding the dose-response for formaldehyde-induced nasal cancer in rats is complicated by (1) the uneven distribution of inhaled formaldehyde…”
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