Search Results - "CONNOR, J. R"

Layered rare-earth hydroxides as multi-modal medical imaging probes: particle size optimisation and compositional exploration by Strimaite, Margarita, Wells, Connor J R, Prior, Timothy J, Stuckey, Daniel J, Wells, Jack A, Davies, Gemma-Louise, Williams, Gareth R

“…Recently, layered rare-earth hydroxides (LRHs) have received growing attention in the field of theranostics. We have previously reported the hydrothermal…”
Get more information

Transition Metal Synthetic Ferrimagnets: Tunable Media for All-Optical Switching Driven by Nanoscale Spin Current by Da̧browski, Maciej, Scott, Jade N, Hendren, William R, Forbes, Colin M, Frisk, Andreas, Burn, David M, Newman, David G, Sait, Connor R. J, Keatley, Paul S, N’Diaye, Alpha T, Hesjedal, Thorsten, van der Laan, Gerrit, Bowman, Robert M, Hicken, Robert J

“…All-optical switching of magnetization has great potential for use in future ultrafast and energy efficient nanoscale magnetic storage devices. So far,…”
Get full text

Ferritin: a novel mechanism for delivery of iron to the brain and other organs by Fisher, J, Devraj, K, Ingram, J, Slagle-Webb, B, Madhankumar, A B, Liu, X, Klinger, M, Simpson, I A, Connor, J R

“…Traditionally, transferrin has been considered the primary mechanism for cellular iron delivery, despite suggestive evidence for additional iron delivery…”
Get more information

A CSF biomarker panel for identification of patients with amyotrophic lateral sclerosis by MITCHELL, R. M, FREEMAN, W. M, RANDAZZO, W. T, STEPHENS, H. E, BEARD, J. L, SIMMONS, Z, CONNOR, J. R

“…Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease with complicated pathogenesis that poses challenges with respect to diagnosis…”
Get full text

Hypoxia-inducible factor pathway activation in restless legs syndrome patients by Patton, S. M., Ponnuru, P., Snyder, A. M., Podskalny, G. D., Connor, J. R.

“…Background and purpose:  These studies tested the hypothesis that hypoxia inducible factor‐1α (HIF‐1α) pathway activation occurs in substantia nigra neurons…”
Get full text

Cellular iron status influences the functional relationship between microglia and oligodendrocytes by Zhang, X., Surguladze, N., Slagle-Webb, B., Cozzi, A., Connor, J. R.

“…Previously, we have reported that there is a spatiotemporal relationship between iron accumulation in microglia and oligodendrocytes during normal development…”
Get full text

pH-Responsive nanocomposite fibres allowing MRI monitoring of drug release by Zhang, Ziwei, Wells, Connor J R, King, Aaron M, Bear, Joseph C, Davies, Gemma-Louise, Williams, Gareth R

“…Magnetic resonance imaging (MRI) is one of the most widely-used non-invasive clinical imaging tools, producing detailed anatomical images whilst avoiding side…”
Get more information

Profile of altered brain iron acquisition in restless legs syndrome by CONNOR, James R, PONNURU, Padmavathi, WANG, Xin-Sheng, PATTON, Stephanie M, ALLEN, Richard P, EARLEY, Christopher J

“…Restless legs syndrome is a neurological disorder characterized by an urgency to move the legs during periods of rest. Data from a variety of sources provide a…”
Get full text

Cerebrospinal Fluid Ceruloplasmin, Haptoglobin, and Vascular Endothelial Growth Factor Are Associated with Neurocognitive Impairment in Adults with HIV Infection by Kallianpur, A. R., Gittleman, H., Letendre, S., Ellis, R., Barnholtz-Sloan, J. S., Bush, W. S., Heaton, R., Samuels, D. C., Franklin, D. R., Rosario-Cookson, D., Clifford, D. B., Collier, A. C., Gelman, B., Marra, C. M., McArthur, J. C., McCutchan, J. A., Morgello, S., Grant, I., Simpson, D., Connor, J. R., Hulgan, T.

“…Dysregulated iron transport and a compromised blood–brain barrier are implicated in HIV-associated neurocognitive disorders (HAND). We quantified the levels of…”
Get full text

Magnetically driven preparation of 1-D nano-necklaces capable of MRI relaxation enhancement by King, Aaron M, Insinna, Teresa, Wells, Connor J. R, Raby, Isabel A, Gun'ko, Yurii K, Davies, Gemma-Louise

“…We report a novel magnetically-facilitated approach to produce 1-D 'nano-necklace' arrays composed of 0-D magnetic nanoparticles, which are assembled and…”
Get full text

Multivariate Modulation of the Zr MOF UiO‐66 for Defect‐Controlled Combination Anticancer Drug Delivery by Abánades Lázaro, Isabel, Wells, Connor J. R., Forgan, Ross S.

“…Metal–organic frameworks (MOFs) are emerging as leading candidates for nanoscale drug delivery, as a consequence of their high drug capacities, ease of…”
Get full text

Decreased transferrin receptor expression by neuromelanin cells in restless legs syndrome by CONNOR, J. R, WANG, X. S, PATTON, S. M, MENZIES, S. L, TRONCOSO, J. C, EARLEY, C. J, ALLEN, R. P

“…Restless legs syndrome (RLS) is a sensory-movement disorder affecting 5 to 10% of the population. Its etiology is unknown, but MRI analyses and…”
Get full text

Abnormalities in CSF concentrations of ferritin and transferrin in restless legs syndrome by EARLEY, C. J, CONNOR, J. R, BEARD, J. L, MALECKI, E. A, EPSTEIN, D. K, ALLEN, R. P

“…CSF and serum were obtained from 16 patients with idiopathic restless legs syndrome (RLS) and 8 age-matched healthy control subjects. Patients with RLS had…”
Get full text

SHP2 inhibition diminishes KRASG12C cycling and promotes tumor microenvironment remodeling by Fedele, Carmine, Li, Shuai, Teng, Kai Wen, Foster, Connor J R, Peng, David, Ran, Hao, Mita, Paolo, Geer, Mitchell J, Hattori, Takamitsu, Koide, Akiko, Wang, Yubao, Tang, Kwan Ho, Leinwand, Joshua, Wang, Wei, Diskin, Brian, Deng, Jiehui, Chen, Ting, Dolgalev, Igor, Ozerdem, Ugur, Miller, George, Koide, Shohei, Wong, Kwok-Kin, Neel, Benjamin G

“…KRAS is the most frequently mutated human oncogene, and KRAS inhibition has been a longtime goal. Recently, inhibitors were developed that bind KRASG12C-GDP…”
Get full text

Distribution of divalent metal transporter-1 in the monkey basal ganglia by Huang, E., Ong, W.Y., Connor, J.R.

“…An accumulation of iron occurs in the brain with age, and it is thought that this may contribute to the pathology of certain neurodegenerative diseases,…”
Get full text

Mechanisms and regulation of transferrin and iron transport in a model blood–brain barrier system by Burdo, J.R, Antonetti, D.A, Wolpert, E.B, Connor, J.R

“…For peripheral iron to reach the brain, it must transverse the blood–brain barrier. In order for the brain to obtain iron, transferrin receptors are present in…”
Get full text

Genetically Defined, Syngeneic Organoid Platform for Developing Combination Therapies for Ovarian Cancer by Zhang, Shuang, Iyer, Sonia, Ran, Hao, Dolgalev, Igor, Gu, Shengqing, Wei, Wei, Foster, Connor J R, Loomis, Cynthia A, Olvera, Narciso, Dao, Fanny, Levine, Douglas A, Weinberg, Robert A, Neel, Benjamin G

“…The paucity of genetically informed, immunocompetent tumor models impedes evaluation of conventional, targeted, and immune therapies. By engineering mouse…”
Get more information

The effect of formulation morphology on stimuli-triggered co-delivery of chemotherapeutic and MRI contrast agents by Zhang, Ziwei, Wells, Connor J.R., Davies, Gemma-Louise, Williams, Gareth R.

“…[Display omitted] Most conventional chemotherapeutics have narrow therapeutic windows, and thus their delivery remains challenging and often raises safety and…”
Get full text

Quantitative phosphoproteomic analysis reveals involvement of PD-1 in multiple T cell functions by Tocheva, Anna S., Peled, Michael, Strazza, Marianne, Adam, Kieran R., Lerrer, Shalom, Nayak, Shruti, Azoulay-Alfaguter, Inbar, Foster, Connor J.R., Philips, Elliot A., Neel, Benjamin G., Ueberheide, Beatrix, Mor, Adam

“…Programmed cell death protein 1 (PD-1) is a critical inhibitory receptor that limits excessive T cell responses. Cancer cells have evolved to evade these…”
Get full text

Transferrin and iron in normal, Alzheimer's disease, and Parkinson's disease brain regions by Loeffler, D A, Connor, J R, Juneau, P L, Snyder, B S, Kanaley, L, DeMaggio, A J, Nguyen, H, Brickman, C M, LeWitt, P A

“…Oxidant-mediated damage is suspected to be involved in the pathogenesis of several neurodegenerative disorders. Iron promotes conversion of hydrogen peroxide…”
Get more information