Search Results - "CONNOLLY, T. M."

Impact of a surgical site infection reduction strategy after colorectal resection by Connolly, T. M., Foppa, C., Kazi, E., Denoya, P. I., Bergamaschi, R.

“…Aim This study was performed to determine the impact of a surgical site infection (SSI) reduction strategy on SSI rates following colorectal resection. Method…”
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Design defects can close a study by Popa, D., Connolly, T. M., Barbon, C., Bergamaschi, R.

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Disagregin is a fibrinogen receptor antagonist lacking the Arg-Gly-Asp sequence from the tick, Ornithodoros moubata by Karczewski, J, Endris, R, Connolly, T.M

“…A platelet aggregation inhibitor was identified in the salivary gland of the tick Ornithodoros moubata and isolated by gel filtration and reverse phase high…”
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Inositol phosphates: synthesis and degradation by Majerus, P W, Connolly, T M, Bansal, V S, Inhorn, R C, Ross, T S, Lips, D L

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Isolation of an inhibitor selective for collagen-stimulated platelet aggregation from the soft tick Ornithodoros moubata by Waxman, L, Connolly, T.M

“…Soluble extracts from the soft tick Ornithodoros moubata were found to inhibit collagen-, ADP-, and thrombin-stimulated platelet aggregation. One inhibitory…”
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Tying up loose ends by Yang, K., Connolly, T. M., Bergamaschi, R.

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P‐selectin antagonism reduces thrombus formation in humans by CHELLIAH, R., LUCKING, A. J., TATTERSALL, L., DAGA, S., BERESFORD‐CLEARY, N. J., CORTAS, K., FOX, K. A. A., FEUERSTEIN, G. Z., CONNOLLY, T. M., NEWBY, D. E.

“…Background: Interaction of P‐selectin with its glycoprotein ligand (P‐selectin glycoprotein ligand type 1) mediates inflammatory processes that may also…”
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Evidence that Na+/H+ exchange regulates receptor-mediated phospholipase A2 activation in human platelets by Sweatt, J D, Connolly, T M, Cragoe, E J, Limbird, L E

“…Data in the previous paper suggest that epinephrine can mobilize a small pool of arachidonic acid via an enzymatic pathway distinct from phospholipase C and…”
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Cloning of the cDNA and expression of moubatin, an inhibitor of platelet aggregation by Keller, P.M, Waxman, L, Arnold, B.A, Schultz, L.D, Condra, C, Connolly, T.M

“…Moubatin, a new type of specific inhibitor of collagen-induced platelet aggregation, has been isolated from the soft tick Ornithodoros moubata (Waxman, L., and…”
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Identification and Isolation of a 75-kDa Inositol Polyphosphate-5-phosphatase from Human Platelets by Mitchell, C A, Connolly, T M, Majerus, P W

“…We have identified, isolated, and characterized a second inositol polyphosphate-5-phosphatase enzyme from the soluble fraction of human platelets. The enzyme…”
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An inhibitor of collagen-stimulated platelet activation from the salivary glands of the Haementeria officinalis leech. I. Identification, isolation, and characterization by CONNOLLY, T. M, JACOBS, J. W, CONDRA, C

“…A protein that blocks collagen-stimulated platelet aggregation has been identified and isolated from the soluble fraction of salivary glands from Haementeria…”
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The Metabolism of Phosphoinositide-Derived Messenger Molecules by Majerus, Philip W., Connolly, Thomas M., Deckmyn, Hans, Ross, Theodora S., Bross, Teresa E., Ishii, Hidemi, Bansal, Vinay S., Wilson, David B.

“…The phosphoinositides are minor phospholipids present in all eukaryotic cells. They are storage forms for messenger molecules that transmit signals across the…”
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Platelet aggregation monitored in a 96 well microplate reader is useful for evaluation of platelet agonists and antagonists by Bednar, Bohumil, Condra, Cindra, Gould, Robert J., Connolly, Thomas M.

“…Optimal conditions for a method to simultaneously measure aggregation in 96 samples using a microplate reader were developed. The temperature of the assay was…”
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An antibody against the exosite of the cloned thrombin receptor inhibits experimental arterial thrombosis in the African green monkey by COOK, J. J, SITKO, G. R, BEDNAR, B, CONDRA, C, MELLOTT, M. J, DONG-MEI FENG, NUTT, R. F, SHAFER, J. A, GOULD, R. J, CONNOLLY, T. M

“…Thrombin inhibitors have been shown to be efficacious in animal models of thrombosis and in initial human clinical trials. It is unknown if their efficacy is…”
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Species variability in platelet and other cellular responsiveness to thrombin receptor-derived peptides by Connolly, T M, Condra, C, Feng, D M, Cook, J J, Stranieri, M T, Reilly, C F, Nutt, R F, Gould, R J

“…The aggregation of platelets from a variety of animal species in response to thrombin receptor-derived activating peptides was evaluated. A series of…”
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Effect of the small molecule plasminogen activator inhibitor‐1 (PAI‐1) inhibitor, PAI‐749, in clinical models of fibrinolysis by LUCKING, A. J., VISVANATHAN, A., PHILIPPOU, H., FRASER, S., GRANT, P. J., CONNOLLY, T. M., GARDELL, S. J., FEUERSTEIN, G. Z., FOX, K. A. A., BOOTH, N. A., NEWBY, D. E.

“…Background: The principal inhibitor of fibrinolysis in vivo is plasminogen activator inhibitor‐1 (PAI‐1). PAI‐749 is a small molecule inhibitor of PAI‐1 with…”
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Protein kinase C phosphorylates human platelet inositol trisphosphate 5'-phosphomonoesterase, increasing the phosphatase activity by Connolly, T M, Lawing, Jr, W J, Majerus, P W

“…Phosphoinositide breakdown in response to thrombin stimulation of human platelets results in the formation of the calcium-mobilizing messenger molecules…”
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The structure of leech anti-platelet protein, an inhibitor of haemostasis by Huizinga, Eric G., Schouten, Arie, Connolly, Thomas M., Kroon, Jan, Sixma, Jan J., Gros, Piet

“…Leech anti‐platelet protein (LAPP) from the leech Haementeria officinalis is a collagen‐binding protein that inhibits the collagen‐mediated adhesion of blood…”
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Isolation of a phosphomonoesterase from human platelets that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate by Connolly, T M, Bross, T E, Majerus, P W

“…Platelets, and a variety of other cells, rapidly hydrolyze the phosphoinositides in response to stimulation by agonists. One of the products of hydrolysis of…”
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Isolation and characterization of the inositol cyclic phosphate products of polyphosphoinositide cleavage by phospholipase C. Physiological effects in permeabilized platelets and Limulus photoreceptor cells by Wilson, D B, Connolly, T M, Bross, T E, Majerus, P W, Sherman, W R, Tyler, A N, Rubin, L J, Brown, J E

“…Cleavage of the polyphosphoinositides, catalyzed by phospholipase C purified from ram seminal vesicles, produces phosphorylated inositols containing cyclic…”
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