Search Results - "CONNELLY, P. R"

Enthalpy of Hydrogen Bond Formation in a Protein-Ligand Binding Reaction by Connelly, Patrick R., Aldape, Robert A., Bruzzese, Frank J., Chambers, Stephen P., Fitzgibbon, Matthew J., Fleming, Mark A., Itoh, Susumu, Livingston, David J., Navia, manuel A., Thomson, John A., Wilson, Keith P.

“…Parallel measurements of the thermodynamics (free-energy, enthalpy, entropy and heat-capacity changes) of ligand binding to FK506 binding protein (FKBP-12) in…”
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Heat Capacity Changes and Hydrophobic Interactions in the Binding of FK506 and Rapamycin to the FK506 Binding Protein by Connelly, Patrick R., Thomson, John A.

“…Differential interactions among nonpolar moieties at protein/ligand interfaces, and of these nonpolar groups with water, collectively termed hydrophobic…”
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Esophageal atresia with tracheoesophageal fistula: Suggested mechanism in faulty organogenesis by Crisera, Christopher A, Connelly, Patrick R, Marmureanu, Alexander R, Colen, Kari L, Rose, Michael I, Li, Min, Longaker, Michael T, Gittes, George K

“…Background/Purpose : The organogenesis of esophageal atresia with tracheoesophageal fistula (EA-TEF) is unknown. Using an established model for EA-TEF in rats,…”
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Heat capacity changes for protein-peptide interactions in the ribonuclease S system by Varadarajan, Raghavan, Connelly, Patrick R, Sturtevant, Julian M, Richards, Frederic M

“…Two fragments of pancreatic ribonuclease A, a truncated version of S-peptide (residues 1-15) and S-protein (residues 21-124), combine to give a catalytically…”
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Vascular development in the mouse embryonic pancreas and lung by Colen, Kari L., Crisera, Christopher A., Rose, Michael I., Connelly, Patrick R., Longaker, Michael T., Gittes, George K.

“…Purpose: The purpose of this study was to analyze the formation of blood vessels in the developing mouse pancreas and lung by studying two ligands,…”
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Thermodynamics of protein-peptide interactions in the ribonuclease S system studied by titration calorimetry by Connelly, Patrick R, Varadarajan, Raghavan, Sturtevant, Julian M, Richards, Frederic M

“…Two fragments of pancreatic ribonuclease A, a truncated version of S-peptide (residues 1-15) and S-protein (residues 21-124), combine to give a catalytically…”
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Probing hydration contributions to the thermodynamics of ligand binding by proteins. Enthalpy and heat capacity changes of tacrolimus and rapamycin binding to FK506 binding protein in D2O and H2O by CONNELLY, P. R, THOMSON, J. A, FITZGIBBON, M. J, BRUZZESE, F. J

“…The stabilities of native proteins and protein-ligand complexes result from differential interactions among numerous polar and nonpolar atoms within the…”
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Thermodynamics of interaction of FK 506-binding protein and its ligands by Connelly, P R

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Tailoring the structural and optical properties of HiPIMS TiO2 thin films for photovoltaic applications by Zinai, N., Bouzidi, A., Saoula, N., Miloua, R., Medles, M., Filali, W., Garoudja, E., Azibi, M., Connelly, P.R., Nakrela, A.

“…Titanium dioxide (TiO2) thin films are deposited onto glass and silicon substrates by high power impulse magnetron sputtering (HiPIMS) at various substrate…”
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Analysis and parameter resolution in highly cooperative systems by Gill, S J, Connelly, P R, Di Cera, E, Robert, C H

“…We have examined common methods of analysis of highly cooperative systems such as oxygen binding by hemoglobin and thermal denaturation. Through extensive…”
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Carbon monoxide binding to human hemoglobin A0 by Di Cera, Enrico, Doyle, Michael L, Connelly, Patrick R, Gill, Stanley J

“…The carbon monoxide binding curve to human hemoglobin A0 has been measured to high precision in experimental conditions of 600 microM heme, 0.1 M…”
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Nested allosteric interaction in tarantula hemocyanin revealed through the binding of oxygen and carbon monoxide by Decker, Heinz, Connelly, Patrick R, Robert, Charles H, Gill, Stanley J

“…We have examined the competitive binding of oxygen and carbon monoxide to the multisubunit hemocyanin of the tarantula Eurypelma californicum. Employment of…”
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Allosteric Properties of Inosine Monophosphate Dehydrogenase Revealed through the Thermodynamics of Binding of Inosine 5‘-Monophosphate and Mycophenolic Acid. Temperature Dependent Heat Capacity of Binding as a Signature of Ligand-Coupled Conformational Equilibria by Bruzzese, Frank J, Connelly, Patrick R

“…The thermodynamic properties of binding of the substrate, inosine monophosphate (IMP), and the uncompetitive inhibitor, mycophenolic acid, to inosine…”
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Binding of oxygen and carbon monoxide to the hemocyanin from the spiny lobster by Connelly, P R, Johnson, C R, Robert, C H, Bak, H J, Gill, S J

“…A high precision, two-dimensional study of oxygen and carbon monoxide binding to Panulirus interruptus hemocyanin has been carried out. Global data analysis of…”
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Analysis of zeros of binding polynomials for tetrameric hemoglobins by Connelly, P R, Robert, C H, Briggs, W E, Gill, S J

“…A quantitative measure of the validity of the MWC description of cooperative binding equilibria has been obtained which uses only the Adair constants. This is…”
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In vitro prefabrication of human cartilage shapes using fibrin glue and human chondrocytes by Ting, V, Sims, C D, Brecht, L E, McCarthy, J G, Kasabian, A K, Connelly, P R, Elisseeff, J, Gittes, G K, Longaker, M T

“…We report the first generation of human cartilage from fibrin glue using a technique of molding chondrocytes in fibrin glue developed in our laboratory. Human…”
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TTF-1 and HNF-3β in the developing tracheoesophageal fistula: Further evidence for the respiratory origin of the ‘distal esophagus’ by Crisera, Christopher A., Connelly, Patrick R., Marmureanu, Alexander R., Li, Min, Rose, Michael I., Longaker, Michael T., Gittes, George K.

“…Purpose : Using an established rat model of esophageal atresia with tracheoesophageal fistula (EA-TEF), the authors have studied the organogenesis of this…”
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Determination of the Differential Effects of Hydrogen Bonding and Water Release on the Binding of FK506 to Native and Tyr82→Phe82 FKBP-12 Proteins using Free Energy Simulations by Pearlman, David A., Connelly, Patrick R.

“…We use the thermodynamic integration technique to calculate the free energy associated with the Tyr82→Phe82 mutation (Y82F) in the protein FKBP-12, both free…”
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Thermodynamics of the helix-coil transition: Binding of S15 and a hybrid sequence, disulfide stabilized peptide to the S-protein by Bastos, Margarida, Pease, Joseph H.B., Wemmer, David E., Murphy, Kenneth P., Connelly, Patrick R.

“…Pancreatic ribonuclease A may be cleaved to produce two fragments: the S‐peptide (residues 1–20) and the S‐protein (residues 21–124). The S‐peptide, or a…”
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Acquisition and use of calorimetric data for prediction of the thermodynamics of ligand-binding and folding reactions of proteins by Connelly, P R

“…The commercialization of high-precision microcalorimeters has led to a sharp increase in the acquisition and utilization of calorimetric data on the binding…”
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