Search Results - "CONNELL, John M"

Serum Soluble ST2: A Potential Novel Mediator in Left Ventricular and Infarct Remodeling After Acute Myocardial Infarction by WEIR, Robin A. P, MILLER, Ashley M, MURPHY, Grace E. J, CLEMENTS, Suzanne, STEEDMAN, Tracey, CONNELL, John M. C, MCINNES, Iain B, DARGIE, Henry J, MCMURRAY, John J. V

“…This study sought to assess, for the first time, the relationship between serum concentrations of the soluble interleukin-1 receptor family member ST2 (sST2)…”
Get full text

Health Status of Adults with Congenital Adrenal Hyperplasia: A Cohort Study of 203 Patients by Arlt, Wiebke, Willis, Debbie S, Wild, Sarah H, Krone, Nils, Doherty, Emma J, Hahner, Stefanie, Han, Thang S, Carroll, Paul V, Conway, Gerry S, Rees, D. Aled, Stimson, Roland H, Walker, Brian R, Connell, John M. C, Ross, Richard J

“…Context: No consensus exists for management of adults with congenital adrenal hyperplasia (CAH) due to a paucity of data from cohorts of meaningful size…”
Get full text

MicroRNA-24 Is a Novel Regulator of Aldosterone and Cortisol Production in the Human Adrenal Cortex by Robertson, Stacy, MacKenzie, Scott M., Alvarez-Madrazo, Samantha, Diver, Louise A., Lin, Junjun, Stewart, Paul M., Fraser, Robert, Connell, John M., Davies, Eleanor

“…Dysregulation of aldosterone or cortisol production can predispose to hypertension, as seen in aldosterone-producing adenoma, a form of primary aldosteronism…”
Get full text

A Lifetime of Aldosterone Excess: Long-Term Consequences of Altered Regulation of Aldosterone Production for Cardiovascular Function by Connell, John M. C, MacKenzie, Scott M, Freel, E. Marie, Fraser, Robert, Davies, Eleanor

“…Up to 15% of patients with essential hypertension have inappropriate regulation of aldosterone; although only a minority have distinct adrenal tumors, recent…”
Get full text

Genome-wide Association Study Identifies Genes for Biomarkers of Cardiovascular Disease: Serum Urate and Dyslipidemia by Wallace, Chris, Newhouse, Stephen J., Braund, Peter, Zhang, Feng, Tobin, Martin, Falchi, Mario, Ahmadi, Kourosh, Dobson, Richard J., Marçano, Ana Carolina B., Hajat, Cother, Burton, Paul, Deloukas, Panagiotis, Brown, Morris, Connell, John M., Dominiczak, Anna, Lathrop, G. Mark, Webster, John, Farrall, Martin, Spector, Tim, Samani, Nilesh J., Caulfield, Mark J., Munroe, Patricia B.

“…Many common diseases are accompanied by disturbances in biochemical traits. Identifying the genetic determinants could provide novel insights into disease…”
Get full text

Resting Heart Rate Pattern During Follow-Up and Mortality in Hypertensive Patients by Paul, Laura, Hastie, Claire E, Li, Weiling S, Harrow, Craig, Muir, Scott, Connell, John M.C, Dominiczak, Anna F, McInnes, Gordon T, Padmanabhan, Sandosh

“…There is a linear relationship between resting heart rate (HR) and mortality in normotensive and untreated hypertensive individuals. However, it is not clear…”
Get full text

Depot-specific steroidogenic gene transcription in human adipose tissue by MacKenzie, Scott M., Huda, Shahzya S., Sattar, Naveed, Fraser, Robert, Connell, John M. C., Davies, Eleanor

“…Summary Context  Sex steroids (androgens and oestrogens) and corticosteroids (glucocorticoids and mineralocorticoids) have a major impact on fat distribution…”
Get full text

The new biology of aldosterone by Connell, John M C, Davies, Eleanor

“…Classically, aldosterone is synthesised in the adrenal zona glomerulosa and binds to specific mineralocorticoid receptors located in the cytosol of target…”
Get full text

Comparison of Diagnostic Accuracy of Urinary Free Metanephrines, Vanillyl Mandelic Acid, and Catecholamines and Plasma Catecholamines for Diagnosis of Pheochromocytoma by Boyle, James G., Davidson, D. Fraser, Perry, Colin G., Connell, John M. C.

“…Context: Recent evidence suggests that plasma-free metanephrines provide a highly sensitive test in patients requiring exclusion of pheochromocytoma. The…”
Get full text

Demonstration of Blood Pressure-Independent Noninfarct Myocardial Fibrosis in Primary Aldosteronism: A Cardiac Magnetic Resonance Imaging Study by MARIE FREEL, E, MARK, Patrick B, WEIR, Robin A. P, MCQUARRIE, Emily P, ALLAN, Karen, DARGIE, Henry J, MCCLURE, John D, JARDINE, Alan G, DAVIES, Eleanor, CONNELL, John M

“…Primary aldosteronism (PA) is common and associates with excess cardiovascular morbidity independent of blood pressure. Exposure to aldosterone and sodium…”
Get full text

ACTH and Polymorphisms at Steroidogenic Loci as Determinants of Aldosterone Secretion and Blood Pressure by MacKenzie, Scott M, Freel, E Marie, Connell, John M, Fraser, Robert, Davies, Eleanor

“…The majority of genes contributing to the heritable component of blood pressure remain unidentified, but there is substantial evidence to suggest that common…”
Get full text

Regulation of Corticosteroidogenic Genes by MicroRNAs by Davies, Eleanor, MacKenzie, Scott M., Fraser, Robert, Ejaz, Ayesha, Livie, Craig, Alvarez-Madrazo, Samantha, Diver, Louise A., Robertson, Stacy, Connell, John M.

“…The loss of normal regulation of corticosteroid secretion is important in the development of cardiovascular disease. We previously showed that microRNAs…”
Get full text

Rosiglitazone Stimulates Nitric Oxide Synthesis in Human Aortic Endothelial Cells via AMP-activated Protein Kinase by Boyle, James G., Logan, Pamela J., Ewart, Marie-Ann, Reihill, James A., Ritchie, Stuart A., Connell, John M.C., Cleland, Stephen J., Salt, Ian P.

“…The thiazolidinedione anti-diabetic drugs increase activation of endothelial nitric-oxide (NO) synthase by phosphorylation at Ser-1177 and increase NO…”
Get full text

Steroid Biomarkers and Genetic Studies Reveal Inactivating Mutations in Hexose-6-Phosphate Dehydrogenase in Patients with Cortisone Reductase Deficiency by Lavery, Gareth G., Walker, Elizabeth A., Tiganescu, Ana, Ride, Jon P., Shackleton, Cedric H. L., Tomlinson, Jeremy W., Connell, John M. C., Ray, David W., Biason-Lauber, Anna, Malunowicz, Ewa M., Arlt, Wiebke, Stewart, Paul M.

“…Context: Cortisone reductase deficiency (CRD) is characterized by a failure to regenerate cortisol from cortisone via 11β-hydroxysteroid dehydrogenase type 1…”
Get full text

Familial and Phenotypic Associations of the Aldosterone Renin Ratio by Alvarez-Madrazo, Samantha, Padmanabhan, Sandosh, Mayosi, Bongani M., Watkins, Hugh, Avery, Peter, Wallace, A. Michael, Fraser, Robert, Davies, Eleanor, Keavney, Bernard, Connell, John M.

“…Context: The aldosterone to renin ratio (ARR) is a marker of aldosterone excess, widely used to screen for primary aldosteronism (PA). The significance of a…”
Get full text

Does Total Implantability Reduce Infection With the Use of a Left Ventricular Assist Device? The LionHeart Experience in Europe by Pae, Walter E., MD, Connell, John M., MD, MPH, Adelowo, Amos, MPH, Boehmer, John P., MD, Korfer, Reiner, MD, El-Banayosy, Aly, MD, Hetzer, Roland, MD, Vigano, Mario, MD, Pavie, Alain, MD

“…Background Infection is the leading cause of death for left ventricular assist device (LVAD) patients with end-stage heart failure. Decreased infection may be…”
Get full text

Non-adrenal synthesis of aldosterone: A reality check by MacKenzie, Scott M., Connell, John M.C., Davies, Eleanor

“…► Technical advances gave partial evidence of extra-adrenal aldosterone biosynthesis. ► The cardiovascular and central nervous systems have attracted most…”
Get full text

Urinary corticosteroid excretion predicts left ventricular mass and proteinuria in chronic kidney disease by McQuarrie, Emily P, Freel, E Marie, Mark, Patrick B, Fraser, Robert, Patel, Rajan K, Dargie, Henry G, Connell, John M C, Jardine, Alan G

“…Blockade of the MR (mineralocorticoid receptor) in CKD (chronic kidney disease) reduces LVMI [LV (left ventricular) mass index] and proteinuria. The MR can be…”
Get more information

Insulin-stimulated phosphorylation of endothelial nitric oxide synthase at serine-615 contributes to nitric oxide synthesis by Ritchie, Stuart A, Kohlhaas, Christine F, Boyd, Alasdair R, Yalla, Krishna C, Walsh, Kenneth, Connell, John M C, Salt, Ian P

“…Insulin stimulates endothelial NO (nitric oxide) synthesis via PKB (protein kinase B)/Akt-mediated phosphorylation and activation of eNOS (endothelial NO…”
Get more information

The role of insulin and the adipocytokines in regulation of vascular endothelial function by Ritchie, Stuart A, Ewart, Marie-Ann, Perry, Colin G, Connell, John M C, Salt, Ian P

“…Vascular integrity in the healthy endothelium is maintained through the release of a variety of paracrine factors such as NO (nitric oxide). Endothelial…”
Get more information