Search Results - "CONLON, P"
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Catch-me-if-you-can: the overshoot problem and the weak/inflation hierarchy
Published in The journal of high energy physics (28-11-2022)“…A bstract We study the overshoot problem in the context of post-inflationary string cosmology (in particular LVS). LVS cosmology features a long kination epoch…”
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Exploring the holographic Swampland
Published in The journal of high energy physics (01-04-2022)“…A bstract We extend studies of holographic aspects of moduli stabilisation scenarios to both fibred versions of LVS and the type IIA DGKT flux vacua. We study…”
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3
Putting the boot into the swampland
Published in The journal of high energy physics (01-03-2019)“…A bstract The swampland program of delineating the space of effective field theories consistent with quantum gravity appears similar to the bootstrap program…”
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Activated ClpP kills persisters and eradicates a chronic biofilm infection
Published in Nature (London) (21-11-2013)“…Chronic infections are difficult to treat with antibiotics but are caused primarily by drug-sensitive pathogens. Dormant persister cells that are tolerant to…”
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Kination, meet Kasner: on the asymptotic cosmology of string compactifications
Published in The journal of high energy physics (23-08-2023)“…A bstract We study runaway, kination-dominated epochs in string cosmology. We show how the apparent classical decompactification runaway of the volume modulus,…”
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A new antibiotic kills pathogens without detectable resistance
Published in Nature (London) (22-01-2015)“…Antibiotic resistance is spreading faster than the introduction of new compounds into clinical practice, causing a public health crisis. Most antibiotics were…”
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Convergence of Staphylococcus aureus Persister and Biofilm Research: Can Biofilms Be Defined as Communities of Adherent Persister Cells?
Published in PLoS pathogens (29-12-2016)Get full text
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Constraints on Axion-like Particles from X-Ray Observations of NGC1275
Published in The Astrophysical journal (01-10-2017)“…Axion-like particles (ALPs) can induce localized oscillatory modulations in the spectra of photon sources passing through astrophysical magnetic fields…”
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Excess astrophysical photons from a 0.1-1 keV cosmic axion background
Published in Physical review letters (11-10-2013)“…Primordial decays of string theory moduli at z~10(12) naturally generate a dark radiation cosmic axion background with 0.1-1 keV energies. This cosmic axion…”
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Antibiotic efficacy in the complex infection environment
Published in Current opinion in microbiology (01-04-2018)“…•The infection environment influences antibiotic susceptibility.•Clinical susceptibility assays frequently fail to predict drug efficacy in patients.•Host…”
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Pseudomonas aeruginosa exoproducts determine antibiotic efficacy against Staphylococcus aureus
Published in PLoS biology (27-11-2017)“…Chronic coinfections of Staphylococcus aureus and Pseudomonas aeruginosa frequently fail to respond to antibiotic treatment, leading to significant patient…”
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A population-based study of skin cancer incidence and prevalence in renal transplant recipients
Published in British journal of dermatology (1951) (01-03-2006)“…Summary Background Cancers occurring following solid organ transplantation are a rapidly growing public health concern. Defining the extent of the problem has…”
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Stochastic Variation in Expression of the Tricarboxylic Acid Cycle Produces Persister Cells
Published in mBio (17-09-2019)“…Chronic bacterial infections are difficult to eradicate, though they are caused primarily by drug-susceptible pathogens. Antibiotic-tolerant persisters largely…”
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Moduli Stabilisation and the Holographic Swampland
Published in Letters in high energy physics (31-03-2020)“…We investigate whether Swampland constraints on the low-energy dynamics of weakly coupled, moduli- stabilised string vacua in AdS can be related to…”
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SUMOylation of ROR-γt inhibits IL-17 expression and inflammation via HDAC2
Published in Nature communications (30-10-2018)“…Dysregulated ROR-γt-mediated IL-17 transcription is central to the pathogenesis of several inflammatory disorders, yet the molecular mechanisms that govern the…”
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Equine or porcine synovial fluid as a novel ex vivo model for the study of bacterial free-floating biofilms that form in human joint infections
Published in PloS one (15-08-2019)“…Bacterial invasion of synovial joints, as in infectious or septic arthritis, can be difficult to treat in both veterinary and human clinical practice…”
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Interventions for protecting renal function in the perioperative period
Published in Cochrane database of systematic reviews (11-09-2013)“…Various methods have been used to try to protect kidney function in patients undergoing surgery. These most often include pharmacological interventions such as…”
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Shooting yourself in the foot: How immune cells induce antibiotic tolerance in microbial pathogens
Published in PLoS pathogens (22-07-2021)“…Antibiotic treatment failure of infection is common and frequently occurs in the absence of genetically encoded antibiotic resistance mechanisms. In such…”
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Antibiotic tolerance and the alternative lifestyles of Staphylococcus aureus
Published in Essays in biochemistry (28-02-2017)“…has an incredible ability to survive, either by adapting to environmental conditions or defending against exogenous stress. Although there are certainly…”
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Twenty‐Year Survivors of Kidney Transplantation
Published in American journal of transplantation (01-12-2012)“…There have been few studies of patients with renal allografts functioning for more than 20 years. We sought to identify clinical factors associated with ultra…”
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