Search Results - "CONKLYN, M. J"

Leukotriene B4 plays a critical role in the progression of collagen-induced arthritis by Griffiths, R J, Pettipher, E R, Koch, K, Farrell, C A, Breslow, R, Conklyn, M J, Smith, M A, Hackman, B C, Wimberly, D J, Milici, A J

“…Leukotriene B4 (LTB4) is a product of the 5-lipoxygenase pathway of arachidonic acid metabolism. LTB4 is a potent chemotactic factor for neutrophils and has…”
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Expression and biologic characterization of the murine chemokine KC by Bozic, CR, Kolakowski, LF, Jr, Gerard, NP, Garcia-Rodriguez, C, von Uexkull- Guldenband, C, Conklyn, MJ, Breslow, R, Showell, HJ, Gerard, C

“…KC, the product of an immediate early gene induced in mouse fibroblasts by platelet-derived growth factor, was expressed in Escherichia coli by using a maltose…”
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The Duffy antigen/receptor for chemokines (DARC) is expressed in endothelial cells of Duffy negative individuals who lack the erythrocyte receptor by Peiper, S C, Wang, Z X, Neote, K, Martin, A W, Showell, H J, Conklyn, M J, Ogborne, K, Hadley, T J, Lu, Z H, Hesselgesser, J, Horuk, R

“…The Duffy antigen/receptor for chemokines (DARC), first identified on erythrocytes, functions not only as a promiscuous chemokine receptor but also as a…”
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The murine interleukin 8 type B receptor homologue and its ligands. Expression and biological characterization by C R Bozic, N P Gerard, C von Uexkull-Guldenband, L F Kolakowski, Jr, M J Conklyn, R Breslow, H J Showell, C Gerard

“…KC, the product of an immediate early gene induced in mouse fibroblasts by platelet-derived growth factor, was synthesized as a recombinant protein in…”
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The preclinical pharmacological profile of the potent and selective leukotriene B4 antagonist CP-195543 by Showell, H J, Conklyn, M J, Alpert, R, Hingorani, G P, Wright, K F, Smith, M A, Stam, E, Salter, E D, Scampoli, D N, Meltzer, S, Reiter, L A, Koch, K, Piscopio, A D, Cortina, S R, Lopez-Anaya, A, Pettipher, E R, Milici, A J, Griffiths, R J

“…CP-195543 [(+)-2-(3-benzyl-4-hydroxy-chroman-7-yl)-4-trifluoromethyl-benzoic acid] is a structurally novel, selective and potent leukotriene B4 (LTB4) receptor…”
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The in vitro and in vivo pharmacologic activity of the potent and selective leukotriene B4 receptor antagonist CP-105696 by Showell, H J, Pettipher, E R, Cheng, J B, Breslow, R, Conklyn, M J, Farrell, C A, Hingorani, G P, Salter, E D, Hackman, B C, Wimberly, D J

“…CP-105696, (+)-1-(3S,4R)-[3-(4-phenyl-benzyl)-4-hydroxy-chroman-7-yl] cyclopentane carboxylic acid, is a structurally novel, selective and potent leukotriene…”
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Characterization of the pharmacological profile of the potent LTB4 antagonist CP‐105,696 on murine LTB4 receptors in vitro by Showell, H.J., Breslow, R., Conklyn, M.J., Hingorani, G.P., Koch, K.

“…1 Binding of [3H]‐leukotriene B4 ([3H]‐LTB4) to murine spleen membranes (MSM) was determined. 2 Scatchard analyses of [3H]‐LTB4 binding indicated the presence…”
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Production and characterization of guinea pig IL-5 in baculovirus-infected insect cells by Mansour, M, Karmilowicz, M, Hawrylik, S J, Nalcerio, B, Angilly, J, Conklyn, M J, Lilly, C M, Drazen, J M, Lee, S E, Auperin, D D, De Wet, J R, Cohan, V L, Showell, H J, Danley, D E

“…To study the role interleukin (IL)-5 may play in altering airway function in asthma, we have produced recombinant protein for exogenous administration to…”
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In vitro and in vivo effects of leukotriene B4 antagonism in a primate model of asthma by Turner, C R, Breslow, R, Conklyn, M J, Andresen, C J, Patterson, D K, Lopez-Anaya, A, Owens, B, Lee, P, Watson, J W, Showell, H J

“…To test the hypothesis that leukotriene (LT) B4 antagonists may be clinically useful in the treatment of asthma, CP-105,696 was evaluated in vitro, using…”
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Evidence that peptidoleukotriene is a prerequisite for antigen-dependent thromboxane synthesis in IgG1-passively sensitized guinea pig lungs by Cheng, J B, Pillar, J S, Conklyn, M J, Breslow, R, Shirley, J T, Showell, H J

“…Lungs from guinea pigs passively sensitized with an affinity-purified IgG1 antibody produce both leukotriene (LT)D4 and thromboxane (Tx)B2 upon ex vivo antigen…”
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Tyrosine phosphorylation is an early signaling event common to Fc receptor crosslinking in human neutrophils and rat basophilic leukemia cells (RBL-2H3) by Connelly, P A, Farrell, C A, Merenda, J M, Conklyn, M J, Showell, H J

“…Phosphotyrosine-containing proteins were detected by western blotting of whole cell lysates of purified human neutrophils or rat basophilic leukemia cells…”
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Pharmacokinetics and pharmacodynamics of the leukotriene B4 receptor antagonist CP‐105,696 in man following single oral administration by Liston, Theodore E., Conklyn, Maryrose J., Houser, Janet, Wilner, Keith D., Johnson, Arlene, Apseloff, Glen, Whitacre, Caroline, Showell, Henry J.

“…Aims  CP‐105,696, (+)‐1‐(3S,4R)‐[3‐(4‐phenylbenzyl)‐4‐hydroxy‐chroman‐7‐yl] cyclopropane carboxylic acid is a potent, novel LTB4 receptor antagonist advanced…”
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Chemokine-Dependent Upregulation of CD11b on Specific Leukocyte Subpopulations in Human Whole Blood: Effect of Anticoagulant on Rantes and MIP-1β Stimulation by Conklyn, Maryrose J., Neote, Kuldep, Showell, Henry J.

“…The effect of anticoagulant (heparin vs EDTA) on chemokine induced CD11b upregulation on neutrophils, eosinophils, and monocytes in human whole blood was…”
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Biological activity C-X-C and C-C chemokines on leukocyte subpopulations in human whole blood by Conklyn, M J, Showell, H J

“…We have described an assay that monitors the activating effects of a variety of chemokines on leukocyte subsets in human whole blood. This procedure has the…”
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trans-3-benzyl-4-hydroxy-7-chromanylbenzoic acid derivatives as antagonists of the leukotriene B4 (LTB4) receptor by REITER, L. A, KOCH, K, DIBRINO, J. N, DOMINY, B. W, FARRELL, C. A, HINGORANI, G. P, MARTINELLI, G. J, RAMCHANDANI, M, WRIGHT, K. F, PISCOPIO, A. D, SHOWELL, H. J, ALPERT, R, BIGGERS, M. S, CHAMBERS, R. J, CONKLYN, M. J, COOPER, K, CORTINA, S. R

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Properties of lymphocyte 5'nucleotidase in normal subjects and patients with chronic lymphocytic leukemia by Conklyn, M J, Silber, R

“…Heterogeneity for 5'nucleotidase has been demonstrated in chronic lymphocytic leukemia [12]. The enzyme is not detectable in the lymphocytes from the majority…”
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Inhibition of IgE-mediated N-acetylglucosaminidase and serotonin release from rat basophilic leukemia cells (RBL-2H3) by tenidap: a novel anti-inflammatory agent by Conklyn, M J, Kadin, S B, Showell, H J

“…Tenidap [(Z)-5-chloro-2,3-dihydro-3-(hydroxy-2-thienylmethylene)-2-oxo-1H- indole-1-carboxamide] is a novel anti-inflammatory compound of the oxindole class…”
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Antigen-dependent leukotriene synthesis and histamine release from IgG1 passively-sensitized guinea pig lungs ex vivo: relationship between serum levels of antigen-specific IgG1 and mediator synthesis/release by Cheng, J B, Pillar, J S, Conklyn, M J, Breslow, R, Shirley, J T, Gerard, N P, Showell, H J

“…Naive guinea-pigs were passively sensitized with varying amounts of affinity column purified, homologous, anti-ovalbumin IgG1 (anti-OA IgG1) and then examined…”
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Structural and (patho)physiological diversity of PAF by Pinckard, R N, Woodard, D S, Showell, H J, Conklyn, M J, Novak, M J, McManus, L M

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trans-3-Benzyl-4-hydroxy-7-chromanylbenzoic acid derivatives as antagonists of the leukotriene B4 (LTB4) receptor by Reiter, L A, Koch, K, Piscopio, A D, Showell, H J, Alpert, R, Biggers, M S, Chambers, R J, Conklyn, M J, Cooper, K, Cortina, S R, Dibrino, J N, Dominy, B W, Farrell, C A, Hingorani, G P, Martinelli, G J, Ramchandani, M, Wright, K F

“…The SAR of a series of 2-(7-chromanyl)benzoic acids has been investigated with the aim of identifying potent and selective LTB4 receptor antagonists that…”
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