Search Results - "CONKLIN, J"
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Acute cardiopulmonary toxicity of inhaled aldehydes: role of TRPA1
Published in Annals of the New York Academy of Sciences (01-06-2016)“…Inhalation of high‐level volatile aldehydes, as present in smoke from wildfires and in tobacco smoke, is associated with both acute and chronic cardiopulmonary…”
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Flavorings in Tobacco Products Induce Endothelial Cell Dysfunction
Published in Arteriosclerosis, thrombosis, and vascular biology (01-07-2018)“…OBJECTIVE—Use of alternative tobacco products including electronic cigarettes is rapidly rising. The wide variety of flavored tobacco products available is of…”
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Polystyrene bead ingestion promotes adiposity and cardiometabolic disease in mice
Published in Ecotoxicology and environmental safety (01-03-2022)“…Vast amounts of plastic materials are produced in the modern world and despite recycling efforts, large amounts are disposed in water systems and landfills…”
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Resolvin D2 Enhances Postischemic Revascularization While Resolving Inflammation
Published in Circulation (New York, N.Y.) (30-08-2016)“…BACKGROUND:Resolvins are lipid mediators generated by leukocytes during the resolution phase of inflammation. They have been shown to regulate the transition…”
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Evaluation of Ultrafast Wave-CAIPI MPRAGE for Visual Grading and Automated Measurement of Brain Tissue Volume
Published in American journal of neuroradiology : AJNR (01-08-2020)“…Volumetric brain MR imaging typically has long acquisition times. We sought to evaluate an ultrafast MPRAGE sequence based on Wave-CAIPI (Wave-MPRAGE) compared…”
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TRPA1 channel contributes to myocardial ischemia-reperfusion injury
Published in American journal of physiology. Heart and circulatory physiology (01-04-2019)“…Myocardial ischemia-reperfusion (I/R) results in the generation of free radicals, accumulation of lipid peroxidation-derived unsaturated aldehydes, variable…”
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E-cigarettes and their lone constituents induce cardiac arrhythmia and conduction defects in mice
Published in Nature communications (25-10-2022)“…E-cigarette use has surged, but the long-term health effects remain unknown. E-cigarette aerosols containing nicotine and acrolein, a combustion and…”
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Association Between Residential Greenness and Cardiovascular Disease Risk
Published in Journal of the American Heart Association (18-12-2018)“…Background Exposure to green vegetation has been linked to positive health, but the pathophysiological processes affected by exposure to vegetation remain…”
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Aldehyde Detection in Electronic Cigarette Aerosols
Published in ACS omega (31-03-2017)“…Acetaldehyde, acrolein, and formaldehyde are the principal toxic aldehydes present in cigarette smoke and contribute to the risk of cardiovascular disease and…”
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Evaluation of esophageal motor function in clinical practice
Published in Neurogastroenterology and motility (01-02-2013)“…Esophageal motor function is highly coordinated between central and enteric nervous systems and the esophageal musculature, which consists of proximal skeletal…”
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Prenatal Exposure to Gutkha, a Globally Relevant Smokeless Tobacco Product, Induces Hepatic Changes in Adult Mice
Published in International journal of environmental research and public health (28-10-2020)“…Maternal exposures during pregnancy affect the onset and progression of adult diseases in the offspring. A prior mouse study indicated that maternal tobacco…”
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Role of TRPA1 in acute cardiopulmonary toxicity of inhaled acrolein
Published in Toxicology and applied pharmacology (01-06-2017)“…Acrolein is a highly toxic, volatile, unsaturated aldehyde generated during incomplete combustion as in tobacco smoke and indoor fires. Because the transient…”
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Benzene exposure is associated with cardiovascular disease risk
Published in PloS one (08-09-2017)“…Benzene is a ubiquitous, volatile pollutant present at high concentrations in toxins (e.g. tobacco smoke) known to increase cardiovascular disease (CVD) risk…”
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A Simplified Model for Intravoxel Incoherent Motion Perfusion Imaging of the Brain
Published in American journal of neuroradiology : AJNR (01-12-2016)“…Despite a recent resurgence, intravoxel incoherent motion MRI faces practical challenges, including limited SNR and demanding acquisition and postprocessing…”
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Anti‐inflammatory effects of miR‐21 in the macrophage response to peritonitis
Published in Journal of leukocyte biology (01-02-2016)“…MiRNA‐21 is beneficial in survival following induction of peritonitis with LPS by limiting the pro‐inflammatory phase of the innate response. We investigated…”
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Transient Cell Cycle Induction in Cardiomyocytes to Treat Subacute Ischemic Heart Failure
Published in Circulation (New York, N.Y.) (26-04-2022)“…The regenerative capacity of the heart after myocardial infarction is limited. Our previous study showed that ectopic introduction of 4 cell cycle factors (4F;…”
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The oncogenic microRNA miR-21 promotes regulated necrosis in mice
Published in Nature communications (20-05-2015)“…MicroRNAs (miRNAs) regulate apoptosis, yet their role in regulated necrosis remains unknown. miR-21 is overexpressed in nearly all human cancer types and its…”
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Intermittent hypoxia-induced cardiomyopathy and its prevention by Nrf2 and metallothionein
Published in Free radical biology & medicine (01-11-2017)“…The mechanism for intermittent hypoxia (IH)-induced cardiomyopathy remains obscure. We reported the prevention of acute and chronic IH-induced cardiac damage…”
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Validation of Highly Accelerated Wave-CAIPI SWI Compared with Conventional SWI and T2-Weighted Gradient Recalled-Echo for Routine Clinical Brain MRI at 3T
Published in American journal of neuroradiology : AJNR (01-12-2019)“…SWI is valuable for characterization of intracranial hemorrhage and mineralization but has long acquisition times. We compared a highly accelerated…”
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Pod-based e-liquids impair human vascular endothelial cell function
Published in PloS one (26-01-2023)“…Pod-based electronic (e-) cigarettes more efficiently deliver nicotine using a protonated formulation. The cardiovascular effects associated with these devices…”
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