Search Results - "CONE, ROBERT E"

The sympathetic nervous system modulates CD4+FoxP3+ regulatory T cells via a TGF-β-dependent mechanism by Bhowmick, Sourojit, Singh, Anurag, Flavell, Richard A., Clark, Robert B., O'Rourke, James, Cone, Robert E.

“…The sympathetic nervous system can control the number of regulatory T cells by modulating the level of TGF‐β in the periphery. CD4+FoxP3+ Tregs are essential…”
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Immune amplification of murine CD8 suppressor T cells induced via an immune-privileged site: quantifying suppressor T cells functionally by Sharafieh, Roshanak, Lemire, Yen, Powell, Sabrina, O'Rourke, James, Cone, Robert E

“…CD8(+) suppressor T cells exert antigen-specific suppression of the expression of hypersensitivity by activated T cells. Therefore, CD8(+) suppressor T cells…”
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Antigen-specific splenic CD4+ and CD8+ regulatory T cells generated via the eye, suppress experimental autoimmune encephalomyelitis either at the priming or at the effector phase by Bhowmick, Sourojit, Clark, Robert B, Brocke, Stefan, Cone, Robert E

“…The injection of antigen into the ocular anterior chamber (AC) induces the generation of splenic CD4(+) and CD8(+) regulatory T (Treg) cells, specific for the…”
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Implication for the CD94/NKG2A-Qa-1 system in the generation and function of ocular-induced splenic CD8+ regulatory T cells by Chattopadhyay, Subhasis, O'Rourke, James, Cone, Robert E.

“…The injection of antigen into the anterior chamber (AC) induces the production of antigen-specific splenic CD8+ regulatory T cells (Tregs) /suppressor T cells…”
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An intracameral injection of antigen induces in situ chemokines and cytokines required for the generation of circulating immunoregulatory monocytes by Pais, Roshan, Bhowmick, Sourojit, Chattopadhyay, Subhasis, Lemire, Yen, Sharafieh, Roshanak, Yadav, Rajwahrdan, O'Rourke, James, Cone, Robert E

“…Anterior Chamber-Associated Immune Deviation (ACAID) induced by an intracameral injection of antigen generates antigen-specific regulatory splenic T cells that…”
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Paradoxical effect of pertussis toxin on the delayed hypersensitivity response to autoantigens in mice by Yadav, Rajwahrdhan, Bhowmick, Sourojit, Gorecki, Philip, O'Rourke, James, Cone, Robert E

“…Pertussis toxin (PTX), an exotoxin of Bordetella pertussis, enhances the development of experimental autoimmune diseases such as experimental autoimmune…”
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T cell sensitivity to TGF-β is required for the effector function but not the generation of splenic CD8+ regulatory T cells induced via the injection of antigen into the anterior chamber by Cone, Robert E., Chattopadhyay, Subhasis, Sharafieh, Roshanak, Lemire, Yen, O'Rourke, James, Flavell, Richard A., Clark, Robert B.

“…The introduction of antigen into the anterior chamber (AC) of the eye induces the production of antigen-specific splenic CD8+ regulatory T cells (AC-SPL cells)…”
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Blood mononuclear cells induce regulatory NK T thymocytes in anterior chamber-associated immune deviation by Wang, Yafei, Goldschneider, Irving, O’Rourke, James, Cone, Robert E.

“…Injection of antigen into the anterior chamber (AC) of the eye, animmunologically privileged site, is associated with the inductionof immune deviation, as…”
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Anterior Chamber-Associated Immune Deviation (ACAID): An Acute Response to Ocular Insult Protects from Future Immune-Mediated Damage? by Cone, Robert E., Pais, Roshan

“…Robert E. Cone and Roshan PaisDepartment of Immunology, Connecticut Lions Vascular Vision Center, Farmington Connecticut, USA. AbstractThe "immune privilege"…”
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Increased Levels of Candida albicans Mannan-Specific T-Cell-Derived Antigen Binding Molecules in Patients with Invasive Candidiasis by Kosonen, Jan, Rantala, Arto, Little, Colin H, Lintu, Päivi, Harjamäki, Pirjo-Riitta, Georgiou, George M, Cone, Robert E, Savolainen, Johannes

“…Classifications Services CVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Cbl-b(-/-) T cells demonstrate in vivo resistance to regulatory T cells but a context-dependent resistance to TGF-beta by Adams, Catherine O, Housley, William J, Bhowmick, Sourojit, Cone, Robert E, Rajan, Thiruchandurai V, Forouhar, Faripour, Clark, Robert B

“…Cbl-b is an E3 ubiquitin ligase that negatively regulates T cell activation. Cbl-b(-/-) mice develop spontaneous autoimmunity, and Cbl-b dysregulation has been…”
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Storage and Release of Tissue Plasminogen Activator by Sympathetic Axons in Resistance Vessel Walls by Jiang, Xi, Wang, Yafei, Hand, Arthur R., Gillies, Concettina, Cone, Robert E., Kirk, Jayson, O'Rourke, James

“…We studied the immunolocalization of tissue plasminogen activator (t-PA) in rat precapillary arteries, arterioles, and terminal arterioles. Lack of information…”
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A central role for peripheral dendritic cells in the induction of acquired thymic tolerance by Goldschneider, Irving, Cone, Robert E.

“…Despite extensive negative selection in the thymus, numerous clones of self-reactive T cells are normally exported to the periphery. In most instances,…”
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The suppression of delayed‐type hypersensitivity by CD8+ regulatory T cells requires interferon‐γ by Cone, Robert E., Li, Xingya, Sharafieh, Roshanak, O'Rourke, James, Vella, Anthony T.

“…Summary CD8+ regulatory (suppressor) T cells are induced by complex cellular pathways in the spleens of mice that have received an injection of antigen into…”
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The suppression of hypersensitivity by ocular-induced CD8 T cells requires compatibility in the Qa-1 haplotype by Cone, Robert E, Chattopadhyay, Subhasis, Sharafieh, Roshanak, Lemire, Yen, O'Rourke, James

“…The injection of antigen into the anterior chamber (AC, intracameral injection) of a murine eye induces the generation of splenic CD8+ regulatory T cells…”
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New transgenic evidence for a system of sympathetic axons able to express tissue plasminogen activator (t-PA) within arterial/arteriolar walls by Hao, Zhifang, Guo, Caiying, Jiang, Xi, Krueger, Susan, Pietri, Thomas, Dufour, Sylvie, Cone, Robert E., O'Rourke, James

“…Sympathetic axons embedded in a few arterioles and vasa vasora were recently shown to store tissue plasminogen activator (t-PA) in vesicles. But the extension…”
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The induction of splenic suppressor T cells through an immune-privileged site requires an intact sympathetic nervous system by Li, Xingya, Taylor, Shiv, Zegarelli, Benjamin, Shen, Shujing, O'Rourke, James, Cone, Robert E

“…Antigen injection into the eye's anterior chamber (AC) induces the antigen-specific suppression of delayed-type hypersensitivity (DTH) that is mediated by NKT…”
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Distribution of sympathetic tissue plasminogen activator (tPA) to a distant microvasculature by O'Rourke, James, Jiang, Xi, Hao, Zhifang, Cone, Robert E., Hand, Arthur R.

“…Tissue plasminogen activator (tPA) is the predominant plasminogen activator present in the vascular and nervous systems. Prior studies of the two have…”
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Cytokines and sympathy: the control of regulatory T cells by Cone, Robert, Bhowmick

“…To ensure protection from external invaders, mitigate collateral damage from immune reactions, and prevent immune system responses against self, the immune…”
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Subcutaneous late phase responses are augmented during local inhalational tolerance in a murine asthma model by Singh, Anurag, Thrall, Roger S, Guernsey, Linda A, Carson, William F, Secor, Eric R, Cone, Robert E, Rajan, Thiruchandurai V, Schramm, Craig M

“…Acute exposure of sensitized mice to antigen elicits allergic airway disease (AAD) characterized by Th2 cytokine‐dependent pulmonary eosinophilia, methacholine…”
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