Search Results - "CONDEELIS, John"

Chemotaxis in cancer by Condeelis, John S, Patsialou, Antonia, Roussos, Evanthia T

“…Key Points Chemotaxis is the phenomenon by which cell movement is directed in response to an extracellular chemical gradient. Factors that mediate chemotaxis…”
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Regulation of the actin cytoskeleton in cancer cell migration and invasion by Yamaguchi, Hideki, Condeelis, John

“…Malignant cancer cells utilize their intrinsic migratory ability to invade adjacent tissues and the vasculature, and ultimately to metastasize. Cell migration…”
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Directed cell invasion and migration during metastasis by Bravo-Cordero, Jose Javier, Hodgson, Louis, Condeelis, John

“…Highlights ► Invadopodium degrading protrusion facilitate degradation of basement membranes by tumor cells. ► Motility is an important feature of invasive…”
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Tumor Cell Invadopodia: Invasive Protrusions that Orchestrate Metastasis by Eddy, Robert J, Weidmann, Maxwell D, Sharma, Ved P, Condeelis, John S

“…Invadopodia are a subset of invadosomes that are implicated in the integration of signals from the tumor microenvironment to support tumor cell invasion and…”
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Chemotherapy-induced metastasis: mechanisms and translational opportunities by Karagiannis, George S., Condeelis, John S., Oktay, Maja H.

“…Tumors often overcome the cytotoxic effects of chemotherapy through either acquired or environment-mediated drug resistance. In addition, signals from the…”
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Intravital imaging to study cancer progression and metastasis by Entenberg, David, Oktay, Maja H., Condeelis, John S.

“…Navigation through the bulk tumour, entry into the blood vasculature, survival in the circulation, exit at distant sites and resumption of proliferation are…”
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Chemotherapy-Induced Metastasis: Molecular Mechanisms, Clinical Manifestations, Therapeutic Interventions by Karagiannis, George S, Condeelis, John S, Oktay, Maja H

“…Chemotherapy offers long-term clinical benefits to many patients with advanced cancer. However, recent evidence has linked the cytotoxic effects of…”
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Primary tumor associated macrophages activate programs of invasion and dormancy in disseminating tumor cells by Borriello, Lucia, Coste, Anouchka, Traub, Brian, Sharma, Ved P., Karagiannis, George S., Lin, Yu, Wang, Yarong, Ye, Xianjun, Duran, Camille L., Chen, Xiaoming, Friedman, Madeline, Sosa, Maria Soledad, Sun, Dan, Dalla, Erica, Singh, Deepak K., Oktay, Maja H., Aguirre-Ghiso, Julio A., Condeelis, John S., Entenberg, David

“…Metastases are initiated by disseminated tumor cells (DTCs) that colonize distant organs. Growing evidence suggests that the microenvironment of the primary…”
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Multiparametric classification links tumor microenvironments with tumor cell phenotype by Gligorijevic, Bojana, Bergman, Aviv, Condeelis, John

“…While it has been established that a number of microenvironment components can affect the likelihood of metastasis, the link between microenvironment and tumor…”
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An EMT-driven alternative splicing program occurs in human breast cancer and modulates cellular phenotype by Shapiro, Irina M, Cheng, Albert W, Flytzanis, Nicholas C, Balsamo, Michele, Condeelis, John S, Oktay, Maja H, Burge, Christopher B, Gertler, Frank B

“…Epithelial-mesenchymal transition (EMT), a mechanism important for embryonic development, plays a critical role during malignant transformation. While much is…”
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Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function by Zervantonakis, Ioannis K, Hughes-Alford, Shannon K, Charest, Joseph L, Condeelis, John S, Gertler, Frank B, Kamm, Roger D

“…Entry of tumor cells into the blood stream is a critical step in cancer metastasis. Although significant progress has been made in visualizing tumor cell…”
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The emerging roles of macrophages in cancer metastasis and response to chemotherapy by Sanchez, Luis Rivera, Borriello, Lucia, Entenberg, David, Condeelis, John S., Oktay, Maja H., Karagiannis, George S.

“…Macrophages represent a heterogeneous group of cells, capable of carrying out distinct functions in a variety of organs and tissues. Even within individual…”
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A Unidirectional Transition from Migratory to Perivascular Macrophage Is Required for Tumor Cell Intravasation by Arwert, Esther N., Harney, Allison S., Entenberg, David, Wang, Yarong, Sahai, Erik, Pollard, Jeffrey W., Condeelis, John S.

“…Tumor-associated macrophages (TAMs) are critical for tumor metastasis. Two TAM subsets support cancer cell intravasation: migratory macrophages guide cancer…”
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The cofilin activity cycle in lamellipodia and invadopodia by Oser, Matthew, Condeelis, John

“…The actin severing protein cofilin is essential for directed cell migration and chemotaxis, in many cell types and is also important for tumor cell invasion…”
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Live tumor imaging shows macrophage induction and TMEM-mediated enrichment of cancer stem cells during metastatic dissemination by Sharma, Ved P., Tang, Binwu, Wang, Yarong, Duran, Camille L., Karagiannis, George S., Xue, Emily A., Entenberg, David, Borriello, Lucia, Coste, Anouchka, Eddy, Robert J., Kim, Gina, Ye, Xianjun, Jones, Joan G., Grunblatt, Eli, Agi, Nathan, Roy, Sweta, Bandyopadhyaya, Gargi, Adler, Esther, Surve, Chinmay R., Esposito, Dominic, Goswami, Sumanta, Segall, Jeffrey E., Guo, Wenjun, Condeelis, John S., Wakefield, Lalage M., Oktay, Maja H.

“…Cancer stem cells (CSCs) play an important role during metastasis, but the dynamic behavior and induction mechanisms of CSCs are not well understood. Here, we…”
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Neoadjuvant chemotherapy induces breast cancer metastasis through a TMEM-mediated mechanism by Karagiannis, George S, Pastoriza, Jessica M, Wang, Yarong, Harney, Allison S, Entenberg, David, Pignatelli, Jeanine, Sharma, Ved P, Xue, Emily A, Cheng, Esther, D'Alfonso, Timothy M, Jones, Joan G, Anampa, Jesus, Rohan, Thomas E, Sparano, Joseph A, Condeelis, John S, Oktay, Maja H

“…Breast cancer cells disseminate through TIE2/MENA /MENA -dependent cancer cell intravasation sites, called tumor microenvironment of metastasis (TMEM), which…”
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Homophilic CD44 Interactions Mediate Tumor Cell Aggregation and Polyclonal Metastasis in Patient-Derived Breast Cancer Models by Liu, Xia, Taftaf, Rokana, Kawaguchi, Madoka, Chang, Ya-Fang, Chen, Wenjing, Entenberg, David, Zhang, Youbin, Gerratana, Lorenzo, Huang, Simo, Patel, Dhwani B, Tsui, Elizabeth, Adorno-Cruz, Valery, Chirieleison, Steven M, Cao, Yue, Harney, Allison S, Patel, Shivani, Patsialou, Antonia, Shen, Yang, Avril, Stefanie, Gilmore, Hannah L, Lathia, Justin D, Abbott, Derek W, Cristofanilli, Massimo, Condeelis, John S, Liu, Huiping

“…Circulating tumor cells (CTC) seed cancer metastases; however, the underlying cellular and molecular mechanisms remain unclear. CTC clusters were less…”
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The cofilin pathway in breast cancer invasion and metastasis by Condeelis, John, Wang, Weigang, Eddy, Robert

“…Recent evidence indicates that metastatic capacity is an inherent feature of breast tumours and not a rare, late acquired event. This has led to new models of…”
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Intravital Imaging Techniques for Biomedical and Clinical Research by Coste, Anouchka, Oktay, Maja H., Condeelis, John S., Entenberg, David

“…Intravital imaging, the direct visualization of cells and tissues within a living animal, is a technique that has been employed for the better part of a…”
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Macrophages orchestrate breast cancer early dissemination and metastasis by Linde, Nina, Casanova-Acebes, Maria, Sosa, Maria Soledad, Mortha, Arthur, Rahman, Adeeb, Farias, Eduardo, Harper, Kathryn, Tardio, Ethan, Reyes Torres, Ivan, Jones, Joan, Condeelis, John, Merad, Miriam, Aguirre-Ghiso, Julio A.

“…Cancer cell dissemination during very early stages of breast cancer proceeds through poorly understood mechanisms. Here we show, in a mouse model of HER2 +…”
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