Search Results - "CONBOY, J. G"

FIRMA: a method for detection of alternative splicing from exon array data by Purdom, E., Simpson, K. M., Robinson, M. D., Conboy, J. G., Lapuk, A. V., Speed, T.P.

“…Motivation: Analyses of EST data show that alternative splicing is much more widespread than once thought. The advent of exon and tiling microarrays means that…”
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Cloning and Characterization of 4.1G (EPB41L2), a New Member of the Skeletal Protein 4.1 (EPB41) Gene Family by Parra, M., Gascard, P., Walensky, L.D., Snyder, S.H., Mohandas, N., Conboy, J.G.

“…The prototypical erythrocyte membrane skeletal protein 4.1 (HGMW-approved symbol EPB41), here designated 4.1R, is encoded by a large, complexly spliced gene…”
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Characterization of multiple isoforms of protein 4.1R expressed during erythroid terminal differentiation by GASCARD, P, LEE, G, COULOMBEL, L, AUFFRAY, I, LUM, M, PARRA, M, CONBOY, J. G, MOHANDAS, N, CHASIS, J. A

“…In erythrocytes, 80-kD protein 4.1R regulates critical membrane properties of deformability and mechanical strength. However, previously obtained data suggest…”
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Mechanochemistry of the alternatively spliced spectrin-actin binding domain in membrane skeletal protein 4.1 by DISCHER, D, PARRA, M, CONBOY, J. G, MOHANDAS, N

“…Protein 4.1's interaction with the erythroid skeletal proteins spectrin and actin and its essential role in regulating membrane strength are both attributable…”
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Structure, function, and molecular genetics of erythroid membrane skeletal protein 4.1 in normal and abnormal red blood cells by Conboy, J G

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Mechanochemistry of Protein 4.1's Spectrin-Actin-Binding Domain: Ternary Complex Interactions, Membrane Binding, Network Integration, Structural Strengthening by Discher, Dennis E., Winardi, Ricky, Schischmanoff, P. Olivier, Parra, Marilyn, Conboy, John G., Mohandas, Narla

“…Mechanical strength of the red cell membrane is dependent on ternary interactions among the skeletal proteins, spectrin, actin, and protein 4.1. Protein 4.1's…”
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Multiple Protein 4.1 Isoforms Produced by Alternative Splicing in Human Erythroid Cells by Conboy, John G., Chan, Jefferson, Mohandas, Narla, Kan, Yuet W.

“…Protein 4.1 is a multifunctional structural protein located in the erythrocyte membrane skeleton and in many nonerythroid cells. Molecular characterization of…”
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Tissue- and development-specific alternative RNA splicing regulates expression of multiple isoforms of erythroid membrane protein 4.1 by CONBOY, J. G, CHAN, J. Y, CHASIS, J. A, YUET WAI KAN, MOHANDAS, N

“…Protein 4.1, a multifunctional structural protein originally described as an 80-kDa component of the erythroid membrane skeleton, exhibits tissue- and…”
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Four Paralogous Protein 4.1 Genes Map to Distinct Chromosomes in Mouse and Human by Peters, Luanne L., Weier, Heinz-Ulrich G., Walensky, Loren D., Snyder, Solomon H., Parra, Marilyn, Mohandas, Narla, Conboy, John G.

“…Four highly conserved members of the skeletal protein 4.1 gene family encode a diverse array of protein isoforms via tissue-specific transcription and…”
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Alternative splicing of protein 4.1R exon 16: ordered excision of flanking introns ensures proper splice site choice by GEE, S. L, AOYAGI, K, LERSCH, R, HOU, V, WU, M, CONBOY, J. G

“…Alternative splicing plays a major role in regulating tissue-specific expression of cytoskeletal protein 4.1R isoforms. In particular, expression of the…”
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Human erythroid 5-aminolevulinate synthase. Gene structure and species-specific differences in alternative RNA splicing by CONBOY, J. G, COX, T. C, BOTTOMLEY, S. S, BAWDEN, M. J, MAY, B. K

“…Erythroid 5-aminolevulinate synthase (ALAS) is expressed exclusively in differentiating erythroid cells as the principal isoform of the enzyme to catalyze the…”
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Hereditary Elliptocytosis Due To Both Qualitative and Quantitative Defects in Membrane Skeletal Protein 4.1 by Conboy, J.G., Shitamoto, R., Parra, M., Winardi, R., Kabra, A., Smith, J., Mohandas, N.

“…Protein 4.1 is an important structural component of the membrane skeleton that helps determine erythrocyte morphology and membrane mechanical properties. In a…”
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Mouse erythroid cells express multiple putative RNA helicase genes exhibiting high sequence conservation from yeast to mammals by Gee, S L, Conboy, J G

“…RNA secondary structure is a critical determinant of RNA function in ribosome assembly, pre-mRNA splicing, mRNA translation and RNA stability. The 'DEAD/H'…”
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Evolutionarily Conserved Alternative Pre-mRNA Splicing Regulates Structure and Function of the Spectrin-Actin Binding Domain of Erythroid Protein 4.1 by Winardi, Ricky, Discher, Dennis, Kelley, Clare, Zon, Len, Mays, Karen, Mohandas, Narla, Conboy, John G.

“…A developmental alternative splicing switch, involving exon 16 of protein 4.1 pre-mRNA, occurs during mammalian erythropoiesis. By controlling expression of a…”
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Isolation and Characterization of cDNA Clones for Human Erythrocyte β -spectrin by Prchal, Josef T., Morley, Bernard J., Yoon, Sa-Hyun, Coetzer, Theresa L., Palek, Jiri, Conboy, John G., Kan, Yuet Wai

“…Spectrin is an important structural component of the membrane skeleton that underlies and supports the erythrocyte plasma membrane. It is composed of…”
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Computational analysis of candidate intron regulatory elements for tissue-specific alternative pre-mRNA splicing by Brudno, M, Gelfand, M S, Spengler, S, Zorn, M, Dubchak, I, Conboy, J G

“…Alternative pre-mRNA splicing is a major cellular process by which functionally diverse proteins can be generated from the primary transcript of a single gene,…”
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Molecular and Functional Characterization of Protein 4.1B, a Novel Member of the Protein 4.1 Family with High Level, Focal Expression in Brain by Parra, Marilyn, Gascard, Philippe, Walensky, Loren D., Gimm, J.Aura, Blackshaw, Seth, Chan, Nadine, Takakuwa, Yuichi, Berger, Trish, Lee, Gloria, Chasis, Joel A., Snyder, Solomon H., Mohandas, Narla, Conboy, John G.

“…Brain-enriched isoforms of skeletal proteins in the spectrin and ankyrin gene families have been described. Here we characterize protein 4.1B, a novel homolog…”
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A Novel Neuron-Enriched Homolog of the Erythrocyte Membrane Cytoskeletal Protein 4.1 by Walensky, Loren D, Blackshaw, Seth, Liao, Dezhi, Watkins, Crystal C, Weier, Heinz-Ulrich G, Parra, Marilyn, Huganir, Richard L, Conboy, John G, Mohandas, Narla, Snyder, Solomon H

“…We report the molecular cloning and characterization of 4.1N, a novel neuronal homolog of the erythrocyte membrane cytoskeletal protein 4.1 (4.1R). The 879…”
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The 13-kD FK506 Binding Protein, FKBP13, Interacts with a Novel Homologue of the Erythrocyte Membrane Cytoskeletal Protein 4.1 by Walensky, Loren D., Gascard, Philippe, Fields, Michael E., Blackshaw, Seth, Conboy, John G., Mohandas, Narla, Snyder, Solomon H.

“…We have identified a novel generally expressed homologue of the erythrocyte membrane cytoskeletal protein 4.1, named 4.1G, based on the interaction of its…”
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Protein 4.1R-deficient mice are viable but have erythroid membrane skeleton abnormalities by Shi, Z T, Afzal, V, Coller, B, Patel, D, Chasis, J A, Parra, M, Lee, G, Paszty, C, Stevens, M, Walensky, L, Peters, L L, Mohandas, N, Rubin, E, Conboy, J G

“…A diverse family of protein 4.1R isoforms is encoded by a complex gene on human chromosome 1. Although the prototypical 80-kDa 4.1R in mature erythrocytes is a…”
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