Search Results - "COMBS, Dan"

Albumin Binding as a General Strategy for Improving the Pharmacokinetics of Proteins by Dennis, Mark S, Zhang, Min, Meng, Y Gloria, Kadkhodayan, Miryam, Kirchhofer, Daniel, Combs, Dan, Damico, Lisa A

“…Plasma protein binding can be an effective means of improving the pharmacokinetic properties of otherwise short lived molecules. Using peptide phage display,…”
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Population Pharmacokinetics of Rituximab (Anti-CD20 Monoclonal Antibody) in Rheumatoid Arthritis Patients During a Phase II Clinical Trial by Ng, Chee M., Bruno, Rene, Combs, Dan, Davies, Brian

“…Rituximab is a B cell‐depleting anti‐CD20 chimeric IgGK monoclonal antibody being investigated for the treatment of rheumatoid arthritis. The purpose of this…”
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Rituximab therapy for CNS lymphomas: targeting the leptomeningeal compartment by Rubenstein, James L., Combs, Dan, Rosenberg, Jay, Levy, Arthur, McDermott, Michael, Damon, Lloyd, Ignoffo, Robert, Aldape, Kenneth, Shen, Arthur, Lee, Dana, Grillo-Lopez, Antonio, Shuman, Marc A.

“…Most lymphomas that involve the central nervous system are B-cell neoplasms that express the cell surface molecule CD20. After intravenous administration,…”
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Pharmacokinetics and pharmacodynamics of tenecteplase in fibrinolytic therapy of acute myocardial infarction by TANSWELL, Paul, MODI, Nishit, COMBS, Dan, DANAYS, Thierry

“…Tenecteplase is a novel fibrinolytic protein bioengineered from human tissue plasminogen activator (alteplase) for the therapy of acute ST-segment elevation…”
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0998 Cloud-Based Evaluation of Wearable-Derived Sleep Data in Insomnia Trials by Berryhill, Sarah, Patel, Salma I, Provencio, Natalie, Combs, Dan, Havens, Cody, Parthasarathy, Sairam

“…Introduction Evaluating the efficacy and response to cognitive behavioral therapy for insomnia (CBTi) is challenging to conduct in real time as it requires…”
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Assessment of Safety, Tolerability, Pharmacokinetics, and Pharmacological Effect of Orally Administered CORT125134: An Adaptive, Double‐Blind, Randomized, Placebo‐Controlled Phase 1 Clinical Study by Hunt, Hazel, Donaldson, Kirsteen, Strem, Mark, Zann, Vanessa, Leung, Pui, Sweet, Suzanne, Connor, Alyson, Combs, Dan, Belanoff, Joseph

“…CORT125134 is an orally active, high‐affinity, selective antagonist of the glucocorticoid receptor that is being developed for indications that may benefit…”
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Safety, Pharmacokinetics, and Pharmacodynamics of Trazpiroben (TAK‐906), a Novel Selective D2/D3 Receptor Antagonist: A Phase 1 Randomized, Placebo‐Controlled Single‐ and Multiple‐Dose Escalation Study in Healthy Participants by Whiting, Roger L., Darpo, Borje, Chen, Chunlin, Fletcher, Margaret, Combs, Dan, Xue, Hongqi, Stoltz, Randall R.

“…Gastroparesis is a chronic neuromuscular disorder of the upper gastrointestinal tract in which episodic exacerbation can lead to frequent hospitalizations and…”
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Safety, Pharmacokinetics, and Pharmacodynamics of Trazpiroben (TAK-906), a Novel Selective D 2 /D 3 Receptor Antagonist: A Phase 1 Randomized, Placebo-Controlled Single- and Multiple-Dose Escalation Study in Healthy Participants by Whiting, Roger L, Darpo, Borje, Chen, Chunlin, Fletcher, Margaret, Combs, Dan, Xue, Hongqi, Stoltz, Randall R

“…Gastroparesis is a chronic neuromuscular disorder of the upper gastrointestinal tract in which episodic exacerbation can lead to frequent hospitalizations and…”
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Advances in Positive Airway Pressure Treatment Modalities for Hypoventilation Syndromes by Combs, Daniel, MD, Shetty, Safal, MD, Parthasarathy, Sairam, MD

“…Positive airway pressure therapy for hypoventilation syndromes can improve health-related quality of life. Sleep-disordered breathing is complex and requires…”
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Depletion of B cells by a humanized anti-CD20 antibody PRO70769 in Macaca fascicularis by Vugmeyster, Yulia, Beyer, Joseph, Howell, Kathy, Combs, Dan, Fielder, Paul, Yang, Jihong, Qureshi, Ferhan, Sandlund, Bryan, Kawaguchi, Ly, Dummer, Wolfgang, Lowman, Henry, McKeever, Kathleen

“…PRO70769 is a humanized IgG1 monoclonal antibody against the CD20 molecule that is present on normal and malignant B cells. PRO70769 is being evaluated for…”
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Depletion of B cells by a humanized anti-CD20 antibody PR070769 in Macaca fascicularis by VUGMEYSTER, Yulia, BEYER, Joseph, LOWMAN, Henry, MCKEEVER, Kathleen, HOWELL, Kathy, COMBS, Dan, FIELDER, Paul, JIHONG YANG, QURESHI, Ferhan, SANDLUND, Bryan, KAWAGUCHI, Ly, DUMMER, Wolfgang

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Craig S. Johnson 1971-1994 by Combs, Dan, Clark, Joe

“…Wildlife biology Master's degree candidate Craig S. Johnson died Oct 8, 1994 in an aircraft accident. Johnson and his work with Florida panther research are…”
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