Search Results - "COMB, Michael J"

Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome by Kim, Woong, Bennett, Eric J., Huttlin, Edward L., Guo, Ailan, Li, Jing, Possemato, Anthony, Sowa, Mathew E., Rad, Ramin, Rush, John, Comb, Michael J., Harper, J. Wade, Gygi, Steven P.

“…Despite the diverse biological pathways known to be regulated by ubiquitylation, global identification of substrates that are targeted for ubiquitylation has…”
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Immunoaffinity Enrichment and Mass Spectrometry Analysis of Protein Methylation by Guo, Ailan, Gu, Hongbo, Zhou, Jing, Mulhern, Daniel, Wang, Yi, Lee, Kimberly A., Yang, Vicky, Aguiar, Mike, Kornhauser, Jon, Jia, Xiaoying, Ren, Jianmin, Beausoleil, Sean A., Silva, Jeffrey C., Vemulapalli, Vidyasiri, Bedford, Mark T., Comb, Michael J.

“…Protein methylation is a common posttranslational modification that mostly occurs on arginine and lysine residues. Arginine methylation has been reported to…”
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Phosphoproteomics Screen Reveals Akt Isoform-Specific Signals Linking RNA Processing to Lung Cancer by Sanidas, Ioannis, Polytarchou, Christos, Hatziapostolou, Maria, Ezell, Scott A., Kottakis, Filippos, Hu, Lan, Guo, Ailan, Xie, Jianxin, Comb, Michael J., Iliopoulos, Dimitrios, Tsichlis, Philip N.

“…The three Akt isoforms are functionally distinct. Here we show that their phosphoproteomes also differ, suggesting that their functional differences are due to…”
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Survey of tyrosine kinase signaling reveals ROS kinase fusions in human cholangiocarcinoma by Gu, Ting-Lei, Deng, Xiaxing, Huang, Feizhou, Tucker, Meghan, Crosby, Katherine, Rimkunas, Victoria, Wang, Yi, Deng, Gang, Zhu, Lei, Tan, Zhiping, Hu, Yerong, Wu, Chunlin, Nardone, Julie, MacNeill, Joan, Ren, Jianmin, Reeves, Cynthia, Innocenti, Gregory, Norris, Brett, Yuan, Jin, Yu, Jian, Haack, Herbert, Shen, Baiyong, Peng, Chenghong, Li, Hongwei, Zhou, Xinmin, Liu, Xunyang, Rush, John, Comb, Michael J

“…Cholangiocarcinoma, also known as bile duct cancer, is the second most common primary hepatic carcinoma with a median survival of less than 2 years. The…”
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Loss of the major Type I arginine methyltransferase PRMT1 causes substrate scavenging by other PRMTs by Dhar, Surbhi, Vemulapalli, Vidyasiri, Patananan, Alexander N., Huang, Grace L., Di Lorenzo, Alessandra, Richard, Stephane, Comb, Michael J., Guo, Ailan, Clarke, Steven G., Bedford, Mark T.

“…Arginine methylation is a common posttranslational modification that is found on both histone and non-histone proteins. Three types of arginine methylation…”
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Akt-RSK-S6 kinase signaling networks activated by oncogenic receptor tyrosine kinases by Moritz, Albrecht, Li, Yu, Guo, Ailan, Villén, Judit, Wang, Yi, MacNeill, Joan, Kornhauser, Jon, Sprott, Kam, Zhou, Jing, Possemato, Anthony, Ren, Jian Min, Hornbeck, Peter, Cantley, Lewis C, Gygi, Steven P, Rush, John, Comb, Michael J

“…Receptor tyrosine kinases (RTKs) activate pathways mediated by serine-threonine kinases, such as the PI3K (phosphatidylinositol 3-kinase)-Akt pathway, the…”
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Global Survey of Phosphotyrosine Signaling Identifies Oncogenic Kinases in Lung Cancer by Rikova, Klarisa, Guo, Ailan, Zeng, Qingfu, Possemato, Anthony, Yu, Jian, Haack, Herbert, Nardone, Julie, Lee, Kimberly, Reeves, Cynthia, Li, Yu, Hu, Yerong, Tan, Zhiping, Stokes, Matthew, Sullivan, Laura, Mitchell, Jeffrey, Wetzel, Randy, MacNeill, Joan, Ren, Jian Min, Yuan, Jin, Bakalarski, Corey E., Villen, Judit, Kornhauser, Jon M., Smith, Bradley, Li, Daiqiang, Zhou, Xinmin, Gygi, Steven P., Gu, Ting-Lei, Polakiewicz, Roberto D., Rush, John, Comb, Michael J.

“…Despite the success of tyrosine kinase-based cancer therapeutics, for most solid tumors the tyrosine kinases that drive disease remain unknown, limiting our…”
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Signaling networks assembled by oncogenic EGFR and c-Met by Guo, Ailan, Villén, Judit, Kornhauser, Jon, Lee, Kimberly A, Stokes, Matthew P, Rikova, Klarisa, Possemato, Anthony, Nardone, Julie, Innocenti, Gregory, Wetzel, Randall, Wang, Yi, MacNeill, Joan, Mitchell, Jeffrey, Gygi, Steven P, Rush, John, Polakiewicz, Roberto D, Comb, Michael J

“…A major question regarding the sensitivity of solid tumors to targeted kinase inhibitors is why some tumors respond and others do not. The observation that…”
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Calorie restriction alters mitochondrial protein acetylation by Schwer, Bjoern, Eckersdorff, Mark, Li, Yu, Silva, Jeffrey C., Fermin, Damian, Kurtev, Martin V., Giallourakis, Cosmas, Comb, Michael J., Alt, Frederick W., Lombard, David B.

“…Summary Calorie restriction (CR) increases lifespan in organisms ranging from budding yeast through mammals. Mitochondrial adaptation represents a key…”
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A proteomics approach for the identification and cloning of monoclonal antibodies from serum by Cheung, Wan Cheung, Beausoleil, Sean A, Zhang, Xiaowu, Sato, Shuji, Schieferl, Sandra M, Wieler, James S, Beaudet, Jason G, Ramenani, Ravi K, Popova, Lana, Comb, Michael J, Rush, John, Polakiewicz, Roberto D

“…The ability to identify antibodies circulating in the bloodstream would advance immunology and vaccinology research and the development of therapeutics. Cheung…”
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Immunoaffinity profiling of tyrosine phosphorylation in cancer cells by Comb, Michael J, Rush, John, Moritz, Albrecht, Lee, Kimberly A, Guo, Ailan, Goss, Valerie L, Spek, Erik J, Zhang, Hui, Zha, Xiang-Ming, Polakiewicz, Roberto D

“…Tyrosine kinases play a prominent role in human cancer, yet the oncogenic signaling pathways driving cell proliferation and survival have been difficult to…”
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Profiling of UV-induced ATM/ATR signaling pathways by Stokes, Matthew P, Rush, John, MacNeill, Joan, Ren, Jian Min, Sprott, Kam, Nardone, Julie, Yang, Vicky, Beausoleil, Sean A, Gygi, Steven P, Livingstone, Mark, Zhang, Hui, Polakiewicz, Roberto D, Comb, Michael J

“…To ensure survival in the face of genomic insult, cells have evolved complex mechanisms to respond to DNA damage, termed the DNA damage checkpoint. The…”
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Identification of Anaplastic Lymphoma Kinase as a Potential Therapeutic Target in Ovarian Cancer by HONG REN, TAN, Zhi-Ping, YI ZHANG, ZHOU, Xin-Min, GU, Ting-Lei, YANG, Yi-Feng, COMB, Michael J, XIN ZHU, CROSBY, Katherine, HAACK, Herbert, REN, Jian-Min, BEAUSOLEIL, Sean, MORITZ, Albrecht, INNOCENTI, Gregory, RUSH, John

“…Ovarian cancer is the leading cause of death from gynecologic cancer. Improvement in the clinical outcome of patients is likely to be achieved by the…”
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Mutation-Specific Antibodies for the Detection of EGFR Mutations in Non–Small-Cell Lung Cancer by JIAN YU, KANE, Susan, FERRANTE, Michelle, WAN CHEUNG CHEUNG, XIQIANG HONG, CHIRIEAC, Lucian R, SHOLL, Lynette M, HAACK, Herbert, SMITH, Bradley L, POLAKIEWICZ, Roberto D, YI TAN, GU, Ting-Lei, JIONG WU, LODA, Massimo, XINMIN ZHOU, COMB, Michael J, BENEDETTINI, Elisa, DAIQIANG LI, REEVES, Cynthia, INNOCENTI, Gregory, WETZEL, Randy, CROSBY, Katherine, BECKER, Alison

“…Purpose: Activating mutations within the tyrosine kinase domain of epidermal growth factor receptor (EGFR) are found in approximately 10% to 20% of…”
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protein kinase Akt1 regulates the interferon response through phosphorylation of the transcriptional repressor EMSY by Ezell, Scott A, Polytarchou, Christos, Hatziapostolou, Maria, Guo, Ailan, Sanidas, Ioannis, Bihani, Teeru, Comb, Michael J, Sourvinos, George, Tsichlis, Philip N

“…The protein kinases Akt1, Akt2, and Akt3 possess nonredundant signaling properties, few of which have been investigated. Here, we present evidence for an…”
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A Phosphorylation State-specific Antibody Recognizes Hsp27, a Novel Substrate of Protein Kinase D by Döppler, Heike, Storz, Peter, Li, Jing, Comb, Michael J., Toker, Alex

“…The use of phosphorylation state-specific antibodies has revolutionized the field of cellular signaling by Ser/Thr protein kinases. A more recent application…”
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High Throughput Proteome Screening for Biomarker Detection by Pan, Sheng, Zhang, Hui, Rush, John, Eng, Jimmy, Zhang, Ning, Patterson, Dale, Comb, Michael J, Aebersold, Ruedi

“…Mass spectrometry-based quantitative proteomics has become an important component of biological and clinical research. Current methods, while highly developed…”
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Phosphoprotein Analysis Using Antibodies Broadly Reactive against Phosphorylated Motifs by Zhang, Hui, Zha, Xiangming, Tan, Yi, Hornbeck, Peter V, Mastrangelo, Allison J, Alessi, Dario R, Polakiewicz, Roberto D, Comb, Michael J

“…The substrates of most protein kinases remain unknown because of the difficulty tracing signaling pathways and identifying sites of protein phosphorylation…”
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A common phosphotyrosine signature for the Bcr-Abl kinase by Goss, Valerie L., Lee, Kimberly A., Moritz, Albrecht, Nardone, Julie, Spek, Erik J., MacNeill, Joan, Rush, John, Comb, Michael J., Polakiewicz, Roberto D.

“…The Bcr-Abl fusion kinase drives oncogenesis in chronic myeloid leukemia (CML). CML patients are currently treated with the Abl tyrosine kinase inhibitor…”
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The enzymatic activity of 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase is enhanced by NPM-ALK: new insights in ALK-mediated pathogenesis and the treatment of ALCL by Boccalatte, Francesco E., Voena, Claudia, Riganti, Chiara, Bosia, Amalia, D'Amico, Lucia, Riera, Ludovica, Cheng, Mangeng, Ruggeri, Bruce, Jensen, Ole N., Goss, Valerie L., Lee, Kimberly, Nardone, Julie, Rush, John, Polakiewicz, Roberto D., Comb, Michael J., Chiarle, Roberto, Inghirami, Giorgio

“…Anaplastic large cell lymphoma represents a subset of neoplasms caused by translocations that juxtapose the anaplastic lymphoma kinase (ALK) to dimerization…”
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