Search Results - "COLONNA, Marco"

Microglia Function in the Central Nervous System During Health and Neurodegeneration by Colonna, Marco, Butovsky, Oleg

“…Microglia are resident cells of the brain that regulate brain development, maintenance of neuronal networks, and injury repair. Microglia serve as brain…”
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TREM2 variants: new keys to decipher Alzheimer disease pathogenesis by Colonna, Marco, Wang, Yaming

“…A series of genetic studies has implicated the microglial immune receptor TREM2 in the pathogenesis of Alzheimer disease (AD). Here, Colonna and Wang describe…”
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The identity and function of microglia in neurodegeneration by Song, Wilbur M., Colonna, Marco

“…The predominant type of immune cell in the brain is the microglia, a type of tissue-resident macrophage. In a variety of neurodegenerative settings, microglia…”
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Interleukin-22-Producing Natural Killer Cells and Lymphoid Tissue Inducer-like Cells in Mucosal Immunity by Colonna, Marco

“…Blood, lymphoid tissues, and placenta contain diverse subpopulations of natural killer (NK) cells that possess distinct immune functions. Recent studies have…”
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TLR pathways and IFN‐regulatory factors: To each its own by Colonna, Marco

“…TLR trigger the induction of type I IFN (IFN‐alpha/beta), providing a crucial mechanism of anti‐viral defense. Until recently, TLR were thought to induce type…”
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The Natural Cytotoxicity Receptors in Health and Disease by Barrow, Alexander David, Martin, Claudia Jane, Colonna, Marco

“…The Natural Cytotoxicity Receptors (NCRs), NKp46, NKp44, and NKp30, were some of the first human activating Natural Killer (NK) cell receptors involved in the…”
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Disease-Associated Microglia: A Universal Immune Sensor of Neurodegeneration by Deczkowska, Aleksandra, Keren-Shaul, Hadas, Weiner, Assaf, Colonna, Marco, Schwartz, Michal, Amit, Ido

“…A major challenge in the field of neurodegenerative diseases and brain aging is to identify the body’s intrinsic mechanism that could sense the central nervous…”
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AHR: Making the Keratinocytes Thick Skinned by Colonna, Marco

“…Dysregulated signals from the external environment and/or the internal milieu of the skin can lead to pathological conditions such as psoriasis. Di Meglio…”
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Innate Lymphoid Cells in Mucosal Immunity by Panda, Santosh K, Colonna, Marco

“…Innate lymphoid cells (ILCs) are innate counterparts of T cells that contribute to immune responses by secreting effector cytokines and regulating the…”
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Unraveling the functions of plasmacytoid dendritic cells during viral infections, autoimmunity, and tolerance by Swiecki, Melissa, Colonna, Marco

“…Plasmacytoid dendritic cells (pDCs) are bone marrow-derived cells that secrete large amounts of type I interferon (IFN) in response to viruses. Type I IFNs are…”
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Aryl hydrocarbon receptor: Linking environment to immunity by Cella, Marina, Colonna, Marco

“…Highlights • AHR links environmental clues to host immune responses. • AHR is activated by exogenous and endogenous ligands; their interplay is still poorly…”
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Innate lymphoid cell function in the context of adaptive immunity by Bando, Jennifer K, Colonna, Marco

“…The redundant or specialized roles of innate lymphoid cells (ILCs) relative to those of T cells in vivo remain hard to delineate experimentally. Bando and…”
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Expansion of human NK-22 cells with IL-7, IL-2, and IL-1β reveals intrinsic functional plasticity by Cella, Marina, Otero, Karel, Colonna, Marco

“…Natural killer-22 (NK-22) cells are a human NK cell subset situated in mucosal-associated lymphoid tissues that specialize in IL-22 secretion in response to…”
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Elucidating the Role of TREM2 in Alzheimer’s Disease by Ulrich, Jason D., Ulland, Tyler K., Colonna, Marco, Holtzman, David M.

“…Alzheimer’s disease (AD) is the sixth leading cause of death in the United States and the most common cause of dementia in the elderly. Genetic factors, such…”
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Skull and vertebral bone marrow are myeloid cell reservoirs for the meninges and CNS parenchyma by Cugurra, Andrea, Mamuladze, Tornike, Rustenhoven, Justin, Dykstra, Taitea, Beroshvili, Giorgi, Greenberg, Zev J, Baker, Wendy, Papadopoulos, Zach, Drieu, Antoine, Blackburn, Susan, Kanamori, Mitsuhiro, Brioschi, Simone, Herz, Jasmin, Schuettpelz, Laura G, Colonna, Marco, Smirnov, Igor, Kipnis, Jonathan

“…The meninges are a membranous structure enveloping the central nervous system (CNS) that host a rich repertoire of immune cells mediating CNS immune…”
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TREM2 dependent and independent functions of microglia in Alzheimer's disease by Hou, Jinchao, Chen, Yun, Grajales-Reyes, Gary, Colonna, Marco

“…Microglia are central players in brain innate immunity and have been the subject of extensive research in Alzheimer's disease (AD). In this review, we aim to…”
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TREM2 sustains microglial expansion during aging and response to demyelination by Poliani, Pietro Luigi, Wang, Yaming, Fontana, Elena, Robinette, Michelle L, Yamanishi, Yoshinori, Gilfillan, Susan, Colonna, Marco

“…Microglia contribute to development, homeostasis, and immunity of the CNS. Like other tissue-resident macrophage populations, microglia express the surface…”
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Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism by Song, Wilbur M, Joshita, Satoru, Zhou, Yingyue, Ulland, Tyler K, Gilfillan, Susan, Colonna, Marco

“…Alzheimer's disease (AD) is a neurodegenerative disease that causes late-onset dementia. The R47H variant of the microglial receptor TREM2 triples AD risk in…”
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Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner by Jaitin, Diego Adhemar, Adlung, Lorenz, Thaiss, Christoph A., Weiner, Assaf, Li, Baoguo, Descamps, Hélène, Lundgren, Patrick, Bleriot, Camille, Liu, Zhaoyuan, Deczkowska, Aleksandra, Keren-Shaul, Hadas, David, Eyal, Zmora, Niv, Eldar, Shai Meron, Lubezky, Nir, Shibolet, Oren, Hill, David A., Lazar, Mitchell A., Colonna, Marco, Ginhoux, Florent, Shapiro, Hagit, Elinav, Eran, Amit, Ido

“…Immune cells residing in white adipose tissue have been highlighted as important factors contributing to the pathogenesis of metabolic diseases, but the…”
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Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer's disease model by Wang, Shoutang, Mustafa, Meer, Yuede, Carla M, Salazar, Santiago Viveros, Kong, Philip, Long, Hua, Ward, Michael, Siddiqui, Omer, Paul, Robert, Gilfillan, Susan, Ibrahim, Adiljan, Rhinn, Hervé, Tassi, Ilaria, Rosenthal, Arnon, Schwabe, Tina, Colonna, Marco

“…TREM2 is a receptor for lipids expressed in microglia. The R47H variant of human TREM2 impairs ligand binding and increases Alzheimer's disease (AD) risk. In…”
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