Search Results - "COLLINS, James J"

Cellular Decision Making and Biological Noise: From Microbes to Mammals by Balázsi, Gábor, van Oudenaarden, Alexander, Collins, James J.

“…Cellular decision making is the process whereby cells assume different, functionally important and heritable fates without an associated genetic or…”
Get full text

Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip by Kim, Hyun Jung, Li, Hu, Collins, James J., Ingber, Donald E.

“…A human gut-on-a-chip microdevice was used to coculture multiple commensal microbes in contact with living human intestinal epithelial cells for more than a…”
Get full text

Synthetic biology devices for in vitro and in vivo diagnostics by Slomovic, Shimyn, Keith Pardee, James J. Collins

“…There is a growing need to enhance our capabilities in medical and environmental diagnostics. Synthetic biologists have begun to focus their biomolecular…”
Get full text

Synthetic biology: applications come of age by Collins, James J, Khalil, Ahmad S

“…Key Points Early synthetic biology designs, namely the genetic toggle switch and repressilator, showed that regulatory components can be characterized and…”
Get full text

Microbial Persistence and the Road to Drug Resistance by Cohen, Nadia R., Lobritz, Michael A., Collins, James J.

“…Microbial drug persistence is a widespread phenomenon in which a subpopulation of microorganisms is able to survive antimicrobial treatment without acquiring…”
Get full text

Next-Generation Machine Learning for Biological Networks by Camacho, Diogo M., Collins, Katherine M., Powers, Rani K., Costello, James C., Collins, James J.

“…Machine learning, a collection of data-analytical techniques aimed at building predictive models from multi-dimensional datasets, is becoming integral to…”
Get full text

Targeting Antibiotic Tolerance, Pathogen by Pathogen by Meylan, Sylvain, Andrews, Ian W., Collins, James J.

“…Antibiotic tolerance, the capacity of genetically susceptible bacteria to survive the lethal effects of antibiotic treatment, plays a critical and…”
Get full text

Toehold switches: de-novo-designed regulators of gene expression by Green, Alexander A, Silver, Pamela A, Collins, James J, Yin, Peng

“…Efforts to construct synthetic networks in living cells have been hindered by the limited number of regulatory components that provide wide dynamic range and…”
Get full text

Systematically improved in vitro culture conditions reveal new insights into the reproductive biology of the human parasite Schistosoma mansoni by Wang, Jipeng, Chen, Rui, Collins, 3rd, James J

“…Schistosomes infect over 200 million people. The prodigious egg output of these parasites is the sole driver of pathology due to infection, yet our…”
Get full text

Paper-based synthetic gene networks by Pardee, Keith, Green, Alexander A, Ferrante, Tom, Cameron, D Ewen, DaleyKeyser, Ajay, Yin, Peng, Collins, James J

“…Synthetic gene networks have wide-ranging uses in reprogramming and rewiring organisms. To date, there has not been a way to harness the vast potential of…”
Get full text

How antibiotics kill bacteria: from targets to networks by Collins, James J, Kohanski, Michael A, Dwyer, Daniel J

“…Key Points Substantial progress has been made in our understanding of the mechanistic details of bacterial cell death induced by bactericidal antibiotics. In…”
Get full text

Metabolite-enabled eradication of bacterial persisters by aminoglycosides by Allison, Kyle R., Brynildsen, Mark P., Collins, James J.

“…How metabolic 'helpers' kill persistent pathogens Bacterial cells can enter a dormant 'persister' state that leaves them more resistant to stress conditions,…”
Get full text

Antibiotic-Induced Bacterial Cell Death Exhibits Physiological and Biochemical Hallmarks of Apoptosis by Dwyer, Daniel J., Camacho, Diogo M., Kohanski, Michael A., Callura, Jarred M., Collins, James J.

“…Programmed cell death is a gene-directed process involved in the development and homeostasis of multicellular organisms. The most common mode of programmed…”
Get full text

Adult somatic stem cells in the human parasite Schistosoma mansoni by Collins III, James J., Wang, Bo, Lambrus, Bramwell G., Tharp, Marla E., Iyer, Harini, Newmark, Phillip A.

“…This study reports the identification of adult stem cells in the human parasite Schistosoma mansoni (blood fluke); the cells proliferate and differentiate into…”
Get full text

Understanding Biological Regulation Through Synthetic Biology by Bashor, Caleb J, Collins, James J

“…Engineering synthetic gene regulatory circuits proceeds through iterative cycles of design, building, and testing. Initial circuit designs must rely on…”
Get full text

Unraveling the Physiological Complexities of Antibiotic Lethality by Dwyer, Daniel J, Collins, James J, Walker, Graham C

“…We face an impending crisis in our ability to treat infectious disease brought about by the emergence of antibiotic-resistant pathogens and a decline in the…”
Get full text

Fungicidal Drugs Induce a Common Oxidative-Damage Cellular Death Pathway by Belenky, Peter, Camacho, Diogo, Collins, James J.

“…Amphotericin, miconazole, and ciclopirox are antifungal agents from three different drug classes that can effectively kill planktonic yeast, yet their complete…”
Get full text

Engineering microbial division of labor for plastic upcycling by Bao, Teng, Qian, Yuanchao, Xin, Yongping, Collins, James J., Lu, Ting

“…Plastic pollution is rapidly increasing worldwide, causing adverse impacts on the environment, wildlife and human health. One tempting solution to this crisis…”
Get full text

Syntrophic exchange in synthetic microbial communities by Mee, Michael T., Collins, James J., Church, George M., Wang, Harris H.

“…Metabolic crossfeeding is an important process that can broadly shape microbial communities. However, little is known about specific crossfeeding principles…”
Get full text

Sublethal Antibiotic Treatment Leads to Multidrug Resistance via Radical-Induced Mutagenesis by Kohanski, Michael A., DePristo, Mark A., Collins, James J.

“…Antibiotic resistance arises through mechanisms such as selection of naturally occurring resistant mutants and horizontal gene transfer. Recently, oxidative…”
Get full text