Search Results - "COLLIER, Timothy J"

Aging and Parkinson's disease: Different sides of the same coin? by Collier, Timothy J., Kanaan, Nicholas M., Kordower, Jeffrey H.

“…ABSTRACT Despite abundant epidemiological evidence in support of aging as the primary risk factor for PD, biological correlates of a connection have been…”
Get full text

Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration by Paumier, Katrina L, Luk, Kelvin C, Manfredsson, Fredric P, Kanaan, Nicholas M, Lipton, Jack W, Collier, Timothy J, Steece-Collier, Kathy, Kemp, Christopher J, Celano, Stephanie, Schulz, Emily, Sandoval, Ivette M, Fleming, Sheila, Dirr, Elliott, Polinski, Nicole K, Trojanowski, John Q, Lee, Virginia M, Sortwell, Caryl E

“…Abstract Previous studies demonstrate that intrastriatal injections of fibrillar alpha-synuclein (α-syn) into mice induce Parkinson's disease (PD)-like Lewy…”
Get full text

Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration by Duffy, Megan F, Collier, Timothy J, Patterson, Joseph R, Kemp, Christopher J, Luk, Kelvin C, Tansey, Malú G, Paumier, Katrina L, Kanaan, Nicholas M, Fischer, D Luke, Polinski, Nicole K, Barth, Olivia L, Howe, Jacob W, Vaikath, Nishant N, Majbour, Nour K, El-Agnaf, Omar M A, Sortwell, Caryl E

“…Converging evidence suggests a role for microglia-mediated neuroinflammation in Parkinson's disease (PD). Animal models of PD can serve as a platform to…”
Get full text

Time course and magnitude of alpha-synuclein inclusion formation and nigrostriatal degeneration in the rat model of synucleinopathy triggered by intrastriatal α-synuclein preformed fibrils by Patterson, Joseph R., Duffy, Megan F., Kemp, Christopher J., Howe, Jacob W., Collier, Timothy J., Stoll, Anna C., Miller, Kathryn M., Patel, Pooja, Levine, Nathan, Moore, Darren J., Luk, Kelvin C., Fleming, Sheila M., Kanaan, Nicholas M., Paumier, Katrina L., El-Agnaf, Omar M.A., Sortwell, Caryl E.

“…Animal models that accurately recapitulate the accumulation of alpha-synuclein (α-syn) inclusions, progressive neurodegeneration of the nigrostriatal system…”
Get full text

Transfer of host-derived alpha synuclein to grafted dopaminergic neurons in rat by Kordower, Jeffrey H, Dodiya, Hemraj B, Kordower, Adam M, Terpstra, Brian, Paumier, Katrina, Madhavan, Lalitha, Sortwell, Caryl, Steece-Collier, Kathy, Collier, Timothy J

“…Abstract Multiple laboratories have recently demonstrated that long-term dopaminergic transplants form Lewy bodies in patients with Parkinson's disease. Debate…”
Get full text

Downregulation of striatal CaV1.3 inhibits the escalation of levodopa-induced dyskinesia in male and female parkinsonian rats of advanced age by Caulfield, Margaret E., Vander Werp, Molly J., Stancati, Jennifer A., Collier, Timothy J., Sortwell, Caryl E., Sandoval, Ivette M., Manfredsson, Fredric P., Steece-Collier, Kathy

“…In the past 25 years, the prevalence of Parkinson's disease (PD) has nearly doubled. Age remains the primary risk factor for PD and as the global aging…”
Get full text

Is Alpha-Synuclein Loss-of-Function a Contributor to Parkinsonian Pathology? Evidence from Non-human Primates by Collier, Timothy J, Redmond, Jr, D Eugene, Steece-Collier, Kathy, Lipton, Jack W, Manfredsson, Fredric P

“…Accumulation of alpha-synuclein (α-syn) in Lewy bodies and neurites of midbrain dopamine neurons is diagnostic for Parkinson's disease (PD), leading to the…”
Get full text

Striatal Nurr1 Facilitates the Dyskinetic State and Exacerbates Levodopa-Induced Dyskinesia in a Rat Model of Parkinson's Disease by Sellnow, Rhyomi C, Steece-Collier, Kathy, Altwal, Feras, Sandoval, Ivette M, Kordower, Jeffrey H, Collier, Timothy J, Sortwell, Caryl E, West, Anthony R, Manfredsson, Fredric P

“…The transcription factor Nurr1 has been identified to be ectopically induced in the striatum of rodents expressing l-DOPA-induced dyskinesia (LID). In the…”
Get full text

Genetic silencing of striatal CaV1.3 prevents and ameliorates levodopa dyskinesia by Steece‐Collier, Kathy, Stancati, Jennifer A., Collier, Nicholas J., Sandoval, Ivette M., Mercado, Natosha M., Sortwell, Caryl E., Collier, Timothy J., Manfredsson, Fredric P.

“…Background Levodopa‐induced dyskinesias are an often debilitating side effect of levodopa therapy in Parkinson's disease. Although up to 90% of individuals…”
Get full text

Subthalamic Nucleus Deep Brain Stimulation Employs trkB Signaling for Neuroprotection and Functional Restoration by Fischer, D Luke, Kemp, Christopher J, Cole-Strauss, Allyson, Polinski, Nicole K, Paumier, Katrina L, Lipton, Jack W, Steece-Collier, Kathy, Collier, Timothy J, Buhlinger, Daniel J, Sortwell, Caryl E

“…Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is the most common neurosurgical treatment for Parkinson's disease motor symptoms. In preclinical…”
Get full text

The BDNF Val66Met polymorphism (rs6265) enhances dopamine neuron graft efficacy and side-effect liability in rs6265 knock-in rats by Mercado, Natosha M., Stancati, Jennifer A., Sortwell, Caryl E., Mueller, Rebecca L., Boezwinkle, Samuel A., Duffy, Megan F., Fischer, D. Luke, Sandoval, Ivette M., Manfredsson, Fredric P., Collier, Timothy J., Steece-Collier, Kathy

“…Prevalent in approximately 20% of the worldwide human population, the rs6265 (also called ‘Val66Met’) single nucleotide polymorphism (SNP) in the gene for…”
Get full text

Design and Assembly of CRISPR/Cas9 Lentiviral and rAAV Vectors for Targeted Genome Editing by Sandoval, Ivette M, Collier, Timothy J, Manfredsson, Fredric P

“…Clustered regularly interspaced short palindromic repeat (CRISPR/Cas) system has emerged as an extremely useful tool for biological research and as a potential…”
Get more information

Loss of VGLUT3 Produces Circadian-Dependent Hyperdopaminergia and Ameliorates Motor Dysfunction and l-Dopa-Mediated Dyskinesias in a Model of Parkinson's Disease by Divito, Christopher B, Steece-Collier, Kathy, Case, Daniel T, Williams, Sean-Paul G, Stancati, Jennifer A, Zhi, Lianteng, Rubio, Maria E, Sortwell, Caryl E, Collier, Timothy J, Sulzer, David, Edwards, Robert H, Zhang, Hui, Seal, Rebecca P

“…The striatum is essential for many aspects of mammalian behavior, including motivation and movement, and is dysfunctional in motor disorders such as…”
Get full text

α-Synuclein antisense oligonucleotides as a disease-modifying therapy for Parkinson's disease by Cole, Tracy A, Zhao, Hien, Collier, Timothy J, Sandoval, Ivette, Sortwell, Caryl E, Steece-Collier, Kathy, Daley, Brian F, Booms, Alix, Lipton, Jack, Welch, Mackenzie, Berman, Melissa, Jandreski, Luke, Graham, Danielle, Weihofen, Andreas, Celano, Stephanie, Schulz, Emily, Cole-Strauss, Allyson, Luna, Esteban, Quach, Duc, Mohan, Apoorva, Bennett, C Frank, Swayze, Eric E, Kordasiewicz, Holly B, Luk, Kelvin C, Paumier, Katrina L

“…Parkinson's disease (PD) is a prevalent neurodegenerative disease with no approved disease-modifying therapies. Multiplications, mutations, and single…”
Get full text

Behavioral phenotyping of a rat model of the BDNF Val66Met polymorphism reveals selective impairment of fear memory by Jaehne, Emily J., Kent, Jessica N., Antolasic, Emily J., Wright, Bradley J., Spiers, Jereme G., Creutzberg, Kerstin C., De Rosa, Federico, Riva, Marco A., Sortwell, Caryl E., Collier, Timothy J., van den Buuse, Maarten

“…The common brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is associated with reduced activity-dependent BDNF release and increased risk for…”
Get full text

Quality Over Quantity: Advantages of Using Alpha-Synuclein Preformed Fibril Triggered Synucleinopathy to Model Idiopathic Parkinson's Disease by Duffy, Megan F, Collier, Timothy J, Patterson, Joseph R, Kemp, Christopher J, Fischer, D Luke, Stoll, Anna C, Sortwell, Caryl E

“…Animal models have significantly advanced our understanding of Parkinson's disease (PD). Alpha-synuclein (α-syn) has taken center stage due to its genetic…”
Get full text

Nortriptyline inhibits aggregation and neurotoxicity of alpha-synuclein by enhancing reconfiguration of the monomeric form by Collier, Timothy J., Srivastava, Kinshuk R., Justman, Craig, Grammatopoulous, Tom, Hutter-Paier, Birgit, Prokesch, Manuela, Havas, Daniel, Rochet, Jean-Christophe, Liu, Fang, Jock, Kevin, de Oliveira, Patrícia, Stirtz, Georgia L., Dettmer, Ulf, Sortwell, Caryl E., Feany, Mel B., Lansbury, Peter, Lapidus, Lisa, Paumier, Katrina L.

“…The pathology of Parkinson's disease and other synucleinopathies is characterized by the formation of intracellular inclusions comprised primarily of…”
Get full text

The longitudinal transcriptomic response of the substantia nigra to intrastriatal 6-hydroxydopamine reveals significant upregulation of regeneration-associated genes by Kanaan, Nicholas M, Collier, Timothy J, Cole-Strauss, Allyson, Grabinski, Tessa, Mattingly, Zachary R, Winn, Mary E, Steece-Collier, Kathy, Sortwell, Caryl E, Manfredsson, Fredric P, Lipton, Jack W

“…We hypothesized that the study of gene expression at 1, 2, 4, 6 and 16 weeks in the substantia nigra (SN) after intrastriatal 6-OHDA in the Sprague-Dawley rat…”
Get full text

Tricyclic antidepressant treatment evokes regional changes in neurotrophic factors over time within the intact and degenerating nigrostriatal system by Paumier, Katrina L., Sortwell, Caryl E., Madhavan, Lalitha, Terpstra, Brian, Daley, Brian F., Collier, Timothy J.

“…In addition to alleviating depression, trophic responses produced by antidepressants may regulate neural plasticity in the diseased brain, which not only…”
Get full text

Advancing age and the rs6265 BDNF SNP are permissive to graft-induced dyskinesias in parkinsonian rats by Mercado, Natosha M., Szarowicz, Carlye, Stancati, Jennifer A., Sortwell, Caryl E., Boezwinkle, Samuel A., Collier, Timothy J., Caulfield, Margaret E., Steece-Collier, Kathy

“…The rs6265 single nucleotide polymorphism (SNP) in the gene for brain-derived neurotrophic factor is a common variant that alters therapeutic outcomes for…”
Get full text