Search Results - "COLLIER, R. John"

Atomic structure of anthrax protective antigen pore elucidates toxin translocation by Jiang, Jiansen, Pentelute, Bradley L., Collier, R. John, Zhou, Z. Hong

“…Cryo-electron microscopy determination of anthrax toxin protective antigen pore structure at a resolution of 2.9 Å, revealing the catalytic Φ-clamp and the…”
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Anthrax toxin: receptor binding, internalization, pore formation, and translocation by Young, John A T, Collier, R John

“…Anthrax toxin consists of three nontoxic proteins that self-assemble at the surface of receptor-bearing mammalian cells or in solution, yielding a series of…”
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Anthrax toxins regulate pain signaling and can deliver molecular cargoes into ANTXR2+ DRG sensory neurons by Yang, Nicole J., Isensee, Jörg, Neel, Dylan V., Quadros, Andreza U., Zhang, Han-Xiong Bear, Lauzadis, Justas, Liu, Sai Man, Shiers, Stephanie, Belu, Andreea, Palan, Shilpa, Marlin, Sandra, Maignel, Jacquie, Kennedy-Curran, Angela, Tong, Victoria S., Moayeri, Mahtab, Röderer, Pascal, Nitzsche, Anja, Lu, Mike, Pentelute, Bradley L., Brüstle, Oliver, Tripathi, Vineeta, Foster, Keith A., Price, Theodore J., Collier, R. John, Leppla, Stephen H., Puopolo, Michelino, Bean, Bruce P., Cunha, Thiago M., Hucho, Tim, Chiu, Isaac M.

“…Bacterial products can act on neurons to alter signaling and function. In the present study, we found that dorsal root ganglion (DRG) sensory neurons are…”
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ANTHRAX TOXIN by Collier, R. John, Young, John A.T

“…Anthrax toxin consists of three nontoxic proteins that associate in binary or ternary combinations to form toxic complexes at the surface of mammalian cells…”
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Receptor-directed chimeric toxins created by sortase-mediated protein fusion by McCluskey, Andrew J, Collier, R John

“…Chimeric protein toxins that act selectively on cells expressing a designated receptor may serve as investigational probes and/or antitumor agents. Here, we…”
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Changing the receptor specificity of anthrax toxin by Mechaly, Adva, McCluskey, Andrew J, Collier, R John

“…The actions of many bacterial toxins depend on their ability to bind to one or more cell-surface receptors. Anthrax toxin acts by a sequence of events that…”
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Protein Translocation through the Anthrax Toxin Transmembrane Pore is Driven by a Proton Gradient by Krantz, Bryan A., Finkelstein, Alan, Collier, R. John

“…Protective antigen (PA) from anthrax toxin assembles into a homoheptamer on cell surfaces and forms complexes with the enzymatic components: lethal factor (LF)…”
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Identification of the cellular receptor for anthrax toxin by Young, John A. T, Bradley, Kenneth A, Mogridge, Jeremy, Mourez, Michael, Collier, R. John

“…The tripartite toxin secreted by Bacillus anthracis, the causative agent of anthrax, helps the bacterium evade the immune system and can kill the host during a…”
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A Phenylalanine Clamp Catalyzes Protein Translocation through the Anthrax Toxin Pore by Krantz, Bryan A., Melnyk, Roman A., Zhang, Sen, Juris, Stephen J., Lacy, D. Borden, Wu, Zhengyan, Finkelstein, Alan, Collier, R. John

“…The protective antigen component of anthrax toxin forms a homoheptameric pore in the endosomal membrane, creating a narrow passageway for the enzymatic…”
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The Holobiont/Hologenome Concept Series by Collier, R John, Casadevall, Arturo

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Ultrasensitive detection of protein translocated through toxin pores in droplet-interface bilayers by Fischer, Audrey, Holden, Matthew A, Pentelute, Brad L, Collier, R. John

“…Many bacterial toxins form proteinaceous pores that facilitate the translocation of soluble effector proteins across cellular membranes. With anthrax toxin…”
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Phenylalanine-427 of anthrax protective antigen functions in both pore formation and protein translocation by Sun, Jianjun, Lang, Alexander E, Aktories, Klaus, Collier, R. John

“…The protective antigen (PA) moiety of anthrax toxin forms a heptameric pore in endosomal membranes of mammalian cells and translocates the enzymatic moieties…”
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Disulfide bonds in the ectodomain of anthrax toxin receptor 2 are required for the receptor-bound protective-antigen pore to function by Sun, Jianjun, Collier, R John

“…Cell-surface receptors play essential roles in anthrax toxin action by providing the toxin with a high-affinity anchor and self-assembly site on the plasma…”
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Structure of Heptameric Protective Antigen Bound to an Anthrax Toxin Receptor: A Role for Receptor in pH-Dependent Pore Formation by Lacy, D. Borden, Wigelsworth, Darran J., Melnyk, Roman A., Harrison, Stephen C., Collier, R. John

“…After binding to cellular receptors and proteolytic activation, the protective antigen component of anthrax toxin forms a heptameric prepore. The prepore later…”
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Evidence That Translocation of Anthrax Toxin's Lethal Factor Is Initiated by Entry of Its N Terminus into the Protective Antigen Channel by Zhang, Sen, Finkelstein, Alan, Collier, R. John, Karlin, Arthur

“…Entry of the enzymatic components of anthrax toxin [lethal factor (LF) and edema factor] into the cytosol of mammalian cells depends on the ability of the…”
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Following Natures Lead: On the Construction of Membrane-Inserted Toxins in Lipid Bilayer Nanodiscs by Akkaladevi, Narahari, Mukherjee, Srayanta, Katayama, Hiroo, Janowiak, Blythe, Patel, Deepa, Gogol, Edward P., Pentelute, Bradley L., John Collier, R., Fisher, Mark T.

“…Bacterial toxin or viral entry into the cell often requires cell surface binding and endocytosis. The endosomal acidification induces a limited…”
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Interactions of anthrax lethal factor with protective antigen defined by site-directed spin labeling by Jennings-Antipov, Laura D, Song, Likai, Collier, R. John

“…The protective antigen (PA) moiety of anthrax toxin forms oligomeric pores that translocate the enzymatic moieties of the toxin--lethal factor (LF) and edema…”
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A Loop Network within the Anthrax Toxin Pore Positions the Phenylalanine Clamp in an Active Conformation by Melnyk, Roman A., Collier, R. John

“…Heptameric pores formed in the endosomal membrane by the protective antigen moiety of anthrax toxin serve as portals for entry of the enzymatic moieties of the…”
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Membrane translocation by anthrax toxin by Collier, R. John

“…Much attention has been focused on anthrax toxin recently, both because of its central role in the pathogenesis of Bacillus anthracis and because it has proven…”
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Replacement of C-Terminal Histidines Uncouples Membrane Insertion and Translocation in Diphtheria Toxin T-Domain by Rodnin, Mykola V., Kyrychenko, Alexander, Kienker, Paul, Sharma, Onkar, Vargas-Uribe, Mauricio, Collier, R. John, Finkelstein, Alan, Ladokhin, Alexey S.

“…The translocation (T) domain plays a key role in the action of diphtheria toxin and is responsible for transferring the N-terminus-attached catalytic domain…”
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