Search Results - "COLLIER, J. JASON"

FGF21 is required for protein restriction to extend lifespan and improve metabolic health in male mice by Hill, Cristal M., Albarado, Diana C., Coco, Lucia G., Spann, Redin A., Khan, Md Shahjalal, Qualls-Creekmore, Emily, Burk, David H., Burke, Susan J., Collier, J. Jason, Yu, Sangho, McDougal, David H., Berthoud, Hans-Rudolf, Münzberg, Heike, Bartke, Andrzej, Morrison, Christopher D.

“…Dietary protein restriction is increasingly recognized as a unique approach to improve metabolic health, and there is increasing interest in the mechanisms…”
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Metabolic Responses to Dietary Protein Restriction Require an Increase in FGF21 that Is Delayed by the Absence of GCN2 by Laeger, Thomas, Albarado, Diana C., Burke, Susan J., Trosclair, Lexus, Hedgepeth, John W., Berthoud, Hans-Rudolf, Gettys, Thomas W., Collier, J. Jason, Münzberg, Heike, Morrison, Christopher D.

“…FGF21 contributes to the metabolic response to dietary protein restriction, and prior data implicate GCN2 as the amino acid sensor linking protein restriction…”
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From pre-clinical efficacy to promising clinical trials that delay Type 1 diabetes by Collier, J. Jason, Hsia, Daniel S., Burke, Susan J.

“…Recent advancements in immunology and islet biology have unveiled remarkable prospects for the postponement of Type 1 diabetes (T1D) through the strategic…”
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FGF21 Signals Protein Status to the Brain and Adaptively Regulates Food Choice and Metabolism by Hill, Cristal M, Laeger, Thomas, Dehner, Madeleine, Albarado, Diana C, Clarke, Blaise, Wanders, Desiree, Burke, Susan J, Collier, J Jason, Qualls-Creekmore, Emily, Solon-Biet, Samantha M, Simpson, Stephen J, Berthoud, Hans-Rudolf, Münzberg, Heike, Morrison, Christopher D

“…Reduced dietary protein intake induces adaptive physiological changes in macronutrient preference, energy expenditure, growth, and glucose homeostasis. We…”
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NF-κB and STAT1 control CXCL1 and CXCL2 gene transcription by Burke, Susan J, Lu, Danhong, Sparer, Tim E, Masi, Thomas, Goff, Matthew R, Karlstad, Michael D, Collier, J Jason

“…Diabetes mellitus results from immune cell invasion into pancreatic islets of Langerhans, eventually leading to selective destruction of the insulin-producing…”
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Lysosomal glucose sensing and glycophagy in metabolism by Mancini, Melina C, Noland, Robert C, Collier, J Jason, Burke, Susan J, Stadler, Krisztian, Heden, Timothy D

“…Lysosomes are cellular organelles that function to catabolize both extra- and intracellular cargo, act as a platform for nutrient sensing, and represent a core…”
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db/db Mice Exhibit Features of Human Type 2 Diabetes That Are Not Present in Weight-Matched C57BL/6J Mice Fed a Western Diet by Jason Collier, J., Boulos, Matthew S., Eder, Adrianna E., Noland, Robert C., Burk, David H., Batdorf, Heidi M., Burke, Susan J., Karlstad, Michael D.

“…To understand features of human obesity and type 2 diabetes mellitus (T2D) that can be recapitulated in the mouse, we compared C57BL/6J mice fed a…”
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NOD mice have distinct metabolic and immunologic profiles when compared with genetically similar MHC-matched ICR mice by Batdorf, Heidi M, Lawes, Luz de Luna, Richardson, Jeremy T, Burk, David H, Dupuy, Samuel D, Karlstad, Michael D, Noland, Robert C, Burke, Susan J, Collier, J Jason

“…Nonobese diabetic (NOD) mice are the most commonly used rodent model to study mechanisms relevant to the autoimmunity and immunology of type 1 diabetes…”
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Low-intensity exercise induces acute shifts in liver and skeletal muscle substrate metabolism but not chronic adaptations in tissue oxidative capacity by Fuller, Scott E, Huang, Tai-Yu, Simon, Jacob, Batdorf, Heidi M, Essajee, Nabil M, Scott, Matthew C, Waskom, Callie M, Brown, John M, Burke, Susan J, Collier, J Jason, Noland, Robert C

“…Adaptations in hepatic and skeletal muscle substrate metabolism following acute and chronic (6 wk; 5 days/wk; 1 h/day) low-intensity treadmill exercise were…”
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Pancreatic Islet Responses to Metabolic Trauma by Burke, Susan J, Karlstad, Michael D, Collier, J Jason

“…ABSTRACTCarbohydrate, lipid, and protein metabolism are largely controlled by the interplay of various hormones, which includes those secreted by the…”
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Regulation of iNOS Gene Transcription by IL-1β and IFN-γ Requires a Coactivator Exchange Mechanism by Burke, Susan J, Updegraff, Barrett L, Bellich, Rachel M, Goff, Matthew R, Lu, Danhong, Minkin, Steven C, Karlstad, Michael D, Collier, J. Jason

“…The proinflammatory cytokines IL-1β and IFN-γ decrease functional islet β-cell mass in part through the increased expression of specific genes, such as…”
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Channel Expansion in the Ligand-Binding Domain of the Glucocorticoid Receptor Contributes to the Activity of Highly Potent Glucocorticoid Analogues by Seaton, Wesley B, Burke, Susan J, Fisch, Alexander R, Schilletter, William A, Beck, Mary Grace A, Cassagne, Gabrielle A, Harvey, Innocence, Fontenot, Molly S, Collier, J Jason, Campagna, Shawn R

“…Glucocorticoids (GCs) act through the glucocorticoid receptor (GR) and are commonly used as anti-inflammatory and immunosuppressant medications. Chronic GC use…”
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Liquid Sucrose Consumption Promotes Obesity and Impairs Glucose Tolerance Without Altering Circulating Insulin Levels by Burke, Susan J., Batdorf, Heidi M., Martin, Thomas M., Burk, David H., Noland, Robert C., Cooley, Christopher R., Karlstad, Michael D., Johnson, William D., Collier, J. Jason

“…Objective Multiple factors contribute to the rising rates of obesity and to difficulties in weight reduction that exist in the worldwide population. Caloric…”
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Oral Corticosterone Administration Reduces Insulitis but Promotes Insulin Resistance and Hyperglycemia in Male Nonobese Diabetic Mice by Burke, Susan J, Batdorf, Heidi M, Eder, Adrianna E, Karlstad, Michael D, Burk, David H, Noland, Robert C, Floyd, Z. Elizabeth, Collier, J. Jason

“…Steroid-induced diabetes is the most common form of drug-induced hyperglycemia. Therefore, metabolic and immunological alterations associated with chronic oral…”
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Special Issue: Emerging Paradigms in Insulin Resistance by Collier, J. Jason, Burke, Susan J.

“…This Biomedicines Special Issue was designed to attract articles that focused on different facets of biology relating to insulin resistance, defined as reduced…”
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CCL20 is elevated during obesity and differentially regulated by NF-κB subunits in pancreatic β-cells by Burke, Susan J., Karlstad, Michael D., Regal, Kellie M., Sparer, Tim E., Lu, Danhong, Elks, Carrie M., Grant, Ryan W., Stephens, Jacqueline M., Burk, David H., Collier, J. Jason

“…Enhanced leukocytic infiltration into pancreatic islets contributes to inflammation-based diminutions in functional β-cell mass. Insulitis (aka islet…”
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Hepatic IKKε expression is dispensable for high-fat feeding-induced increases in liver lipid content and alterations in glucose tolerance by Collier, J Jason, Batdorf, Heidi M, Mendoza, Tamra M, Burk, David H, Martin, Thomas M, Zhang, Jingying, Mynatt, Randall L, Burke, Susan J

“…There are endocrine and immunological changes that occur during onset and progression of the overweight and obese states. The inhibitor of nuclear factor-κB…”
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Special Issue: Islet Inflammation and Metabolic Homeostasis by Burke, Susan J, Collier, J Jason

“…This special issue was commissioned to offer a source of distinct viewpoints and novel data that capture some of the subtleties of the pancreatic islet,…”
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Pancreatic deletion of the interleukin-1 receptor disrupts whole body glucose homeostasis and promotes islet β-cell de-differentiation by Burke, Susan J., Batdorf, Heidi M., Burk, David H., Martin, Thomas M., Mendoza, Tamra, Stadler, Krisztian, Alami, Wateen, Karlstad, Michael D., Robson, Matthew J., Blakely, Randy D., Mynatt, Randall L., Collier, J. Jason

“…Pancreatic tissue, and islets in particular, are enriched in expression of the interleukin-1 receptor type I (IL-1R). Because of this enrichment, islet β-cells…”
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Transcriptional regulation of chemokine genes: a link to pancreatic islet inflammation? by Burke, Susan J, Collier, J Jason

“…Enhanced expression of chemotactic cytokines (aka chemokines) within pancreatic islets likely contributes to islet inflammation by regulating the recruitment…”
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