Search Results - "COLLADO, Manuel"

The power and the promise of oncogene-induced senescence markers by Serrano, Manuel, Collado, Manuel

“…Recently, it has been shown that oncogene-induced senescence (OIS) occurs during the early stages of tumorigenesis. Senescent tumour cells are abundant within…”
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The Ink4/Arf locus is a barrier for iPS cell reprogramming by Serrano, Manuel, Li, Han, Collado, Manuel, Blasco, Maria A, Cañamero, Marta, Ortega, Sagrario, Strati, Katerina, Villasante, Aranzazu

“…The mechanisms involved in the reprogramming of differentiated cells into induced pluripotent stem (iPS) cells by the three transcription factors Oct4 (also…”
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Cell senescence contributes to tissue regeneration in zebrafish by Da Silva‐Álvarez, Sabela, Guerra‐Varela, Jorge, Sobrido‐Cameán, Daniel, Quelle, Ana, Barreiro‐Iglesias, Antón, Sánchez, Laura, Collado, Manuel

“…Cellular senescence is a stress response that limits the proliferation of damaged cells by establishing a permanent cell cycle arrest. Different stimuli can…”
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Pancreatitis-Induced Inflammation Contributes to Pancreatic Cancer by Inhibiting Oncogene-Induced Senescence by Guerra, Carmen, Collado, Manuel, Navas, Carolina, Schuhmacher, Alberto J., Hernández-Porras, Isabel, Cañamero, Marta, Rodriguez-Justo, Manuel, Serrano, Manuel, Barbacid, Mariano

“…Pancreatic acinar cells of adult mice (≥P60) are resistant to transformation by some of the most robust oncogenic insults including expression of K- Ras…”
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The Diet as a Modulator of Tumor Microenvironment in Colorectal Cancer Patients by Collado, Manuel, Castillo, Marién, Muñoz de Mier, Gemma Julia, de la Pinta, Carolina, Peña, Cristina

“…Colorectal cancer (CRC) is one of the most common cancers in Western countries and remains the second most common cause of cancer death worldwide. Many studies…”
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TGFβ2-induced senescence during early inner ear development by Gibaja, Alejandro, Aburto, María R., Pulido, Sara, Collado, Manuel, Hurle, Juan M., Varela-Nieto, Isabel, Magariños, Marta

“…Embryonic development requires the coordinated regulation of apoptosis, survival, autophagy, proliferation and differentiation programs. Senescence has…”
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Oncogenicity of the Developmental Transcription Factor Sox9 by MATHEU, Ander, COLLADO, Manuel, SKOTHEIM, Rolf I, LOTHE, Ragnhild A, DE MUNAIN, Adolfo López, BRISCOE, James, SERRANO, Manuel, LOVELL-BADGE, Robin, WISE, Clare, MANTEROLA, Lorea, CEKAITE, Lina, TYE, Angela J, CANAMERO, Marta, BUJANDA, Luis, SCHEDL, Andreas, CHEAH, Kathryn S. E

“…SOX9 [sex-determining region Y (SRY)-box 9 protein], a high mobility group box transcription factor, plays critical roles during embryogenesis and its activity…”
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p27Kip1 Directly Represses Sox2 during Embryonic Stem Cell Differentiation by Li, Han, Collado, Manuel, Villasante, Aranzazu, Matheu, Ander, Lynch, Cian J., Cañamero, Marta, Rizzoti, Karine, Carneiro, Carmen, Martínez, Gloria, Vidal, Anxo, Lovell-Badge, Robin, Serrano, Manuel

“…The mechanisms responsible for the transcriptional silencing of pluripotency genes in differentiated cells are poorly understood. We have observed that cells…”
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Radiogenomics: Hunting Down Liver Metastasis in Colorectal Cancer Patients by de la Pinta, Carolina, Castillo, María E., Collado, Manuel, Galindo-Pumariño, Cristina, Peña, Cristina

“…Radiomics is a developing new discipline that analyzes conventional medical images to extract quantifiable data that can be mined for new biomarkers that show…”
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Tumor Microenvironment in Metastatic Colorectal Cancer: The Arbitrator in Patients' Outcome by Galindo-Pumariño, Cristina, Collado, Manuel, Herrera, Mercedes, Peña, Cristina

“…Colorectal cancer (CRC) is one of the most common cancers in western countries. Its mortality rate varies greatly, depending on the stage of the disease. The…”
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Current Risk of Dirofilariosis Transmission in the Iberian Peninsula (Spain and Portugal) and the Balearic Islands (Spain) and Its Future Projection under Climate Change Scenarios by Rodríguez-Escolar, Iván, Hernández-Lambraño, Ricardo E, Sánchez-Agudo, José Ángel, Collado, Manuel, Pérez-Pérez, Patricia, Morchón, Rodrigo

“…Dirofilariosis is a vector-borne zoonotic disease whose distribution is linked to the presence of culicid mosquitoes. Spain and Portugal are considered endemic…”
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p19ARF Deficiency Reduces Macrophage and Vascular Smooth Muscle Cell Apoptosis and Aggravates Atherosclerosis by González-Navarro, Herminia, PhD, Abu Nabah, Yafa Naim, PhD, Vinué, Ángela, BSc, Andrés-Manzano, María J., BSc, Collado, Manuel, PhD, Serrano, Manuel, PhD, Andrés, Vicente, PhD

“…Objectives The goal of this study was to investigate the role in atherosclerosis of the tumor suppressor protein ARF (human p14ARF , mouse p19ARF ) encoded by…”
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Microbiological profile in patients hospitalized for burns by Hernández, Carlos Manuel Collado, Machado, Arbenys Alexis Blanco, Núnez, Vivian Pérez

“…Introduction: Injuries caused by burns are a global health problem that affects all age groups, not only because of the frequency in which they occur but…”
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Author Correction: Identification and characterization of Cardiac Glycosides as senolytic compounds by Triana-Martínez, Francisco, Picallos-Rabina, Pilar, Da Silva-Álvarez, Sabela, Pietrocola, Federico, Llanos, Susana, Rodilla, Verónica, Soprano, Enrica, Pedrosa, Pablo, Ferreirós, Alba, Barradas, Marta, Hernández-González, Fernanda, Lalinde, Marta, Prats, Neus, Bernadó, Cristina, González, Patricia, Gómez, María, Ikonomopoulou, Maria P., Fernández-Marcos, Pablo J., García-Caballero, Tomás, del Pino, Pablo, Arribas, Joaquín, Vidal, Anxo, González-Barcia, Miguel, Serrano, Manuel, Loza, María I., Domínguez, Eduardo, Collado, Manuel

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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The Senescent Side of Tumor Suppression by Collado, Manuel, Serrano, Manuel

“…Neoplastic transformation of human cells is a rare event that requires overcoming anti-tumoral cellular responses. Oncogene-induced senescence (OIS) is…”
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Regulation of Ebola virus VP40 matrix protein by SUMO by Baz-Martínez, Maite, El Motiam, Ahmed, Ruibal, Paula, Condezo, Gabriela N., de la Cruz-Herrera, Carlos F., Lang, Valerie, Collado, Manuel, San Martín, Carmen, Rodríguez, Manuel S., Muñoz-Fontela, Cesar, Rivas, Carmen

“…The matrix protein of Ebola virus (EBOV) VP40 regulates viral budding, nucleocapsid recruitment, virus structure and stability, viral genome replication and…”
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Anti‐aging activity of the Ink4/Arf locus by Matheu, Ander, Maraver, Antonio, Collado, Manuel, Garcia‐Cao, Isabel, Cañamero, Marta, Borras, Consuelo, Flores, Juana M., Klatt, Peter, Viña, Jose, Serrano, Manuel

“…Summary The proteins encoded by the Ink4/Arf locus, p16Ink4a, p19Arf and p15Ink4b are major tumour suppressors that oppose aberrant mitogenic signals. The…”
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Extracellular plasma RNA from colon cancer patients is confined in a vesicle-like structure and is mRNA-enriched by García, José Miguel, García, Vanesa, Peña, Cristina, Domínguez, Gemma, Silva, Javier, Diaz, Raquel, Espinosa, Pablo, Citores, Maria Jesús, Collado, Manuel, Bonilla, Félix

“…Little is yet known about the origin and protective mechanism of free nucleic acids in plasma. We investigated the possibility of these free nucleic acids…”
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Senescence in tumours: evidence from mice and humans by Collado, Manuel, Serrano, Manuel

“…Key Points Senescence is a stress response prevalent in the aberrant environment of tumours. Senescent cells are incapable of further proliferation and…”
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Generation and characterization of the human iPSC line IDISi001-A isolated from blood cells of a CADASIL patient carrying a NOTCH3 mutation by Fernández-Susavila, Héctor, Mora, Cristina, Aramburu-Núñez, Marta, Quintas-Rey, Rita, Arias, Susana, Collado, Manuel, López-Arias, Esteban, Sobrino, Tomás, Castillo, José, Dell'Era, Patrizia, Campos, Francisco

“…Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common form of hereditary stroke disorder. It…”
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