Search Results - "COLHOUN, HELEN"

Biomarkers of diabetic kidney disease by Colhoun, Helen M., Marcovecchio, M. Loredana

“…Diabetic kidney disease (DKD) remains one of the leading causes of reduced lifespan in diabetes. The quest for both prognostic and surrogate endpoint…”
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Efficacy and safety of the proprotein convertase subtilisin/kexin type 9 inhibitor alirocumab among high cardiovascular risk patients on maximally tolerated statin therapy: The ODYSSEY COMBO I study by Kereiakes, Dean J., MD, FACC, FSCAI, Robinson, Jennifer G., MD, MPH, Cannon, Christopher P., MD, Lorenzato, Christelle, MSc, Pordy, Robert, MD, Chaudhari, Umesh, MD, Colhoun, Helen M., MD, MFPHM, FRCP(Ed)

“…Background The ODYSSEY COMBO I study ( http://clinicaltrials.gov/show/NCT01644175 ) evaluated efficacy and safety of alirocumab as add-on therapy to stable…”
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Efficacy and safety of alirocumab in high cardiovascular risk patients with inadequately controlled hypercholesterolaemia on maximally tolerated doses of statins: the ODYSSEY COMBO II randomized controlled trial by Cannon, Christopher P, Cariou, Bertrand, Blom, Dirk, McKenney, James M, Lorenzato, Christelle, Pordy, Robert, Chaudhari, Umesh, Colhoun, Helen M

“…To compare the efficacy [low-density lipoprotein cholesterol (LDL-C) lowering] and safety of alirocumab, a fully human monoclonal antibody to proprotein…”
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Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes by Lincoff, A. Michael, Brown-Frandsen, Kirstine, Colhoun, Helen M., Deanfield, John, Emerson, Scott S., Esbjerg, Sille, Hardt-Lindberg, Søren, Hovingh, G. Kees, Kahn, Steven E., Kushner, Robert F., Lingvay, Ildiko, Oral, Tugce K., Michelsen, Marie M., Plutzky, Jorge, Tornøe, Christoffer W., Ryan, Donna H.

“…In a trial in patients with cardiovascular disease and overweight or obesity but no diabetes, semaglutide was superior to placebo in lowering the risk of major…”
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Effect of Vaccination on Transmission of SARS-CoV-2 by Shah, Anoop S.V, Gribben, Ciara, Bishop, Jennifer, Hanlon, Peter, Caldwell, David, Wood, Rachael, Reid, Martin, McMenamin, Jim, Goldberg, David, Stockton, Diane, Hutchinson, Sharon, Robertson, Chris, McKeigue, Paul M, Colhoun, Helen M, McAllister, David A

“…In this report from Scotland, vaccination of health care workers for SARS-CoV-2 was associated with a decrease in household transmission…”
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Relation of Incident Type 1 Diabetes to Recent COVID-19 Infection: Cohort Study Using e-Health Record Linkage in Scotland by McKeigue, Paul M, McGurnaghan, Stuart, Blackbourn, Luke, Bath, Louise E, McAllister, David A, Caparrotta, Thomas M, Wild, Sarah H, Wood, Simon N, Stockton, Diane, Colhoun, Helen M

“…Studies using claims databases reported that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection >30 days earlier was associated with an…”
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Baseline and on-statin treatment lipoprotein(a) levels for prediction of cardiovascular events: individual patient-data meta-analysis of statin outcome trials by Willeit, Peter, Ridker, Paul M, Nestel, Paul J, Simes, John, Tonkin, Andrew M, Pedersen, Terje R, Schwartz, Gregory G, Olsson, Anders G, Colhoun, Helen M, Kronenberg, Florian, Drechsler, Christiane, Wanner, Christoph, Mora, Samia, Lesogor, Anastasia, Tsimikas, Sotirios

“…Elevated lipoprotein(a) is a genetic risk factor for cardiovascular disease in general population studies. However, its contribution to risk for cardiovascular…”
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Rapid Epidemiological Analysis of Comorbidities and Treatments as risk factors for COVID-19 in Scotland (REACT-SCOT): A population-based case-control study by McKeigue, Paul M, Weir, Amanda, Bishop, Jen, McGurnaghan, Stuart J, Kennedy, Sharon, McAllister, David, Robertson, Chris, Wood, Rachael, Lone, Nazir, Murray, Janet, Caparrotta, Thomas M, Smith-Palmer, Alison, Goldberg, David, McMenamin, Jim, Ramsay, Colin, Hutchinson, Sharon, Colhoun, Helen M

“…The objectives of this study were to identify risk factors for severe coronavirus disease 2019 (COVID-19) and to lay the basis for risk stratification based on…”
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Cardiovascular Disease, Cancer, and Mortality Among People With Type 2 Diabetes and Alcoholic or Nonalcoholic Fatty Liver Disease Hospital Admission by Wild, Sarah H, Walker, Jeremy J, Morling, Joanne R, McAllister, David A, Colhoun, Helen M, Farran, Bassam, McGurnaghan, Stuart, McCrimmon, Rory, Read, Stephanie H, Sattar, Naveed, Byrne, Christopher D

“…To describe associations between alcoholic liver disease (ALD) or nonalcoholic fatty liver disease (NAFLD) hospital admission and cardiovascular disease (CVD),…”
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Efficacy and safety of adding alirocumab to rosuvastatin versus adding ezetimibe or doubling the rosuvastatin dose in high cardiovascular-risk patients: The ODYSSEY OPTIONS II randomized trial by Farnier, Michel, Jones, Peter, Severance, Randall, Averna, Maurizio, Steinhagen-Thiessen, Elisabeth, Colhoun, Helen M, Du, Yunling, Hanotin, Corinne, Donahue, Stephen

“…Abstract Objective To compare lipid-lowering efficacy of adding alirocumab to rosuvastatin versus other treatment strategies (NCT01730053). Methods Patients…”
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Risk of cardiovascular disease and total mortality in adults with type 1 diabetes: Scottish registry linkage study by Livingstone, Shona J, Looker, Helen C, Hothersall, Eleanor J, Wild, Sarah H, Lindsay, Robert S, Chalmers, John, Cleland, Stephen, Leese, Graham P, McKnight, John, Morris, Andrew D, Pearson, Donald W M, Peden, Norman R, Petrie, John R, Philip, Sam, Sattar, Naveed, Sullivan, Frank, Colhoun, Helen M

“…Randomized controlled trials have shown the importance of tight glucose control in type 1 diabetes (T1DM), but few recent studies have evaluated the risk of…”
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Incidence of Hospitalization for Heart Failure and Case-Fatality Among 3.25 Million People With and Without Diabetes Mellitus by McAllister, David A, Read, Stephanie H, Kerssens, Jan, Livingstone, Shona, McGurnaghan, Stuart, Jhund, Pardeep, Petrie, John, Sattar, Naveed, Fischbacher, Colin, Kristensen, Soren Lund, McMurray, John, Colhoun, Helen M, Wild, Sarah H

“…BACKGROUND:Recent clinical trials of new glucose-lowering treatments have drawn attention to the importance of hospitalization for heart failure as a…”
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Amputation-free survival in 17,353 people at high risk for foot ulceration in diabetes: a national observational study by Vadiveloo, Thenmalar, Jeffcoate, William, Donnan, Peter T., Colhoun, Helen C., McGurnaghan, Stuart, Wild, Sarah, McCrimmon, Rory, Leese, Graham P.

“…Aims/hypothesis Our aim was to investigate amputation-free survival in people at high risk for foot ulceration in diabetes (‘high-risk foot’), and to compare…”
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Semaglutide Effects on Cardiovascular Outcomes in People With Overweight or Obesity (SELECT) rationale and design by Ryan, Donna H., Lingvay, Ildiko, Colhoun, Helen M., Deanfield, John, Emerson, Scott S., Kahn, Steven E., Kushner, Robert F., Marso, Steve, Plutzky, Jorge, Brown-Frandsen, Kirstine, Gronning, Marianne O.L., Hovingh, G. Kees, Holst, Anders Gaarsdal, Ravn, Henrik, Lincoff, A. Michael

“…Cardiovascular disease (CVD) is a major cause of morbidity and mortality. Although it has been widely appreciated that obesity is a major risk factor for CVD,…”
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Diabetes and pregnancy: national trends over a 15 year period by Mackin, Sharon T., Nelson, Scott M., Kerssens, Joannes J., Wood, Rachael, Wild, Sarah, Colhoun, Helen M., Leese, Graham P., Philip, Sam, Lindsay, Robert S.

“…Aims/hypothesis We aimed to examine time trends in national perinatal outcomes in pregnancies complicated by pre-existing type 1 or type 2 diabetes. Methods We…”
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Estimated Life Expectancy in a Scottish Cohort With Type 1 Diabetes, 2008-2010 by Livingstone, Shona J, Levin, Daniel, Looker, Helen C, Lindsay, Robert S, Wild, Sarah H, Joss, Nicola, Leese, Graham, Leslie, Peter, McCrimmon, Rory J, Metcalfe, Wendy, McKnight, John A, Morris, Andrew D, Pearson, Donald W. M, Petrie, John R, Philip, Sam, Sattar, Naveed A, Traynor, Jamie P, Colhoun, Helen M

“…IMPORTANCE: Type 1 diabetes has historically been associated with a significant reduction in life expectancy. Major advances in treatment of type 1 diabetes…”
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Biomarkers of rapid chronic kidney disease progression in type 2 diabetes by Looker, Helen C, Colombo, Marco, Hess, Sibylle, Brosnan, Mary J, Farran, Bassam, Dalton, R Neil, Wong, Max C, Turner, Charles, Palmer, Colin N A, Nogoceke, Everson, Groop, Leif, Salomaa, Veikko, Dunger, David B, Agakov, Felix, McKeigue, Paul M, Colhoun, Helen M

“…Here we evaluated the performance of a large set of serum biomarkers for the prediction of rapid progression of chronic kidney disease (CKD) in patients with…”
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Semaglutide for cardiovascular event reduction in people with overweight or obesity: SELECT study baseline characteristics by Lingvay, Ildiko, Brown‐Frandsen, Kirstine, Colhoun, Helen M., Deanfield, John, Emerson, Scott S., Esbjerg, Sille, Hardt‐Lindberg, Søren, Hovingh, G. Kees, Kahn, Steven E., Kushner, Robert F., Lincoff, A. Michael, Marso, Steven P., Fries, Tea Monk, Plutzky, Jorge, Ryan, Donna H.

“…Objective This paper describes the baseline characteristics of the Semaglutide Effects on Heart Disease and Stroke in Patients with Overweight or Obesity…”
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No effect of PCSK9 inhibitor alirocumab on the incidence of diabetes in a pooled analysis from 10 ODYSSEY Phase 3 studies by Colhoun, Helen M, Ginsberg, Henry N, Robinson, Jennifer G, Leiter, Lawrence A, Müller-Wieland, Dirk, Henry, Robert R, Cariou, Bertrand, Baccara-Dinet, Marie T, Pordy, Robert, Merlet, Laurence, Eckel, Robert H

“…Statins have modest adverse effects on glycaemic control. Alirocumab, a proprotein convertase subtilisin/kexin type 9 inhibitor, lowers low-density lipoprotein…”
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Genome-wide aggregated trans-effects on risk of type 1 diabetes: A test of the “omnigenic” sparse effector hypothesis of complex trait genetics by Iakovliev, Andrii, McGurnaghan, Stuart J., Hayward, Caroline, Colombo, Marco, Lipschutz, Debby, Spiliopoulou, Athina, Colhoun, Helen M., McKeigue, Paul M.

“…The “omnigenic” hypothesis postulates that the polygenic effects of common SNPs on a typical complex trait are mediated through trans-effects on expression of…”
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