Search Results - "COLEMAN, Mathew L"

Hypoxia, hypoxia-inducible factors (HIF), HIF hydroxylases and oxygen sensing by Webb, James D, Coleman, Mathew L, Pugh, Christopher W

“…This article outlines the need for a homeostatic response to alterations in cellular oxygenation. It describes work on erythropoietin control that led to the…”
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The hypoxia-inducible transcription factor pathway regulates oxygen sensing in the simplest animal, Trichoplax adhaerens by Loenarz, Christoph, Coleman, Mathew L, Boleininger, Anna, Schierwater, Bernd, Holland, Peter W H, Ratcliffe, Peter J, Schofield, Christopher J

“…The hypoxic response in humans is mediated by the hypoxia‐inducible transcription factor (HIF), for which prolyl hydroxylases (PHDs) act as oxygen‐sensing…”
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Optimal Translational Termination Requires C4 Lysyl Hydroxylation of eRF1 by Feng, Tianshu, Yamamoto, Atsushi, Wilkins, Sarah E., Sokolova, Elizaveta, Yates, Luke A., Münzel, Martin, Singh, Pooja, Hopkinson, Richard J., Fischer, Roman, Cockman, Matthew E., Shelley, Jake, Trudgian, David C., Schödel, Johannes, McCullagh, James S.O., Ge, Wei, Kessler, Benedikt M., Gilbert, Robert J., Frolova, Ludmila Y., Alkalaeva, Elena, Ratcliffe, Peter J., Schofield, Christopher J., Coleman, Mathew L.

“…Efficient stop codon recognition and peptidyl-tRNA hydrolysis are essential in order to terminate translational elongation and maintain protein sequence…”
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OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation by Singleton, Rachelle S., Liu-Yi, Phebee, Formenti, Fabio, Ge, Wei, Sekirnik, Rok, Fischer, Roman, Adam, Julie, Pollard, Patrick J., Wolf, Alexander, Thalhammer, Armin, Loenarz, Christoph, Flashman, Emily, Yamamoto, Atsushi, Coleman, Mathew L., Kessler, Benedikt M., Wappner, Pablo, Schofield, Christopher J., Ratcliffe, Peter J., Cockman, Matthew E.

“…2-Oxoglutarate (2OG) and Fe(II)-dependent oxygenase domain-containing protein 1 (OGFOD1) is predicted to be a conserved 2OG oxygenase, the catalytic domain of…”
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Precisely Tuned Inhibition of HIF Prolyl Hydroxylases Is Key for Cardioprotection After Ischemia by Jatho, Aline, Zieseniss, Anke, Brechtel-Curth, Katja, Yamamoto, Atsushi, Coleman, Mathew L., Vergel Leon, Ana M., Biggs, Daniel, Davies, Ben, Pugh, Chris W., Ratcliffe, Peter J., Katschinski, Dörthe M.

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Systemic silencing of PHD2 causes reversible immune regulatory dysfunction by Yamamoto, Atsushi, Hester, Joanna, Macklin, Philip S, Kawai, Kento, Uchiyama, Masateru, Biggs, Daniel, Bishop, Tammie, Bull, Katherine, Cheng, Xiaotong, Cawthorne, Eleanor, Coleman, Mathew L, Crockford, Tanya L, Davies, Ben, Dow, Lukas E, Goldin, Rob, Kranc, Kamil, Kudo, Hiromi, Lawson, Hannah, McAuliffe, James, Milward, Kate, Scudamore, Cheryl L, Soilleux, Elizabeth, Issa, Fadi, Ratcliffe, Peter J, Pugh, Chris W

“…Physiological effects of cellular hypoxia are sensed by prolyl hydroxylase (PHD) enzymes which regulate HIFs. Genetic interventions on HIF/PHD pathways reveal…”
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Myc-induced nuclear antigen constrains a latent intestinal epithelial cell-intrinsic anthelmintic pathway by Pillai, Meenu R, Mihi, Belgacem, Ishiwata, Kenji, Nakamura, Kiminori, Sakuragi, Naoya, Finkelstein, David B, McGargill, Maureen A, Nakayama, Toshinori, Ayabe, Tokiyoshi, Coleman, Mathew L, Bix, Mark

“…Expulsion of parasitic gastrointestinal nematodes requires diverse effector mechanisms coordinated by a Th2-type response. The evolutionarily conserved JmjC…”
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RAS and RHO GTPases in G1-phase cell-cycle regulation by Olson, Michael F, Coleman, Mathew L, Marshall, Christopher J

“…As RAS mutations are among the most frequent alterations in human cancers, RAS proteins and their signalling pathways have been studied intensively. Here, we…”
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Impaired protein hydroxylase activity causes replication stress and developmental abnormalities in humans by Fletcher, Sally C, Hall, Charlotte, Kennedy, Tristan J, Pajusalu, Sander, Wojcik, Monica H, Boora, Uncaar, Li, Chan, Oja, Kaisa Teele, Hendrix, Eline, Westrip, Christian Ae, Andrijes, Regina, Piasecka, Sonia K, Singh, Mansi, El-Asrag, Mohammed E, Ptasinska, Anetta, Tillmann, Vallo, Higgs, Martin R, Carere, Deanna A, Beggs, Andrew D, Pappas, John, Rabin, Rachel, Smerdon, Stephen J, Stewart, Grant S, Õunap, Katrin, Coleman, Mathew L

“…Although protein hydroxylation is a relatively poorly characterized posttranslational modification, it has received significant recent attention following…”
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Asparaginyl Hydroxylation of the Notch Ankyrin Repeat Domain by Factor Inhibiting Hypoxia-inducible Factor by Coleman, Mathew L., McDonough, Michael A., Hewitson, Kirsty S., Coles, Charlotte, Mecinovicí, Jasmin, Edelmann, Mariola, Cook, Kristina M., Cockman, Matthew E., Lancaster, David E., Kessler, Benedikt M., Oldham, Neil J., Ratcliffe, Peter J., Schofield, Christopher J.

“…The stability and activity of hypoxia-inducible factor (HIF) are regulated by the post-translational hydroxylation of specific prolyl and asparaginyl residues…”
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Posttranslational Hydroxylation of Ankyrin Repeats in IκB Proteins by the Hypoxia-Inducible Factor (HIF) Asparaginyl Hydroxylase, Factor Inhibiting HIF (FIH) by Cockman, Matthew E., Lancaster, David E., Stolze, Ineke P., Hewitson, Kirsty S., McDonough, Michael A., Coleman, Mathew L., Coles, Charlotte H., Yu, Xiaohong, Hay, Ronald T., Ley, Steven C., Pugh, Christopher W., Oldham, Neil J., Masson, Norma, Schofield, Christopher J., Ratcliffe, Peter J.

“…Studies on hypoxia-sensitive pathways have revealed a series of Fe(ll)-dependent dioxygenases that regulate hypoxia-inducible factor (HIF) by prolyl and…”
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Asparagine and Aspartate Hydroxylation of the Cytoskeletal Ankyrin Family Is Catalyzed by Factor-inhibiting Hypoxia-inducible Factor by Yang, Ming, Ge, Wei, Chowdhury, Rasheduzzaman, Claridge, Timothy D.W., Kramer, Holger B., Schmierer, Bernhard, McDonough, Michael A., Gong, Lingzhi, Kessler, Benedikt M., Ratcliffe, Peter J., Coleman, Mathew L., Schofield, Christopher J.

“…Factor-inhibiting hypoxia-inducible factor (FIH) catalyzes the β-hydroxylation of an asparagine residue in the C-terminal transcriptional activation domain of…”
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Actin-myosin-based contraction is responsible for apoptotic nuclear disintegration by Croft, Daniel R, Coleman, Mathew L, Li, Shuixing, Robertson, David, Sullivan, Teresa, Stewart, Colin L, Olson, Michael F

“…Membrane blebbing during the apoptotic execution phase results from caspase-mediated cleavage and activation of ROCK I. Here, we show that ROCK activity,…”
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OH, the Places You’ll Go! Hydroxylation, Gene Expression, and Cancer by Ploumakis, Athanasios, Coleman, Mathew L.

“…Hydroxylation is an emerging modification generally catalyzed by a family of ∼70 enzymes that are dependent on oxygen, Fe(II), ascorbate, and the Kreb’s cycle…”
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Tumour hypoxia causes DNA hypermethylation by reducing TET activity by Thienpont, Bernard, Steinbacher, Jessica, Zhao, Hui, D’Anna, Flora, Kuchnio, Anna, Ploumakis, Athanasios, Ghesquière, Bart, Van Dyck, Laurien, Boeckx, Bram, Schoonjans, Luc, Hermans, Els, Amant, Frederic, Kristensen, Vessela N., Koh, Kian Peng, Mazzone, Massimiliano, Coleman, Mathew L., Carell, Thomas, Carmeliet, Peter, Lambrechts, Diether

“…Hypermethylation of the promoters of tumour suppressor genes represses transcription of these genes, conferring growth advantages to cancer cells. How these…”
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Human 2-oxoglutarate-dependent oxygenases: nutrient sensors, stress responders, and disease mediators by Fletcher, Sally C, Coleman, Mathew L

“…Fe(II)/2-oxoglutarate (2OG)-dependent oxygenases are a conserved enzyme class that catalyse diverse oxidative reactions across nature. In humans, these enzymes…”
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MYPT1, the targeting subunit of smooth-muscle myosin phosphatase, is a substrate for the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH) by Webb, James D, Murányi, Andrea, Pugh, Christopher W, Ratcliffe, Peter J, Coleman, Mathew L

“…The asparaginyl hydroxylase FIH [factor inhibiting HIF (hypoxia-inducible factor)] was first identified as a protein that inhibits transcriptional activation…”
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Oxygen sensing and hypoxia-induced responses by Coleman, Mathew L, Ratcliffe, Peter J

“…Low cellular oxygenation (hypoxia) represents a significant threat to the viability of affected tissues. Multicellular organisms have evolved a highly…”
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The emerging roles of ribosomal histidyl hydroxylases in cell biology, physiology and disease by Bundred, James R., Hendrix, Eline, Coleman, Mathew L.

“…Hydroxylation is a novel protein modification catalyzed by a family of oxygenases that depend on fundamental nutrients and metabolites for activity. Protein…”
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Developmentally regulated GTPases: structure, function and roles in disease by Westrip, Christian A. E., Zhuang, Qinqin, Hall, Charlotte, Eaton, Charlotte D., Coleman, Mathew L.

“…GTPases are a large superfamily of evolutionarily conserved proteins involved in a variety of fundamental cellular processes. The developmentally regulated…”
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