Search Results - "COLEMAN, Kevin G"

PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer by Raina, Kanak, Lu, Jing, Qian, Yimin, Altieri, Martha, Gordon, Deborah, Rossi, Ann Marie K., Wang, Jing, Chen, Xin, Dong, Hanqing, Siu, Kam, Winkler, James D., Crew, Andrew P., Crews, Craig M., Coleman, Kevin G.

“…Prostate cancer has the second highest incidence among cancers in men worldwide and is the second leading cause of cancer deaths of men in the United States…”
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Identification and Characterization of Von Hippel-Lindau-Recruiting Proteolysis Targeting Chimeras (PROTACs) of TANK-Binding Kinase 1 by Crew, Andrew P, Raina, Kanak, Dong, Hanqing, Qian, Yimin, Wang, Jing, Vigil, Dominico, Serebrenik, Yevgeniy V, Hamman, Brian D, Morgan, Alicia, Ferraro, Caterina, Siu, Kam, Neklesa, Taavi K, Winkler, James D, Coleman, Kevin G, Crews, Craig M

“…Proteolysis targeting chimeras (PROTACs) are bifunctional molecules that recruit an E3 ligase to a target protein to facilitate ubiquitination and subsequent…”
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PARP inhibitor synthetic lethality in ATM biallelic mutant cancer cell lines is associated with BRCA1/2 and RAD51 downregulation by Muvaffak, Asli, Coleman, Kevin G

“…Ataxia telangiectasia-mutated (ATM) kinase is a central regulator of the DNA damage response (DDR) signaling pathway, and its function is critical for the…”
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Proteolysis-Targeting Chimeras: Harnessing the Ubiquitin-Proteasome System to Induce Degradation of Specific Target Proteins by Coleman, Kevin G, Crews, Craig M

“…The ubiquitin-proteasome system plays a central role in regulating protein homeostasis in mammalian cells. It is a multistep process involving the…”
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Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2 by Peng, Xiao-Ding, Xu, Pei-Zhang, Chen, Mei-Ling, Hahn-Windgassen, Annett, Skeen, Jennifer, Jacobs, Joel, Sundararajan, Deepa, Chen, William S, Crawford, Susan E, Coleman, Kevin G, Hay, Nissim

“…To elucidate the functions of the serine/threonine kinase Akt/PKB in vivo, we generated mice lacking both akt1 and akt2 genes. Akt1/Akt2 double-knockout (DKO)…”
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Protein targeting chimeric molecules specific for bromodomain and extra-terminal motif family proteins are active against pre-clinical models of multiple myeloma by Zhang, Xiaohui, Lee, Hans C., Shirazi, Fazal, Baladandayuthapani, Veerabhadran, Lin, Heather, Kuiatse, Isere, Wang, Hua, Jones, Richard J., Berkova, Zuzana, Singh, Ram Kumar, Lu, Jing, Qian, Yimin, Raina, Kanak, Coleman, Kevin G., Crews, Craig M., Li, Bingzong, Wang, Huihan, Hailemichael, Yared, Thomas, Sheeba K., Wang, Zhiqiang, Davis, R. Eric, Orlowski, Robert Z.

“…Bromodomain and extraterminal (BET) domain containing protein (BRD)-4 modulates the expression of oncogenes such as c-myc , and is a promising therapeutic…”
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Biochemical and pharmacological characterization of human c-Met neutralizing monoclonal antibody CE-355621 by Michaud, Neil R., Jani, Jitesh P., Hillerman, Stephen, Tsaparikos, Konstantinos E., Barbacci-Tobin, Elsa G., Knauth, Elisabeth, Putz Jr, Henry, Campbell, Mary, Karam, George A., Chrunyk, Boris, Gebhard, David F., Green, Larry L., Xu, Jinghai J., Dunn, Margaret C., Coskran, Tim M., Lapointe, Jean-Martin, Cohen, Bruce D., Coleman, Kevin G., Bedian, Vahe, Vincent, Patrick, Kajiji, Shama, Steyn, Stefan J., Borzillo, Gary V., Los, Gerrit

“…The c-Met proto-oncogene is a multifunctional receptor tyrosine kinase that is stimulated by its ligand, hepatocyte growth factor (HGF), to induce cell growth,…”
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Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta by Garofalo, Robert S, Orena, Stephen J, Rafidi, Kristina, Torchia, Anthony J, Stock, Jeffrey L, Hildebrandt, Audrey L, Coskran, Timothy, Black, Shawn C, Brees, Dominique J, Wicks, Joan R, McNeish, John D, Coleman, Kevin G

“…The serine/threonine kinase Akt/PKB plays key roles in the regulation of cell growth, survival, and metabolism. It remains unclear, however, whether the…”
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Discovery and pharmacologic characterization of CP-724,714, a selective ErbB2 tyrosine kinase inhibitor by JANI, Jitesh P, FINN, Richard S, MORRIS, Joel, MOYER, James D, PUSTILNIK, Leslie R, RAFIDI, Kristina, RALSTON, Sherry, ROSSI, Ann Marie K, STEYN, Stefanus J, WAGNER, Larry, WINTER, Steven M, BHATTACHARYA, Samit K, CAMPBELL, Mary, COLEMAN, Kevin G, CONNELL, Richard D, CURRIER, Nicolas, EMERSON, Erling O, FLOYD, Eugenia, HARRIMAN, Shawn, KATH, John C

“…Amplification and overexpression of erbB2 (Her-2/neu) proto-oncogene has been linked to human malignancies including tumors of the breast, ovary, and stomach…”
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Abstract 2379: Elaborating the mechanism of PARP synthetic lethality in ATM loss by Muvaffak, Asli, Coleman, Kevin G.

“…PARP inhibitors have transformed the treatment for ovarian cancer, which is known to have high incidence of homologous recombination (HR) deficiency through…”
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Expression of engrailed proteins in arthropods, annelids, and chordates by Patel, N H, Martin-Blanco, E, Coleman, K G, Poole, S J, Ellis, M C, Kornberg, T B, Goodman, C S

“…engrailed is a homeobox gene that has an important role in Drosophila segmentation. Genes homologous to engrailed have been identified in several other…”
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Phosphorylation of serine residues in histidine-tag sequences attached to recombinant protein kinases: A cause of heterogeneity in mass and complications in function by Du, Ping, Loulakis, Pat, Luo, Chun, Mistry, Anil, Simons, Samuel P., LeMotte, Peter K., Rajamohan, Francis, Rafidi, Kristina, Coleman, Kevin G., Geoghegan, Kieran F., Xie, Zhi

“…High-level recombinant expression of protein kinases in eukaryotic cells or Escherichia coli commonly gives products that are phosphorylated by autocatalysis…”
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Identification of CDK4 Sequences Involved in Cyclin D1 and p16 Binding by Coleman, Kevin G., Wautlet, Barri Swain, Morrissey, David, Mulheron, Janet, Sedman, Sylvia A., Brinkley, Pamela, Price, Sandy, Webster, Kevin R.

“…Activation of CDK4 is regulated, in part, by its association with a D-type cyclin. Conversely, CDK4 activity is inhibited when it is bound to the…”
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Abstract A091: Targeting homologous recombination repair defects in lung cancer by Muvaffak, Asli, Zhou, Yinghui, Feng, Bin, Wang, Sarah, Wang, Jing Ju, Ramaswamy, Sridhar, Coleman, Kevin G

“…Non-Small Cell Lung Cancer (NSCLC) is the leading cause of cancer related mortality worldwide, and accounts for 80-85% of all lung cancer diagnoses. While…”
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Novel BET protein proteolysis-targeting chimera exerts superior lethal activity than bromodomain inhibitor (BETi) against post-myeloproliferative neoplasm secondary (s) AML cells by Saenz, D T, Fiskus, W, Qian, Y, Manshouri, T, Rajapakshe, K, Raina, K, Coleman, K G, Crew, A P, Shen, A, Mill, C P, Sun, B, Qiu, P, Kadia, T M, Pemmaraju, N, DiNardo, C, Kim, M-S, Nowak, A J, Coarfa, C, Crews, C M, Verstovsek, S, Bhalla, K N

“…The PROTAC (proteolysis-targeting chimera) ARV-825 recruits bromodomain and extraterminal (BET) proteins to the E3 ubiquitin ligase cereblon, leading to…”
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Abstract 3242: Triple checkpoint blockade targeting PD-1, TIM-3, and LAG-3 reinvigorates ovarian cancer-infiltrating T cells by increasing T cell polyfunctionality and effector function by Kaufmann, Johanna K., Flynn, Brianna, Morse, Kevin, Speranza, Maria C., Zhou, Jing, Ramaswamy, Sridhar, Mackay, Sean, Coleman, Kevin G.

“…Co-expression of immune checkpoint receptors (ICRs) PD-1, TIM-3, and LAG-3 characterizes chronically activated and exhausted tumor-infiltrating T cells (TILs),…”
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Abstract 6175: CDK8 inhibition potentiates the efficacy of niraparib in homologous recombination proficient cancer cell lines by Simon-Crevatis, Karen A., Metkar, Shailesh R., Hardcastle, Justin T., Jansson, Keith, Shabon, Usman, Choudhury, Rajarshi, Stronach, Euan A., Coleman, Kevin G., Muvaffak, Asli

“…While cyclin dependent kinases (CDKs) were originally implicated in cell cycle regulation, several CDKs including CDK7, CDK8, and CDK9 play critical roles in…”
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Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta by Garofalo, R S, Orena, S J, Rafidi, K, Torchia, A J, Stock, J L, Hildebrandt, AL, Coskran, T, Black, S C, Brees, D J, Wicks, J R, McNeish, J D, Coleman, K G

“…The serine/threonine kinase Akt/PKB plays key roles in the regulation of cell growth, survival, and metabolism. It remains unclear, however, whether the…”
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Abstract 5067: BET protein proteolysis targeting chimera (BETP-PROTACs) exert more potent activity than BETP bromodomain inhibitor (BETi) against post-myeloproliferative neoplasm (MPN) secondary (s) AML cells by Saenz, Dyana T., Fiskus, Warren C., Raina, Kanak, Manshouri, Taghi, Coleman, Kevin G., Qian, Yimin, Crew, Andrew P., Shen, Angela, Mill, Christopher P., Sun, Baohua, Kim, Misun, Nowak, Agnieszka J., Verstovsek, Srdan, Crews, Craig M., Bhalla, Kapil N.

“…In BCR-ABL1-negative myeloproliferative neoplasms with myelofibrosis (MPN-MF) transformation to AML (sAML) occurs in up to 20% of patients. Ruxolitinib (R) is…”
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Temperature-sensitive lethal mutations on yeast chromosome I appear to define only a small number of genes [Saccharomyces cerevisiae] by Kaback, David B, Oeller, Paul W, Steensma, H. Yde, Hirschman, Janet, Ruezinsky, Diane, Coleman, Kevin G, Pringle, John R

“…A method was developed for isolating large numbers of mutations on chromosome I of the yeast Saccharomyces cerevisiae. A strain monosomic for chromosome I…”
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