Search Results - "COKER, Mytsi L"

A matrix metalloproteinase induction/activation system exists in the human left ventricular myocardium and is upregulated in heart failure by SPINALE, Francis G, COKER, Mytsi L, HEUNG, Lena J, BOND, Brian R, GUNASINGHE, Himali R, ETOH, Takuma, GOLDBERG, Aron T, ZELLNER, James L, CRUMBLEY, A. Jackson

“…Matrix metalloproteinases (MMPs) contribute to matrix remodeling in disease states such as tumor metastases. Extracellular matrix metalloproteinase inducer…”
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Matrix metalloproteinase inhibition attenuates left ventricular remodeling and dysfunction in a rat model of progressive heart failure by PETERSON, J. Thomas, HALLAK, Hussein, JOHNSON, Linda, HUA LI, O'BRIEN, Patrick M, SLISKOVIC, Drago R, BOCAN, Thomas M. A, COKER, Mytsi L, ETOH, Takuma, SPINALE, Francis G

“…Matrix metalloproteinase (MMP) activation contributes to tissue remodeling in several disease states, and increased MMP activity has been observed in left…”
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Plasma matrix metalloproteinase and inhibitor profiles in patients with heart failure by Wilson, Eric M., Gunasinghe, Himali R., Coker, Mytsi L., Sprunger, Philip, Lee-Jackson, Dorellyn, Bozkurt, Biykem, Deswal, Anita, Mann, Douglas L., Spinale, Francis G.

“…Background: Changes in myocardial matrix metalloproteinases (MMPs) and the inhibitors of MMPs (TIMPs) have been demonstrated in congestive heart failure (CHF)…”
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Matrix metalloproteinase expression and activity in isolated myocytes after neurohormonal stimulation by Coker, M L, Jolly, J R, Joffs, C, Etoh, T, Holder, J R, Bond, B R, Spinale, F G

“…Changes in myocardial matrix metalloproteinase (MMP) activity and expression have been associated with left ventricular (LV) remodeling. A recent study…”
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Left ventricular remodeling in transgenic mice with cardiac restricted overexpression of tumor necrosis factor by SIVASUBRAMANIAN, Natarajan, COKER, Mytsi L, KURRELMEYER, Karla M, MACLELLAN, William R, DEMAYO, Francesco J, SPINALE, Francis G, MANN, Douglas L

“…The mechanisms responsible for tumor necrosis factor (TNF)-induced LV structural remodeling in the adult heart are not known. We generated a line of transgenic…”
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Increased matrix metalloproteinase activity and selective upregulation in LV myocardium from patients with end-stage dilated cardiomyopathy by THOMAS, C. V, COKER, M. L, ZELLNER, J. L, HANDY, J. R, CRUMBLEY, A. J, SPINALE, F. G

“…One of the hallmarks of dilated cardiomyopathy (DCM) is left ventricular (LV) remodeling. The matrix metalloproteinases (MMPs) are a family of enzymes that…”
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Matrix Metalloproteinase Inhibition During the Development of Congestive Heart Failure: Effects on Left Ventricular Dimensions and Function by Spinale, Francis G, Coker, Mytsi L, Krombach, Stephen R, Mukherjee, Rupak, Hallak, Hussein, Houck, Ward V, Clair, Mark J, Kribbs, Scott B, Johnson, Linda L, Peterson, J Thomas, Zile, Michael R

“…The development of congestive heart failure (CHF) is associated with left ventricle (LV) dilation and myocardial remodeling. The matrix metalloproteinases…”
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Time-Dependent Changes in Matrix Metalloproteinase Activity and Expression During the Progression of Congestive Heart Failure: Relation to Ventricular and Myocyte Function by Spinale, Francis G, Coker, Mytsi L, Thomas, Chadwick V, Walker, Jennifer D, Mukherjee, Rupak, Hebbar, Latha

“…The development of congestive heart failure (CHF) is associated with left ventricular (LV) dilation and myocardial remodeling. However, fundamental mechanisms…”
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Selective Matrix Metalloproteinase Inhibition With Developing Heart Failure: Effects on Left Ventricular Function and Structure by King, Mary K, Coker, Mytsi L, Goldberg, Aaron, McElmurray, James H, Gunasinghe, Himali R, Mukherjee, Rupak, Zile, Michael R, O’Neill, Timothy P, Spinale, Francis G

“…ABSTRACT—The matrix metalloproteinases (MMPs) are an endogenous family of proteolytic enzymes implicated to contribute to LV remodeling. However,…”
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Differential effects of pressure or volume overload on myocardial MMP levels and inhibitory control by Nagatomo, Y, Carabello, B A, Coker, M L, McDermott, P J, Nemoto, S, Hamawaki, M, Spinale, F G

“…Left ventricular (LV) pressure (PO) or volume (VO) overload is accompanied by myocardial remodeling, but mechanisms that contribute to this progressive…”
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Matrix metalloproteinase synthesis and expression in isolated LV myocyte preparations by Coker, M L, Doscher, M A, Thomas, C V, Galis, Z S, Spinale, F G

“…In several cardiac disease states, alterations in myocyte and extracellular matrix (ECM) structure occur with left ventricular (LV) remodeling and are…”
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Effects of Gene Deletion of the Tissue Inhibitor of the Matrix Metalloproteinase-type 1 (TIMP-1) on Left Ventricular Geometry and Function in Mice by Roten, Lisa, Nemoto, Shintaro, Simsic, Janet, Coker, Mytsi L, Rao, Vijay, Baicu, Simona, Defreyte, Gilberto, Soloway, Paul J, Zile, Michael R, Spinale, Francis G

“…L. Roten, S. Nemoto, J. Simsic, M. L. Coker, V. Rao, S. Baicu, G. Defreyte, P. J. Soloway, M. R. Zile and F. G. Spinale. Effects of Gene Deletion of the Tissue…”
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Myocardial matrix metalloproteinase activity and abundance with congestive heart failure by Coker, M L, Thomas, C V, Clair, M J, Hendrick, J W, Krombach, R S, Galis, Z S, Spinale, F G

“…The left ventricular (LV) myocardial collagen matrix has been proposed to participate in the maintenance of LV geometry. Thus alterations in the composition of…”
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Myocardial matrix degradation and metalloproteinase activation in the failing heart: a potential therapeutic target by Spinale, F G, Coker, M L, Bond, B R, Zellner, J L

“…A fundamental structural event in the progression of heart failure due to dilated cardiomyopathy is left ventricular (LV) myocardial remodeling. The matrix…”
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Defects in Matrix Metalloproteinase Inhibitory Stoichiometry and Selective MMP Induction in Patients with Nonischemic or Ischemic Dilated Cardiomyopathy by COKER, MYTSI L., ZELLNER, JAMES L., CRUMBLEY, ARTHUR J., SPINALE, FRANCIS G.

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Myocardial Extracellular Matrix Remodeling with the Development of Pacing Induced Congestive Heart Failure by Coker, Mytsi L., Spinale, Francis G.

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Identification of novel matrix metalloproteinase inducers and activators in normal adult human left ventricular myocytes by Bond, Brian R., Coker, Mytsi L., Heung, Lena J., Zellner, James L., Spinale, Francis G.

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Matrix metalloproteinase synthesis and expression in isolated LV myocyte preparations by Coker, Mytsi L., Doscher, Melissa A., Thomas, Chadwick V., Galist, Zorina S., Spinale, Francis G.

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A novel MMP stimulatory protein, EMMPRIN, is expressed in human myocardium and is upregulated in dilated cardiomyopathy by Coker, Mytsi L., Heung, Lena J., Morrison, Allison E., Zellner, James L., Crumbley, Arthur J., Spinale, Francis G.

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Increased matrix metalloproteinase activity and selective upregulation in LV myocardium from patients with end-stage dilated cardiomyopathy by Thomas, Chadwick V., Coker, Mytsi L., Zellner, James L., Handy, John R., Crumbley, Jackson, Spinale, Francis G.

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