Search Results - "COHEN, Stanley N"
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Formation and release of arrestin domain-containing protein 1-mediated microvesicles (ARMMs) at plasma membrane by recruitment of TSG101 protein
Published in Proceedings of the National Academy of Sciences - PNAS (13-03-2012)“…Mammalian cells are capable of delivering multiple types of membrane capsules extracellularly. The limiting membrane of late endosomes can fuse with the plasma…”
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2
DNA cloning: A personal view after 40 years
Published in Proceedings of the National Academy of Sciences - PNAS (24-09-2013)“…In November 1973, my colleagues A. C. Y. Chang, H. W. Boyer, R. B. Helling, and I reported in PNAS that individual genes can be cloned and isolated by…”
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3
Stenting versus Endarterectomy for Treatment of Carotid-Artery Stenosis
Published in The New England journal of medicine (01-07-2010)“…In this randomized comparison of stenting and endarterectomy as treatment for carotid-artery stenosis, there was no significant difference in the rate of the…”
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4
Spt4 Is Selectively Required for Transcription of Extended Trinucleotide Repeats
Published in Cell (17-02-2012)“…Lengthy trinucleotide repeats encoding polyglutamine (polyQ) stretches characterize the variant proteins of Huntington's disease and certain other inherited…”
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5
Effects on murine behavior and lifespan of selectively decreasing expression of mutant huntingtin allele by supt4h knockdown
Published in PLoS genetics (01-03-2015)“…Production of protein containing lengthy stretches of polyglutamine encoded by multiple repeats of the trinucleotide CAG is a hallmark of Huntington's disease…”
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6
Calpain-dependent cytoskeletal rearrangement exploited for anthrax toxin endocytosis
Published in Proceedings of the National Academy of Sciences - PNAS (15-10-2013)“…The protective antigen component of Bacillus anthracis toxins can interact with at least three distinct proteins on the host cell surface, capillary…”
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7
Global Analysis of mRNA Decay and Abundance in Escherichia coli at Single-Gene Resolution Using Two-Color Fluorescent DNA Microarrays
Published in Proceedings of the National Academy of Sciences - PNAS (23-07-2002)“…Much of the information available about factors that affect mRNA decay in Escherichia coli, and by inference in other bacteria, has been gleaned from study of…”
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Heterodimeric integrin complexes containing β1-integrin promote internalization and lethality of anthrax toxin
Published in Proceedings of the National Academy of Sciences - PNAS (31-08-2010)“…To kill macrophages, the lethal factor component of Bacillus anthracis toxin binds to a carrier protein (PA), which then interacts with the CMG2 receptor…”
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Correction: Improved Control of Tuberculosis and Activation of Macrophages in Mice Lacking Protein Kinase R
Published in PloS one (05-10-2018)“…[This corrects the article DOI: 10.1371/journal.pone.0030512.]…”
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10
Inhibition of HIV Budding by a Genetically Selected Cyclic Peptide Targeting the Gag−TSG101 Interaction
Published in ACS chemical biology (19-12-2008)“…The egress of HIV particles from virus-infected cells is accomplished by the recruitment of proteins that normally mediate host cell endocytic functions. This…”
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Upregulation of the Host SLC11A1 Gene by Clostridium difficile Toxin B Facilitates Glucosylation of Rho GTPases and Enhances Toxin Lethality
Published in Infection and Immunity (01-08-2013)“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Reversible antibiotic tolerance induced in Staphylococcus aureus by concurrent drug exposure
Published in mBio (13-01-2015)“…Resistance of Staphylococcus aureus to beta-lactam antibiotics has led to increasing use of the glycopeptide antibiotic vancomycin as a life-saving treatment…”
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13
Improved control of tuberculosis and activation of macrophages in mice lacking protein kinase R
Published in PloS one (16-02-2012)“…Host factors that microbial pathogens exploit for their propagation are potential targets for therapeuic countermeasures. No host enzyme has been identified…”
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PpsA-mediated alternative pathway to complement RNase E essentiality in Escherichia coli
Published in Archives of microbiology (01-07-2016)“…Escherichia coli cells require RNase E, encoded by the essential gene rne , to propagate. The growth properties on different carbon sources of E. coli cells…”
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15
Identification of agents effective against multiple toxins and viruses by host-oriented cell targeting
Published in Scientific reports (27-08-2015)“…A longstanding and still-increasing threat to the effective treatment of infectious diseases is resistance to antimicrobial countermeasures. Potentially, the…”
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TSG101 Interaction with HRS Mediates Endosomal Trafficking and Receptor Down-Regulation
Published in Proceedings of the National Academy of Sciences - PNAS (24-06-2003)“…Down-regulation of mitogenic signaling in mammalian cells relies in part on endosomal trafficking of activated receptors into lysosomes, where the receptors…”
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17
DSIF modulates RNA polymerase II occupancy according to template G + C content
Published in NAR genomics and bioinformatics (01-09-2022)“…Abstract The DSIF complex comprising the Supt4h and Supt5h transcription elongation proteins clamps RNA polymerase II (RNAPII) onto DNA templates, facilitating…”
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Second-Site Suppression of RNase E Essentiality by Mutation of the deaD RNA Helicase in Escherichia coli
Published in Journal of Bacteriology (01-04-2012)“…Escherichia coli cells normally require RNase E activity to propagate and form colonies. Using random Tn10 insertion mutagenesis, we screened for second-site…”
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Global Analysis of Escherichia coli RNA Degradosome Function Using DNA Microarrays
Published in Proceedings of the National Academy of Sciences - PNAS (02-03-2004)“…RNase E, an essential endoribonuclease of Escherichia coli, interacts through its C-terminal region with multiple other proteins to form a complex termed the…”
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20
Human genetic variation altering anthrax toxin sensitivity
Published in Proceedings of the National Academy of Sciences - PNAS (21-02-2012)“…The outcome of exposure to infectious microbes or their toxins is influenced by both microbial and host genes. Some host genes encode defense mechanisms,…”
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