Search Results - "COHEN, P. D"

Clinical benefit of continuing ALK inhibition with crizotinib beyond initial disease progression in patients with advanced ALK-positive NSCLC by Ou, S.-H. I., Jänne, P.A., Bartlett, C.H., Tang, Y., Kim, D.-W., Otterson, G.A., Crinò, L., Selaru, P., Cohen, D.P., Clark, J.W., Riely, G.J.

“…Crizotinib is approved to treat advanced ALK-positive non-small-cell lung cancer (NSCLC), but most patients ultimately develop progressive disease (PD). We…”
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Hypertension as a potential biomarker of efficacy in patients with gastrointestinal stromal tumor treated with sunitinib by George, S., Reichardt, P., Lechner, T., Li, S., Cohen, D.P., Demetri, G.D.

“…Reliable biomarkers of sunitinib response in gastrointestinal stromal tumor (GIST) are lacking. Hypertension (HTN), an on-target class effect of vascular…”
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Clinical evaluation of continuous daily dosing of sunitinib malate in patients with advanced gastrointestinal stromal tumour after imatinib failure by George, S, Blay, J.Y, Casali, P.G, Le Cesne, A, Stephenson, P, DePrimo, S.E, Harmon, C.S, Law, C.N.J, Morgan, J.A, Ray-Coquard, I, Tassell, V, Cohen, D.P, Demetri, G.D

“…Abstract Aims To assess the antitumour activity, safety, pharmacokinetics and pharmacodynamics of continuous daily sunitinib dosing in patients with…”
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The impact of comorbid disease and injuries on resource use and expenditures in parkinsonism by PRESSLEY, J. C, LOUIS, E. D, TANG, M.-X, COTE, L, COHEN, P. D, GLIED, S, MAYEUX, R

“…Persons with parkinsonism have high rates of both associated and unrelated prevalent comorbid conditions. A better understanding of patterns of care and…”
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Sufficiency of Single‐Arm Studies to Support Registration of Targeted Agents in Molecularly Selected Patients with Cancer: Lessons from the Clinical Development of Crizotinib by Selaru, P, Tang, Y, Huang, B, Polli, A, Wilner, KD, Donnelly, E, Cohen, DP

“…In order to demonstrate a statistically significant and clinically meaningful benefit of one therapy over another, these trials generally enrolled large…”
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Understanding the Fe i Line Measurements Returned by the Helioseismic and Magnetic Imager (HMI) by Cohen, D. P., Criscuoli, S., Farris, L., Tritschler, A.

“…The Helioseismic and Magnetic Imager (HMI) onboard the Solar Dynamics Observatory (SDO) observes the Sun at the Fe i 6173 Å line and returns full-disk maps of…”
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The Finnish follicle-stimulating hormone receptor gene mutation is rare in North American women with 46,XX ovarian failure by Layman, L C, Amde, S, Cohen, D P, Jin, M, Xie, J

“…To determine whether FSH receptor gene missense mutation in Finnish women with premature ovarian failure (POF) is present in North American women with POF…”
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Comparative cannabis use data by Abraham, M D, Cohen, P D, Beukenhorst, D J

“…[...]MacCoun & Reuter state that the lifetime prevalence of cannabis in The Netherlands has increased consistently and sharply in the age group 18-20, stating:…”
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Molecular evaluation of the gonadotropin-releasing hormone receptor by Cohen, D P

“…The gonadotropin-releasing hormone receptor (GnRHR) is a guanine nucleotide-binding protein-coupled receptor with a characteristic seven transmembrane domain…”
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Molecular analysis of the gonadotropin-releasing hormone receptor in patients with polycystic ovary syndrome by Cohen, D P, Stein, E M, Li, Z, Matulis, C K, Ehrmann, D A, Layman, L C

“…To determine whether a mutation in the GnRH receptor gene is responsible for polycystic ovary syndrome (PCOS). Molecular analysis of human genomic DNA…”
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Vesicular transport of myelin proteolipid and cerebroside sulfates to the myelin membrane by Brown, M C, Besio Moreno, M, Bongarzone, E R, Cohen, P D, Soto, E F, Pasquini, J M

“…The possibility that cerebroside sulfates and myelin proteolipid (PLP) could be simultaneously located in transport vesicles destined to be assembled in myelin…”
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Codeine misuse among service users on a methadone treatment programme by Cohen, D. P., Unoh, E., Barry, H., O’Connor, J. J.

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Mutations in gonadotropin-releasing hormone receptor gene cause hypogonadotropic hypogonadism by Layman, Lawrence C, Cohen, David P, Jin, Mei, Xie, Jun, Li, Zhu, Reindollar, Richard H, Bolbolan, Shahla, Bick, David P, Sherins, Richard R, Duck, L. Wayne, Musgrove, Lois C, Sellers, Jeffrey C, Neill, Jimmy D

“…Idiopathic hypogonadotropic hypogonadism (IHH) is one of the most common causes of hereditary hypogonadism. Affected males and females present with…”
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Elevated levels of protein kinase C activity and alpha-isoenzyme expression in murine peritoneal B cells by Cohen, DP, Rothstein, TL

“…Conventional murine splenic B cells are stimulated to initiate DNA synthesis by the combination of a phorbol ester protein kinase C (PKC) agonist, and a…”
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Pre-clinical evaluation of SN-38 and novel camptothecin analogs against human chronic B-cell lymphocytic leukemia lymphocytes by Cohen, Darrel P, Adams, David J, Flowers, James L, Wall, Monroe E, Wani, Mansukh C, Manikumar, G, Colvin, O.Michael, Silber, Robert

“…The topoisomerase I inhibitor camptothecin and its analogs have potent activity against a wide range of solid tumors and several hematologic malignancies…”
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Hypertension as a Biomarker of Efficacy in Patients With Metastatic Renal Cell Carcinoma Treated With Sunitinib by RINI, Brian I, COHEN, Darrel P, LU, Dongrui R, CHEN, Isan, HARIHARAN, Subramanian, GORE, Martin E, FIGLIN, Robert A, BAUM, Michael S, MOTZER, Robert J

“…Hypertension (HTN) is an on-target effect of the vascular endothelial growth factor pathway inhibitor, sunitinib. We evaluated the association of…”
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TEMPORAL CORRELATIONS BETWEEN OPTICAL AND GAMMA-RAY ACTIVITY IN BLAZARS by Cohen, Daniel P, Romani, Roger W, Filippenko, Alexei V, Cenko, S Bradley, Lott, Benoit, Zheng, Kang, Li, Weidong

“…We have been using the 0.76 m Katzman Automatic Imaging Telescope (KAIT) at Lick Observatory to optically monitor a sample of 157 blazars that are bright in…”
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Induction of phorbol ester responsiveness in conventional B cells after activation via surface Ig by Rothstein, TL, Kolber, DL, Murphy, TP, Cohen, DP

“…The signals required to induce S phase entry in murine splenic B cells were found to be altered by prolonged treatment with low doses of anti-Ig antibody…”
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Familial gonadotropin-releasing hormone resistance and hypogonadotropic hypogonadism in a family with multiple affected individuals by Layman, L C, McDonough, P G, Cohen, D P, Maddox, M, Tho, S P, Reindollar, R H

“…To characterize the phenotype of idiopathic hypogonadotropic hypogonadism due to compound heterozygous GnRHR gene mutations (Arg262Gln/Tyr284Cys)…”
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The shortest path is not the one you know: application of biological network resources in precision oncology research by Kuperstein, Inna, Grieco, Luca, Cohen, David P A, Thieffry, Denis, Zinovyev, Andrei, Barillot, Emmanuel

“…Several decades of molecular biology research have delivered a wealth of detailed descriptions of molecular interactions in normal and tumour cells. This…”
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