Search Results - "COHEN, I. R"

Antigen microarrays identify CNS-produced autoantibodies in RRMS by QUINTANA, F. J, FAREZ, M. F, IZQUIERDO, G, LUCAS, M, COHEN, I. R, WEINER, H. L

“…Multiple sclerosis (MS) is characterized by the local production of antibodies in the CNS and the presence of oligoclonal bands in the CSF. Antigen arrays…”
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Treatment of new-onset type 1 diabetes with peptide DiaPep277® is safe and associated with preserved beta-cell function: extension of a randomized, double-blind, phase II trial by Raz, I., Avron, A., Tamir, M., Metzger, M., Symer, L., Eldor, R., Cohen, I. R., Elias, D.

“…Background Treatment with DiaPep277®, a peptide derived from HSP60, has been shown to preserve beta‐cell function in non‐obese diabetic mouse (NOD) mice and in…”
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Autoimmune T cells as potential neuroprotective therapy for spinal cord injury by Hauben, E, Nevo, U, Yoles, E, Moalem, G, Agranov, E, Mor, F, Akselrod, S, Neeman, M, Cohen, IR, Schwartz, M

“…Autoimmune T cells against central nervous system myelin associated peptide reduce the spread of damage and promote recovery in injured rat spinal cord,…”
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Exploring oligodendrocyte guidance: ‘to boldly go where no cell has gone before’ by Cohen, R. I

“…Oligodendrocytes, the myelinating cells of the central nervous system (CNS), originate early in the formation of the brain in specific foci, and migrate…”
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Innate and adaptive immune responses can be beneficial for CNS repair by Schwartz, Michal, Moalem, Gila, Leibowitz-Amit, Raya, Cohen, Irun R.

“…The limitation of immune responsiveness in the mammalian CNS has been attributed to the intricate nature of neuronal networks, which would appear to be more…”
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Peptide therapy for diabetes in NOD mice by Elias, D, Cohen, I R

“…NOD mice spontaneously develop autoimmune diabetes that mimics insulin-dependent diabetes mellitus (IDDM) in man. A peptide of the 60 kDa heat shock protein…”
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T Cell Proliferative Responses of Type 1 Diabetes Patients and Healthy Individuals to Human hsp60 and its Peptides by Abulafia-Lapid, R., Elias, D., Raz, I., Keren-Zur, Y., Atlan, H., Cohen, I.R.

“…T cell responses to peptide epitopes of the 60kDa heat shock protein (hsp60) have been shown to play a role in the pathogenesis of type 1 insulin-dependent…”
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T cell vaccination in multiple sclerosis relapsing–remitting nonresponders patients by Achiron, A., Lavie, G., Kishner, I., Stern, Y., Sarova-Pinhas, I., Ben-Aharon, T., Barak, Y., Raz, H., Lavie, M., Barliya, T., Faibel, M., Cohen, I.R., Mandel, M.

“…Myelin autoreactive T cells are involved in the pathogenesis of multiple sclerosis (MS) and lead to propagation of the disease. We evaluated the efficacy of T…”
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Vaccination with Empty Plasmid DNA or CpG Oligonucleotide Inhibits Diabetes in Nonobese Diabetic Mice: Modulation of Spontaneous 60-kDa Heat Shock Protein Autoimmunity by Quintana, Francisco J, Rotem, Asaf, Carmi, Pnina, Cohen, Irun R

“…Nonobese diabetic (NOD) mice develop insulitis and diabetes through a process involving autoimmunity to the 60-kDa heat shock protein (HSP60). Treatment of NOD…”
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Peptide therapy for Type I diabetes: the immunological homunculus and the rationale for vaccination by COHEN, I. R

“…The autoimmune process that produces Type I (insulin-dependent) diabetes mellitus seems to respond favourably to therapeutic vaccination with a peptide of the…”
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Vaccination Against Autoimmune Mouse Diabetes with a T-Cell Epitope of the Human 65-kDa Heat Shock Protein by Elias, Dana, Reshef, Tamara, Birk, Ohad S., van der Zee, Ruurd, Walker, Michael D., Cohen, Irun R.

“…Insulin-dependent diabetes mellitus is caused by autoimmune destruction of the insulin-producing beta cells resident in the pancreatic islets. We recently…”
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Alpha tropomyosin as a self‐antigen in patients with Behçet's disease by Mahesh, S. P., Li, Zhuqing, Buggage, R., Mor, F., Cohen, I. R., Chew, E. Y., Nussenblatt, R. B.

“…Summary We report for the first time a significant increased lymphoproliferative response to alpha tropomyosin as well as observing autoantibodies to…”
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Antigen-Chip Technology for Accessing Global Information about the State of the Body by Quintana, FJ, Merbl, Y, Sahar, E, Domany, E, Cohen, IR

“…Traditionally, immunologic diagnosis has been based on an attempt to correlate each disease with a specific immune reactivity, such as an antibody or a T-cell…”
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Immunological efficacy of heat shock protein 60 peptide DiaPep277TM therapy in clinical type I diabetes by Huurman, V.A.L, van der Meide, P.E, Duinkerken, G, Willemen, S, Cohen, I.R, Elias, D, Roep, B.O

“…An immunogenic peptide (p277) from the 60-kDa heat shock protein (hsp60) arrested beta-cell destruction in non-obese diabetic mice. A randomized, double-blind,…”
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Crystal‐ball gazing − the future of immunological research viewed from the cutting edge by Brent, L., Cohen, I. R., Doherty, P. C., Feldmann, M., Matzinger, P., Holgate, S. T., Lachmann, P., Mitchison, N. A., Nossal, G., Rose, N. R., Zinkernagel, R.

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Low-dose low-molecular-weight heparin (enoxaparin) is beneficial in lichen planus: a preliminary report by Hodak, Emmilia, Yosipovitch, Gil, David, Michael, Ingber, Arieh, Chorev, Liran, Lider, Ofer, Cahalon, Leora, Cohen, Irun R.

“…Background: Low-dose heparin devoid of anticoagulant activity inhibits T-lymphocyte heparanase activity, which is crucial in T-cell migration to target…”
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Hsp60 peptide therapy of NOD mouse diabetes induces a Th2 cytokine burst and downregulates autoimmunity to various beta-cell antigens by Elias, D., Meilin, A., Ablamunits, V., Birk, O. S., Carmi, P., Konen-Waisman, S., Cohen, I. R.

“…Hsp60 peptide therapy of NOD mouse diabetes induces a Th2 cytokine burst and downregulates autoimmunity to various beta-cell antigens. D Elias , A Meilin , V…”
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Adult Still's disease and respiratory failure in a 74 year old woman by Stoica, G S, Cohen, R I, Rossoff, L J

“…A case of adult onset Still's disease in an elderly woman, that was associated with severe respiratory failure and multiorgan dysfunction, is reported…”
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Suppression of Experimental Autoimmune Encephalomyelitis by Intravenously Administered Polyclonal Immunoglobulins by Achiron, A, Mor, F, Margalit, R, Cohen, I.R, Lider, O, Miron, S

“…Experimental autoimmune encephalomyelitis (EAE) was induced in Lewis rats either by active immunization with myelin basic protein (MBP) or by adoptive transfer…”
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The pathogenicity of islet‐infiltrating lymphocytes in the non‐obese diabetic (NOD) mouse by ABLAMUNITS, V., ELIAS, D., COHEN, I. R.

“…The aim of the present study was to investigate the pathogenic properties of islet‐infiltrating lymphocytes related to the severity of the autoimmune…”
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