Search Results - "COFFING, S. L"

Design, Synthesis, and Biological Evaluation of a Series of Lavendustin A Analogues That Inhibit EGFR and Syk Tyrosine Kinases, as Well as Tubulin Polymerization by Mu, Fanrong, Coffing, Stephanie L, Riese, David J, Geahlen, Robert L, Verdier-Pinard, Pascal, Hamel, Ernest, Johnson, Jill, Cushman, Mark

“…A series of N-alkylamide analogues of the lavendustin A pharmacophore were synthesized and tested for inhibition of the epidermal growth factor receptor (EGFR)…”
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Exposure of mammalian cell cultures to benzo[a]pyrene and light results in oxidative DNA damage as measured by 8-hydroxydeoxyguanosine formation by Mauthe, R J, Cook, V M, Coffing, S L, Baird, W M

“…Carcinogenic polycyclic aromatic hydrocarbons induce DNA damage through direct covalent interactions with nucleotides of the DNA in cells in which they are…”
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Metabolic activation of benzo[g]chrysene in the human mammary carcinoma cell line MCF-7 by AGARWAL, R, COFFING, S. L, BAIRD, W. M, KISELYOV, A. S, HARVEY, R. G, DIPPLE, A

“…Benzo[g]chrysene (BgC) is an environmental pollutant, and recent studies have demonstrated that anti- BgC-11,12-dihydrodiol 13,14-epoxide (anti-BgCDE) is a…”
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Neuregulin isoforms exhibit distinct patterns of ErbB family receptor activation by HOBBS, Stuart S, COFFING, Stephanie L, LE, Ann T. D, CAMERON, Elizabeth M, WILLIAMS, Eric E, ANDREW, Michelle, BLOMMEL, Erika N, HAMMER, Robert P, CHANG, Han, RIESE, David J

“…During the last decade, several novel members of the Epidermal Growth Factor family of peptide growth factors have been identified. Most prominent among these…”
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Anilinodialkoxyquinazolines:  Screening Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors for Potential Tumor Imaging Probes by VanBrocklin, Henry F, Lim, John K, Coffing, Stephanie L, Hom, Darren L, Negash, Kitaw, Ono, Michele Y, Gilmore, Jennifer L, Bryant, Ianthe, Riese, David J

“…The epidermal growth factor receptor (EGFR), a long-standing drug development target, is also a desirable target for imaging. Sixteen dialkoxyquinazoline…”
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Stable Expression of Human Cytochrome P450 1B1 in V79 Chinese Hamster Cells and Metabolically Catalyzed DNA Adduct Formation of Dibenzo[a,l]pyrene by Luch, Andreas, Coffing, Stephanie L, Tang, Yong M, Schneider, Anneliese, Soballa, Volker, Greim, Helmut, Jefcoate, Colin R, Seidel, Albrecht, Greenlee, William F, Baird, William M, Doehmer, Johannes

“…Chinese hamster V79 cell lines were constructed for stable expression of human cytochrome P450 1B1 (P450 1B1) in order to study its role in the metabolic…”
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The time-dependent increase in the binding of benzo[a]pyrene to DNA through (+)-anti-benzo[a]pyrene-7,8-diol-9,10-epoxide in primary rat hepatocyte cultures results from induction of cytochrome P450IA1 by benzo[a]pyrene treatment by Eberhart, J, Coffing, S L, Anderson, J N, Marcus, C, Kalogeris, T J, Baird, W M, Park, S S, Gelboin, H V

“…The proportion and amount of benzo[a]pyrene (B[a]P) that binds to DNA through the carcinogenic (+)-anti-benzo[a]pyrene-7,8-diol-9,10-epoxide [(+)-anti-BPDE]…”
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Inhibition of benzo[ a]pyrene metabolism by insulin, FITC-insulin and an FITC-insulin-antibody conjugate in the human hepatoma cell line HepG2 by Polzer, Robert J., Coffing, Stephanie L., Marcus, Craig B., Park, Sang S., Gelboin, Harry V., Baird, William M.

“…Benzo[ a]pyrene (BaP) can be metabolically activated to an ultimate carcinogen, (+)- anti-BaP-7,8-dihydrodiol-9, 10-epoxide [(+)- anti-BaPDE] by cells in…”
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Five carboxyl-terminal residues of neuregulin2 are critical for stimulation of signaling by the ErbB4 receptor tyrosine kinase by HOBBS, Stuart S, CAMERON, Elizabeth M, HAMMER, Robert P, LE, Ann T. D, GALLO, Richard M, BLOMMEL, Erika N, COFFING, Stephanie L, HAN CHANG, RIESE, David J

“…The neuregulins (NRGs) are members of the epidermal growth factor (EGF) family of peptide growth factors. These hormones are agonists for the ErbB family of…”
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Effects of biochanin A on metabolism, DNA binding and mutagenicity of benzo[a]pyrene in mammalian cell cultures by Chae, Y H, Coffing, S L, Cook, V M, Ho, D K, Cassady, J M, Baird, W M

“…The search for potential chemopreventive agents from higher plants based upon alteration of benzo[a]pyrene (B[a]P) metabolism in cell cultures resulted in…”
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Stereoselective Activation of Dibenzo[a,l]pyrene and Its trans-11,12-Dihydrodiol to Fjord Region 11,12-Diol 13,14-Epoxides in a Human Mammary Carcinoma MCF-7 Cell-Mediated V79 Cell Mutation Assay by Ralston, Sherry L, Coffing, Stephanie L, Seidel, Albrecht, Luch, Andreas, Platt, Karl-Ludwig, Baird, William M

“…Dibenzo[a,l]pyrene (DB[a,l]P) represents the most potent carcinogenic polycyclic aromatic hydrocarbon (PAH) yet discovered. Like other PAHs, DB[a,l]P requires…”
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Metabolic Activation of 4H-Cyclopenta[def]chrysene in Human Mammary Carcinoma MCF-7 Cell Cultures by Agarwal, Rajiv, Coffing, Stephanie L, Baird, William M, Harvey, Ronald G, Dipple, Anthony

“…The tumor initiating activities of 4H-cyclopenta[def]chrysene (C[def]C) and its two putative reactive metabolites,…”
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Analysis of polycyclic aromatic hydrocarbon-DNA adducts by postlabelling with the weak beta-emitters 35S-phosphorothioate and 33P-phosphate, immobilized boronate chromatography and high-performance liquid chromatography by Baird, W M, Lau, H H, Schmerold, I, Coffing, S L, Brozich, S L, Lee, H, Harvey, R G

“…The wide range of carcinogenic activities of optical isomers of bay-region diol-epoxides of polycyclic aromatic hydrocarbons (PAHs) demands analytical…”
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Stereoselectivity of Activation of 7,12-Dimethylbenz[a]anthracene 3,4-Dihydrodiol to the anti-Diol Epoxide Metabolite in a Human Mammary Carcinoma MCF-7 Cell-Mediated V79 Cell Mutation Assay by Lau, Hudson H. S, Coffing, Stephanie L, Lee, Hongmee, Harvey, Ronald G, Baird, William M

“…7,12-Dimethylbenz[a]anthracene (DMBA), one of the most carcinogenic polycyclic aromatic hydrocarbons in rodent bioassays, is metabolically activated in many…”
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DNA Modification Induced After Metabolic Activation of the Potent Carcinogen Dibenzo[a, l]pyrene in V79 Chinese Hamster Cells Stably Expressing Single Cytochromes P450 by Luch, Andreas, Coffing, Stephanie L., Seidel, Albrecht, Greim, Helmut, Baird, William M., Doehmer, Johannes

“…The polycyclic aromatic hydrocarbon (PAH) dibenzo[a, l]pyrene (DB[a, l]P) has been found to be an environmental pollutant and, considering the available data…”
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