Search Results - "COETZEE, WILLIAM A."

Multiplicity of effectors of the cardioprotective agent, diazoxide by COETZEE, William A

“…Diazoxide has been identified over the past 50years to have a number of physiological effects, including lowering the blood pressure and rectifying…”
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Short Communication: Flecainide Exerts an Antiarrhythmic Effect in a Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia by Increasing the Threshold for Triggered Activity by Liu, Nian, Denegri, Marco, Ruan, Yanfei, Avelino-Cruz, José Everardo, Perissi, Andrea, Negri, Sara, Napolitano, Carlo, Coetzee, William A, Boyden, Penelope A, Priori, Silvia G

“…RATIONALE:Flecainide prevents arrhythmias in catecholaminergic polymorphic ventricular tachycardia, but the antiarrhythmic mechanism remains unresolved. It is…”
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Ankyrin-G mediates targeting of both Na+ and KATP channels to the rat cardiac intercalated disc by Yang, Hua-Qian, Pérez-Hernández, Marta, Sanchez-Alonso, Jose, Shevchuk, Andriy, Gorelik, Julia, Rothenberg, Eli, Delmar, Mario, Coetzee, William A

“…We investigated targeting mechanisms of Na + and K ATP channels to the intercalated disk (ICD) of cardiomyocytes. Patch clamp and surface biotinylation data…”
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Lethal arrhythmias in Tbx3-deficient mice reveal extreme dosage sensitivity of cardiac conduction system function and homeostasis by Frank, Deborah U., Carter, Kandis L., Thomas, Kirk R., Burr, R. Michael, Bakker, Martijn L., Coetzee, William A., Tristani-Firouzi, Martin, Bamshad, Michael J., Christoffels, Vincent M., Moon, Anne M.

“…TBX3 is critical for human development: mutations in TBX3 cause congenital anomalies in patients with ulnar-mammary syndrome. Data from mice and humans suggest…”
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CL-705G: a novel chemical Kir6.2-specific KATP channel opener by Gando, Ivan, Becerra Flores, Manuel, Chen, I.-Shan, Yang, Hua-Qian, Nakamura, Tomoe Y., Cardozo, Timothy J., Coetzee, William A.

“…Background: K ATP channels have diverse roles, including regulation of insulin secretion and blood flow, and protection against biological stress responses and…”
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Plasticity of sarcolemmal KATP channel surface expression: relevance during ischemia and ischemic preconditioning by Yang, Hua-Qian, Foster, Monique N, Jana, Kundan, Ho, Joanne, Rindler, Michael J, Coetzee, William A

“…Myocardial ischemia remains the primary cause of morbidity and mortality in the United States. Ischemic preconditioning (IPC) is a powerful form of endogenous…”
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Rab35 GTPase positively regulates endocytic recycling of cardiac KATP channels by Yang, Bo, Yao, Jia-Lu, Huo, Jian-Yi, Feng, Yu-Long, Coetzee, William A., Xu, Guang-Yin, Yang, Hua-Qian

“…ATP-sensitive K + (K ATP ) channel couples membrane excitability to intracellular energy metabolism. Maintaining K ATP channel surface expression is key to…”
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The sarcoplasmic reticulum luminal thiol oxidase ERO1 regulates cardiomyocyte excitation‐coupled calcium release and response to hemodynamic load by Chin, King‐Tung, Kang, Guoxin, Qu, Jiaxiang, Gardner, Lawrence B., Coetzee, William A., Zito, Ester, Fishman, Glenn I., Ron, David

“…ABSTRACT Two related ER oxidation 1 (ERO1) proteins, ERO1α and ERO1β, dynamically regulate the redox environment in the mammalian endoplasmic reticulum (ER)…”
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KATP Channels in the Cardiovascular System by Foster, Monique N, Coetzee, William A

“…KATP channels are integral to the functions of many cells and tissues. The use of electrophysiological methods has allowed for a detailed characterization of…”
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Exercise-induced expression of cardiac ATP-sensitive potassium channels promotes action potential shortening and energy conservation by Zingman, Leonid V, Zhu, Zhiyong, Sierra, Ana, Stepniak, Elizabeth, Burnett, Colin M.-L, Maksymov, Gennadiy, Anderson, Mark E, Coetzee, William A, Hodgson-Zingman, Denice M

“…Abstract Physical activity is one of the most important determinants of cardiac function. The ability of the heart to increase delivery of oxygen and metabolic…”
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Disruption of ATP-sensitive potassium channel function in skeletal muscles promotes production and secretion of musclin by Sierra, Ana, Subbotina, Ekaterina, Zhu, Zhiyong, Gao, Zhan, Koganti, Siva Rama Krishna, Coetzee, William A., Goldhamer, David J., Hodgson-Zingman, Denice M., Zingman, Leonid V.

“…Sarcolemmal ATP-sensitive potassium (KATP) channels control skeletal muscle energy use through their ability to adjust membrane excitability and related cell…”
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Transcriptional remodeling of ion channel subunits by flow adaptation in human coronary artery endothelial cells by Kefaloyianni, Eirini, Coetzee, William A

“…Endothelial cells (ECs) are constantly exposed to blood flow-induced shear forces in the vessels and this is a major determinant of endothelial function. Ion…”
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Comparative proteomic analysis of the ATP-sensitive K+ channel complex in different tissue types by Kefaloyianni, Eirini, Lyssand, John S., Moreno, Cesar, Delaroche, Diane, Hong, Miyoun, Fenyö, David, Mobbs, Charles V., Neubert, Thomas A., Coetzee, William A.

“…ATP‐sensitive K+ (KATP) channels are expressed ubiquitously, but have diverse roles in various organs and cells. Their diversity can partly be explained by…”
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Sulfonylurea Receptor 1 Subunits of ATP-Sensitive Potassium Channels and Myocardial Ischemia/Reperfusion Injury by Lefer, David J, Nichols, Colin G, Coetzee, William A

“…KATP channels are generally cardioprotective under conditions of metabolic impairment, consisting of pore-forming (Kir6.1 and/or Kir6.2) and…”
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Measuring and evaluating the role of ATP-sensitive K+ channels in cardiac muscle by Kefaloyianni, Eirini, Bao, Li, Rindler, Michael J, Hong, Miyoun, Patel, Tejaskumar, Taskin, Eylem, Coetzee, William A

“…Abstract Since ion channels move electrical charge during their activity, they have traditionally been studied using electrophysiological approaches. This was…”
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Novel insights into hydrogen sulfide--mediated cytoprotection by Calvert, John W, Coetzee, William A, Lefer, David J

“…Hydrogen sulfide (H(2)S) is a colorless, water soluble, flammable gas that has the characteristic smell of rotten eggs. Like other members of the…”
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Role of Sulfonylurea Receptor Type 1 Subunits of ATP-Sensitive Potassium Channels in Myocardial Ischemia/Reperfusion Injury by ELROD, John W, HARRELL, Maddison, FLAGG, Thomas P, GUNDEWAR, Susheel, MAGNUSON, Mark A, NICHOLS, Colin G, COETZEE, William A, LEFER, David J

“…Opening of cardiac ATP-sensitive potassium channels (K(ATP) channels) is a well-characterized protective mechanism against ischemia and reperfusion injury…”
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Palmitoylation of the KATP channel Kir6.2 subunit promotes channel opening by regulating PIP₂ sensitivity by Yang, Hua-Qian, Martinez-Ortiz, Wilnelly, Hwang, JongIn, Fan, Xuexin, Cardozo, Timothy J., Coetzee, William A.

“…A physiological role for long-chain acyl-CoA esters to activate ATPsensitive K⁺ (KATP) channels is well established. Circulating palmitate is transported into…”
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Phosphatidylinositol 3-phosphate indirectly activates KCa3.1 via 14 amino acids in the carboxy terminus of KCa3.1 by Srivastava, Shekhar, Choudhury, Papiya, Li, Zhai, Liu, Gongxin, Nadkarni, Vivek, Ko, Kyung, Coetzee, William A, Skolnik, Edward Y

“…KCa3.1 is an intermediate conductance Ca2+-activated K+ channel that is expressed predominantly in hematopoietic cells, smooth muscle cells, and epithelia…”
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Molecular autopsy: using the discovery of a novel de novo pathogenic variant in the KCNH2 gene to inform healthcare of surviving family by Dong, Jingyun, Williams, Nori, Cerrone, Marina, Borck, Christopher, Wang, Dawei, Zhou, Bo, Eng, Lucy S., Subbotina, Ekaterina, Um, Sung Yon, Lin, Ying, Ruiter, Kevin, Rojas, Lisa, Coetzee, William A., Sampson, Barbara A., Tang, Yingying

“…Molecular testing of the deceased (Molecular Autopsy) is an overlooked area in the United States healthcare system and is not covered by medical insurance,…”
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