Search Results - "CODONY, Xavier"

Repeated Sigma-1 Receptor Antagonist MR309 Administration Modulates Central Neuropathic Pain Development After Spinal Cord Injury in Mice by Castany, Sílvia, Codony, Xavier, Zamanillo, Daniel, Merlos, Manuel, Verdú, Enrique, Boadas-Vaello, Pere

“…Up to two-thirds of patients affected by spinal cord injury (SCI) develop central neuropathic pain (CNP), which has a high impact on their quality of life…”
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Sigma receptors: biology and therapeutic potential by GUITART, Xavier, CODONY, Xavier, MONROY, Xavier

“…More than 20 years after the identification of the sigma receptors as a unique binding site in the brain and in the peripheral organs, several questions…”
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Sigma-1 receptor antagonism as opioid adjuvant strategy: Enhancement of opioid antinociception without increasing adverse effects by Vidal-Torres, Alba, de la Puente, Beatriz, Rocasalbas, Maria, Touriño, Clara, Andreea Bura, Simona, Fernández-Pastor, Begoña, Romero, Luz, Codony, Xavier, Zamanillo, Daniel, Buschmann, Helmut, Merlos, Manuel, Manuel Baeyens, José, Maldonado, Rafael, Vela, José Miguel

“…While opioids are potent analgesics widely used in the management of pain, a number of well-known adverse effects limit their use. The sigma-1 receptor is a…”
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Pharmacological activation of 5-HT7 receptors reduces nerve injury-induced mechanical and thermal hypersensitivity by Brenchat, Alex, Nadal, Xavier, Romero, Luz, Ovalle, Sergio, Muro, Asunción, Sánchez-Arroyos, Ricard, Portillo-Salido, Enrique, Pujol, Marta, Montero, Ana, Codony, Xavier, Burgueño, Javier, Zamanillo, Daniel, Hamon, Michel, Maldonado, Rafael, Vela, José Miguel

“…The involvement of the 5-HT7 receptor in nociception and pain, particularly chronic pain (i.e., neuropathic pain), has been poorly investigated. In the present…”
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Bispecific sigma-1 receptor antagonism and mu-opioid receptor partial agonism: WLB-73502, an analgesic with improved efficacy and safety profile compared to strong opioids by Vidal-Torres, Alba, Fernández-Pastor, Begoña, García, Mónica, Ayet, Eva, Cabot, Anna, Burgueño, Javier, Monroy, Xavier, Aubel, Bertrand, Codony, Xavier, Romero, Luz, Pascual, Rosalía, Serafini, Maria Teresa, Encina, Gregorio, Almansa, Carmen, Zamanillo, Daniel, Merlos, Manuel, Vela, José Miguel

“…Opioids are the most effective painkillers, but their benefit-risk balance often hinder their therapeutic use. WLB-73502 is a dual, bispecific compound that…”
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Generation and phenotypic analysis of sigma receptor type I (σ1) knockout mice by Langa, Francina, Codony, Xavier, Tovar, Victoria, Lavado, Alfonso, Giménez, Estela, Cozar, Patricia, Cantero, Marta, Dordal, Albert, Hernández, Enric, Pérez, Raquel, Monroy, Xavier, Zamanillo, Daniel, Guitart, Xavier, Montoliu, Lluís

“…Sigma (σ) sites are a type of nonopiate receptor whose role has been associated with several behaviours, including anxiety, depression, analgesia, learning…”
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Administration of a co-crystal of tramadol and celecoxib in a 1:1 molecular ratio produces synergistic antinociceptive effects in a postoperative pain model in rats by Merlos, Manuel, Portillo-Salido, Enrique, Brenchat, Alex, Aubel, Bertrand, Buxens, Jordi, Fisas, Angels, Codony, Xavier, Romero, Luz, Zamanillo, Daniel, Vela, José Miguel

“…Drug combination for the treatment of pain is common clinical practice. Co-crystal of Tramadol-Celecoxib (CTC) consists of two active pharmaceutical…”
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E-6801, a 5-HT6 receptor agonist, improves recognition memory by combined modulation of cholinergic and glutamatergic neurotransmission in the rat by Kendall, Ian, Slotten, Helge A., Codony, Xavier, Burgueño, Javier, Pauwels, Peter J., Vela, Jose M., Fone, Kevin C. F.

“…Rationale and objectives In rats, 5-hydroxytryptamine 6 (5-HT 6 ) receptor antagonists improve learning and memory, but the effects of agonists are poorly…”
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Medicinal chemistry strategies to 5-HT6 receptor ligands as potential cognitive enhancers and antiobesity agents by HOLENZ, Jörg, PAUWELS, Petrus J, DIAZ, José Luis, MERCE, Ramon, CODONY, Xavier, BUSCHMANN, Helmut

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Chronic 5‐HT6 receptor modulation by E‐6837 induces hypophagia and sustained weight loss in diet‐induced obese rats by Fisas, Angels, Codony, Xavier, Romero, Gonzalo, Dordal, Alberto, Giraldo, Jesus, Mercé, Ramon, Holenz, Jörg, Heal, David, Buschmann, Helmut, Pauwels, Petrus Johan

“…1 E‐6837 is a novel, selective and high‐affinity 5‐HT6 receptor ligand (pKi: 9.13) which in vitro demonstrates partial agonism at a presumably silent rat 5‐HT6…”
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Efficacy of selective 5‐HT6 receptor ligands determined by monitoring 5‐HT6 receptor‐mediated cAMP signaling pathways by Romero, Gonzalo, Sánchez, Elisabeth, Pujol, Marta, Pérez, Pilar, Codony, Xavier, Holenz, Jörg, Buschmann, Helmut, Pauwels, Petrus J

“…1 Two novel selective 5‐HT6 receptor ligands E‐6801 (6‐chloro‐N‐(3‐(2‐(dimethylamino)ethyl)‐1H‐indol‐5‐yl)imidazo[2,1‐b]thiazole‐5‐sulfonamide) and E‐6837…”
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Medicinal Chemistry Driven Approaches Toward Novel and Selective Serotonin 5-HT6 Receptor Ligands by Holenz, Jörg, Mercè, Ramon, Díaz, José Luis, Guitart, Xavier, Codony, Xavier, Dordal, Alberto, Romero, Gonzalo, Torrens, Antoni, Mas, Josep, Andaluz, Blas, Hernández, Susana, Monroy, Xavier, Sánchez, Elisabeth, Hernández, Enrique, Pérez, Raquel, Cubí, Roger, Sanfeliu, Olga, Buschmann, Helmut

“…Based on a medicinal chemistry guided hypothetical pharmacophore model, novel series of indolyl sulfonamides have been designed and prepared as selective and…”
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E-6801, a 5-HT sub(6) receptor agonist, improves recognition memory by combined modulation of cholinergic and glutamatergic neurotransmission in the rat by Kendall, Ian, Slotten, Helge A, Codony, Xavier, Burgueno, Javier, Pauwels, Peter J, Vela, Jose M, Fone, Kevin CF

“…Rationale and objectives: In rats, 5-hydroxytryptamine sub(6) (5-HT sub(6)) receptor antagonists improve learning and memory, but the effects of agonists are…”
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E-6801, a 5-HT^sub 6^ receptor agonist, improves recognition memory by combined modulation of cholinergic and glutamatergic neurotransmission in the rat by Kendall, Ian, Slotten, Helge A, Codony, Xavier, Burgueño, Javier, Pauwels, Peter J, Vela, Jose M, Fone, Kevin C; F

“…Issue Title: Special Issue on Serotonin Revisited In rats, 5-hydroxytryptamine^sub 6^ (5-HT^sub 6^) receptor antagonists improve learning and memory, but the…”
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E-6801, a 5-HT6 receptor agonist, improves recognition memory by combined modulation of cholinergic and glutamatergic neurotransmission in the rat: Special Issue on Serotonin Revisited by KENDALL, Ian, SLOTTEN, Helge A, CODONY, Xavier, BURGUENO, Javier, PAUWELS, Peter J, VELA, Jose M, FONE, Kevin C. F

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Pharmacological activation of 5-HT 7 receptors reduces nerve injury-induced mechanical and thermal hypersensitivity by Brenchat, Alex, Nadal, Xavier, Romero, Luz, Ovalle, Sergio, Muro, Asunción, Sánchez-Arroyos, Ricard, Portillo-Salido, Enrique, Pujol, Marta, Montero, Ana, Codony, Xavier, Burgueño, Javier, Zamanillo, Daniel, Hamon, Michel, Maldonado, Rafael, Vela, José Miguel

“…The involvement of the 5-HT 7 receptor in nociception and pain, particularly chronic pain (i.e., neuropathic pain), has been poorly investigated. In the…”
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Chronic 5‐HT 6 receptor modulation by E‐6837 induces hypophagia and sustained weight loss in diet‐induced obese rats by Fisas, Angels, Codony, Xavier, Romero, Gonzalo, Dordal, Alberto, Giraldo, Jesus, Mercé, Ramon, Holenz, Jörg, Heal, David, Buschmann, Helmut, Pauwels, Petrus Johan

“…E‐6837 is a novel, selective and high‐affinity 5‐HT 6 receptor ligand (p K i : 9.13) which in vitro demonstrates partial agonism at a presumably silent rat…”
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5-HT6 receptor signal transduction second messenger systems by Codony, Xavier, Burgueño, Javier, Ramírez, Maria Javier, Vela, José Miguel

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Medicinal chemistry strategies to 5-HT(6) receptor ligands as potential cognitive enhancers and antiobesity agents by Holenz, Jörg, Pauwels, Petrus J, Díaz, José Luis, Mercè, Ramon, Codony, Xavier, Buschmann, Helmut

“…Although the 5-hydroxytryptamine(6) (5-HT(6)) receptor was discovered only recently, its almost exclusive distribution in the brain makes it a promising,…”
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Medicinal chemistry strategies to 5-HT 6 receptor ligands as potential cognitive enhancers and antiobesity agents by Holenz, Jörg, Pauwels, Petrus J., Díaz, José Luis, Mercè, Ramon, Codony, Xavier, Buschmann, Helmut

“…Although the 5-hydroxytryptamine 6 (5-HT 6) receptor was discovered only recently, its almost exclusive distribution in the brain makes it a promising, novel,…”
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