Search Results - "COCKAYNE, Alan"

The role of toxin A and toxin B in Clostridium difficile infection by Heap, John T, Kelly, Michelle L, Minton, Nigel P, Cockayne, Alan, Kuehne, Sarah A, Cartman, Stephen T

“…Clostridium difficile infection is the leading cause of healthcare-associated diarrhoea in Europe and North America. During infection, C. difficile produces…”
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Combinatorial discovery of polymers resistant to bacterial attachment by Hook, Andrew L, Chang, Chien-Yi, Yang, Jing, Luckett, Jeni, Cockayne, Alan, Atkinson, Steve, Mei, Ying, Bayston, Roger, Irvine, Derek J, Langer, Robert, Anderson, Daniel G, Williams, Paul, Davies, Martyn C, Alexander, Morgan R

“…Bacterial attachment and biofilm formation are problematic for medical devices. Hook et al . present a high-throughput method to find materials that resist…”
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Control of Bacterial Aggregation by Thermoresponsive Glycopolymers by Pasparakis, George, Cockayne, Alan, Alexander, Cameron

“…Thermoresponsive polymers with pendant glucose functionality form aggregates with bacterial cells that can be assembled/disassembled reversibly through…”
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Iron-Regulated Biofilm Formation in Staphylococcus aureus Newman Requires ica and the Secreted Protein Emp by Johnson, Miranda, Cockayne, Alan, Morrissey, Julie A

“…Staphylococcus aureus biofilm formation is induced in iron-restricted growth conditions in vitro. In this study, we showed that Emp and Eap play important…”
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Crystal Structure of the Heme-IsdC Complex, the Central Conduit of the Isd Iron/Heme Uptake System in Staphylococcus aureus by Sharp, Katherine H., Schneider, Sabine, Cockayne, Alan, Paoli, Max

“…Pathogens such as Staphylococcus aureus require iron to survive and have evolved specialized proteins to steal heme from their host. IsdC is the central…”
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Comparison of the Regulation, Metabolic Functions, and Roles in Virulence of the Glyceraldehyde-3-Phosphate Dehydrogenase Homologues gapA and gapB in Staphylococcus aureus by Purves, Joanne, Cockayne, Alan, Moody, Peter C.E, Morrissey, Julie A

“…The Gram-positive bacterium Staphylococcus aureus contains two glyceraldehyde-3-phosphate dehydrogenase (GAPDH) homologues known as GapA and GapB. GapA has…”
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N-Acylhomoserine Lactones Antagonize Virulence Gene Expression and Quorum Sensing in Staphylococcus aureus by Qazi, Saara, Middleton, Barry, Muharram, Siti Hanna, Cockayne, Alan, Hill, Philip, O'Shea, Paul, Chhabra, Siri Ram, Cámara, Miguel, Williams, Paul

“…Many gram-negative bacteria employ N-acylhomoserine lactone (AHL)-mediated quorum sensing to control virulence. To determine whether gram-positive bacteria…”
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Colonisation Factor CD0873, an Attractive Oral Vaccine Candidate against Clostridioides difficile by Karyal, Cansu, Hughes, Jaime, Kelly, Michelle L, Luckett, Jeni C, Kaye, Philip V, Cockayne, Alan, Minton, Nigel P, Griffin, Ruth

“…is the main cause of health-care-associated infectious diarrhoea. Toxins, TcdA and TcdB, secreted by this bacterium damage colonic epithelial cells and in…”
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Iron-Responsive Regulation of Biofilm Formation in Staphylococcus aureus Involves Fur-Dependent and Fur-Independent Mechanisms by JOHNSON, Miranda, COCKAYNE, Alan, WILLIAMS, Peter H, MORRISSEY, Julie A

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Synthesis and Deformylation of Staphylococcus aureus δ-Toxin Are Linked to Tricarboxylic Acid Cycle Activity by Somerville, Greg A, Cockayne, Alan, Dürr, Manuela, Peschel, Andreas, Otto, Michael, Musser, James M

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The Staphylococcal Ferritins Are Differentially Regulated in Response to Iron and Manganese and via PerR and Fur by MORRISSEY, Julie A, COCKAYNE, Alan, BRUMMELL, Kirsty, WILLIAMS, Paul

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NapA protects Helicobacter pylori from oxidative stress damage, and its production is influenced by the ferric uptake regulator by Cooksley, Clare, Jenks, Peter J, Green, Andrew, Cockayne, Alan, Logan, Robert P. H, Hardie, Kim R

“…1 Institute of Infections and Immunity, Queen's Medical Centre, C-floor West Block, Nottingham NG7 2UH, UK 2 Division of Gastroenterology, University Hospital,…”
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Molecular Cloning and Analysis of a Putative Siderophore ABC Transporter from Staphylococcus aureus by MORRISSEY, Julie A, COCKAYNE, Alan, HILL, Philip J, WILLIAMS, Paul

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Side-chain-to-tail thiolactone peptide inhibitors of the staphylococcal quorum-sensing system by Scott, R.John, Lian, Lu-Yun, Muharram, S.Hanna, Cockayne, Alan, Wood, Stewart J, Bycroft, Barrie W, Williams, Paul, Chan, Weng C

“…The expression of many staphylococcal virulence factors are regulated by the agr locus via a two-component signal transduction system (TCSTS), which is…”
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Molecular Cloning of a 32-Kilodalton Lipoprotein Component of a Novel Iron-Regulated Staphylococcus epidermidis ABC Transporter by COCKAYNE, A, HILL, P. J, POWELL, N. B. L, BISHOP, K, SIMS, C, WILLIAMS, P

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Conservation, Surface Exposure, and In Vivo Expression of the Frp Family of Iron-Regulated Cell Wall Proteins in Staphylococcus aureus by MORRISSEY, Julie A, COCKAYNE, Alan, HAMMACOTT, Jane, BISHOP, Keith, DENMAN-JOHNSON, Amy, HILL, Philip J, WILLIAMS, Paul

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Importance of Toxin A, Toxin B, and CDT in Virulence of an Epidemic Clostridium difficile Strain by Kuehne, Sarah A., Collery, Mark M., Kelly, Michelle L., Cartman, Stephen T., Cockayne, Alan, Minton, Nigel P.

“…Clostridium difficile infection is the main cause of healthcareacquired diarrhea in the developed world. In addition to the main virulence factors toxin A and…”
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Pathogenesis of Clostridium difficile Infection and Its Potential Role in Inflammatory Bowel Disease by Monaghan, Tanya M, Cockayne, Alan, Mahida, Yashwant R

“…Colonization with toxigenic Clostridium difficile may be associated with a wide spectrum of clinical presentation ranging from asymptomatic carriage to mild…”
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Antibiotic Spider Silk: Site‐Specific Functionalization of Recombinant Spider Silk Using “Click” Chemistry by Harvey, David, Bardelang, Philip, Goodacre, Sara L., Cockayne, Alan, Thomas, Neil R.

“…In a new, versatile approach to fun­ction­alizing recombinant spider silk, L‐azidohomoalanine is introduced residue‐specifically in the minispidroin protein…”
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Generation of a fully erythromycin-sensitive strain of Clostridioides difficile using a novel CRISPR-Cas9 genome editing system by Ingle, Patrick, Groothuis, Daphne, Rowe, Peter, Huang, He, Cockayne, Alan, Kuehne, Sarah A., Jiang, Weihong, Gu, Yang, Humphreys, Christopher M., Minton, Nigel P.

“…Understanding the molecular pathogenesis of Clostridioides difficile has relied on the use of ermB -based mutagens in erythromycin-sensitive strains. However,…”
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