Search Results - "COBB, Ronald R"

Zika Virus: Medical Countermeasure Development Challenges by Malone, Robert W, Homan, Jane, Callahan, Michael V, Glasspool-Malone, Jill, Damodaran, Lambodhar, Schneider, Adriano De Bernardi, Zimler, Rebecca, Talton, James, Cobb, Ronald R, Ruzic, Ivan, Smith-Gagen, Julie, Janies, Daniel, Wilson, James

“…Reports of high rates of primary microcephaly and Guillain-Barré syndrome associated with Zika virus infection in French Polynesia and Brazil have raised…”
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Vero cell technology for rapid development of inactivated whole virus vaccines for emerging viral diseases by Barrett, P Noel, Terpening, Sara J, Snow, Doris, Cobb, Ronald R, Kistner, Otfried

“…Rapid development and production of vaccines against emerging diseases requires well established, validated, robust technologies to allow industrial scale…”
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Safety and Pharmacokinetics of a Four Monoclonal Antibody Combination Against Botulinum C and D Neurotoxins by Snow, Doris M, Riling, Kathryn, Kimbler, Angie, Espinoza, Yero, Wong, David, Pham, Khanh, Martinez, Zachary, Kraus, Carl N, Conrad, Fraser, Garcia-Rodriguez, Consuelo, Cobb, Ronald R, Marks, James D, Tomic, Milan T

“…Botulism is caused by botulinum neurotoxin (BoNT), the most poisonous substance known. BoNTs are also classified as Tier 1 biothreat agents due to their high…”
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Evaluation of strategies to modify Anti-SARS-CoV-2 monoclonal antibodies for optimal functionality as therapeutics by House, Robert V, Broge, Thomas A, Suscovich, Todd J, Snow, Doris M, Tomic, Milan T, Nonet, Genevieve, Bajwa, Kamaljit, Zhu, Guangyu, Martinez, Zachary, Hackett, Kyal, Earnhart, Christopher G, Dorsey, Nicole M, Hopkins, Svetlana A, Natour, Dalia S, Davis, Heather D, Anderson, Michael S, Gainey, Melicia R, Cobb, Ronald R

“…The current global COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in a public health crisis with more…”
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Intranasal delivery of a bivalent norovirus vaccine formulated in an in situ gelling dry powder by Ball, Jordan P, Springer, Michael J, Ni, Yawei, Finger-Baker, Isaac, Martinez, Juan, Hahn, Jessica, Suber, John F, DiMarco, Ashley V, Talton, James D, Cobb, Ronald R

“…The global health community is beginning to understand the burden of norovirus-associated disease, which has a significant impact in both developed and…”
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Neutralizing Concentrations of Anti-Botulinum Toxin Antibodies Positively Correlate with Mouse Neutralization Assay Results in a Guinea Pig Model by Tomic, Milan T, Farr-Jones, Shauna, Syar, Emily S, Niemuth, Nancy, Kobs, Dean, Hackett, Michael J, Espinoza, Yero, Martinez, Zacchary, Pham, Khanh, Snow, Doris M, Marks, James D, Cobb, Ronald R

“…Botulinum neurotoxins (BoNT) are some of the most toxic proteins known and can induce respiratory failure requiring long-term intensive care. Treatment of…”
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A Monoclonal Antibody Combination against both Serotypes A and B Botulinum Toxin Prevents Inhalational Botulism in a Guinea Pig Model by Snow, Doris M, Cobb, Ronald R, Martinez, Juan, Finger-Baker, Isaac, Collins, Laura, Terpening, Sara, Syar, Emily S, Niemuth, Nancy, Kobs, Dean, Barnewall, Roy, Farr-Jones, Shauna, Marks, James D, Tomic, Milan T

“…Botulinum neurotoxins (BoNT) are extremely potent and can induce respiratory failure, requiring long-term intensive care to prevent death. Recombinant…”
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Pharmacokinetics of Human Recombinant Anti-Botulinum Toxin Antibodies in Rats by Espinoza, Yero, Wong, David, Ahene, Ago, Der, Kenneth, Martinez, Zachary, Pham, John, Cobb, Ronald R, Farr-Jones, Shauna, Marks, James D, Tomic, Milan T

“…Botulinum neurotoxins (BoNT) are potential biothreat agents due to their high lethality, potency, and ease of distribution, thus the development of antitoxins…”
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Monoclonal Antibody Combinations Prevent Serotype A and Serotype B Inhalational Botulism in a Guinea Pig Model by Tomic, Milan T, Espinoza, Yero, Martinez, Zachary, Pham, Khanh, Cobb, Ronald R, Snow, Doris M, Earnhart, Christopher G, Pals, Traci, Syar, Emily S, Niemuth, Nancy, Kobs, Dean J, Farr-Jones, Shauna, Marks, James D

“…Botulinum neurotoxins (BoNT) are some of the most toxic proteins known, with a human LD of ~1 ng/kg. Equine antitoxin has a half-life in circulation of less…”
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Modern Development and Production of a New Live Attenuated Bacterial Vaccine, SCHU S4 ΔclpB, to Prevent Tularemia by Conlan, J., Sjöstedt, Anders, Gelhaus, H., Fleming, Perry, McRae, Kevan, Cobb, Ronald, De Pascalis, Roberto, Elkins, Karen

“…Inhalation of small numbers of Francisella tularensis subspecies tularensis (Ftt) in the form of small particle aerosols causes severe morbidity and mortality…”
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Immunofocusing humoral immunity potentiates the functional efficacy of the AnAPN1 malaria transmission-blocking vaccine antigen by Bender, Nicole G., Khare, Prachi, Martinez, Juan, Tweedell, Rebecca E., Nyasembe, Vincent O., López-Gutiérrez, Borja, Tripathi, Abhai, Miller, Dustin, Hamerly, Timothy, Vela, Eric M., Davis, Ryan R., Howard, Randall F., Nsango, Sandrine, Cobb, Ronald R., Harbers, Matthias, Dinglasan, Rhoel R.

“…Malaria transmission-blocking vaccines (TBVs) prevent the completion of the developmental lifecycle of malarial parasites within the mosquito vector,…”
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Identification of a novel prostate tumor target, Mindin/RG-1, for antibody-based radiotherapy of prostate cancer by PARRY, Renate, SCHNEIDER, Doug, BIROC, Sandra, KRETSCHMER, Peter J, HALKS-MILLER, Meredith, KLOCKER, Helmut, YING ZHU, LARSEN, Brent, COBB, Ronald R, BRINGMANN, Peter, ROTH, Georg, LEWIS, Jason S, HUDSON, Debra, DINTER, Harald, PARRY, Gordon, PARKES, Debbie, XUAN, Jian-Ai, NEWTON, Alicia, TOY, Pam, LIN, Rick, HARKINS, Rick, ALICKE, Bruno

“…Gene expression analysis showed that a human mindin homologue, mindin/RG-1, is expressed selectively in prostate tissues and that its expression level is…”
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High levels of protein expression using different mammalian CMV promoters in several cell lines by Xia, Wei, Bringmann, Peter, McClary, John, Jones, Patrick P., Manzana, Warren, Zhu, Ying, Wang, Soujuan, Liu, Yi, Harvey, Susan, Madlansacay, Mary Rose, McLean, Kirk, Rosser, Mary P., MacRobbie, Jean, Olsen, Catherine L., Cobb, Ronald R.

“…With the recent completion of the human genome sequencing project, scientists are faced with the daunting challenge of deciphering the function of these newly…”
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Histological and Radiographic Evaluations of Demineralized Bone Matrix and Coralline Hydroxyapatite in the Rabbit Tibia by Zhukauskas, Rasa, Dodds, Robert A., Hartill, Caroline, Arola, Travis, Cobb, Ronald R., Fox, Casey

“…Complex fractures resulting in bone loss or impaired fracture healing remain problematic in trauma and orthopedic surgeries. Many bone graft substitutes have…”
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Anti-EphA2 Antibodies Decrease EphA2 Protein Levels in Murine CT26 Colorectal and Human MDA-231 Breast Tumors But Do Not Inhibit Tumor Growth by Kiewlich, David, Zhang, Jianhuan, Gross, Cynthia, Xia, Wei, Larsen, Brent, Cobb, Ronald R., Biroc, Sandra, Gu, Jian-Ming, Sato, Takashi, Light, David R., Heitner, Tara, Willuda, Joerg, Vogel, David, Monteclaro, Felipe, Citkowicz, Andrzej, Roffler, Steve R., Zajchowski, Deborah A.

“…The EphA2 receptor tyrosine kinase has been shown to be over-expressed in cancer and a monoclonal antibody (mAb) that activates and down-modulates EphA2 was…”
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Development of a synthetic Vi polysaccharide vaccine for typhoid fever by Ni, Yawei, Springer, Michael J., Guo, Jianhua, Finger-Baker, Isaac, Wilson, James P., Cobb, Ronald R., Turner, Debra, Tizard, Ian

“…Typhoid fever remains a serious public health problem with a high impact on toddlers and young children. Vaccines against the Vi capsular polysaccharide are…”
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Preclinical dose-ranging studies of a novel dry powder norovirus vaccine formulation by Springer, Michael J, Ni, Yawei, Finger-Baker, Isaac, Ball, Jordan P, Hahn, Jessica, DiMarco, Ashley V, Kobs, Dean, Horne, Bobbi, Talton, James D, Cobb, Ronald R

“…Abstract Norovirus is the primary cause of viral gastroenteritis in humans with multiple genotypes currently circulating worldwide. The development of a…”
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Human adipose-derived side population stem cells cultured on demineralized bone matrix for bone tissue engineering by Supronowicz, Peter, Gill, Elise, Trujillo, Angelica, Thula, Taili, Zhukauskas, Rasa, Ramos, Thomas, Cobb, Ronald R

“…Tissue engineering of new bone relies on the combination and application of osteoconductive, osteoinductive, and osteogenic elements. Natural scaffolds, such…”
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Multipotent adult progenitor cell-loaded demineralized bone matrix for bone tissue engineering by Supronowicz, Peter, Gill, Elise, Trujillo, Angelica, Thula, Taili, Zhukauskas, Rasa, Perry, Robert, Cobb, Ronald R.

“…Multipotent adult progenitor cells (MAPCs) from bone marrow have been shown to be capable of forming bone, cartilage and other connective tissues. In addition,…”
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A combination of two human neutralizing antibodies prevents SARS-CoV-2 infection in cynomolgus macaques by Cobb, Ronald R, Nkolola, Joseph, Gilchuk, Pavlo, Chandrashekar, Abishek, Yu, Jingyou, House, Robert V, Earnhart, Christopher G, Dorsey, Nicole M, Hopkins, Svetlana A, Snow, Doris M, Chen, Rita E, VanBlargan, Laura A, Hechenblaickner, Manuel, Hoppe, Brian, Collins, Laura, Tomic, Milan T, Nonet, Genevieve H, Hackett, Kyal, Slaughter, James C, Lewis, Mark G, Andersen, Hanne, Cook, Anthony, Diamond, Michael S, Carnahan, Robert H, Barouch, Dan H, Crowe, Jr, James E

“…Human monoclonal antibody (mAb) treatments are promising for COVID-19 prevention or therapy. The pre-exposure prophylactic efficacy of neutralizing antibodies…”
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