Search Results - "COATE, Katie C"

Regulation of Hepatic Glucose Uptake and Storage In Vivo by Moore, Mary Courtney, Coate, Katie C., Winnick, Jason J., An, Zhibo, Cherrington, Alan D.

“…In the postprandial state, the liver takes up and stores glucose to minimize the fluctuation of glycemia. Elevated insulin concentrations, an increase in the…”
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Hyperaminoacidemia induces pancreatic α cell proliferation via synergism between the mTORC1 and CaSR-Gq signaling pathways by Gong, Yulong, Yang, Bingyuan, Zhang, Dingdong, Zhang, Yue, Tang, Zihan, Yang, Liu, Coate, Katie C., Yin, Linlin, Covington, Brittney A., Patel, Ravi S., Siv, Walter A., Sellick, Katelyn, Shou, Matthew, Chang, Wenhan, Danielle Dean, E., Powers, Alvin C., Chen, Wenbiao

“…Glucagon has emerged as a key regulator of extracellular amino acid (AA) homeostasis. Insufficient glucagon signaling results in hyperaminoacidemia, which…”
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Glucagon's effect on liver protein metabolism in vivo by Kraft, Guillaume, Coate, Katie C, Winnick, Jason J, Dardevet, Dominique, Donahue, E Patrick, Cherrington, Alan D, Williams, Phillip E, Moore, Mary Courtney

“…The postprandial state is characterized by a storage of nutrients in the liver, muscle, and adipose tissue for later utilization. In the case of a protein-rich…”
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Chronic overeating impairs hepatic glucose uptake and disposition by Coate, Katie C, Kraft, Guillaume, Shiota, Masakazu, Smith, Marta S, Farmer, Ben, Neal, Doss W, Williams, Phil, Cherrington, Alan D, Moore, Mary Courtney

“…Dogs consuming a hypercaloric high-fat and -fructose diet (52 and 17% of total energy, respectively) or a diet high in either fructose or fat for 4 wk…”
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Impact of hematopoietic cyclooxygenase-1 deficiency on obesity-linked adipose tissue inflammation and metabolic disorders in mice by Saraswathi, Viswanathan, Ramnanan, Christopher J, Wilks, Anson W, Desouza, Cyrus V, Eller, Amy A, Murali, Ganesan, Ramalingam, Ramesh, Milne, Ginger L, Coate, Katie C, Edgerton, Dale S

“…Abstract Objective Adipose tissue (AT)-specific inflammation is considered to mediate the pathological consequences of obesity and macrophages are known to…”
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Canine body composition quantification using 3 tesla fat-water MRI by Gifford, Aliya, Kullberg, Joel, Berglund, Johan, Malmberg, Filip, Coate, Katie C., Williams, Phillip E., Cherrington, Alan D., Avison, Malcolm J., Welch, E. Brian

“…Purpose To test the hypothesis that a whole‐body fat–water MRI (FWMRI) protocol acquired at 3 Tesla combined with semi‐automated image analysis techniques…”
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SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 Are Expressed in the Microvasculature and Ducts of Human Pancreas but Are Not Enriched in β Cells by Coate, Katie C., Cha, Jeeyeon, Shrestha, Shristi, Wang, Wenliang, Gonçalves, Luciana Mateus, Almaça, Joana, Kapp, Meghan E., Fasolino, Maria, Morgan, Ashleigh, Dai, Chunhua, Saunders, Diane C., Bottino, Rita, Aramandla, Radhika, Jenkins, Regina, Stein, Roland, Kaestner, Klaus H., Vahedi, Golnaz, Brissova, Marcela, Powers, Alvin C.

“…Isolated reports of new-onset diabetes in individuals with COVID-19 have led to the hypothesis that SARS-CoV-2 is directly cytotoxic to pancreatic islet β…”
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FGF21 Is an Exocrine Pancreas Secretagogue by Coate, Katie C., Hernandez, Genaro, Thorne, Curtis A., Sun, Shengyi, Le, Thao D.V., Vale, Kevin, Kliewer, Steven A., Mangelsdorf, David J.

“…The metabolic stress hormone FGF21 is highly expressed in exocrine pancreas, where its levels are increased by refeeding and chemically induced pancreatitis…”
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GP73 links SARS-CoV-2 infection with dysglycaemia by Coate, Katie C.

“…Severe COVID-19 is often associated with detrimental elevations in blood glucose, but the mechanisms are poorly understood. In this issue of Nature Metabolism…”
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Defining unique structural features in the MAFA and MAFB transcription factors that control insulin gene activity by Cha, Jeeyeon, Tong, Xin, Coate, Katie C., Guo, Min, Liu, Jin-hua, Reynolds, Garrett, Walker, Emily M., Stein, Richard A., Mchaourab, Hassane, Stein, Roland

“…MAFA and MAFB are related basic-leucine-zipper domain-containing transcription factors which have important overlapping and distinct regulatory roles in a…”
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Profound Sensitivity of the Liver to the Direct Effect of Insulin Allows Peripheral Insulin Delivery to Normalize Hepatic but Not Muscle Glucose Uptake in the Healthy Dog by Kraft, Guillaume, Coate, Katie C, Smith, Marta, Farmer, Ben, Scott, Melanie, Hastings, Jon, Cherrington, Alan D, Edgerton, Dale S

“…Endogenous insulin secretion is a key regulator of postprandial hepatic glucose metabolism, but this process is dysregulated in diabetes. Subcutaneous insulin…”
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Enhanced insulin sensitivity in skeletal muscle and liver by physiological overexpression of SIRT6 by Anderson, Jason G, Ramadori, Giorgio, Ioris, Rafael M, Galiè, Mirco, Berglund, Eric D, Coate, Katie C, Fujikawa, Teppei, Pucciarelli, Stefania, Moreschini, Benedetta, Amici, Augusto, Andreani, Cristina, Coppari, Roberto

“…Abstract Objective Available treatment for obesity and type 2 diabetes mellitus (T2DM) is suboptimal. Thus, identifying novel molecular target(s) exerting…”
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The Importance of the Mechanisms by Which Insulin Regulates Meal-Associated Liver Glucose Uptake in the Dog by Kraft, Guillaume, Coate, Katie C, Smith, Marta, Farmer, Ben, Scott, Melanie, Cherrington, Alan D, Edgerton, Dale S

“…Hepatic glucose uptake (HGU) is critical for maintaining normal postprandial glucose metabolism. Insulin is clearly a key regulator of HGU, but the physiologic…”
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1742-P: Loss of MAFB Compromises a-Cell Identity and Glucagon Secretion in Adult Human Islets by COATE, KATIE C., TONG, XIN, LIU, JIN-HUA, JENKINS, REGINA, ARAMANDLA, RADHIKA, DEY, NANDITA, KIM, SEUNG, BRISSOVA, MARCELA, POWERS, ALVIN C., STEIN, ROLAND

“…Islet-enriched transcription factors (TFs) are critical regulators of α and β cell development and function. One such TF, MAFB, exhibits a distinct expression…”
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Integration of metabolic flux with hepatic glucagon signaling and gene expression profiles in the conscious dog by Coate, Katie C, Ramnanan, Christopher J, Smith, Marta, Winnick, Jason J, Kraft, Guillaume, Irimia-Dominguez, Jose, Farmer, Ben, Donahue, E Patrick, Roach, Peter J, Cherrington, Alan D, Edgerton, Dale S

“…Glucagon rapidly and profoundly stimulates hepatic glucose production (HGP), but for reasons that are unclear, this effect normally wanes after a few hours,…”
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365-OR: Interruption of Glucagon Signaling Increases Delta-Cell Proliferation in Mouse and Human Islets by DAI, CHUNHUA, BRADLEY, AMBER, SPEARS, ERICK, SINGH, AJAY K., OLADIPUPO, FAVOUR O., JENKINS, REGINA, COATE, KATIE C., POWERS, ALVIN C.

“…The determinants of delta cell mass are not known. As part of studies showing interruption of glucagon signaling (IGS) stimulates alpha cell proliferation in…”
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1262-P: Circulating Lysophosphatidic Acid Levels Suggest a Metabolic Pathway in T3cDM and Distinguish It from T2DM by KETAVARAPU, VIJAYASARATHY, ASLAM, MOHSIN, TALUKDAR, RUPJYOTI, AMANCHY, RAMARS, SRIPADI, PRABHAKAR, POWERS, ALVIN C., VENKAT NARAYAN, K.M., COATE, KATIE C., STAIMEZ, LISA R., JAGANNATHAN, RAM, REDDY D, NAGESHWAR, SASIKALA, MITNALA

“…Introduction: Diabetes associated with chronic pancreatitis (T3cDM) has distinct clinical features. We investigated metabolomics signature to distinguish T3cDM…”
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1341-P: Dietary Fat and Fructose Impair Glucagon-Stimulated Liver Glucose Metabolism by EDGERTON, DALE S., KRAFT, GUILLAUME, COATE, KATIE C., FARMER, BEN, SMITH, MARTA S., SCOTT, MELANIE, HASTINGS, JON R., MOORE, MARY C., CHERRINGTON, ALAN D.

“…High fat and fructose diets (HFFD) disrupt glucose metabolism. The aim of this study was to determine the effect of HFFD on glucagon (GGN) effectiveness. Dogs…”
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260-LB: Elucidating the Role of NTPDase3 and Purinergic Signaling in Islet Hormone Secretion by RICHARDSON, TIFFANY M., DAI, CHUNHUA, ARAMANDLA, RADHIKA, DURAI, HEATHER H., REIHSMANN, CONRAD, DAVIS, COREY, MEI, SHAOJUN, GIBSON, DANNIELLE, SHRESTHA, SHRISTI, SAUNDERS, DIANE C., COATE, KATIE C., ROBSON, SIMON C., POWERS, ALVIN C., BRISSOVA, MARCELA

“…ATP release from β cell secretory vesicles during insulin exocytosis is postulated to modulate islet hormone secretion via purinergic signaling in an autocrine…”
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Morning Hyperinsulinemia Primes the Liver for Glucose Uptake and Glycogen Storage Later in the Day by Moore, Mary Courtney, Smith, Marta S, Farmer, Ben, Coate, Katie C, Kraft, Guillaume, Shiota, Masakazu, Williams, Phillip E, Cherrington, Alan D

“…We observed that a 4-h morning (AM) duodenal infusion of glucose versus saline doubled hepatic glucose uptake (HGU) and storage during a…”
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