Search Results - "CNS neuroscience & therapeutics"

Peripheral inflammation and blood–brain barrier disruption: effects and mechanisms by Huang, Xiaowen, Hussain, Basharat, Chang, Junlei

“…The blood–brain barrier (BBB) is an important physiological barrier that separates the central nervous system (CNS) from the peripheral circulation, which…”
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Zinc attenuates ferroptosis and promotes functional recovery in contusion spinal cord injury by activating Nrf2/GPX4 defense pathway by Ge, Ming‐hao, Tian, He, Mao, Liang, Li, Dao‐yong, Lin, Jia‐quan, Hu, Heng‐shuo, Huang, Shuo‐cheng, Zhang, Chuan‐jie, Mei, Xi‐fan

“…Aim Spinal cord injury (SCI) involves multiple pathological processes. Ferroptosis has been shown to play a critical role in the injury process. We wanted to…”
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Neurological manifestations in COVID‐19 caused by SARS‐CoV‐2 by Baig, Abdul Mannan

“…The possible entry of SARS‐CoV‐2 to reach the brain via cribriform plate (B) or after systemic circulatory dissemination following infection of the lung (C),…”
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Baicalin mitigates cognitive impairment and protects neurons from microglia‐mediated neuroinflammation via suppressing NLRP3 inflammasomes and TLR4/NF‐κB signaling pathway by Jin, Xin, Liu, Ming‐Yan, Zhang, Dong‐Fang, Zhong, Xin, Du, Ke, Qian, Ping, Yao, Wei‐Fan, Gao, Hua, Wei, Min‐Jie

“…Summary Aims Baicalin (BAI), a flavonoid compound isolated from the root of Scutellaria baicalensis Georgi, has been established to have potent…”
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B Vitamins in the nervous system: Current knowledge of the biochemical modes of action and synergies of thiamine, pyridoxine, and cobalamin by Calderón‐Ospina, Carlos Alberto, Nava‐Mesa, Mauricio Orlando

“…Background Neurotropic B vitamins play crucial roles as coenzymes and beyond in the nervous system. Particularly vitamin B1 (thiamine), B6 (pyridoxine), and…”
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Inhibition of ferroptosis attenuates tissue damage and improves long‐term outcomes after traumatic brain injury in mice by Xie, Bao‐Shu, Wang, Yi‐Qin, Lin, Yong, Mao, Qing, Feng, Jun‐Feng, Gao, Guo‐Yi, Jiang, Ji‐Yao

“…Summary Aims Ferroptosis, a new form of iron‐dependent programmed cell death, has been shown to be involved in a range of diseases. However, the role of…”
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Brain structure alterations in depression: Psychoradiological evidence by Zhang, Fei‐Fei, Peng, Wei, Sweeney, John A., Jia, Zhi‐Yun, Gong, Qi‐Yong

“…Summary Depression is the leading cause of disability around the world, but little is known about its pathology. Currently, the diagnosis of depression is made…”
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Astrocyte morphology: Diversity, plasticity, and role in neurological diseases by Zhou, Bin, Zuo, Yun‐Xia, Jiang, Ruo‐Tian

“…Summary Astrocytes are the most abundant glial cells in the central nervous system (CNS) and participate in synaptic, circuit, and behavioral functions. The…”
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Mitochondrial dysfunction in neurodegenerative diseases and the potential countermeasure by Wang, Yan, Xu, Erin, Musich, Phillip R., Lin, Fang

“…Summary Mitochondria not only supply the energy for cell function, but also take part in cell signaling. This review describes the dysfunctions of mitochondria…”
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Mitochondrial Dysfunction and Biogenesis in Neurodegenerative diseases: Pathogenesis and Treatment by Golpich, Mojtaba, Amini, Elham, Mohamed, Zahurin, Azman Ali, Raymond, Mohamed Ibrahim, Norlinah, Ahmadiani, Abolhassan

“…Summary Neurodegenerative diseases are a heterogeneous group of disorders that are incurable and characterized by the progressive degeneration of the function…”
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Machine learning in major depression: From classification to treatment outcome prediction by Gao, Shuang, Calhoun, Vince D., Sui, Jing

“…Aims Major depression disorder (MDD) is the single greatest cause of disability and morbidity, and affects about 10% of the population worldwide. Currently,…”
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A brain network model for depression: From symptom understanding to disease intervention by Li, Bao‐Juan, Friston, Karl, Mody, Maria, Wang, Hua‐Ning, Lu, Hong‐Bing, Hu, De‐Wen

“…Understanding the neural substrates of depression is crucial for diagnosis and treatment. Here, we review recent studies of functional and effective…”
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Mechanisms and roles of mitophagy in neurodegenerative diseases by Wang, Yan, Liu, Na, Lu, Bingwei

“…Mitochondria are double‐membrane‐encircled organelles existing in most eukaryotic cells and playing important roles in energy production, metabolism, Ca2+…”
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Microglial/Macrophage polarization and function in brain injury and repair after stroke by Lyu, Junxuan, Xie, Di, Bhatia, Tarun N., Leak, Rehana K., Hu, Xiaoming, Jiang, Xiaoyan

“…Stroke is a leading cause of disability and mortality, with limited treatment options. After stroke injury, microglia and CNS‐resident macrophages are rapidly…”
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Melatonin protects against ischemic stroke by modulating microglia/macrophage polarization toward anti‐inflammatory phenotype through STAT3 pathway by Liu, Zong‐Jian, Ran, Yuan‐Yuan, Qie, Shu‐Yan, Gong, Wei‐Jun, Gao, Fu‐Hai, Ding, Zi‐Tong, Xi, Jia‐Ning

“…Aims Microglia and infiltrated macrophages play important roles in inflammatory processes after ischemic stroke. Modulating microglia/macrophage polarization…”
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Perioperative neurocognitive disorders: A narrative review focusing on diagnosis, prevention, and treatment by Kong, Hao, Xu, Long‐Ming, Wang, Dong‐Xin

“…Perioperative neurocognitive disorders (NCDs) refer to neurocognitive abnormalities detected during the perioperative periods, including preexisting cognitive…”
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Neurovascular Unit: A critical role in ischemic stroke by Wang, Liyun, Xiong, Xiaoxing, Zhang, Luyuan, Shen, Jian

“…Ischemic stroke (IS), a common cerebrovascular disease, results from a sudden blockage of a blood vessel in the brain, thereby restricting blood supply to the…”
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Ferroptosis‐related gene signature predicts prognosis and immunotherapy in glioma by Wan, Rong‐Jun, Peng, Wang, Xia, Qin‐Xuan, Zhou, Hong‐Hao, Mao, Xiao‐Yuan

“…Aims Glioma is a highly invasive brain tumor, which makes prognosis challenging and renders patients resistant to various treatments. Induction of cell death…”
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Melatonin Stimulates the SIRT1/Nrf2 Signaling Pathway Counteracting Lipopolysaccharide (LPS)‐Induced Oxidative Stress to Rescue Postnatal Rat Brain by Shah, Shahid Ali, Khan, Mehtab, Jo, Myeung‐Hoon, Jo, Min Gi, Amin, Faiz Ul, Kim, Myeong Ok

“…Summary Aims Lipopolysaccharide (LPS) induces oxidative stress and neuroinflammation both in vivo and in vitro. Here, we provided the first detailed…”
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Research progress on adenosine in central nervous system diseases by Liu, Ying‐Jiao, Chen, Jiao, Li, Xun, Zhou, Xin, Hu, Yao‐Mei, Chu, Shi‐Feng, Peng, Ye, Chen, Nai‐Hong

“…As an endogenous neuroprotectant agent, adenosine is extensively distributed and is particularly abundant in the central nervous system (CNS). Under…”
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