Search Results - "CLUBB, Robert T"

Sortase enzymes in Gram‐positive bacteria by Spirig, Thomas, Weiner, Ethan M., Clubb, Robert T.

“…Summary In Gram‐positive bacteria proteins are displayed on the cell surface using sortase enzymes. These cysteine transpeptidases join proteins bearing an…”
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Trichomonas vaginalis homolog of macrophage migration inhibitory factor induces prostate cell growth, invasiveness, and inflammatory responses by Twu, Olivia, Dessí, Daniele, Vu, Anh, Mercer, Frances, Stevens, Grant C., de Miguel, Natalia, Rappelli, Paola, Cocco, Anna Rita, Clubb, Robert T., Fiori, Pier Luigi, Johnson, Patricia J.

“…The human-infective parasite Trichomonas vaginalis causes the most prevalent nonviral sexually transmitted infection worldwide. Infections in men may result in…”
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NEAr Transporter (NEAT) Domains: Unique Surface Displayed Heme Chaperones That Enable Gram-Positive Bacteria to Capture Heme-Iron From Hemoglobin by Ellis-Guardiola, Ken, Mahoney, Brendan J, Clubb, Robert T

“…Iron is an important micronutrient that is required by bacteria to proliferate and to cause disease. Many bacterial pathogens forage iron from human hemoglobin…”
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Human COQ10A and COQ10B are distinct lipid-binding START domain proteins required for coenzyme Q function[S] by Tsui, Hui S., Pham, NguyenV.B., Amer, Brendan R., Bradley, Michelle C., Gosschalk, Jason E., Gallagher-Jones, Marcus, Ibarra, Hope, Clubb, Robert T., Blaby-Haas, Crysten E., Clarke, Catherine F.

“…Coenzyme Q (CoQ or ubiquinone) serves as an essential redox-active lipid in respiratory electron and proton transport during cellular energy metabolism. CoQ…”
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The Structure of the Staphylococcus aureus Sortase-Substrate Complex Reveals How the Universally Conserved LPXTG Sorting Signal Is Recognized by Suree, Nuttee, Liew, Chu Kong, Villareal, Valerie A., Thieu, William, Fadeev, Evgeny A., Clemens, Jeremy J., Jung, Michael E., Clubb, Robert T.

“…In Gram-positive bacteria, sortase enzymes assemble surface proteins and pili in the cell wall envelope. Sortases catalyze a transpeptidation reaction that…”
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A genomic analysis reveals the diversity of cellulosome displaying bacteria by Minor, Christine M., Takayesu, Allen, Ha, Sung Min, Salwinski, Lukasz, Sawaya, Michael R., Pellegrini, Matteo, Clubb, Robert T.

“…Introduction Several species of cellulolytic bacteria display cellulosomes, massive multi-cellulase containing complexes that degrade lignocellulosic plant…”
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The Streptococcus pyogenes Shr protein captures human hemoglobin using two structurally unique binding domains by Macdonald, Ramsay, Cascio, Duilio, Collazo, Michael J., Phillips, Martin, Clubb, Robert T.

“…In order to proliferate and mount an infection, many bacterial pathogens need to acquire iron from their host. The most abundant iron source in the body is the…”
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Energetics underlying hemin extraction from human hemoglobin by Staphylococcus aureus by Sjodt, Megan, Macdonald, Ramsay, Marshall, Joanna D., Clayton, Joseph, Olson, John S., Phillips, Martin, Gell, David A., Wereszczynski, Jeff, Clubb, Robert T.

“…Staphylococcus aureus is a leading cause of life-threatening infections in the United States. It actively acquires the essential nutrient iron from human…”
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Structure and mechanism of TagA, a novel membrane-associated glycosyltransferase that produces wall teichoic acids in pathogenic bacteria by Kattke, Michele D, Gosschalk, Jason E, Martinez, Orlando E, Kumar, Garima, Gale, Robert T, Cascio, Duilio, Sawaya, Michael R, Philips, Martin, Brown, Eric D, Clubb, Robert T

“…Staphylococcus aureus and other bacterial pathogens affix wall teichoic acids (WTAs) to their surface. These highly abundant anionic glycopolymers have…”
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A Cell-based Screen in Actinomyces oris to Identify Sortase Inhibitors by Gosschalk, Jason E., Chang, Chungyu, Sue, Christopher K., Siegel, Sara D., Wu, Chenggang, Kattke, Michele D., Yi, Sung Wook, Damoiseaux, Robert, Jung, Michael E., Ton-That, Hung, Clubb, Robert T.

“…Sortase enzymes are attractive antivirulence drug targets that attach virulence factors to the surface of Staphylococcus aureus and other medically significant…”
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Native Top-down Mass Spectrometry for the Structural Characterization of Human Hemoglobin by Zhang, Jiang, Malmirchegini, G. Reza, Clubb, Robert T., Loo, Joseph A.

“…Native mass spectrometry (MS) has become an invaluable tool for the characterization of proteins and noncovalent protein complexes under near physiological…”
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Structure and Mechanism of LcpA, a Phosphotransferase That Mediates Glycosylation of a Gram-Positive Bacterial Cell Wall-Anchored Protein by Siegel, Sara D, Amer, Brendan R, Wu, Chenggang, Sawaya, Michael R, Gosschalk, Jason E, Clubb, Robert T, Ton-That, Hung

“…The widely conserved LytR-CpsA-Psr (LCP) family of enzymes in Gram-positive bacteria is known to attach glycopolymers, including wall teichoic acid, to the…”
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A Comparative Genome Analysis Identifies Distinct Sorting Pathways in Gram-Positive Bacteria by COMFORT, David, CLUBB, Robert T

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Interaction between Reverse Transcriptase and Integrase Is Required for Reverse Transcription during HIV-1 Replication by Tekeste, Shewit S, Wilkinson, Thomas A, Weiner, Ethan M, Xu, Xiaowen, Miller, Jennifer T, Le Grice, Stuart F J, Clubb, Robert T, Chow, Samson A

“…Human immunodeficiency virus type 1 (HIV-1) replication requires reverse transcription of its RNA genome into a double-stranded cDNA copy, which is then…”
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Crystal Structure of the Streptomyces coelicolor Sortase E1 Transpeptidase Provides Insight into the Binding Mode of the Novel Class E Sorting Signal by Kattke, Michele D, Chan, Albert H, Duong, Andrew, Sexton, Danielle L, Sawaya, Michael R, Cascio, Duilio, Elliot, Marie A, Clubb, Robert T

“…Many species of Gram-positive bacteria use sortase transpeptidases to covalently affix proteins to their cell wall or to assemble pili. Sortase-displayed…”
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Structure of the Hemoglobin-IsdH Complex Reveals the Molecular Basis of Iron Capture by Staphylococcus aureus by Dickson, Claire F., Kumar, Kaavya Krishna, Jacques, David A., Malmirchegini, G. Reza, Spirig, Thomas, Mackay, Joel P., Clubb, Robert T., Guss, J. Mitchell, Gell, David A.

“…Staphylococcus aureus causes life-threatening disease in humans. The S. aureus surface protein iron-regulated surface determinant H (IsdH) binds to mammalian…”
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Structural and Computational Studies of the Staphylococcus aureus Sortase B-Substrate Complex Reveal a Substrate-stabilized Oxyanion Hole by Jacobitz, Alex W., Wereszczynski, Jeff, Yi, Sung Wook, Amer, Brendan R., Huang, Grace L., Nguyen, Angelyn V., Sawaya, Michael R., Jung, Michael E., McCammon, J.Andrew, Clubb, Robert T.

“…Sortase cysteine transpeptidases covalently attach proteins to the bacterial cell wall or assemble fiber-like pili that promote bacterial adhesion. Members of…”
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Novel Mechanism of Hemin Capture by Hbp2, the Hemoglobin-binding Hemophore from Listeria monocytogenes by Malmirchegini, G. Reza, Sjodt, Megan, Shnitkind, Sergey, Sawaya, Michael R., Rosinski, Justin, Newton, Salete M., Klebba, Phillip E., Clubb, Robert T.

“…Iron is an essential nutrient that is required for the growth of the bacterial pathogen Listeria monocytogenes. In cell cultures, this microbe secretes…”
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Functionally Distinct NEAT (NEAr Transporter) Domains within the Staphylococcus aureus IsdH/HarA Protein Extract Heme from Methemoglobin by Pilpa, Rosemarie M., Robson, Scott A., Villareal, Valerie A., Wong, Melissa L., Phillips, Martin, Clubb, Robert T.

“…The pathogen Staphylococcus aureus uses iron-regulated surface determinant (Isd) proteins to scavenge the essential nutrient iron from host hemoproteins. The…”
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Identification of agents effective against multiple toxins and viruses by host-oriented cell targeting by Zilbermintz, Leeor, Leonardi, William, Jeong, Sun-Young, Sjodt, Megan, McComb, Ryan, Ho, Chi-Lee C., Retterer, Cary, Gharaibeh, Dima, Zamani, Rouzbeh, Soloveva, Veronica, Bavari, Sina, Levitin, Anastasia, West, Joel, Bradley, Kenneth A., Clubb, Robert T., Cohen, Stanley N., Gupta, Vivek, Martchenko, Mikhail

“…A longstanding and still-increasing threat to the effective treatment of infectious diseases is resistance to antimicrobial countermeasures. Potentially, the…”
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