Search Results - "CLOUSTON, ANDREW D"

Links Between Hepatic Fibrosis, Ductular Reaction, and Progenitor Cell Expansion by Williams, Michael J, Clouston, Andrew D, Forbes, Stuart J

“…Interactions between cells and their extracellular matrix have been shown to be crucial in a wide range of biological processes, including the proliferation…”
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The portal inflammatory infiltrate and ductular reaction in human nonalcoholic fatty liver disease by Gadd, Victoria L., Skoien, Richard, Powell, Elizabeth E., Fagan, Kevin J., Winterford, Clay, Horsfall, Leigh, Irvine, Katharine, Clouston, Andrew D.

“…Although nonalcoholic fatty liver disease (NAFLD) is conventionally assessed histologically for lobular features of inflammation, development of portal…”
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MHC Class II Antigen Presentation by the Intestinal Epithelium Initiates Graft-versus-Host Disease and Is Influenced by the Microbiota by Koyama, Motoko, Mukhopadhyay, Pamela, Schuster, Iona S., Henden, Andrea S., Hülsdünker, Jan, Varelias, Antiopi, Vetizou, Marie, Kuns, Rachel D., Robb, Renee J., Zhang, Ping, Blazar, Bruce R., Thomas, Ranjeny, Begun, Jakob, Waddell, Nicola, Trinchieri, Giorgio, Zeiser, Robert, Clouston, Andrew D., Degli-Esposti, Mariapia A., Hill, Geoffrey R.

“…Graft-versus-host disease (GVHD) in the gastrointestinal (GI) tract is the principal determinant of lethality following allogeneic bone marrow transplantation…”
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Complexity of ballooned hepatocyte feature recognition: Defining a training atlas for artificial intelligence-based imaging in NAFLD by Brunt, Elizabeth M., Clouston, Andrew D., Goodman, Zachary, Guy, Cynthia, Kleiner, David E., Lackner, Carolin, Tiniakos, Dina G., Wee, Aileen, Yeh, Matthew, Leow, Wei Qiang, Chng, Elaine, Ren, Yayun, Boon Bee, George Goh, Powell, Elizabeth E., Rinella, Mary, Sanyal, Arun J., Neuschwander-Tetri, Brent, Younossi, Zobair, Charlton, Michael, Ratziu, Vlad, Harrison, Stephen A., Tai, Dean, Anstee, Quentin M.

“…Histologically assessed hepatocyte ballooning is a key feature discriminating non-alcoholic steatohepatitis (NASH) from steatosis (NAFL). Reliable…”
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Ductular reactions in human liver: Diversity at the interface by Gouw, Annette S. H., Clouston, Andrew D., Theise, Neil D.

“…Interest in hepatic ductular reactions (DRs) has risen in recent years because of a greater appreciation of their potential roles in regeneration,…”
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A clinicopathological and molecular analysis of 200 traditional serrated adenomas by Bettington, Mark L, Walker, Neal I, Rosty, Christophe, Brown, Ian S, Clouston, Andrew D, McKeone, Diane M, Pearson, Sally-Ann, Klein, Kerenaftali, Leggett, Barbara A, Whitehall, Vicki LJ

“…The traditional serrated adenoma is the least common colorectal serrated polyp. The clinicopathological features and molecular drivers of these polyps require…”
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IL-6 dysregulation originates in dendritic cells and mediates graft-versus-host disease via classical signaling by Wilkinson, Andrew N., Chang, Karshing, Kuns, Rachel D., Henden, Andrea S., Minnie, Simone A., Ensbey, Kathleen S., Clouston, Andrew D., Zhang, Ping, Koyama, Motoko, Hidalgo, Juan, Rose-John, Stefan, Varelias, Antiopi, Vuckovic, Slavica, Gartlan, Kate H., Hill, Geoffrey R.

“…Graft-versus-host disease (GVHD) after allogeneic stem cell transplantation (alloSCT) is characterized by interleukin-6 (IL-6) dysregulation. IL-6 can mediate…”
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Steatosis: co-factor in other liver diseases by Powell, Elizabeth E, Jonsson, Julie R, Clouston, Andrew D

“…The prevalence of fatty liver is rising in association with the global increase in obesity and type 2 diabetes. In the past, simple steatosis was regarded as…”
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Acute graft-versus-host disease is regulated by an IL-17–sensitive microbiome by Varelias, Antiopi, Ormerod, Kate L., Bunting, Mark D., Koyama, Motoko, Gartlan, Kate H., Kuns, Rachel D., Lachner, Nancy, Locke, Kelly R., Lim, Chun Y., Henden, Andrea S., Zhang, Ping, Clouston, Andrew D., Hasnain, Sumaira Z., McGuckin, Michael A., Blazar, Bruce R., MacDonald, Kelli P.A., Hugenholtz, Philip, Hill, Geoffrey R.

“…Donor T-cell–derived interleukin-17A (IL-17A) can mediate late immunopathology in graft-versus-host disease (GVHD), however protective roles remain unclear…”
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Ductular reaction in hereditary hemochromatosis: The link between hepatocyte senescence and fibrosis progression by Wood, Marnie J., Gadd, Victoria L., Powell, Lawrie W., Ramm, Grant A., Clouston, Andrew D.

“…The development of portal fibrosis following the iron loading of hepatocytes is the first stage of fibrogenesis in hereditary hemochromatosis. In other chronic…”
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Lung parenchyma-derived IL-6 promotes IL-17A–dependent acute lung injury after allogeneic stem cell transplantation by Varelias, Antiopi, Gartlan, Kate H., Kreijveld, Ellen, Olver, Stuart D., Lor, Mary, Kuns, Rachel D., Lineburg, Katie E., Teal, Bianca E., Raffelt, Neil C., Cheong, Melody, Alexander, Kylie A., Koyama, Motoko, Markey, Kate A., Sturgeon, Elise, Leach, Justine, Reddy, Pavan, Kennedy, Glen A., Yanik, Gregory A., Blazar, Bruce R., Tey, Siok-Keen, Clouston, Andrew D., MacDonald, Kelli P.A., Cooke, Kenneth R., Hill, Geoffrey R.

“…Idiopathic pneumonia syndrome (IPS) is a relatively common, frequently fatal clinical entity, characterized by noninfectious acute lung inflammation following…”
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Magnetic resonance imaging and spectroscopy accurately estimate the severity of steatosis provided the stage of fibrosis is considered by McPherson, Stuart, Jonsson, Julie R, Cowin, Gary J, O’Rourke, Peter, Clouston, Andrew D, Volp, Andrew, Horsfall, Leigh, Jothimani, Dinesh, Fawcett, Jonathan, Galloway, Graham J, Benson, Mark, Powell, Elizabeth E

“…Background/Aims Currently the diagnosis and severity of hepatic steatosis can be established accurately only by liver biopsy. Previous small studies found that…”
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Multiplex Serum Protein Analysis Identifies Novel Biomarkers of Advanced Fibrosis in Patients with Chronic Liver Disease with the Potential to Improve Diagnostic Accuracy of Established Biomarkers by Irvine, Katharine M, Wockner, Leesa F, Hoffmann, Isabell, Horsfall, Leigh U, Fagan, Kevin J, Bijin, Veonice, Lee, Bernett, Clouston, Andrew D, Lampe, Guy, Connolly, John E, Powell, Elizabeth E

“…Non-invasive markers of liver fibrosis are urgently required, especially for use in non-specialist settings. The aim of this study was to identify novel serum…”
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Magnetic resonance imaging and spectroscopy for monitoring liver steatosis by Cowin, Gary J., Jonsson, Julie R., Bauer, Judith D., Ash, Susan, Ali, Azmat, Osland, Emma J., Purdie, David M., Clouston, Andrew D., Powell, Elizabeth E., Galloway, Graham J.

“…Purpose To compare noninvasive MRI and magnetic resonance spectroscopy (MRS) methods with liver biopsy to quantify liver fat content. Materials and Methods…”
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Therapeutic potential of macrophage colony-stimulating factor in chronic liver disease by Keshvari, Sahar, Genz, Berit, Teakle, Ngari, Caruso, Melanie, Cestari, Michelle F, Patkar, Omkar L, Tse, Brian W C, Sokolowski, Kamil A, Ebersbach, Hilmar, Jascur, Julia, MacDonald, Kelli P A, Miller, Gregory, Ramm, Grant A, Pettit, Allison R, Clouston, Andrew D, Powell, Elizabeth E, Hume, David A, Irvine, Katharine M

“…Resident and recruited macrophages control the development and proliferation of the liver. We have previously shown in multiple species that treatment with a…”
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Interleukin‐32: A new proinflammatory cytokine involved in hepatitis C virus‐related liver inflammation and fibrosis by Moschen, Alexander R., Fritz, Teresa, Clouston, Andrew D., Rebhan, Ilka, Bauhofer, Oliver, Barrie, Helen D., Powell, Elizabeth E., Kim, Soo‐Hyun, Dinarello, Charles A., Bartenschlager, Ralf, Jonsson, Julie R., Tilg, Herbert

“…Interleukin 32 (IL‐32) is a recently described proinflammatory cytokine that activates p38 mitogen‐activated protein kinase (MAPK) and nuclear factor kappa B…”
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Pathologic Features of Hereditary Cholestatic Diseases by Clouston, Andrew D., MBBS, PhD, FRCPA

“…Abstract The inherited diseases causing conjugated hyperbilirubinemia are diverse, with variability in clinical severity, histologic appearance, and time of…”
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Type I-IFNs control GVHD and GVL responses after transplantation by Robb, Renee J., Kreijveld, Ellen, Kuns, Rachel D., Wilson, Yana A., Olver, Stuart D., Don, Alistair L.J., Raffelt, Neil C., De Weerd, Nicole A., Lineburg, Katie E., Varelias, Antiopi, Markey, Kate A., Koyama, Motoko, Clouston, Andrew D., Hertzog, Paul J., MacDonald, Kelli P.A., Hill, Geoffrey R.

“…Although the effects of type II-IFN (IFN-γ) on GVHD and leukemia relapse are well studied, the effects of type I-interferon (type I-IFN, IFN-α/β) remain…”
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Obesity and steatosis influence serum and hepatic inflammatory markers in chronic hepatitis C by Jonsson, Julie R., Barrie, Helen D., O'Rourke, Peter, Clouston, Andrew D., Powell, Elizabeth E.

“…Obesity and fatty liver are commonly observed among patients with chronic hepatitis C virus (HCV) and are risk factors for increased hepatic fibrosis. Obesity…”
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Promoting regulation via the inhibition of DNAM-1 after transplantation by Koyama, Motoko, Kuns, Rachel D., Olver, Stuart D., Lineburg, Katie E., Lor, Mary, Teal, Bianca E., Raffelt, Neil C., Leveque, Lucie, Chan, Christopher J., Robb, Renee J., Markey, Kate A., Alexander, Kylie A., Varelias, Antiopi, Clouston, Andrew D., Smyth, Mark J., MacDonald, Kelli P.A., Hill, Geoffrey R.

“…Donor T cells play pivotal roles in graft-versus-host disease (GVHD) and graft-versus-leukemia (GVL) effects following bone marrow transplantation (BMT). DNAX…”
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