Search Results - "CLOUGHESY, Timothy F"

Adult Glioblastoma by Alexander, Brian M, Cloughesy, Timothy F

“…Glioblastoma (GBM) is a rare tumor and one of the most challenging malignancies to treat in all of oncology. Although advances have been made in the treatment…”
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Modified Criteria for Radiographic Response Assessment in Glioblastoma Clinical Trials by Ellingson, Benjamin M., Wen, Patrick Y., Cloughesy, Timothy F.

“…Radiographic endpoints including response and progression are important for the evaluation of new glioblastoma therapies. The current RANO criteria was…”
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Glioblastoma: from molecular pathology to targeted treatment by Cloughesy, Timothy F, Cavenee, Webster K, Mischel, Paul S

“…Glioblastoma (GBM) is one of the most lethal human cancers. Genomic analyses are defining the molecular architecture of GBM, uncovering relevant subsets of…”
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Ivosidenib in Isocitrate Dehydrogenase 1 - Mutated Advanced Glioma by Mellinghoff, Ingo K, Ellingson, Benjamin M, Touat, Mehdi, Maher, Elizabeth, De La Fuente, Macarena I, Holdhoff, Matthias, Cote, Gregory M, Burris, Howard, Janku, Filip, Young, Robert J, Huang, Raymond, Jiang, Liewen, Choe, Sung, Fan, Bin, Yen, Katharine, Lu, Min, Bowden, Chris, Steelman, Lori, Pandya, Shuchi S, Cloughesy, Timothy F, Wen, Patrick Y

“…Diffuse gliomas are malignant brain tumors that include lower-grade gliomas (LGGs) and glioblastomas. Transformation of low-grade glioma into a higher tumor…”
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mTOR Complex 2 Controls Glycolytic Metabolism in Glioblastoma through FoxO Acetylation and Upregulation of c-Myc by Masui, Kenta, Tanaka, Kazuhiro, Akhavan, David, Babic, Ivan, Gini, Beatrice, Matsutani, Tomoo, Iwanami, Akio, Liu, Feng, Villa, Genaro R., Gu, Yuchao, Campos, Carl, Zhu, Shaojun, Yang, Huijun, Yong, William H., Cloughesy, Timothy F., Mellinghoff, Ingo K., Cavenee, Webster K., Shaw, Reuben J., Mischel, Paul S.

“…Aerobic glycolysis (the Warburg effect) is a core hallmark of cancer, but the molecular mechanisms underlying it remain unclear. Here, we identify an…”
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Vorasidenib, a Dual Inhibitor of Mutant IDH1/2, in Recurrent or Progressive Glioma; Results of a First-in-Human Phase I Trial by Mellinghoff, Ingo K, Penas-Prado, Marta, Peters, Katherine B, Burris, 3rd, Howard A, Maher, Elizabeth A, Janku, Filip, Cote, Gregory M, de la Fuente, Macarena I, Clarke, Jennifer L, Ellingson, Benjamin M, Chun, Saewon, Young, Robert J, Liu, Hua, Choe, Sung, Lu, Min, Le, Kha, Hassan, Islam, Steelman, Lori, Pandya, Shuchi S, Cloughesy, Timothy F, Wen, Patrick Y

“…Lower grade gliomas (LGGs) are malignant brain tumors. Current therapy is associated with short- and long-term toxicity. Progression to higher tumor grade is…”
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Design and Evaluation of an External Control Arm Using Prior Clinical Trials and Real-World Data by Ventz, Steffen, Lai, Albert, Cloughesy, Timothy F, Wen, Patrick Y, Trippa, Lorenzo, Alexander, Brian M

“…We discuss designs and interpretable metrics of bias and statistical efficiency of "externally controlled" trials (ECT) and compare ECT performance to…”
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Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling by Bi, Junfeng, Ichu, Taka-Aki, Zanca, Ciro, Yang, Huijun, Zhang, Wei, Gu, Yuchao, Chowdhry, Sudhir, Reed, Alex, Ikegami, Shiro, Turner, Kristen M., Zhang, Wenjing, Villa, Genaro R., Wu, Sihan, Quehenberger, Oswald, Yong, William H., Kornblum, Harley I., Rich, Jeremy N., Cloughesy, Timothy F., Cavenee, Webster K., Furnari, Frank B., Cravatt, Benjamin F., Mischel, Paul S.

“…Advances in DNA sequencing technologies have reshaped our understanding of the molecular basis of cancer, providing a precise genomic view of tumors…”
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Orally administered colony stimulating factor 1 receptor inhibitor PLX3397 in recurrent glioblastoma: an Ivy Foundation Early Phase Clinical Trials Consortium phase II study by Butowski, Nicholas, Colman, Howard, De Groot, John F, Omuro, Antonio M, Nayak, Lakshmi, Wen, Patrick Y, Cloughesy, Timothy F, Marimuthu, Adhirai, Haidar, Sam, Perry, Arie, Huse, Jason, Phillips, Joanna, West, Brian L, Nolop, Keith B, Hsu, Henry H, Ligon, Keith L, Molinaro, Annette M, Prados, Michael

“…The colony stimulating factor 1 receptor (CSF1R) ligands, CSF1 and interleukin-34, and the KIT ligand, stem cell factor, are expressed in glioblastoma (GB)…”
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mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT by Gu, Yuchao, Albuquerque, Claudio P., Braas, Daniel, Zhang, Wei, Villa, Genaro R., Bi, Junfeng, Ikegami, Shiro, Masui, Kenta, Gini, Beatrice, Yang, Huijun, Gahman, Timothy C., Shiau, Andrew K., Cloughesy, Timothy F., Christofk, Heather R., Zhou, Huilin, Guan, Kun-Liang, Mischel, Paul S.

“…Mutations in cancer reprogram amino acid metabolism to drive tumor growth, but the molecular mechanisms are not well understood. Using an unbiased proteomic…”
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Targeted Therapy Resistance Mediated by Dynamic Regulation of Extrachromosomal Mutant EGFR DNA by Nathanson, David A., Gini, Beatrice, Mottahedeh, Jack, Visnyei, Koppany, Koga, Tomoyuki, Gomez, German, Estin, Ascia, Hwang, Kiwook, Wang, Jun, Masui, Kenta, Paucar, Andres, Yang, Huijun, Ohashi, Minori, Zhu, Shaojun, Wykosky, Jill, Reed, Rachel, Nelson, Stanley F., Cloughesy, Timothy F., James, C. David, Rao, P. Nagesh, Kornblum, Harley I., Heath, James R., Cavenee, Webster K., Furnari, Frank B., Mischel, Paul S.

“…Intratumoral heterogeneity contributes to cancer drug resistance, but the underlying mechanisms are not understood. Single-cell analyses of patient-derived…”
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EGFR Mutation Promotes Glioblastoma through Epigenome and Transcription Factor Network Remodeling by Liu, Feng, Hon, Gary C., Villa, Genaro R., Turner, Kristen M., Ikegami, Shiro, Yang, Huijun, Ye, Zhen, Li, Bin, Kuan, Samantha, Lee, Ah Young, Zanca, Ciro, Wei, Bowen, Lucey, Greg, Jenkins, David, Zhang, Wei, Barr, Cathy L., Furnari, Frank B., Cloughesy, Timothy F., Yong, William H., Gahman, Timothy C., Shiau, Andrew K., Cavenee, Webster K., Ren, Bing, Mischel, Paul S.

“…Epidermal growth factor receptor (EGFR) gene amplification and mutations are the most common oncogenic events in glioblastoma (GBM), but the mechanisms by…”
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Updated Response Assessment Criteria for High-Grade Gliomas: Response Assessment in Neuro-Oncology Working Group by WEN, Patrick Y, MACDONALD, David R, TSIEN, Christina, MIKKELSEN, Tom, WONG, Eric T, CHAMBERLAIN, Marc C, STUPP, Roger, LAMBORN, Kathleen R, VOGELBAUM, Michael A, VAN DEN BENT, Martin J, CHANG, Susan M, REARDON, David A, CLOUGHESY, Timothy F, SORENSEN, A. Gregory, GALANIS, Evanthia, DEGROOT, John, WICK, Wolfgang, GILBERT, Mark R, LASSMAN, Andrew B

“…Currently, the most widely used criteria for assessing response to therapy in high-grade gliomas are based on two-dimensional tumor measurements on computed…”
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The procurement, storage, and quality assurance of frozen blood and tissue biospecimens in pathology, biorepository, and biobank settings by Shabihkhani, Maryam, Lucey, Gregory M., Wei, Bowen, Mareninov, Sergey, Lou, Jerry J., Vinters, Harry V., Singer, Elyse J., Cloughesy, Timothy F., Yong, William H.

“…Well preserved frozen biospecimens are ideal for evaluating the genome, transcriptome, and proteome. While papers reviewing individual aspects of frozen…”
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Perfusion and diffusion MRI signatures in histologic and genetic subtypes of WHO grade II–III diffuse gliomas by Leu, Kevin, Ott, Garrett A., Lai, Albert, Nghiemphu, Phioanh L., Pope, Whitney B., Yong, William H., Liau, Linda M., Cloughesy, Timothy F., Ellingson, Benjamin M.

“…The value of perfusion and diffusion-weighted MRI in differentiating histological subtypes according to the 2007 WHO glioma classification scheme (i.e…”
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2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling by Fu, Xudong, Chin, Randall M., Vergnes, Laurent, Hwang, Heejun, Deng, Gang, Xing, Yanpeng, Pai, Melody Y., Li, Sichen, Ta, Lisa, Fazlollahi, Farbod, Chen, Chuo, Prins, Robert M., Teitell, Michael A., Nathanson, David A., Lai, Albert, Faull, Kym F., Jiang, Meisheng, Clarke, Steven G., Cloughesy, Timothy F., Graeber, Thomas G., Braas, Daniel, Christofk, Heather R., Jung, Michael E., Reue, Karen, Huang, Jing

“…We discovered recently that the central metabolite α-ketoglutarate (α-KG) extends the lifespan of C. elegans through inhibition of ATP synthase and TOR…”
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Single-Cell Phosphoproteomics Resolves Adaptive Signaling Dynamics and Informs Targeted Combination Therapy in Glioblastoma by Wei, Wei, Shin, Young Shik, Xue, Min, Matsutani, Tomoo, Masui, Kenta, Yang, Huijun, Ikegami, Shiro, Gu, Yuchao, Herrmann, Ken, Johnson, Dazy, Ding, Xiangming, Hwang, Kiwook, Kim, Jungwoo, Zhou, Jian, Su, Yapeng, Li, Xinmin, Bonetti, Bruno, Chopra, Rajesh, James, C. David, Cavenee, Webster K., Cloughesy, Timothy F., Mischel, Paul S., Heath, James R., Gini, Beatrice

“…Intratumoral heterogeneity of signaling networks may contribute to targeted cancer therapy resistance, including in the highly lethal brain cancer glioblastoma…”
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Glucose-dependent acetylation of Rictor promotes targeted cancer therapy resistance by Masui, Kenta, Kazuhiro Tanaka, Shiro Ikegami, Genaro R. Villa, Huijun Yang, William H. Yong, Timothy F. Cloughesy, Kanato Yamagata, Nobutaka Arai, Webster K. Cavenee, Paul S. Mischel

“…Cancer cells adapt their signaling in response to nutrient availability. To uncover the mechanisms regulating this process and its functional consequences, we…”
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TLR agonists polarize interferon responses in conjunction with dendritic cell vaccination in malignant glioma: a randomized phase II Trial by Everson, Richard G., Hugo, Willy, Sun, Lu, Antonios, Joseph, Lee, Alexander, Ding, Lizhong, Bu, Melissa, Khattab, Sara, Chavez, Carolina, Billingslea-Yoon, Emma, Salazar, Andres, Ellingson, Benjamin M., Cloughesy, Timothy F., Liau, Linda M., Prins, Robert M.

“…In this randomized phase II clinical trial, we evaluated the effectiveness of adding the TLR agonists, poly-ICLC or resiquimod, to autologous tumor…”
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Platform trials arrive on time for glioblastoma by Alexander, Brian M, Cloughesy, Timothy F

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