Search Results - "CLOAREC, O"

Chemical mapping of the colorectal cancer microenvironment via MALDI imaging mass spectrometry (MALDI-MSI) reveals novel cancer-associated field effects by Mirnezami, R., Spagou, K., Vorkas, P.A., Lewis, M.R., Kinross, J., Want, E., Shion, H., Goldin, R.D., Darzi, A., Takats, Z., Holmes, E., Cloarec, O., Nicholson, J.K.

“…Matrix-assisted laser desorption ionisation imaging mass spectrometry (MALDI-MSI) is a rapidly advancing technique for intact tissue analysis that allows…”
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Probing Latent Biomarker Signatures and in Vivo Pathway Activity in Experimental Disease States via Statistical Total Correlation Spectroscopy (STOCSY) of Biofluids:  Application to HgCl2 Toxicity by Holmes, E, Cloarec, O, Nicholson, J. K

“…A new multivariate statistical approach, based on the novel combination of projection on latent structure analysis with an inbuilt orthogonal filter (OPLS-DA)…”
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Subtle metabolic and liver gene transcriptional changes underlie diet-induced fatty liver susceptibility in insulin-resistant mice by TOYE, A. A, DUMAS, M. E, BARTON, R. H, HOLMES, E, MCCARTHY, M. I, TATOUD, R, NICHOLSON, J. K, SCOTT, J, GAUGUIER, D, BLANCHER, C, ROTHWELL, A. R, FEARNSIDE, J. F, WILDER, S. P, BIHOREAU, M. T, CLOAREC, O, AZZOUZI, I, YOUNG, S

“…Complex changes in gene expression are associated with insulin resistance and non-alcoholic fatty liver disease (NAFLD) promoted by feeding a high-fat diet…”
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Colonization-induced host-gut microbial metabolic interaction by Claus, Sandrine P, Ellero, Sandrine L, Berger, Bernard, Krause, Lutz, Bruttin, Anne, Molina, Jérôme, Paris, Alain, Want, Elizabeth J, de Waziers, Isabelle, Cloarec, Olivier, Richards, Selena E, Wang, Yulan, Dumas, Marc-Emmanuel, Ross, Alastair, Rezzi, Serge, Kochhar, Sunil, Van Bladeren, Peter, Lindon, John C, Holmes, Elaine, Nicholson, Jeremy K

“…The gut microbiota enhances the host's metabolic capacity for processing nutrients and drugs and modulate the activities of multiple pathways in a variety of…”
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Improvement of UV spectrophotometry methodology for the determination of total polycyclic aromatic compounds in contaminated soils by Cloarec, O., Gonzalez, C., Touraud, E., Thomas, O.

“…Solid phase extraction (SPE) and UV spectrophotometry is used for the determination of polycyclic aromatic hydrocarbons in soils. A combination of aminopropyl…”
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Scaling and Normalization Effects in NMR Spectroscopic Metabonomic Data Sets by Craig, Andrew, Cloarec, Olivier, Holmes, Elaine, Nicholson, Jeremy K, Lindon, John C

“…Considerable confusion appears to exist in the metabonomics literature as to the real need for, and the role of, preprocessing the acquired spectroscopic data…”
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Pharmaco-metabonomic phenotyping and personalized drug treatment by Nicholson, Jeremy K, Andrew Clayton, T, Lindon, John C, Cloarec, Olivier, Antti, Henrik, Charuel, Claude, Hanton, Gilles, Provost, Jean-Pierre, Le Net, Jean-Loïc, Baker, David, Walley, Rosalind J, Everett, Jeremy R

“…There is a clear case for drug treatments to be selected according to the characteristics of an individual patient, in order to improve efficacy and reduce the…”
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Metabonomic Investigations in Mice Infected with Schistosoma mansoni: An Approach for Biomarker Identification by Wang, Yulan, Holmes, Elaine, Nicholson, Jeremy K., Cloarec, Olivier, Chollet, Jacques, Tanner, Marcel, Singer, Burton H., Utzinger, Jürg

“…Schistosomiasis, a chronic and debilitating parasitic disease, affects ≈200 million people in the developing world and imposes a substantial public health and…”
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Xenobiotic-Metabolizing Enzymes and Transporters in the Normal Human Brain: Regional and Cellular Mapping as a Basis for Putative Roles in Cerebral Function by Dutheil, Fabien, Dauchy, Sandrine, Diry, Monique, Sazdovitch, Véronique, Cloarec, Olivier, Mellottée, Lucille, Bièche, Ivan, Ingelman-Sundberg, Magnus, Flinois, Jean-Pierre, de Waziers, Isabelle, Beaune, Philippe, Declèves, Xavier, Duyckaerts, Charles, Loriot, Marie-Anne

“…Cytochrome P450 (P450) enzymes and ATP-binding cassette (ABC) transporters modulate the transport and metabolism of both endogenous and exogenous substrates…”
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Statistical Correlation and Projection Methods for Improved Information Recovery from Diffusion-Edited NMR Spectra of Biological Samples by Smith, Leon M, Maher, Anthony D, Cloarec, Olivier, Rantalainen, Mattias, Tang, Huiru, Elliott, Paul, Stamler, Jeremiah, Lindon, John C, Holmes, Elaine, Nicholson, Jeremy K

“…Although NMR spectroscopic techniques coupled with multivariate statistics can yield much useful information for classifying biological samples based on…”
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Probing Latent Biomarker Signatures and in Vivo Pathway Activity in Experimental Disease States via Statistical Total Correlation Spectroscopy (STOCSY) of Biofluids:  Application to HgCl 2 Toxicity by Holmes, E., Cloarec, O., Nicholson, J. K.

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Statistical Search Space Reduction and Two-Dimensional Data Display Approaches for UPLC−MS in Biomarker Discovery and Pathway Analysis by Crockford, Derek J, Lindon, John C, Cloarec, Olivier, Plumb, Robert S, Bruce, Stephen J, Zirah, Severine, Rainville, Paul, Stumpf, Chris L, Johnson, Kelly, Holmes, Elaine, Nicholson, Jeremy K

“…A new analytical strategy for biomarker recovery from directly coupled ultra-performance liquid chromatography time-of-flight mass spectrometry (UPLC Tof MS)…”
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Multivariate analysis of integrated and full-resolution 1H-NMR spectral data from complex pharmaceutical preparations: St. John's wort by Rasmussen, Bonnie, Cloarec, Olivier, Tang, Huiru, Staerk, Dan, Jaroszewski, Jerzy W

“…Commercial herbal preparations are typically very complex mixtures and the relationship between content of various constituents and pharmacological action of…”
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