Search Results - "CLIFFORD, Jeremiah J"

Exploratory and habituation phenotype of heterozygous and homozygous COMT knockout mice by Babovic, Daniela, O’Tuathaigh, Colm M., O'Sullivan, Gerard J., Clifford, Jeremiah J., Tighe, Orna, Croke, David T., Karayiorgou, Maria, Gogos, Joseph A., Cotter, David, Waddington, John L.

“…Catechol- O-methyltransferase (COMT) inactivates dopamine in prefrontal cortex and is associated clinically with a schizophrenia endophenotype. Using an…”
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Topographical assessment and pharmacological characterization of orofacial movements in mice: dopamine D1-like vs. D2-like receptor regulation by Tomiyama, Katsunori, McNamara, Fergal N, Clifford, Jeremiah J, Kinsella, Anthony, Koshikawa, Noriaki, Waddington, John L

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Susceptibility genes for schizophrenia: Characterisation of mutant mouse models at the level of phenotypic behaviour by O’Tuathaigh, Colm M.P., Babovic, Daniela, O’Meara, Gillian, Clifford, Jeremiah J., Croke, David T., Waddington, John L.

“…A wealth of evidence indicates that schizophrenia is heritable. However, the genetic mechanisms involved are poorly understood. Furthermore, it may be that…”
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Potential and limitations of genetic manipulation in animals by O'Sullivan, Gerard J., O’Tuathaigh, Colm M., Clifford, Jeremiah J., O’Meara, Gillian F., Croke, David T., Waddington, John L.

“…Over the last decade, sequencing and characterisation of the mouse genome has been accompanied by unparalleled advances in functional genomics. In the context…”
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Phenotypic Characterization of an α4 Neuronal Nicotinic Acetylcholine Receptor Subunit Knock-Out Mouse by Ross, Shelley A., Wong, John Y. F., Clifford, Jeremiah J., Kinsella, Anthony, Massalas, Jim S., Horne, Malcolm K., Scheffer, Ingrid E., Kola, Ismail, Waddington, John L., Berkovic, Samuel F., Drago, John

“…Neuronal nicotinic acetylcholine receptors (nAChR) are present in high abundance in the nervous system ( Decker et al., 1995 ). There are a large number of…”
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Topographically Based Search for an “Ethogram” Among a Series of Novel D4 Dopamine Receptor Agonists and Antagonists by Clifford, Jeremiah J, Waddington, John L

“…The effects of three selective D4 antagonists [CP-293,019, L-745,870, and Ro 61-6270] and two putative selective D4 agonists [CP-226,269 and PD 168077] were…”
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Comparative, Topographically-Based Evaluation of Behavioural Phenotype and Specification of D1-Like:D2 Interactions in a Line of Incipient Congenic Mice with D2 Dopamine Receptor ‘Knockout’ by Clifford, Jeremiah J, Kinsella, Anthony, Tighe, Orna, Rubinstein, Marcelo, Grandy, David K, Low, Malcolm J, Croke, David T, Waddington, John L

“…Phenotypes were assessed topographically in mice lacking functional D2 dopamine receptors [‘knockouts’], using an ethologically based approach to assess all…”
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The psychopharmacology-molecular biology interface: exploring the behavioural roles of dopamine receptor subtypes using targeted gene deletion (‘knockout’) by Waddington, John L., Clifford, Jeremiah J., McNamara, Fergal N., Tomiyama, Katsunori, Koshikawa, Noriaki, Croke, David T.

“…1. In the absence of selective agonists and antagonists able to discriminate between individual members of the D 1-like and D 2-like families of dopamine…”
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Heterogeneity of behavioural profile between three new putative selective D3 dopamine receptor antagonists using an ethologically based approach by CLIFFORD, J. J, WADDINGTON, J. L

“…The effects on behaviour of the putative selective D3 dopamine receptor antagonists GR 103691, nafadotride and U 99194A were compared with those of the generic…”
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Topographical Assessment of Ethological and Dopamine Receptor Agonist-Induced Behavioral Phenotype in Mutants with Congenic DARPP-32 'Knockout' by NALLY, Rachel E, MCNAMARA, Fergal N, CLIFFORD, Jeremiah J, KINSELLA, A, TIGHE, Orna, CROKE, David T, FIENBERG, Allen A, GREENGAR, Paul, WADDINGTON, John L

“…Congenic (10 backcrosses into C57BL/6J) mutants with targeted gene deletion of DARPP-32, a neuronal phosphoprotein regarded as an essential mediator of the…”
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Topographical evaluation of behavioural phenotype in a line of mice with targeted gene deletion of the D2 dopamine receptor by CLIFFORD, J. J, USIELLO, A, VALLONE, D, KINSELLA, A, BORRELLI, E, WADDINGTON, J. L

“…The phenotype of spontaneous and dopamine D2-like agonist-induced behaviour was assessed topographically in a line of mice with targeted gene deletion of the…”
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Essential conservation of D1 mutant phenotype at the level of individual topographies of behaviour in mice lacking both D1 and D3 dopamine receptors by WONG, John Y. F, CLIFFORD, Jeremiah J, MASSALAS, Jim S, KINSELLA, Anthony, WADDINGTON, John L, DRAGO, John

“…In the absence of agonists and antagonists evidencing appropriate selectivities, individual and interactive properties of D(1) and D(3) dopamine receptors…”
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Comparative phenotypic resolution of spontaneous, D2-like and D1-like agonist-induced orofacial movement topographies in congenic mutants with dopamine D2 vs. D3 receptor "knockout" by Tomiyama, Katsunori, Mcnamara, Fergal N., Clifford, Jeremiah J., Kinsella, Anthony, Drago, John, Fuchs, Sara, Grandy, David K., Low, Malcolm J., Rubinstein, Marcelo, Tighe, Orna, Croke, David T., Koshikawa, Noriaki, Waddington, John L.

“…Using a novel system, the role of D2‐like dopamine receptors in distinct topographies of orofacial movement was assessed in mutant mice with congenic D2 vs. D3…”
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Neurochemical changes in dopamine D1, D3 and D1/D3 receptor knockout mice by Wong, John Y.F, Clifford, Jeremiah J, Massalas, Jim S, Finkelstein, David I, Horne, Malcolm K, Waddington, John L, Drago, John

“…Neurochemical changes were examined in dopamine D1 receptor knockout (D1 −/−), dopamine D3 receptor knockout (D3 −/−) and dopamine D1/D3 receptor double…”
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Relationship of orofacial movements to behavioural repertoire as assessed topographically over the course of 6-month haloperidol treatment followed by 4-month withdrawal by DE SOUZA, Ian E. J, DAWSON, Niamh M, CLIFFORD, Jeremiah J, WADDINGTON, John L, MEREDITH, Gloria E

“…Late-onset vacuous chewing movements (VCMs) arise in a significant proportion of rats treated chronically with conventional antipsychotic drugs. Given their…”
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D1-Like Dopamine Receptor-Mediated Function in Congenic Mutants with D1 vs. D5 Receptor "Knockout" by O'Sullivan, Gerard J., Clifford, Jeremiah J., Tomiyama, Katsunori, Koshikawa, Noriaki, Drago, John, Sibley, David R., Croke, David T., Waddington, John L.

“…Current understanding of the functional roles of individual dopamine D1-like [D1, D5] and D2-like [D2L S, D3, D4] receptor subtypes remains incomplete. In…”
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Phenotypic Characterization of an alpha 4 Neuronal Nicotinic Acetylcholine Receptor Subunit Knock-Out Mouse by Ross, Shelley A, Wong, John Y. F, Clifford, Jeremiah J, Kinsella, Anthony, Massalas, Jim S, Horne, Malcolm K, Scheffer, Ingrid E, Kola, Ismail, Waddington, John L, Berkovic, Samuel F, Drago, John

“…Neuronal nicotinic acetylcholine receptors (nAChR) are present in high abundance in the nervous system (Decker et al., 1995). There are a large number of…”
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Susceptibility genes for schizophrenia : Characterisation of mutant mouse models at the level of phenotypic behaviour: Neurogenetics and behavior by O'TUATHAIGH, Colm M. P, BABOVIC, Daniela, O'MEARA, Gillian, CLIFFORD, Jeremiah J, CROKE, David T, WADDINGTON, John L

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Heterogeneity of behavioural profile between three new putative selective D 3 dopamine receptor antagonists using an ethologically based approach by Clifford, Jeremiah J., Waddington, J. L.

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Phenotypic, ethologically based resolution of spontaneous and D2-like vs D1-like agonist-induced behavioural topography in mice with congenic D3 dopamine receptor "knockout" by McNamara, Fergal N., Clifford, Jeremiah J., Tighe, Orna, Kinsella, Anthony, Drago, John, Fuchs, Sara, Croke, David T., Waddington, John L.

“…Uncertainty as to the functional role of the D3 dopamine receptor, due primarily to a paucity of selective agonists or antagonists, is being addressed in mice…”
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