Search Results - "CLIFFORD, A. A"

Neutrophils in acute inflammation: current concepts and translational implications by Margraf, Andreas, Lowell, Clifford A., Zarbock, Alexander

“…Modulation of neutrophil recruitment and function is crucial for targeting inflammatory cells to sites of infection to combat invading pathogens while, at the…”
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Triple‐Negative Breast Cancer: An Unmet Medical Need by Hudis, Clifford A., Gianni, Luca

“…Triple‐negative breast cancer, characterized by tumors that do not express estrogen receptor (ER), progesterone receptor (PR), or HER‐2 genes, represents an…”
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The probiotic paradox: live and dead cells are biological response modifiers by Adams, Clifford A.

“…Probiotics are usually defined as products which contain viable non-pathogenic micro-organisms able to confer health benefits to the host. There are specific…”
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Obesity and Cancer Mechanisms: Tumor Microenvironment and Inflammation by Iyengar, Neil M, Gucalp, Ayca, Dannenberg, Andrew J, Hudis, Clifford A

“…Purpose There is growing evidence that inflammation is a central and reversible mechanism through which obesity promotes cancer risk and progression. Methods…”
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The multifaceted functions of neutrophils by Mayadas, Tanya N, Cullere, Xavier, Lowell, Clifford A

“…Neutrophils and neutrophil-like cells are the major pathogen-fighting immune cells in organisms ranging from slime molds to mammals. Central to their function…”
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Cistrome Data Browser: expanded datasets and new tools for gene regulatory analysis by Zheng, Rongbin, Wan, Changxin, Mei, Shenglin, Qin, Qian, Wu, Qiu, Sun, Hanfei, Chen, Chen-Hao, Brown, Myles, Zhang, Xiaoyan, Meyer, Clifford A, Liu, X Shirley

“…Abstract The Cistrome Data Browser (DB) is a resource of human and mouse cis-regulatory information derived from ChIP-seq, DNase-seq and ATAC-seq chromatin…”
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Flashback Foreword: Preoperative Therapy for Operable Breast Cancer and Clinical Features of Triple-Negative Breast Cancer by Hudis, Clifford A

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Hyperuricemia reduces neutrophil function by Lowell, Clifford A.

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Ocean wave energy in the United States: Current status and future perspectives by Lehmann, Marcus, Karimpour, Farid, Goudey, Clifford A., Jacobson, Paul T., Alam, Mohammad-Reza

“…Ocean waves are a more predictable resource with a higher energy density compared to solar and wind. In addition, and specifically for the United States,…”
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Obesity and Cancer: Local and Systemic Mechanisms by Iyengar, Neil M, Hudis, Clifford A, Dannenberg, Andrew J

“…Obesity is a leading modifiable risk factor for the development of several epithelial malignancies. In addition to increasing risk, obesity also confers worse…”
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Cistrome Data Browser: a data portal for ChIP-Seq and chromatin accessibility data in human and mouse by Mei, Shenglin, Qin, Qian, Wu, Qiu, Sun, Hanfei, Zheng, Rongbin, Zang, Chongzhi, Zhu, Muyuan, Wu, Jiaxin, Shi, Xiaohui, Taing, Len, Liu, Tao, Brown, Myles, Meyer, Clifford A, Liu, X Shirley

“…Chromatin immunoprecipitation, DNase I hypersensitivity and transposase-accessibility assays combined with high-throughput sequencing enable the genome-wide…”
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Lisa: inferring transcriptional regulators through integrative modeling of public chromatin accessibility and ChIP-seq data by Qin, Qian, Fan, Jingyu, Zheng, Rongbin, Wan, Changxin, Mei, Shenglin, Wu, Qiu, Sun, Hanfei, Brown, Myles, Zhang, Jing, Meyer, Clifford A, Liu, X Shirley

“…We developed Lisa (http://lisa.cistrome.org/) to predict the transcriptional regulators (TRs) of differentially expressed or co-expressed gene sets. Based on…”
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The ins and outs of leukocyte integrin signaling by Abram, Clare L, Lowell, Clifford A

“…Integrins are the principal cell adhesion receptors that mediate leukocyte migration and activation in the immune system. These receptors signal…”
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Comparative analysis of the efficiency and specificity of myeloid-Cre deleting strains using ROSA-EYFP reporter mice by Abram, Clare L., Roberge, Gray L., Hu, Yongmei, Lowell, Clifford A.

“…Since the first example of conditional gene targeting in mice in 1994, the use of Cre recombinase and loxP flanked sequences has become an invaluable technique…”
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The Neutrophil Btk Signalosome Regulates Integrin Activation during Sterile Inflammation by Volmering, Stephanie, Block, Helena, Boras, Mark, Lowell, Clifford A., Zarbock, Alexander

“…Neutrophils are recruited from the blood to sites of sterile inflammation, where they are involved in wound healing but can also cause tissue damage. During…”
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Relief of tumor hypoxia unleashes the tumoricidal potential of neutrophils by Mahiddine, Karim, Blaisdell, Adam, Ma, Stephany, Créquer-Grandhomme, Amandine, Lowell, Clifford A, Erlebacher, Adrian

“…Polymorphonuclear neutrophils (PMNs) are increasingly recognized to influence solid tumor development, but why their effects are so context dependent and even…”
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Molecular Pathways: Adipose Inflammation as a Mediator of Obesity-Associated Cancer by HOWE, Louise R, SUBBARAMAIAH, Kotha, HUDIS, Clifford A, DANNENBERG, Andrew J

“…The increasing rate of obesity worldwide is predicted to be associated with a surge in diseases. Notably, obesity has been linked to approximately 20% of…”
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Shp1 function in myeloid cells by Abram, Clare L., Lowell, Clifford A.

“…Review on the role of Shp1, and how myeloid‐specific dysregulation may contribute to disease. The motheaten mouse was first described in 1975 as a model of…”
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Sequence determinants of improved CRISPR sgRNA design by Xu, Han, Xiao, Tengfei, Chen, Chen-Hao, Li, Wei, Meyer, Clifford A, Wu, Qiu, Wu, Di, Cong, Le, Zhang, Feng, Liu, Jun S, Brown, Myles, Liu, X Shirley

“…The CRISPR/Cas9 system has revolutionized mammalian somatic cell genetics. Genome-wide functional screens using CRISPR/Cas9-mediated knockout or dCas9…”
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Biology before Anatomy in Early Breast Cancer — Precisely the Point by Hudis, Clifford A

“…Building on a foundation of clinical and laboratory observations, translational research, broad collaborations, and global education, adjuvant therapy for…”
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