Search Results - "CLERMONT, Allen C"

Plasma Kallikrein-Kinin System as a VEGF-Independent Mediator of Diabetic Macular Edema by Kita, Takeshi, Clermont, Allen C, Murugesan, Nivetha, Zhou, Qunfang, Fujisawa, Kimihiko, Ishibashi, Tatsuro, Aiello, Lloyd Paul, Feener, Edward P

“…This study characterizes the kallikrein-kinin system in vitreous from individuals with diabetic macular edema (DME) and examines mechanisms contributing to…”
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Hyperglycemia-induced cerebral hematoma expansion is mediated by plasma kallikrein by Flaumenhaft, Robert, Clermont, Allen C, Gao, Ben-Bo, Blair, Price, Feener, Edward P, Liu, Jia, Sinha, Sukanto, Chilcote, Tamie J

“…Hyperglycemia is associated with greater hematoma expansion and poor clinical outcomes after intracerebral hemorrhage. We show that cerebral hematoma expansion…”
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Oral FXIIa inhibitor KV998086 suppresses FXIIa and single chain FXII mediated kallikrein kinin system activation by Clermont, Allen C, Murugesan, Nivetha, Edwards, Hannah J, Lee, Daniel K, Bayliss, Natasha P, Duckworth, Edward J, Pethen, Stephen J, Hampton, Sally L, Gailani, David, Feener, Edward P

“…The kallikrein kinin system (KKS) is an established pharmacological target for the treatment and prevention of attacks in hereditary angioedema (HAE)…”
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Reduction of Diabetes-Induced Oxidative Stress, Fibrotic Cytokine Expression, and Renal Dysfunction in Protein Kinase Cβ–Null Mice by OHSHIRO, Yuzuru, MA, Ronald C, YASUDA, Yutaka, HIRAOKA-YAMAMOTO, Junko, CLERMONT, Allen C, ISSHIKI, Keiji, YAGI, Kunimasa, ARIKAWA, Emi, KERN, Timothy S, KING, George L

“…Reduction of Diabetes-Induced Oxidative Stress, Fibrotic Cytokine Expression, and Renal Dysfunction in Protein Kinase Cβ–Null Mice Yuzuru Ohshiro 1 , Ronald C…”
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Plasma Kallikrein Mediates Angiotensin II Type 1 Receptor–Stimulated Retinal Vascular Permeability by Phipps, Joanna A, Clermont, Allen C, Sinha, Sukanto, Chilcote, Tamie J, Bursell, Sven-Erik, Feener, Edward P

“…Hypertension is a leading risk factor for the development and progression of diabetic retinopathy and contributes to a variety of other retinal diseases in the…”
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Activation of Vascular Protein Kinase C-β Inhibits Akt-Dependent Endothelial Nitric Oxide Synthase Function in Obesity-Associated Insulin Resistance by NARUSE, Keiko, RASK-MADSEN, Christian, JUNQING ZHANG, GOLDFINE, Allison B, KING, George L, TAKAHARA, Noriko, HA, Sung-Woo, SUZUMA, Kiyoshi, WAY, Kerrie J, JACOBS, Judith R. C, CLERMONT, Alien C, UEKI, Kohjiro, OHSHIRO, Yuzuru

“…Activation of Vascular Protein Kinase C-β Inhibits Akt-Dependent Endothelial Nitric Oxide Synthase Function in Obesity-Associated Insulin Resistance Keiko…”
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Plasma kallikrein mediates brain hemorrhage and edema caused by tissue plasminogen activator therapy in mice after stroke by Simão, Fabrício, Ustunkaya, Tuna, Clermont, Allen C., Feener, Edward P.

“…Thrombolytic therapy using tissue plasminogen activator (tPA) in acute stroke is associated with increased risks of cerebral hemorrhagic transformation and…”
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Retinal Blood Flow in Diabetes by Clermont, Allen C., Bursell, Sven-Erik

“…Objective: This is a review of work focused on characterizing retinal blood flow in diabetes. The review describes results on validation of the methodology for…”
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Vitreous Proteomics and Diabetic Retinopathy by Walia, Saloni, Clermont, Allen C., Gao, Ben-Bo, Aiello, Lloyd Paul, Feener, Edward P.

“…Diabetic retinopathy is the major cause of acquired blindness in working-age adults. Studies of the vitreous proteome have provided insights into the etiology…”
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PM2.5 induces vascular permeability increase through activating MAPK/ERK signaling pathway and ROS generation by Long, Yan-Min, Yang, Xue-Zhi, Yang, Qing-Qing, Clermont, Allen C., Yin, Yong-Guang, Liu, Guang-Liang, Hu, Li-Gang, Liu, Qian, Zhou, Qun-Fang, Liu, Qian S., Ma, Qian-Chi, Liu, Yu-Chen, Cai, Yong

“…[Display omitted] •Vascular permeability is increased upon in-vivo exposure of PM2.5.•The damaged endothelial integrity mediates the disorder of vascular…”
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Retinal proteome associated with bradykinin-induced edema by Murugesan, Nivetha, Fickweiler, Ward, Clermont, Allen C., Zhou, Qunfang, Feener, Edward P.

“…The plasma kallikrein-stimulated generation of bradykinin (BK) has been implicated in diabetic macular edema (DME). This study characterizes the effects of BK…”
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Vascular Endothelial Growth Factor and Severity of Nonproliferative Diabetic Retinopathy Mediate Retinal Hemodynamics In Vivo: A Potential Role for Vascular Endothelial Growth Factor in the Progression of Nonproliferative Diabetic Retinopathy by CLERMONT, ALLEN C., AIELLO, LLOYD PAUL, MORI, FUMIHIKO, AIELLO, LLOYD M., BURSELL, SVEN-ERIK

“…To determine the effect of vascular endothelial growth factor and retinopathy level on retinal hemodynamics in nondiabetic and diabetic rats and to evaluate…”
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Evaluating anesthetic protocols for functional blood flow imaging in the rat eye by Moult, Eric M, Choi, WooJhon, Boas, David A, Baumann, Bernhard, Clermont, Allen C, Feener, Edward P, Fujimoto, James G

“…The purpose of this study is to evaluate the suitability of five different anesthetic protocols (isoflurane, isoflurane-xylazine, pentobarbital,…”
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Iris Malformation and Anterior Segment Dysgenesis in Mice and Humans With a Mutation in PI 3-Kinase by Solheim, Marie H, Clermont, Allen C, Winnay, Jonathon N, Hallstensen, Erlend, Molven, Anders, Njølstad, Pål R, Rødahl, Eyvind, Kahn, C Ronald

“…To determine the ocular consequences of a dominant-negative mutation in the p85α subunit of phosphatidylinositol 3-kinase (PIK3R1) using a knock-in mouse model…”
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Plasma Kallikrein Contributes to Intracerebral Hemorrhage and Hypertension in Stroke-Prone Spontaneously Hypertensive Rats by Guan, Jian, Clermont, Allen C., Pham, Loc-Duyen, Ustunkaya, Tuna, Revenko, Alexey S., MacLeod, A. Robert, Feener, Edward P., Simão, Fabrício

“…Plasma kallikrein (PKa) has been implicated in contributing to hemorrhage following thrombolytic therapy; however, its role in spontaneous intracerebral…”
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Intraocular hemorrhage causes retinal vascular dysfunction via plasma kallikrein by Liu, Jia, Clermont, Allen C, Gao, Ben-Bo, Feener, Edward P

“…Retinal hemorrhages occur in a variety of sight-threatening conditions including ocular trauma, high altitude retinopathy, and chronic diseases such as…”
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Measurement of pulsatile total blood flow in the human and rat retina with ultrahigh speed spectral/Fourier domain OCT by Choi, Woojhon, Baumann, Bernhard, Liu, Jonathan J, Clermont, Allen C, Feener, Edward P, Duker, Jay S, Fujimoto, James G

“…We present an approach to measure pulsatile total retinal arterial blood flow in humans and rats using ultrahigh speed Doppler OCT. The axial blood velocity is…”
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Hyperinsulinemia Does Not Change Atherosclerosis Development in Apolipoprotein E Null Mice by Rask-Madsen, Christian, Buonomo, Erica, Li, Qian, Park, Kyoungmin, Clermont, Allen C, Yerokun, Oluwatobi, Rekhter, Mark, King, George L

“…OBJECTIVE—To determine the contribution of hyperinsulinemia to atherosclerosis development. METHODS AND RESULTS—Apolipoprotein E (Apoe) null mice that had…”
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Negatively charged silver nanoparticles cause retinal vascular permeability by activating plasma contact system and disrupting adherens junction by Long, Yan-Min, Zhao, Xing-Chen, Clermont, Allen C., Zhou, Qun-Fang, Liu, Qian, Feener, Edward P., Yan, Bing, Jiang, Gui-Bin

“…Silver nanoparticles (AgNPs) have been extensively used as antibacterial component in numerous healthcare, biomedical and consumer products. Therefore, their…”
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Decreased cardiac expression of vascular endothelial growth factor and its receptors in insulin-resistant and diabetic states: A possible explanation for impaired collateral formation in cardiac tissue by CHOU, Eva, SUZUMA, Izumi, KING, George L, WAY, Kerrie J, OPLAND, Darren, CLERMONT, Allen C, NARUSE, Keiko, SUZUMA, Kiyoshi, BOWLING, Nancy L, VLAHOS, Chris J, AIELLO, Lloyd Paul

“…Inadequate angiogenic response to ischemia in the myocardium of diabetic patients could result in poor collateral formation. Yet, excessive neovascularization…”
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